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81. 发明申请

US20130071868A1 MUTANT LACTATE OXIDASE WITH INCREASED STABILITY AND PRODUCT, METHODS AND USES INVOLVING THE SAME 有权
标题翻译：具有增加的稳定性和产品的突变性氧化剂，涉及其的方法和用途
公开(公告)号：US20130071868A1
公开(公告)日：2013-03-21
申请号：US13622209
申请日：2012-09-18
申请人： Stefan Leitgeb , Thomas Meier , Bernd Nidetzky , Bernhard Schaffar , Thomas Stoisser
发明人： Stefan Leitgeb , Thomas Meier , Bernd Nidetzky , Bernhard Schaffar , Thomas Stoisser
IPC分类号： C12N9/04 , G01N27/327 , C12N15/63 , G01N21/78 , C12Q1/26 , C12N15/53
CPC分类号： C12N9/0069
摘要： The present disclosure relates to a mutant lactate oxidase having increased stability, a nucleic acid encoding the mutant lactate oxidase, an expression vector comprising the nucleic acid, a host cell comprising the nucleic acid or the expression vector, a method of determining lactate in a sample, the use of the mutant lactate oxidase for determining lactate, a device for determining lactate in a sample using the mutant lactate oxidase and a kit for determining lactate comprising the mutant lactate oxidase.
摘要翻译：本公开涉及具有增加的稳定性的突变体乳酸氧化酶，编码突变型乳酸氧化酶的核酸，包含核酸的表达载体，包含核酸或表达载体的宿主细胞，测定样品中乳酸盐的方法，使用突变型乳酸氧化酶来测定乳酸盐，使用突变型乳酸氧化酶测定样品中乳酸盐的装置和用于测定包含突变型乳酸氧化酶的乳酸盐的试剂盒。

82. 发明授权

US08241389B2 Method and device for producing nitrogen fertilizer, removing phosphate from organic waste products, and limiting the potassium concentration 失效
标题翻译：生产氮肥的方法和装置，从有机废物中去除磷酸盐，限制钾的浓度
公开(公告)号：US08241389B2
公开(公告)日：2012-08-14
申请号：US11887341
申请日：2006-03-21
申请人： Herbert Spindler , Ute Bauermeister , Thomas Meier
发明人： Herbert Spindler , Ute Bauermeister , Thomas Meier
IPC分类号： C05C11/00
CPC分类号： C05B17/00 , C05C3/00 , C05F3/00 , C05F7/00 , Y02A40/205 , Y02A40/213 , Y02E50/343 , Y02P20/145 , Y02W30/47 , C05F3/06
摘要： The invention relates to a method and a device for producing nitrogen fertilizer, removing phosphate from organic waste products in liquid phase, sanitizing said waste or reducing emissions, and limiting the potassium concentration. According to the invention, the waste product is heated to temperatures ranging between 40 DEG C. at a subatmospheric pressure, the escaping gas that contains carbon dioxide and ammonia is contacted with a mineral-aqueous suspension, the excess gas is conducted within the circuit while the subatmospheric pressure is autogenously stabilized, and the formed nitrogen fertilizer is discharged. In order to additionally produce phosphate fertilizer and limit the potassium concentration, the obtained fertilizer product is divided into the liquid and solid portion, and all or some of the solid portion is redirected into the stripping receptacle while the liquid waste product that is stripped of nitrogen and compounds and phosphorus compounds is cooled and mixed with at least one sulfate-containing compound to limit the small amount of a basic mineral powder is added thereto. The last solid portion obtained from said treatment can be used directly as phosphate fertilizer, potassium fertilizer, or phosphate-containing and potassium-containing mixed fertilizer.
摘要翻译：本发明涉及一种生产氮肥的方法和装置，从液相中的有机废物中除去磷酸盐，消毒废物或减少排放物，并限制钾的浓度。根据本发明，将废物在低于大气压的压力下加热到40℃的温度，含有二氧化碳和氨的逸出气体与矿物 - 水悬浮液接触，过剩的气体在电路内传导，而低于大气压自动稳定，形成的氮肥排出。为了额外生产磷肥并限制钾浓度，将所得的肥料分为液体和固体部分，将全部或部分固体部分重新导入剥离容器，同时将脱氮液并将化合物和磷化合物冷却并与至少一种含硫酸盐化合物混合，以限制少量添加碱性矿物粉末。从所述处理得到的最后一个固体部分可以直接用作磷肥，钾肥或含磷酸钾和含钾混合肥料。

