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81. 发明授权

US6131458A Ultrasonic imaging aberration correction system and method 有权
标题翻译：超声成像像差校正系统及方法
公开(公告)号：US6131458A
公开(公告)日：2000-10-17
申请号：US383518
申请日：1999-08-26
申请人： Donald R. Langdon , Gregory L. Holley , John A. Hossack , Pai-Chi Li
发明人： Donald R. Langdon , Gregory L. Holley , John A. Hossack , Pai-Chi Li
IPC分类号： G01N29/06 , G01N29/34 , G01N29/42 , G01S7/52 , G01S15/89 , G01N29/00 , A61B8/00
CPC分类号： G01S15/895 , G01N29/06 , G01N29/348 , G01N29/42 , G01S15/8963 , G01S7/52038 , G01S7/52049 , G01S7/52095 , G01S7/52066 , G01S7/52071
摘要： An ultrasonic imaging system including an aberration correction system uses a harmonic component of the fundamental transmitted frequency for imaging, or for aberration correction, or booth. By properly selecting the frequency pass bands, of filters used in the image signal path and in the aberration correction signal path operating advantages are provided. The aberration correction values may be calculated concurrently with image formation.
摘要翻译：包括像差校正系统的超声波成像系统使用基波传播频率的谐波分量进行成像，或用于像差校正或展位。通过适当地选择频带，提供了在图像信号路径中使用的滤波器和像差校正信号路径操作优点。像差校正值可以与图像形成同时计算。

82. 发明授权

US6116244A Ultrasonic system and method for three-dimensional imaging with opacity control 失效
标题翻译：超声系统和不透明度控制三维成像方法
公开(公告)号：US6116244A
公开(公告)日：2000-09-12
申请号：US89468
申请日：1998-06-02
申请人： John A. Hossack , Ismayil M. Guracar , Joan C. Main
发明人： John A. Hossack , Ismayil M. Guracar , Joan C. Main
IPC分类号： G01S7/52 , G01S15/89 , A61B8/00
CPC分类号： G01S7/52071 , A61B8/483 , G01S15/8979 , G01S15/8993 , G01S7/52034
摘要： A method and system for generating three-dimensional representations using opacity modulation are provided. The opacity level associated with each datum in a 3D volume data set is controlled as a function of at least one Doppler parameter, such as variance. Areas of high variance are assigned a higher level of opacity than areas of low variance. For a Doppler velocity image, velocities associated with high variance are displayed more opaquely than velocities associated with low variance, thereby emphasizing the more opaque regions. The more transparent velocities (i.e., those associated with low variance) still contribute to the image and are displayed. Other Doppler parameters may be used for the image, such as energy, tissue motion or variance. Furthermore, other Doppler parameters may be used to control the opacity, such as velocity, energy or tissue motion.
摘要翻译：提供了使用不透明度调制产生三维表示的方法和系统。与3D体数据集中的每个数据相关联的不透明度水平被控制为至少一个多普勒参数（诸如方差）的函数。高度差异的区域被赋予比低方差区域更高的不透明度水平。对于多普勒速度图像，与高方差相关联的速度比不稳定的速度更不透明地显示，从而强调更不透明的区域。更透明的速度（即与低方差相关的速度）仍然有助于图像并被显示。其他多普勒参数可用于图像，如能量，组织运动或方差。此外，可以使用其他多普勒参数来控制不透明度，例如速度，能量或组织运动。

83. 发明授权

US6108273A Transmit beamformer with frequency dependent focus 有权
标题翻译：发射波束形成器具有频率依赖关系
公开(公告)号：US6108273A
公开(公告)日：2000-08-22
申请号：US366110
申请日：1999-08-02
申请人： John A. Hossack , Jian-Hua Mo , Christopher R. Cole
发明人： John A. Hossack , Jian-Hua Mo , Christopher R. Cole
IPC分类号： G01N29/24 , G01N29/26 , G01N29/34 , G01N29/40 , G01N29/42 , G01N29/46 , G01S7/52 , G01S15/89 , G10K11/34 , G03B42/06
CPC分类号： G01N29/343 , G01N29/2456 , G01N29/2462 , G01N29/262 , G01N29/348 , G01N29/40 , G01N29/42 , G01N29/46 , G01S15/8909 , G01S15/895 , G01S7/52034 , G01S7/52036 , G01S7/52038 , G01S7/52039 , G01S7/52046 , G01S7/52047 , G10K11/341 , G10K11/343 , G01N2291/012 , G01N2291/015 , G01N2291/106
摘要： A transmit beamformer includes multiple transducers, each responsive to a respective transmit waveform to produce a respective transducer waveform. A transmit waveform generator generates the transmit waveforms, and the transmit waveform each include multiple frequency components. Progressively higher frequency components of the transmit waveform are timed to cause corresponding progressively higher frequency components of the transducer waveforms to focus along a line at progressively shorter ranges. In this way, a frequency dependent line focus is achieved.
摘要翻译：发射波束形成器包括多个换能器，每个换能器响应相应的发射波形以产生相应的换能器波形。发送波形发生器产生发送波形，并且发送波形各自包括多个频率分量。发射波形的逐渐更高的频率分量被定时，以使得相应的逐渐更高的频率分量的换能器波形在逐渐缩小的范围内沿着一条线聚焦。以这种方式，实现了频率相关的线焦点。

