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81. 发明授权

US5417682A Device for administering active agent to biological environment 失效
标题翻译：将活性剂投与生物环境的装置
公开(公告)号：US5417682A
公开(公告)日：1995-05-23
申请号：US186046
申请日：1994-01-21
申请人： Patrick S. L. Wong , Felix Theeuwes , Steven D. Larsen , Liang C. Dong
发明人： Patrick S. L. Wong , Felix Theeuwes , Steven D. Larsen , Liang C. Dong
IPC分类号： A61K9/00 , A61K9/22 , A61K9/48
CPC分类号： A61K9/0004 , A61K9/4808
摘要： The present invention is directed to a fluid-imbibing dispensing device for the immediate or almost immediate and extended delivery of an active agent over a prolonged period of time together with the initially delayed pulse delivery of an active agent to a fluid environment of use. The dispenser comprises a housing having a first wall section and a second wall section in slidably telescoping arrangement with each other, which housing maintains its integrity in the environment of use; an internal compartment surrounded and defined by the housing; a first active agent delivery chamber within a portion of the compartment defined by the first wall section, the first delivery chamber including at least one active agent formulation, an exit means for providing communication between the active agent formulation and the environment, and a first expansion means for dispensing the first active agent formulation through the exit means to the environment immediately and over a prolonged period of time; a second active agent delivery chamber within a portion of the compartment defined by the first wall section and adjacent the open end of the first wall section, the second delivery chamber including at least one active agent formulation; and an expansion chamber within a portion of the compartment defined by the second wall section, for separating apart the first and second wall sections of the housing after exposure to the environment of use for dispensing the second active agent formulation to the environment in a pulse after an initially delayed period of time, the expansion chamber including a second expansion means and a partition layer or push plate.
摘要翻译：本发明涉及一种流体吸入分配装置，用于在延长的时间段内立即或几乎立即和延长地递送活性剂，同时将活性剂的初始延迟脉冲输送到使用的流体环境。分配器包括具有彼此可滑动地伸缩布置的第一壁部分和第二壁部分的壳体，该壳体在使用环境中保持其完整性; 由壳体包围和限定的内部隔室; 第一活性剂递送室，位于由第一壁部限定的隔室的一部分内，第一递送室包括至少一种活性剂制剂，用于提供活性剂配方与环境之间的连通的出口装置，以及第一膨胀用于通过出口装置将第一活性剂制剂直接和长时间地分配到环境的装置; 第二活性剂递送室，其在由第一壁部分限定并且邻近第一壁部分的开口端限定的隔室的一部分内，第二递送室包括至少一种活性剂制剂; 以及在由所述第二壁部限定的所述隔室的一部分内的膨胀室，用于在暴露于使用环境之后分离所述壳体的所述第一和第二壁部分，以在所述第二活性剂配方的环境中以脉冲分配所述环境最初延迟的时间段，膨胀室包括第二膨胀装置和分隔层或推板。

82. 发明授权

US5391381A Dispenser capable of delivering plurality of drug units 失效
标题翻译：能够递送多个药物单元的分配器
公开(公告)号：US5391381A
公开(公告)日：1995-02-21
申请号：US60372
申请日：1993-05-11
申请人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
发明人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
IPC分类号： A61K9/00 , A61K9/48 , A61M31/00 , A61K9/24
CPC分类号： A61K9/0004 , A61K9/4808 , A61M31/002
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译：用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。

83. 发明授权

US5284660A Delayed onset transdermal delivery device 失效
标题翻译：延迟发作透皮递送装置
公开(公告)号：US5284660A
公开(公告)日：1994-02-08
申请号：US933423
申请日：1992-08-21
申请人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
发明人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
IPC分类号： A61K9/00 , A61K9/22 , A61K9/70 , A61F13/00
CPC分类号： A61K9/7084 , A61K9/7069 , A61K9/7092
摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir, which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in predetermined temporal patterns at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.
摘要翻译：描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。合适的方法包括设置在释放表面和药剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初不能渗透到试剂中，然后变得可渗透。可以提供由一种或多种这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

84. 发明授权

US5232705A Dosage form for time-varying patterns of drug delivery 失效
标题翻译：药物递送模式的剂型
公开(公告)号：US5232705A
公开(公告)日：1993-08-03
申请号：US864824
申请日：1992-04-01
申请人： Patrick S. Wong , Felix Theeuwes , Atul D. Ayer , Anthony L. Kuczynski
发明人： Patrick S. Wong , Felix Theeuwes , Atul D. Ayer , Anthony L. Kuczynski
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed that comprises means inside the dosage form for providing a substantially drug-free interval before the dosage form delivers a drug from inside the dosage form. The dosage form in an embodiment comprises a drug on the exterior of the dosage form, which drug is available for immediate delivery.
摘要翻译：公开了一种剂型，其包含剂型内的装置，用于在剂型从剂型内部递送药物之前提供基本上无药物的间隔。在一个实施方案中的剂型包含在剂型外部的药物，该药物可用于立即递送。