83. 发明授权

US08096581B2 Convertible motor vehicle with active rollover protection 有权
标题翻译：具有主动侧翻保护的敞篷车
公开(公告)号：US08096581B2
公开(公告)日：2012-01-17
申请号：US12516467
申请日：2007-09-18
申请人： Jan Gaertner , Thomas Meier , Juergen Schrader , Andreas Zygan
发明人： Jan Gaertner , Thomas Meier , Juergen Schrader , Andreas Zygan
IPC分类号： B60R21/13
CPC分类号： B60R21/13 , B60R2021/135
摘要： A convertible motor vehicle with at least two vehicle seating rows and with at least two side doors is provided. A respectively associated door column is arranged in between the doors, and an active rollover protection system is provided in the region thereof. The door columns end upwards in the region of an associated waistline of the motor vehicle, and the rollover protection system is at least substantially arranged below the waistline of the motor vehicle in a retracted position.
摘要翻译：提供具有至少两个车辆座椅排和至少两个侧门的可转换机动车辆。门之间布置有分别关联的门柱，并且在其区域中设置主动侧翻保护系统。门柱在机动车辆的相关腰围的区域中向上延伸，并且翻转保护系统至少基本上布置在机动车辆的腰围处于缩回位置。

84. 发明授权

US07972830B2 Thermostable Taq polymerase fragment 有权
标题翻译：热稳定性Taq聚合酶片段
公开(公告)号：US07972830B2
公开(公告)日：2011-07-05
申请号：US10917157
申请日：2004-08-12
申请人： Thomas Meier , Waltraud Ankenbauer , Annette Deufel , Dieter Heindl , Gisela Betzl , Rainer Schmuck , Bernd Schneidinger , Jessica Strey
发明人： Thomas Meier , Waltraud Ankenbauer , Annette Deufel , Dieter Heindl , Gisela Betzl , Rainer Schmuck , Bernd Schneidinger , Jessica Strey
IPC分类号： C12N9/12
CPC分类号： C12N9/1252
摘要： It was found that a fragment of native Thermus aquaticus DNA polymerase (TaqWT) lacking 288 N-terminal amino acids (TaqΔ288) possesses an increased thermostability over TaqWT, TaqΔ279, and TaqΔ289. The present invention therefore provides TaqΔ288, recombinant expression vectors encoding the same or derivatives thereof, as well as purification protocols for TaqΔ288. The invention also encompasses kits containing TaqΔ288 as well as the use of TaqΔ288 and kits containing TaqΔ288. In addition, the invention encompasses methods for the sequencing a nucleic acid template and methods for amplifying a target nucleic acid.
摘要翻译：发现缺乏288个N-末端氨基酸（Taq＆Dgr; 288）的天然的水生栖热菌水生DNA聚合酶（TaqWT）的片段具有比TaqWT，Taq＆Dgr; 279和Taq＆Dgr; 289增加的热稳定性。因此，本发明提供Taq＆Dgr; 288，编码其相同或衍生物的重组表达载体，以及Taq＆Dgr; 288的纯化方案。本发明还包括含有Taq＆Dgr; 288的试剂盒，以及使用Taq＆Dgr; 288和含有Taq＆Dgr; 288的试剂盒。此外，本发明包括用于测序核酸模板的方法和用于扩增靶核酸的方法。

85. 发明申请

US20100160269A1 Use of N-(dibenz(B,F)oxepin-10-ylmethyl)-N-methyl-N-prop-2-ynylamine or a pharmaceutically acceptable addition salt thereof for the prophylaxis and/or treatment of muscular dystrophy 有权
标题翻译： N-（二苯并（B，F）氧杂七环素-10-基甲基）-N-甲基-N-丙-2-炔胺或其药学上可接受的加成盐用于预防和/或治疗肌营养不良症
公开(公告)号：US20100160269A1
公开(公告)日：2010-06-24
申请号：US12063268
申请日：2006-08-22
申请人： Thomas Meier , Markus A. Ruegg
发明人： Thomas Meier , Markus A. Ruegg
IPC分类号： A61K31/335 , A61K31/56 , A61P21/00
CPC分类号： A61K31/335
摘要： The invention relates to the use of a compound of the formula (I) or a pharmaceutically acceptable addition salt thereof for the preparation of a medicament for the prophylaxis and/or treatment of muscular dystrophy.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的加成盐在制备用于预防和/或治疗肌营养不良症的药物中的用途。