84. 发明授权

US6014473A Multiple ultrasound image registration system, method and transducer 失效
公开(公告)号：US6014473A
公开(公告)日：2000-01-11
申请号：US916585
申请日：1997-08-22
申请人： John A. Hossack , John W. Sliwa, Jr. , Samuel H. Maslak , Edward A. Gardner , Gregory L. Holley , David J. Napolitano
发明人： John A. Hossack , John W. Sliwa, Jr. , Samuel H. Maslak , Edward A. Gardner , Gregory L. Holley , David J. Napolitano
IPC分类号： A61B8/00 , G01S7/52 , G01S15/66 , G01S15/87 , G01S15/89 , G06T7/20 , G06K9/32
CPC分类号： A61B8/145 , A61B8/483 , G01S15/8934 , G01S15/8979 , G01S15/8993 , G01S7/52085 , G06T7/2033 , G01S15/66 , G01S15/87 , G01S7/52034 , G01S7/52065 , G01S7/52071
摘要： An ultrasonic imaging system includes an ultrasonic transducer having an image data array and a tracking array at each end of the image data array. The tracking arrays are oriented transversely to the image data array. Images from the image data array are used to reconstruct a three-dimensional representation of the target. The relative movement between respective frames of the image data is automatically estimated by a motion estimator, based on frames of data from the tracking arrays. As the transducer is rotated about the azimuthal axis of the image data array, features of the target remain within the image planes of the tracking arrays. Movements of these features in the image planes of the tracking arrays are used to estimate motion as required for the three-dimensional reconstruction. Similar techniques estimate motion within the plane of an image to create an extended field of view.

85. 发明授权

US5957852A Ultrasonic harmonic imaging system and method 失效
标题翻译：超声波谐波成像系统及方法
公开(公告)号：US5957852A
公开(公告)日：1999-09-28
申请号：US089463
申请日：1998-06-02
申请人： John A. Hossack , Samuel H. Maslak , Christopher R. Cole
发明人： John A. Hossack , Samuel H. Maslak , Christopher R. Cole
IPC分类号： G01S7/52 , G01S15/89 , A61B8/00
CPC分类号： G01S15/895 , G01S7/52026 , G01S7/52038 , G01S7/52046
摘要： The system described ultrasonically images a target with energy spreading transmissions. Generally, ultrasonic energy corresponding to a line focus is transmitted into a target at a fundamental center frequency. The target may or may not include contrast agents. In either case, echoes are received at a harmonic of the fundamental center frequency. Echoes are also received at the fundamental center frequency. The echoes received at the harmonic center frequency are efficiently compounding with the echoes received at the fundamental center frequency.
摘要翻译：所描述的系统用能量扩散传播超声地对目标进行成像。通常，对应于线焦点的超声能量以基本中心频率发送到目标。靶标可能包含也可能不包括造影剂。在任一种情况下，以基波中心频率的谐波接收回波。回波也被接收在基本的中心频率。在谐波中心频率处接收到的回波与基波中心频率处接收的回波有效地混合。

