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81. 发明授权

US07457664B2 Closed loop cardiac resynchronization therapy using cardiac activation sequence information 有权
标题翻译：闭环心脏再同步治疗使用心脏激活序列信息
公开(公告)号：US07457664B2
公开(公告)日：2008-11-25
申请号：US11125068
申请日：2005-05-09
申请人： Yi Zhang , Yinghong Yu , Aaron R. McCabe , Jiang Ding , Jeffrey E. Stahmann , Carlos Alberto Ricci , Scott A. Meyer
发明人： Yi Zhang , Yinghong Yu , Aaron R. McCabe , Jiang Ding , Jeffrey E. Stahmann , Carlos Alberto Ricci , Scott A. Meyer
IPC分类号： A61N1/365
CPC分类号： A61N1/3712 , A61N1/3627 , A61N1/365 , G06F19/00
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track, and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。心脏信号分离用于使用心脏激活序列信息来检测，监测，跟踪和/或趋向闭环心脏再同步治疗。设备和方法包括使用多个电极感测多个复合心脏信号，所述电极被配置用于植入患者体内。使用所感测的多个复合心脏信号进行源分离，产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。使用一个或多个心脏信号向量和与一个或多个心脏信号载体相关联的信号中的一个或两个来调整心脏再同步治疗。在另外的实施方案中，心脏再同步治疗可以被启动，终止，或者可以改变再同步治疗的一个或多个参数。

82. 发明申请

US20080281367A1 SYSTEM AND METHOD TO DETERMINE HEMODYNAMIC TOLERABILITY 有权
标题翻译：确定血液动力学耐受性的系统和方法
公开(公告)号：US20080281367A1
公开(公告)日：2008-11-13
申请号：US11745016
申请日：2007-05-07
申请人： Yi Zhang , Allan C. Shuros , Dan Li
发明人： Yi Zhang , Allan C. Shuros , Dan Li
IPC分类号： A61N1/362
CPC分类号： A61N1/36521 , A61B5/02028 , A61B5/0464 , A61B5/0535 , A61B5/0538 , A61B5/7264
摘要： An implantable medical device detects a tachyarrhythmia of a heart. During the detected tachyarrhythmia, the device determines a local myocardial impedance. Using the local myocardial impedance, the device determines whether there is sufficient perfusion to the heart. The device can then either deliver a less aggressive device therapy in response to the detected tachyarrhythmia when there is sufficient perfusion to the heart, or deliver a more aggressive device therapy in response to the detected tachyarrhythmia when there is insufficient perfusion to the heart. The perfusion information can also be used to alter tachyarrhythmia detection or classification.
摘要翻译：可植入医疗装置检测心脏的快速性心律失常。在检测到的快速性心律失常期间，该装置确定局部心肌阻抗。使用局部心肌阻抗，该装置确定心脏是否有足够的灌注。然后，当心脏充分灌注时，该装置可以响应于检测到的快速性心律失常而递送较不激进的装置疗法，或者当心脏灌注不充分时响应于检测到的快速性心律失常而递送更积极的装置疗法。灌注信息也可用于改变快速性心律失常检测或分类。

83. 发明申请

US20080262360A1 USING RESPIRATION DISTRESS MANIFESTATIONS FOR HEART FAILURE DETECTION 有权
标题翻译：使用呼吸部分心理失调检测
公开(公告)号：US20080262360A1
公开(公告)日：2008-10-23
申请号：US11736058
申请日：2007-04-17
申请人： Yousufali Dalal , John D. Hatlestad , Yi Zhang , Aaron Lewicke , Jeffrey E. Stahmann
发明人： Yousufali Dalal , John D. Hatlestad , Yi Zhang , Aaron Lewicke , Jeffrey E. Stahmann
IPC分类号： A61B5/0205
CPC分类号： A61B5/0205 , A61B5/0816 , A61B5/1116 , A61B5/4818 , A61B5/686 , A61N1/3627
摘要： Systems and methods for diagnosing one or more respiration distress manifestations by implantably recognizing their occurrence and evaluating information about the same to provide an indication of present or impending worsening heart failure are discussed. Using information produced by an implantable respiration sensor circuit and an implantable physiological sensor circuit, such as at least one of a physical activity sensor circuit or a posture sensor circuit, an implantable or external processor circuit may detect a respiration disturbance and an associated subsequent arousal from stable state occurrence and thereafter evaluate over time arousal from stable state occurrences to provide the indication of present or impending worsening heart failure. In one example, information about a fluid level within a subject is used in determining the indication of worsening heart failure. In various examples, a regimen is initiated or adjusted in response to the indication of present or impending worsening heart failure.
摘要翻译：讨论了通过可植入地识别其发生并评估关于其的信息来诊断一种或多种呼吸困扰表现的系统和方法，以提供现在或即将恶化的心力衰竭的指征。使用由可植入呼吸传感器电路和植入式生理传感器电路产生的信息，例如物理活动传感器电路或姿势传感器电路中的至少一个，可植入或外部处理器电路可以检测呼吸障碍和相关联的随后的唤醒稳定状态发生，然后评估来自稳定状态发生的随着时间的兴奋，以提供目前或即将恶化的心力衰竭的指征。在一个示例中，关于受试者内的液位水平的信息用于确定恶化的心力衰竭的指示。在各种实例中，响应于目前或即将恶化的心力衰竭的指征开始或调整方案。