86. 发明申请

US20100133799A1 Convertible Motor Vehicle With Active Rollover Protection 有权
标题翻译：具有主动翻转保护的敞篷车
公开(公告)号：US20100133799A1
公开(公告)日：2010-06-03
申请号：US12516467
申请日：2007-09-18
申请人： Jan Gaertner , Thomas Meier , Juergen Schrader , Andreas Zygan
发明人： Jan Gaertner , Thomas Meier , Juergen Schrader , Andreas Zygan
IPC分类号： B60R21/13 , B62D25/04
CPC分类号： B60R21/13 , B60R2021/135
摘要： A convertible motor vehicle with at least two vehicle seating rows and with at least two side doors is provided. A respectively associated door column is arranged in between the doors, and an active rollover protection system is provided in the region thereof. The door columns end upwards in the region of an associated waistline of the motor vehicle, and the rollover protection system is at least substantially arranged below the waistline of the motor vehicle in a retracted position.
摘要翻译：提供具有至少两个车辆座椅排和至少两个侧门的可转换机动车辆。门之间布置有分别关联的门柱，并且在其区域中设置主动侧翻保护系统。门柱在机动车辆的相关腰围的区域中向上延伸，并且翻转保护系统至少基本上布置在机动车辆的腰围处于缩回位置。

87. 发明申请

US20090176867A1 USE OF N-(DIBENZ(B,F)OXEPIN-10-YLMETHYL)-N-METHYL-N-PROP-2-YNYLAMINE OR A PHARMACEUTICALLY ACCEPTABLE ADDITION SALT THEREOF FOR THE PROPHYLAXIS AND/OR TREATMENT OF CONGENITAL MUSCULAR DYSTROPHY OR MYOPATHY RESULTING FROM COLLAGEN VI DEFICIENCY 有权
标题翻译： N-（二苯甲基（B，F）OXEPIN-10-YLMETHYL）-N-甲基-N-丙-2-炔基胺或其药物可接受的添加盐用于预防和/或治疗浓缩性乳腺癌或MYOPATHY RESULTING的用途从COLLAGEN VI缺陷
公开(公告)号：US20090176867A1
公开(公告)日：2009-07-09
申请号：US12295801
申请日：2007-04-04
申请人： Thomas Meier
发明人： Thomas Meier
IPC分类号： A61K31/335 , C07D313/12
CPC分类号： A61K31/335
摘要： The invention relates to the use of a compound of the formula (I) or a pharmaceutically acceptable addition salt thereof for the preparation of a medicament for the prophylaxis and/or treatment of muscular dystrophies or myopathies resulting from mutations in genes encoding for collagen VI.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的加成盐在制备用于预防和/或治疗由编码胶原VI的基因突变导致的肌营养不良或肌病的药物中的用途。

