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81. 发明授权

US08560072B2 System for neural control of respiration 有权
标题翻译：呼吸神经控制系统
公开(公告)号：US08560072B2
公开(公告)日：2013-10-15
申请号：US13596595
申请日：2012-08-28
申请人： Anthony V. Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
发明人： Anthony V. Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
IPC分类号： A61N1/18
CPC分类号： A61N1/3601 , A61N1/36114
摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.
摘要翻译：提供了一种用于呼吸神经控制的系统，装置和方法。本公开的一个方面涉及用于在中枢呼吸系统疾病发作期间感测和控制呼吸的可植入医疗装置。根据各种实施例，该装置包括感测电路，用于接收代表中枢呼吸系统疾病发生率的感测信号。该装置还包括适于产生神经刺激信号的神经刺激器，以及响应于检测到中枢性呼吸系统疾病发生率而控制器与感测电路通信并控制神经刺激器以刺激所需神经靶标。在一个实施例中，该装置包括多个传感器，其适于监测生理参数以检测中枢性呼吸系统疾病的发生并向感测电路发送信号。本文提供了其它方面和实施例。

82. 发明授权

US08554323B2 Method and apparatus for neural stimulation with respiratory feedback 有权
标题翻译：呼吸反馈神经刺激的方法和装置
公开(公告)号：US08554323B2
公开(公告)日：2013-10-08
申请号：US13363198
申请日：2012-01-31
申请人： Paul A. Haefner , Kristofer J. James , Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu
发明人： Paul A. Haefner , Kristofer J. James , Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu
IPC分类号： A61N1/365
CPC分类号： A61N1/36053 , A61B5/08 , A61B5/4035 , A61B5/4818 , A61N1/3601 , A61N1/36114
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔将神经刺激脉冲的传送同步到呼吸周期。在另一个实施例中，神经刺激系统检测呼吸障碍，并且作为响应调整神经刺激脉冲的递送和/或递送治疗所检测的呼吸障碍的呼吸治疗。

83. 发明申请

US20130202126A1 HEADPHONES ACTIVATED BY ROTATION OF AN EAR CUP 审中-公开
标题翻译：通过旋转杯子激活的耳机
公开(公告)号：US20130202126A1
公开(公告)日：2013-08-08
申请号：US13368837
申请日：2012-02-08
申请人： Jinsaun Chen , Kent Lee , Tzu Chun Liang
发明人： Jinsaun Chen , Kent Lee , Tzu Chun Liang
IPC分类号： H04R1/10
CPC分类号： H04R1/1041 , H04R1/1066 , H04R2460/03
摘要： Headphones having an ear cup rotatable from a first rest position to a second on position which functions to automatically activate a switch assembly to connect to a power source provided in the headphones. When the ear cup is moved from the first position to the second position, a movable post moves to operate a tactile switch provided in a circuit containing the power source. When the ear cup is moved from the second position to the first position, the circuit including the power source is open and the headphones no longer operate, thereby prolonging the life of the power source. A spring is associated with the ear cup to automatically return that ear cup to the first position when the headphones are removed from the head of a user.
摘要翻译：具有可从第一静止位置旋转到第二开位置的耳罩的耳机，其功能是自动启动开关组件以连接到设置在耳机中的电源。当耳罩从第一位置移动到第二位置时，可动支柱移动以操作设置在包含电源的电路中的触觉开关。当耳罩从第二位置移动到第一位置时，包括电源的电路是断开的，并且耳机不再操作，从而延长了电源的使用寿命。当耳机从用户的头部移除时，弹簧与耳罩相关联以自动地将该耳罩返回到第一位置。

84. 发明申请

US20120323292A1 SYSTEM FOR NEURAL CONTROL OF RESPIRATION 有权
标题翻译：神经控制系统
公开(公告)号：US20120323292A1
公开(公告)日：2012-12-20
申请号：US13596595
申请日：2012-08-28
申请人： Anthony Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
发明人： Anthony Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/36114
摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.
摘要翻译：提供了一种用于呼吸神经控制的系统，装置和方法。本公开的一个方面涉及用于在中枢呼吸系统疾病发作期间感测和控制呼吸的可植入医疗装置。根据各种实施例，该装置包括感测电路，用于接收代表中枢呼吸系统疾病发生率的感测信号。该装置还包括适于产生神经刺激信号的神经刺激器，以及响应于检测到中枢性呼吸系统疾病发生率而控制器与感测电路通信并控制神经刺激器以刺激所需神经靶标。在一个实施例中，该装置包括多个传感器，其适于监测生理参数以检测中枢性呼吸系统疾病的发生并向感测电路发送信号。本文提供了其它方面和实施例。