86. 发明授权

US5769079A Method and apparatus for determining quantitative measures of flow parameters 失效
标题翻译：用于确定流量参数的定量测量的方法和装置
公开(公告)号：US5769079A
公开(公告)日：1998-06-23
申请号：US736048
申请日：1996-10-22
申请人： John A. Hossack
发明人： John A. Hossack
IPC分类号： A61B8/06 , A61B8/00
CPC分类号： A61B8/06 , A61B8/13 , A61B8/145 , G01S15/8915 , G01S15/8984
摘要： A method for making Doppler ultrasound measurements utilizes an ultrasound probe having two transducer arrays oriented at right angles to one another and spaced apart from one another. The first array is used to measure multiple apparent Doppler parameters such as velocity at respective regions within a cross section of a structure such as a blood vessel. The second array is used to measure second apparent Doppler parameters at one of these regions. The first and second apparent Doppler parameters for the same point are used to correct the first apparent Doppler parameters to more nearly equal true velocity or energy.
摘要翻译：用于制造多普勒超声测量的方法利用具有彼此成直角定向并且彼此间隔开的两个换能器阵列的超声波探头。第一阵列用于测量多个表观多普勒参数，例如在诸如血管的结构的横截面内的相应区域处的速度。第二阵列用于测量其中一个区域的第二表观多普勒参数。用于相同点的第一和第二表观多普勒参数用于校正第一表观多普勒参数以更接近相等的真实速度或能量。

87. 发明授权

US5608690A Transmit beamformer with frequency dependent focus 失效
公开(公告)号：US5608690A
公开(公告)日：1997-03-04
申请号：US397833
申请日：1995-03-02
申请人： John A. Hossack , Jian-Hua Mo , Christopher R. Cole
发明人： John A. Hossack , Jian-Hua Mo , Christopher R. Cole
IPC分类号： G01N29/24 , G01N29/26 , G01N29/34 , G01N29/40 , G01N29/42 , G01N29/46 , G01S7/52 , G01S15/89 , G10K11/34 , H04B1/02
CPC分类号： G01N29/343 , G01N29/2456 , G01N29/2462 , G01N29/262 , G01N29/348 , G01N29/40 , G01N29/42 , G01N29/46 , G01S15/8909 , G01S15/895 , G01S7/52034 , G01S7/52036 , G01S7/52038 , G01S7/52039 , G01S7/52046 , G01S7/52047 , G10K11/341 , G10K11/343 , G01N2291/012 , G01N2291/015 , G01N2291/106
摘要： A transmit beamformer includes multiple transducers, each responsive to a respective transmit waveform to produce a respective transducer waveform. A transmit waveform generator generates the transmit waveforms, and the transmit waveforms each include multiple frequency components. Progressively higher frequency components of the transmit waveforms are timed to cause corresponding progressively higher frequency components of the transducer waveforms to focus along a line at progressively shorter ranges. In this way, a frequency dependent line focus is achieved.

88. 发明授权

US09002080B2 Singular value filter for imaging or detection 有权
标题翻译：用于成像或检测的奇异值滤波器
公开(公告)号：US09002080B2
公开(公告)日：2015-04-07
申请号：US13650821
申请日：2012-10-12
申请人： F. William Mauldin, Jr. , John A. Hossack , Abhay V. Patil
发明人： F. William Mauldin, Jr. , John A. Hossack , Abhay V. Patil
IPC分类号： G06K9/00 , G06K9/62 , A61B8/08
CPC分类号： G06K9/6247 , A61B8/0891 , A61B8/481 , A61B8/485 , A61B8/5207 , G01S7/52039 , G01S7/52041 , G01S7/52042 , G01S7/52046 , G01S15/8915 , G01S15/8981
摘要： Apparatus or techniques can include obtaining information indicative of energy, such as ultrasonic energy, reflected from a tissue region, forming respective input matrices representative of the obtained information, the input matrices respectively comprising an ensemble-of-interest and at least one ensemble corresponding to a spatial location nearby a spatial location corresponding to the ensemble-of-interest, performing respective singular value decompositions on the respective input matrices to obtain respective sets of singular values corresponding to respective sets of singular vectors, obtaining respective output matrices including weighting a respective projection of a respective ensemble-of-interest onto at least one of the singular vectors included in a respective set of singular vectors, and, using the respective output matrices, at least one of determining a characteristic, or constructing an image, of at least a portion of the tissue region.
摘要翻译：设备或技术可以包括获得指示诸如超声波能量的信息的信息，例如从组织区域反射，形成表示所获得信息的相应输入矩阵，输入矩阵分别包括感兴趣集合和至少一个对应于相邻于感兴趣集合的空间位置附近的空间位置，在各个输入矩阵上执行各自的奇异值分解，以获得对应于各组奇异矢量的各组奇异值，获得各自的输出矩阵，包括对相应投影加权将相关的感兴趣整体集合到包含在相应的一组奇异矢量中的奇异矢量中的至少一个，并且使用相应的输出矩阵，确定至少一个部分组织区域。