88. 发明申请

US20090078013A1 Method and Device for Producing Nitrogen Fertilizer, Removing Phosphate From Organic Waste Products, and Limiting the Potassium Concentration 失效
标题翻译：生产氮肥的方法和装置，从有机废物中除去磷酸盐，限制钾浓度
公开(公告)号：US20090078013A1
公开(公告)日：2009-03-26
申请号：US11887341
申请日：2006-03-21
申请人： Herbert Spindler , Ute Bauermeister , Thomas Meier
发明人： Herbert Spindler , Ute Bauermeister , Thomas Meier
IPC分类号： C05F11/00 , B01J19/00
CPC分类号： C05B17/00 , C05C3/00 , C05F3/00 , C05F7/00 , Y02A40/205 , Y02A40/213 , Y02E50/343 , Y02P20/145 , Y02W30/47 , C05F3/06
摘要： The invention relates to a method and a device for producing nitrogen fertilizer, removing phosphate from organic waste products in liquid phase, sanitizing said waste or reducing emissions, and limiting the potassium concentration. According to the invention, the waste product is heated to temperatures ranging between 40° C. and 90° C. at a subatmospheric pressure, the escaping gas that contains carbon dioxide and ammonia is contacted with a mineral-aqueous suspension, the excess gas is conducted within the circuit while the subatmospheric pressure is autogenously stabilized, and the formed nitrogen fertilizer is discharged. In order to additionally produce phosphate fertilizer and limit the potassium concentration, the obtained fertilizer product is divided into the liquid and solid portion, and all or some of the solid portion is redirected into the stripping receptacle while the liquid waste product that is stripped of nitrogen compounds and phosphorus compounds is cooled and mixed with at least one sulfate-containing compound to limit the potassium concentration. Optionally, the viscosity of the waste product is specifically reduced and a very small amount of a basic mineral powder is added thereto. The last solid portion obtained from said treatment can be used directly as phosphate fertilizer, potassium fertilizer, or phosphate-containing and potassium-containing mixed fertilizer.
摘要翻译：本发明涉及一种生产氮肥的方法和装置，从液相中的有机废物中除去磷酸盐，消毒废物或减少排放物，并限制钾的浓度。根据本发明，将废物在低于大气压下加热至40℃至90℃的温度，将含有二氧化碳和氨的逸出气体与矿物水悬浮液接触，过量气体为在电路内进行，同时低于大气压自动稳定，并且形成的氮肥被排出。为了额外生产磷肥并限制钾浓度，将所得的肥料分为液体和固体部分，将全部或部分固体部分重新导入剥离容器，同时将脱氮液将化合物和磷化合物冷却并与至少一种含硫酸盐化合物混合以限制钾浓度。任选地，废物的粘度被明确地减少，并且向其中加入极少量的碱性矿物粉末。从所述处理得到的最后一个固体部分可以直接用作磷肥，钾肥或含磷酸钾和含钾混合肥料。

89. 发明申请

US20080016670A1 Flow forming connection of metallic parts and resultant part assembly 审中-公开
标题翻译：金属部件和合成部件组件的流动连接
公开(公告)号：US20080016670A1
公开(公告)日：2008-01-24
申请号：US11488959
申请日：2006-07-19
申请人： Thomas Meier
发明人： Thomas Meier
IPC分类号： B21D39/00 , B21D22/00
CPC分类号： B21D22/14 , B21D39/04 , Y10T29/49913
摘要： A method and apparatus (10) provide a flow formed part assembly (12) having mechanically interlocked first and second metallic parts (22) and (24).
摘要翻译：一种方法和装置（10）提供具有机械互锁的第一和第二金属部件（22）和（24）的流动形成部件组件（12）。

90. 发明授权

US07140667B2 Body structure for a vehicle particularly a passenger car 有权
标题翻译：车身结构特别是客车
公开(公告)号：US07140667B2
公开(公告)日：2006-11-28
申请号：US10606148
申请日：2003-06-26
申请人： Dieter Steinhauser , Thomas Meier
发明人： Dieter Steinhauser , Thomas Meier
IPC分类号： B62D29/04 , B60R21/13
CPC分类号： B60R21/13 , B60R2021/132 , B62D29/04 , B62D29/041
摘要： For optimizing a body structure for a passenger car in the area of the vehicle occupant compartment and of the rollover bar device arranged behind the occupant seats, specifically with respect to a high stability under load, low weight and economical manufacturing, a wall structure of the vehicle occupant compartment extending adjacent to the vehicle occupant seats and the rollover bar device consisting of a high-strength non-metallic material, such as a fiber-reinforced plastic material, e.g., CKF, and being constructionally inseparably combined.
摘要翻译：为了优化乘客车体在车辆乘员舱区域和布置在乘员座椅后方的翻车杆装置的车体结构，具体地说，相对于在负载下的高稳定性，低重量和经济的制造，壁结构车辆乘员舱与车辆乘员座椅相邻延伸，以及由高强度非金属材料如纤维增强塑料材料（例如CKF）组成的翻车杆装置，并且在结构上不可分割地组合。

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