84. 发明申请

US20080248458A1 Purification, Characterization and Reconstitution of a Ubiquitin E3 Ligase 有权
标题翻译：泛素E3连接酶的纯化，表征和重构
公开(公告)号：US20080248458A1
公开(公告)日：2008-10-09
申请号：US11915610
申请日：2006-06-01
申请人： Ru Cao , Hengbin Wang , Yi Zhang
发明人： Ru Cao , Hengbin Wang , Yi Zhang
IPC分类号： C12Q1/00 , C12N9/00 , C12P21/04 , C12N5/06
CPC分类号： C12Q1/25 , C12N9/93 , G01N2333/9015 , G01N2500/02
摘要： The present invention provides a native or reconstituted complex comprising Bmi1 and/or Ring1 and/or Ring2, wherein the complex has ubiquitin E3 ligase activity. Optionally, the complex further comprises HPH2 and/or HPC3. Also disclosed are methods of producing the reconstituted complex, methods of identifying compounds that modulate the ubiquitin E3 ligase activity of the native or reconstituted complex, and methods of identifying candidate compounds for treating cancer. Kits for determining modulation of protein ubiquitination and/or for ubiquitinating a target substrate are further provided.
摘要翻译：本发明提供了包含Bmi1和/或Ring1和/或Ring2的天然或重构的复合物，其中所述复合物具有泛素E3连接酶活性。任选地，复合物还包含HPH 2和/或HPC 3。还公开了产生重构复合物的方法，鉴定调节天然或重构复合物的泛素E3连接酶活性的化合物的方法以及鉴定用于治疗癌症的候选化合物的方法。还提供了用于确定蛋白质泛素化和/或用于泛素化靶基质的调节的试剂盒。

85. 发明申请

US20080177156A1 ISCHEMIA DETECTION USING PRESSURE SENSOR 审中-公开
标题翻译：使用压力传感器进行ISCHEMIA检测
公开(公告)号：US20080177156A1
公开(公告)日：2008-07-24
申请号：US11624974
申请日：2007-01-19
申请人： Yi Zhang , Krzysztof Z. Siejko , Richard Fogoros , Abhilash Patangay
发明人： Yi Zhang , Krzysztof Z. Siejko , Richard Fogoros , Abhilash Patangay
IPC分类号： A61B5/0205 , A61B5/0215
CPC分类号： A61B5/0215 , A61B5/02028 , A61B5/0205 , A61B5/145
摘要： This document discusses, among other things, a system and method for sensing a pulmonary artery pressure (“PAP”) signal of a pulmonary artery (“PA”) and computing an indication of a reduction of blood supply to at least a portion of a heart using information from the PAP signal. The reduction of blood supply to at least a portion of the heart can be detected using a PAP signal characteristic or measurement, using a change in the PAP, using an interval between multiple PAP signal features, using a mitral valve performance, or using information from the PAP and information from a different physiological signal, including a cardiac signal, a heart sound signal, right ventricular pressure signal, a left ventricular pressure signal, a blood pressure signal, and an oxygen saturation signal.
摘要翻译：本文件尤其涉及用于感测肺动脉（“PA”）的肺动脉压（“PAP”）信号的系统和方法，并且计算将血液供应减少到至少一部分心脏使用来自PAP信号的信息。使用PAP信号特征或测量可以使用PAP信号特征或多个PAP信号特征之间的间隔，使用二尖瓣性能来使用PAP信号特征或测量来检测对心脏的至少一部分的血液供应，或使用来自 PAP和来自不同生理信号的信息，包括心脏信号，心音信号，右心室压力信号，左心室压力信号，血压信号和氧饱和度信号。