89. 发明申请

US20120209116A1 Systems and Methods for Ultrasound Imaging and Insonation of Microbubbles 有权
标题翻译：超声成像和微泡绝育的系统和方法
公开(公告)号：US20120209116A1
公开(公告)日：2012-08-16
申请号：US13386391
申请日：2010-07-21
申请人： John A. Hossack , Brian R. Wamhoff , Alexander L. Klibanov , Johnny Chen , Brent A. French
发明人： John A. Hossack , Brian R. Wamhoff , Alexander L. Klibanov , Johnny Chen , Brent A. French
IPC分类号： A61M37/00 , A61K49/22 , A61B8/00
CPC分类号： A61M37/0092 , A61B5/7285 , A61B6/503 , A61B6/504 , A61B6/541 , A61B8/06 , A61B8/0891 , A61B8/12 , A61B8/445 , A61B8/481 , A61B8/543 , A61B17/22 , A61B17/22004 , A61B17/2202 , A61B2017/00893 , A61B2017/22021 , A61B2017/22054 , A61B2017/22067 , A61B2017/22088 , A61B2017/22089 , A61B2090/3735 , A61B2090/3784 , A61M25/00 , A61M25/0082 , A61M25/10 , A61M37/00 , A61M2025/0073 , A61M2025/1052 , A61N7/00 , A61N2007/0039 , A61N2007/0043
摘要： A catheter system including an elongate tubular member having a proximal end portion, a distal end portion and a lumen extending through at least a portion of a length of the elongate tubular member. The distal end portion of the elongate member is dimensioned and adapted to advance to or in proximity to a treatment site of a subject. A microbubble device is in fluid communication with the lumen. The microbubble device includes at least one input port for receiving a flow of material into the device and an output port configured to output microbubbles from the microbubble device. A second tubular member is in fluid communication with one of the at least one input ports. A pressure fitting arrangement is adapted to maintain a seal between the second tubular member and the input port.
摘要翻译：导管系统，其包括细长管状构件，其具有近端部分，远端部分和延伸穿过细长管状构件的长度的至少一部分的内腔。细长构件的远端部分的尺寸和尺寸适于前进到或接近受试者的治疗部位。微泡装置与内腔流体连通。微泡装置包括至少一个用于接收材料流入装置的输入端口和配置成从微泡装置输出微气泡的输出端口。第二管状构件与所述至少一个输入端口中的一个流体连通。压力配合装置适于在第二管状构件和输入端口之间保持密封。

90. 发明申请

US20100331686A1 System for Treatment and Imaging Using Ultrasonic Energy and Microbubbles and Related Method Thereof 有权
标题翻译：超声波和微泡治疗和成像系统及其相关方法
公开(公告)号：US20100331686A1
公开(公告)日：2010-12-30
申请号：US12739128
申请日：2008-10-24
申请人： John A. Hossack , Brian R. Wamhoff , Alexander L. Klibanov
发明人： John A. Hossack , Brian R. Wamhoff , Alexander L. Klibanov
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61N7/00 , A61B8/12 , A61B8/445 , A61B8/481 , A61B17/2202 , A61B2017/22088 , A61B2017/22089 , A61B2090/3782 , A61K41/0028 , A61K49/223 , A61M37/0092
摘要： A method and related system for providing therapy to a treatment site, such as stenosis or other vasculature disease, at one or more locations of a subject, such as the vasculature. The method includes: advancing an ultrasound catheter to or in proximity to the subject's treatment site; infusing microbubbles into or proximal to the treatment site; and delivering ultrasonic energy from the ultrasound catheter. The ultrasonic energy may be adapted for: imaging the treatment site, translating the microbubbles into or in the vicinity of the treatment site and/or rupturing the microbubbles.
摘要翻译：用于在受试者的一个或多个位置（例如脉管系统）向治疗部位提供治疗的方法和相关系统，例如狭窄或其它脉管系统疾病。该方法包括：将超声导管推进到受试者的治疗部位或其附近; 将微泡注入或接近治疗部位; 并从超声导管输送超声波能量。超声波能量可以适于：对治疗部位进行成像，将微泡翻译成治疗部位或其附近和/或破裂微泡。

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