85. 发明授权

US5200196A Improvement in pulsed drug therapy 失效
标题翻译：改善脉冲药物治疗
公开(公告)号：US5200196A
公开(公告)日：1993-04-06
申请号：US640469
申请日：1991-01-11
申请人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
发明人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
摘要翻译：一种剂型，其包含（1）立即可用的有效药物剂量，然后是药物的定时延迟剂量，或（2）定时延迟剂量的药物。

86. 发明授权

US5156850A Dosage form for time-varying patterns of drug delivery 失效
标题翻译：用于药物递送时间变化的剂型
公开(公告)号：US5156850A
公开(公告)日：1992-10-20
申请号：US576042
申请日：1990-08-31
申请人： Patrick S. Wong , Felix Theeuwes , Atul D. Ayer , Anthony L. Kuczynski
发明人： Patrick S. Wong , Felix Theeuwes , Atul D. Ayer , Anthony L. Kuczynski
IPC分类号： A61K9/00 , A61K9/22 , A61K31/155 , A61K31/275 , A61K31/435 , A61K31/55
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed that comprises means inside the dosage form for providing a substantially drug-free interval before the dosage form delivers a drug from inside the dosage form. The dosage form in an embodiment comprises a drug on the exterior of the dosage form, which drug is available for immediate delivery.
摘要翻译：公开了一种剂型，其包含剂型内的装置，用于在剂型从剂型内部递送药物之前提供基本上无药物的间隔。在一个实施方案中的剂型包含在剂型外部的药物，该药物可用于立即递送。

87. 发明授权

US5110597A Multi-unit delivery system 失效
标题翻译：多单元交付系统
公开(公告)号：US5110597A
公开(公告)日：1992-05-05
申请号：US701927
申请日：1991-05-17
申请人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
发明人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
IPC分类号： A61K9/00 , A61K9/48 , A61M31/00
CPC分类号： A61K9/0004 , A61K9/4808 , A61M31/002
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译：用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。

88. 发明授权

US5045059A Intravenous system for delivering a beneficial agent 失效
标题翻译：用于递送有益药物的静脉内系统
公开(公告)号：US5045059A
公开(公告)日：1991-09-03
申请号：US568457
申请日：1990-08-15
申请人： Felix Theeuwes , Su I. Yum
发明人： Felix Theeuwes , Su I. Yum
IPC分类号： A61M5/14
CPC分类号： A61M5/1407
摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a window material which allows the drug to diffuse therethrough but which prevents convective loss of the IV fluid. A flow distributor is provided within the chamber for distributing the flow of IV fluid along the interior surface of the window. A transdermal-type drug delivery device is adhered to the exterior surface of the window. Drug is delivered by the delivery device through the window and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the window itself or by a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the window to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate. A similar window may be placed in an IV bag to deliver a drug into the IV fluid therein.
摘要翻译：提供了用于静脉内给药组的药物制剂室。静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。药物制剂室具有流体入口和流体出口，用于维持IV流体流过腔室的流动。室壁的一部分由允许药物扩散通过但防止IV流体的对流损失的窗口材料构成。在室内提供流动分配器，用于沿着窗口的内表面分配IV流体流。透皮型药物输送装置粘附在窗户的外表面上。药物由输送装置通过窗口输送到流动的IV流体中。该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。从装置向IV流体的药物递送速率由窗口本身或药物递送装置中的膜层控制。多个药物递送装置可以粘附到窗户以递送多种药物或以更高的剂量率递送单一药物。类似的窗口可以放置在IV袋中以将药物递送到其中的IV流体中。

89. 发明授权

US5023088A Multi-unit delivery system 失效
标题翻译：多单元交货系统
公开(公告)号：US5023088A
公开(公告)日：1991-06-11
申请号：US495825
申请日：1990-03-19
申请人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
发明人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
IPC分类号： A61K9/00 , A61K9/48 , A61M31/00
CPC分类号： A61M31/002 , A61K9/0004 , A61K9/4808
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译：用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。

90. 发明授权

US4969872A Intravenous system for delivering a beneficial agent with delivery rate control via permeable surface area variance 失效
标题翻译：用于通过渗透性表面积差异递送有效药物的输送速率控制的静脉内系统
公开(公告)号：US4969872A
公开(公告)日：1990-11-13
申请号：US320732
申请日：1989-03-08
申请人： John Urquhart , Felix Theeuwes
发明人： John Urquhart , Felix Theeuwes
IPC分类号： A61M39/00 , A61M5/14
CPC分类号： A61M5/1409
摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber houses a diffusional or an osmotically driven drug delivery device. The osmotically driven delivery device has a semipermeable, microporous or diffusional wall which surrounds a compartment containing the drug. Drug is delivered through an orifice in the semipermeable/microporous wall or through the diffusional wall itself, into the IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery is controlled by variably adjusting the surface area of the semipermeable/microporous/diffusional wall that is exposed to the IV fluid flowing through the drug formulation chamber.
摘要翻译：提供了用于静脉内给药组的药物制剂室。静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。药物制剂室容纳扩散或渗透驱动的药物递送装置。渗透驱动的输送装置具有围绕包含药物的隔室的半透性，微孔或扩散壁。药物通过半透膜/微孔壁中的孔口或通过扩散壁本身输送到IV液体中。该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。通过可变地调节暴露于流过药物制剂室的IV液体的半透性/微孔/扩散壁的表面积来控制药物递送的速率。

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