86. 发明申请

US20080059639A1 Systems and methods of migrating sessions between computer systems 有权
标题翻译：在计算机系统之间迁移会话的系统和方法
公开(公告)号：US20080059639A1
公开(公告)日：2008-03-06
申请号：US11514543
申请日：2006-08-31
申请人： Yi Zhang
发明人： Yi Zhang
IPC分类号： G06F15/16 , G06F15/173
CPC分类号： G06F9/5083 , H04L29/12481 , H04L61/2557 , H04L67/1002 , H04L67/1008 , H04L67/1017 , H04L67/1019 , H04L67/14
摘要： Embodiments of the present invention include systems and methods of migrating sessions between computer systems. In one embodiment, the present invention includes a session migration method comprising managing, by a session manager, a session between a client and a first server using network address translation, managing, by a first server, a context for the client, wherein the context is related to the session, determining that the session is to be moved from the first server, identifying, by the session manager, a second server other than the first server to manage the context, sending the context from the first server to the second server; managing, by the session manager, the session between the client and the second server using network address translation, and managing, by the second server, the context.
摘要翻译：本发明的实施例包括在计算机系统之间迁移会话的系统和方法。在一个实施例中，本发明包括会话迁移方法，包括由会话管理器使用网络地址转换来管理客户端和第一服务器之间的会话，由第一服务器管理客户端的上下文，其中上下文与会话相关，确定会话将从第一服务器移动，由会话管理器识别除第一服务器之外的第二服务器以管理上下文，将上下文从第一服务器发送到第二服务器 ; 由会话管理器使用网络地址转换来管理客户端和第二服务器之间的会话，并且由第二服务器管理上下文。

87. 发明申请

US20070220098A1 Method for exchanging messages between an email client and a unified messaging system 审中-公开
标题翻译：用于在电子邮件客户端和统一消息系统之间交换消息的方法
公开(公告)号：US20070220098A1
公开(公告)日：2007-09-20
申请号：US11384623
申请日：2006-03-20
申请人： Tom Adams , Yi Zhang , Art Daddona
发明人： Tom Adams , Yi Zhang , Art Daddona
IPC分类号： G06F15/16
CPC分类号： G06Q10/107
摘要： An apparatus and method are disclosed for exchanging messages between an email client and a unified messaging system. An apparatus that incorporates teachings of the present disclosure may include, for example, a unified messaging system (UMS) (102) having a controller (108) that manages operations of a communications interface (104) that communicates with communication devices in a communication system (100). The controller can be programmed to receive (304) from an email client operating in a select one of the communication devices an identification, validate (308) the identification according to subscriber information in a directory, establish (312) a secure communications link with the email client upon validating the identification, identify (314) a message server from the subscriber information, authenticate (316) the email client at the message server, and enable (318) communications between the email client and the message server over the secure communications link. Additional embodiments are disclosed.
摘要翻译：公开了用于在电子邮件客户端和统一消息系统之间交换消息的装置和方法。结合本公开的教导的装置可以包括例如统一消息收发系统（UMS）（102），其具有管理与通信系统中的通信设备通信的通信接口（104）的操作的控制器（108）（100）。控制器可以被编程为从在通信设备中选择的一个操作的电子邮件客户端接收（304）标识，根据目录中的订户信息来验证（308）标识，建立（312）与电子邮件客户端在验证标识时，从用户信息识别（314）消息服务器，在消息服务器处认证（316）电子邮件客户端，并通过安全通信链路启用（318）电子邮件客户端与消息服务器之间的通信。公开了另外的实施例。