85. 发明授权

US08323204B2 Medical event logbook system and method 有权
标题翻译：医疗事件日志系统和方法
公开(公告)号：US08323204B2
公开(公告)日：2012-12-04
申请号：US12403880
申请日：2009-03-13
申请人： Jeffrey E. Stahmann , John D. Hatlestad , Jesse W. Hartley , Quan Ni , Kent Lee
发明人： Jeffrey E. Stahmann , John D. Hatlestad , Jesse W. Hartley , Quan Ni , Kent Lee
IPC分类号： A61B5/08 , A61B5/02
CPC分类号： A61B5/0803 , A61B5/02405 , A61N1/3601
摘要： An event-based approach to collecting and organizing information associated with events affecting respiration is presented. The detection or prediction of an event affecting the respiration of a patient initiates acquisition of information associated with the event. The respiratory logbook system acquires information associated with the event during the event and during intervals proximate in time to the event. The information is organized as a respiratory log entry. The user can access the information by operating a user interface. The information may be presented in textual or graphical form.
摘要翻译：提出了一种基于事件的方法来收集和组织与影响呼吸的事件相关的信息。影响患者呼吸的事件的检测或预测启动与事件相关联的信息的获取。呼吸记录系统在事件期间以及在时间上接近事件的间隔期间获取与事件相关联的信息。信息被组织为呼吸日志条目。用户可以通过操作用户界面访问信息。信息可以以文本或图形形式呈现。

86. 发明授权

US08226570B2 Respiration monitoring for heart failure using implantable device 有权
标题翻译：使用可植入装置进行心力衰竭呼吸监测
公开(公告)号：US08226570B2
公开(公告)日：2012-07-24
申请号：US11463076
申请日：2006-08-08
申请人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
发明人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
IPC分类号： A61B5/08
CPC分类号： A61B5/0816 , A61B5/0031 , A61B5/0452 , A61B5/4818 , A61N1/3627 , A61N1/36521
摘要： An implantable respiration monitor can be used to detect disordered breathing or periodic breathing events that can be categorized, such as according to one or more of sleep, exercise, and resting awake states. The categorized frequency of such events can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with detection of one or more other congestive heart failure (CHF) symptoms to generate a CHF status indicator or to trigger an alarm or responsive therapy or to display one or more trends. The alert can notify the patient or a caregiver, such as via remote monitoring. The sleep state information can be further categorized according to central sleep apnea (CSA) or obstructive sleep apnea (OSA) events.
摘要翻译：可植入式呼吸监测器可用于检测可分类的无序呼吸或定期呼吸事件，例如根据睡眠，运动和休眠状态中的一种或多种。这些事件的分类频率可以与独立指定的阈值进行比较，例如触发警报或响应治疗，或显示一个或多个趋势。该信息还可以与一种或多种其他充血性心力衰竭（CHF）症状的检测相结合，以产生CHF状态指示器或触发警报或反应性治疗或显示一种或多种趋势。该警报可以通过远程监视来通知病人或看护者。睡眠状态信息可以根据中枢性睡眠呼吸暂停（CSA）或阻塞性睡眠呼吸暂停（OSA）事件进一步分类。