88. 发明申请

US20070175406A1 UNIFIED SYSTEM AND METHOD FOR ANIMAL BEHAVIOR CHARACTERIZATION IN HOME CAGES USING VIDEO ANALYSIS 审中-公开
标题翻译：使用视频分析的家庭电影中的动画行为特征的统一系统和方法
公开(公告)号：US20070175406A1
公开(公告)日：2007-08-02
申请号：US11697544
申请日：2007-04-06
申请人： Yiqing Liang , Vikrant Kobla , Xuesheng Bai , Yi Zhang
发明人： Yiqing Liang , Vikrant Kobla , Xuesheng Bai , Yi Zhang
IPC分类号： A01K37/00
CPC分类号： G06K9/00342 , A01K1/031 , A61B5/1113 , A61B5/1116 , A61B5/1118 , A61B5/1128 , A61B5/4094 , A61B5/7264 , A61B5/7267 , A61B2503/40 , A61B2503/42 , G06K9/00335 , G06K9/00369 , G06T7/20 , G06T2207/30004 , G16H40/67
摘要： Systems and methods for finding the position and shape of an animal using video are disclosed. The invention includes a system with a video camera coupled to a computer in which the computer is configured to automatically provide animal segmentation and identification, animal motion tracking (for moving animals), animal posture classification, and behavior identification. In a preferred embodiment, the present invention may use background subtraction for animal identification and tracking, and a combination of decision tree classification and rule-based classification for posture and behavior identification. Thus, the present invention is capable of automatically monitoring a video image to identify, track and classify the actions of various animals and the animal's movements within the image. The image may be provided in real time or from storage.
摘要翻译：公开了使用视频来查找动物的位置和形状的系统和方法。本发明包括具有耦合到计算机的摄像机的系统，其中计算机被配置为自动提供动物分割和识别，动物运动跟踪（用于移动动物），动物姿势分类和行为识别。在优选实施例中，本发明可以使用用于动物识别和跟踪的背景减除，以及用于姿势和行为识别的决策树分类和基于规则的分类的组合。因此，本发明能够自动监视视频图像以识别，跟踪和分类各种动物的动作和图像内动物的动作。图像可以实时地或从存储提供。

89. 发明申请

US20070154481A1 Antibody Molecules Having Specificity For Human IL-6 有权
标题翻译：具有人IL-6特异性的抗体分子
公开(公告)号：US20070154481A1
公开(公告)日：2007-07-05
申请号：US11608408
申请日：2006-12-08
申请人： Richard Gelinas , Mitra Singhal , Yi Zhang , Andrew Popplewell , Ralph Adams
发明人： Richard Gelinas , Mitra Singhal , Yi Zhang , Andrew Popplewell , Ralph Adams
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06 , C07K16/24
CPC分类号： A61K39/3955 , A61K2039/505 , C07K16/248 , C07K2316/96 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/11
摘要： The invention relates to antibody molecules having specificity for antigenic determinants of IL-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
摘要翻译：本发明涉及对IL-6的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。

90. 发明申请

US20070100557A1 Selection of genotyped transfusion donors by cross-matching to genotyped recipients 审中-公开
标题翻译：通过与基因型受体的交叉匹配来选择基因分型的输血供体
公开(公告)号：US20070100557A1
公开(公告)日：2007-05-03
申请号：US11298763
申请日：2005-12-09
申请人： Yi Zhang , Michael Seul
发明人： Yi Zhang , Michael Seul
IPC分类号： G06F19/00
CPC分类号： G06F19/3456 , G06F19/3481 , G16B20/00 , G16B25/00 , G16B30/00 , G16B40/00 , G16H10/60 , G16H50/70
摘要： Disclosed are methods for establishing the compatibility between two bloodtypes on the basis of cross-matching (under a designated rule of stringency) the minor blood group genotypes of recipient and prospective donors. To determine compatibility, the blood group genotypes are mapped to corresponding phenotypes according to the expression states associated with a set of underlying haplotypes, and compatibility is established by establishing the compatibility of bloodtypes constructed as a combination of constituent phenotypes. The bit strings are matched, preferably using an algorithm expression. Where ambiguity in mapping genotypes to haplotypes exists, it can be reduced based on frequency of occurrence of the haplotypes in the sample population, or resolved by gametic phasing. Such reduction or resolution of ambiguity is particularly desirable where mismatches in the antigens expressed by the constituent haplotypes have greater clinical significance.
摘要翻译：公开的是基于接受者和潜在供体的次要血型基因型的交叉匹配（在指定的严格规定）的基础上建立两种血型之间的相容性的方法。为了确定相容性，根据与一组潜在单倍型相关的表达状态，将血型基因型映射到相应的表型，并通过建立构成为构成表型的组合的血型的相容性来建立相容性。比特串匹配，最好使用算法表达式。如果存在将基因型映射到单倍型的歧义，则可以根据样本群体中单倍型的发生频率来减少，或者通过配子定相来解决。在组成单元型表达的抗原中的错配具有更大的临床意义的情况下，这种模糊的减少或解决是特别理想的。

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