87. 发明授权

US08221327B2 Therapy control based on cardiopulmonary status 有权
标题翻译：基于心肺状态的治疗控制
公开(公告)号：US08221327B2
公开(公告)日：2012-07-17
申请号：US12688274
申请日：2010-01-15
申请人： Kent Lee , Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni
发明人： Kent Lee , Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni
IPC分类号： A61B5/08
CPC分类号： A61B5/4818 , A61B5/0205 , A61B5/0809 , A61B5/083 , A61B5/087 , A61B5/091 , A61B5/7275 , A61M11/00 , A61M16/026 , A61M2016/0021 , A61M2016/0036 , A61M2205/3523 , A61M2205/3569 , A61N1/3601 , A61N1/365 , A61N1/36521 , A61N1/3684
摘要： Methods and systems provide an approach to therapy control based on assessment of a patient's cardiopulmonary status. Conditions sensed via sensors of an external respiratory therapy device are used to assess a patient's cardiopulmonary status. The respiratory therapy device sensors may be utilized alone or in combination with other sensors to determine cardiopulmonary status of a patient. Therapy delivered to the patient is controlled based on the cardiopulmonary status assessment. For example, therapy delivered to the patient may be initiated, terminated, and/or modified based on the assessed cardiopulmonary status of the patient. Cardiopulmonary status assessment, therapy control, or both, are performed by an implantable device.
摘要翻译：方法和系统提供了一种基于患者心肺状态评估的治疗控制方法。通过外部呼吸治疗装置的传感器检测到的状况用于评估患者的心肺状态。呼吸治疗装置传感器可以单独使用或与其他传感器组合使用以确定患者的心肺状态。基于心肺状态评估来控制输送给患者的治疗。例如，可以基于评估的患者的心肺状态来开始，终止和/或修改递送给患者的治疗。心肺状态评估，治疗控制或两者都由可植入装置进行。

88. 发明授权

US08135471B2 Method and apparatus for inspiratory muscle stimulation using implantable device 有权
标题翻译：使用可植入装置吸气肌肉刺激的方法和装置
公开(公告)号：US08135471B2
公开(公告)日：2012-03-13
申请号：US11895999
申请日：2007-08-28
申请人： Yi Zhang , Shantha Arcot-Krishnamurthy , Lili Liu , Kenneth C. Beck , Kent Lee , Jonathan Kwok , Zheng Lin
发明人： Yi Zhang , Shantha Arcot-Krishnamurthy , Lili Liu , Kenneth C. Beck , Kent Lee , Jonathan Kwok , Zheng Lin
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/0558
摘要： An inspiratory muscle stimulation system uses an implantable medical device to deliver stimulation to control diaphragmatic contractions for slower and deeper breathing, thereby conditioning and strengthening inspiratory muscles. In various embodiments, respiratory and/or cardiac performance are monitored for controlling parameters of the stimulation.
摘要翻译：吸气肌肉刺激系统使用可植入医疗装置来输送刺激以控制膈肌收缩以减慢和深呼吸，从而调节和加强吸气肌肉。在各种实施例中，监测呼吸和/或心脏性能以控制刺激的参数。

89. 发明授权

US08005540B2 Monitoring of chronobiological rhythms for disease and drug management using one or more implantable device 有权
标题翻译：使用一个或多个可植入装置监测疾病和药物管理的计时生理节律
公开(公告)号：US08005540B2
公开(公告)日：2011-08-23
申请号：US12836441
申请日：2010-07-14
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
IPC分类号： A61N1/02
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译：使用至少一个可植入装置自动评估或预测受试者的健康状况。在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。也可以使用昼夜节律以外的其他时间生理节律。可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。

90. 发明授权

US08002553B2 Sleep quality data collection and evaluation 有权
公开(公告)号：US08002553B2
公开(公告)日：2011-08-23
申请号：US10642998
申请日：2003-08-18
申请人： John D. Hatlestad , Quan Ni , Jeffrey E. Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce H. Kenknight , Douglas R. Daum , Kent Lee
发明人： John D. Hatlestad , Quan Ni , Jeffrey E. Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce H. Kenknight , Douglas R. Daum , Kent Lee
IPC分类号： G09B23/28
CPC分类号： A61B5/4815 , A61B5/0031 , A61B5/0205 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/0809 , A61B5/11 , A61B5/4528 , A61B5/4818 , A61N1/3621 , G06F19/00
摘要： A sleep quality assessment approach involves collecting data based on detected physiological or non-physiological patient conditions. At least one of detecting patient conditions and collecting data is performed using an implantable device. Sleep quality may be evaluated using the collected data by an implantable or patient-external sleep quality processor. One approach to sleep quality evaluation involves computing one or more summary metrics based on occurrences of movement disorders or breathing disorders during sleep.

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