专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明申请

US20080139951A1 Detection of Stenosis 审中-公开
标题翻译：狭窄检测
公开(公告)号：US20080139951A1
公开(公告)日：2008-06-12
申请号：US11608578
申请日：2006-12-08
申请人： Abhilash Patangay , Marina Brockway , Jeffrey E. Stahmann , Yi Zhang , Gerrard M. Carlson
发明人： Abhilash Patangay , Marina Brockway , Jeffrey E. Stahmann , Yi Zhang , Gerrard M. Carlson
IPC分类号： A61B5/026 , A61F2/82
CPC分类号： A61B5/411 , A61B5/0031 , A61B5/02007 , A61B5/02158 , A61B5/026 , A61B5/0402 , A61B5/076 , A61B2562/0204 , A61B2562/0219 , A61F2/02 , A61F2/91 , A61F2250/0002
摘要： A system for detecting stenosis in a patient. The system includes an implantable sensing unit having a turbulence sensor and a communication device for transmitting a signal from the turbulence sensor. The system also includes a cardiac sensor for generating a signal corresponding to cardiac activity and a processing device configured to receive signals from the sensing unit and from the cardiac sensor. The processing device is configured to determine a time window corresponding to cardiac activity, to determine a turbulence level from the turbulence signal within the time window, and to detect the presence of stenosis from the turbulence level.
摘要翻译：一种用于检测患者狭窄的系统。该系统包括具有湍流传感器的可植入感测单元和用于从湍流传感器发送信号的通信装置。该系统还包括用于产生对应于心脏活动的信号的心脏传感器和被配置为从感测单元和心脏传感器接收信号的处理装置。处理装置被配置为确定对应于心脏活动的时间窗口，以确定在时间窗口内的湍流信号的湍流水平，并且从湍流水平检测狭窄的存在。

82. 发明授权

US07062323B2 Maximum atrial tracking rate for cardiac rhythm management system 失效
标题翻译：心律管理系统最大心房跟踪率
公开(公告)号：US07062323B2
公开(公告)日：2006-06-13
申请号：US10040287
申请日：2001-10-19
申请人： Gerrard M. Carlson , Julio C. Spinelli , Qingsheng Zhu
发明人： Gerrard M. Carlson , Julio C. Spinelli , Qingsheng Zhu
IPC分类号： A61N1/18
CPC分类号： A61N1/36542 , A61N1/3622 , A61N1/36521
摘要： A cardiac rhythm management system includes an operational mode in which ventricular pacing pulses are delivered at a rate that tracks a sinoatrial rate up to an appropriate maximum atrial tracking rate (MATR) value determined by the system. In one example, the MATR value is based on a patient activity level and a hemodynamic maximum rate (HMR) determined from a QRS-to-S2 interval, where S2 is an accelerometer-generated fiducial correlative to aortic valve closure (AVC). In a further example, a correlation between the QRS-to-S2 interval and heart rate is established, and the MATR is based on the patient activity level and heart rate. In a further example, a lower rate threshold for providing antitachyarrhythmia therapy is modified based on the MATR. For example, when the MATR exceeds a default value of the antitachyarrhythmia therapy lower rate threshold, the threshold tracks the MATR. In another example, the MATR is based on an active time between a QRS complex and a heart impedance signal maximum slope during the same cardiac cycle.
摘要翻译：心律管理系统包括操作模式，其中心率起搏脉冲以跟踪窦房速率直到由系统确定的合适的最大心房跟踪率（MATR）值的速率递送。在一个示例中，MATR值基于患者活动水平和从QRS至S 2区间确定的血流动力学最大速率（HMR），其中S < 是与主动脉瓣闭合（AVC）相关的加速度计产生的基准。在另一个例子中，建立了QRS-S-SUB间隔和心率之间的相关性，并且MATR基于患者活动水平和心率。在另一个实例中，基于MATR修改用于提供抗心律不齐治疗的较低速率阈值。例如，当MATR超过抗心律不齐治疗较低速率阈值的默认值时，阈值跟踪MATR。在另一个例子中，MATR基于在相同心动周期期间QRS波形与心脏阻抗信号最大斜率之间的活动时间。

83. 发明授权

US06963777B2 Cardiac rhythm management system and method using time between mitral valve closure and aortic ejection 有权
标题翻译：心脏节律管理系统和方法使用二尖瓣关闭和主动脉夹层之间的时间
公开(公告)号：US06963777B2
公开(公告)日：2005-11-08
申请号：US10099865
申请日：2002-03-13
申请人： William C. Lincoln , Gerrard M. Carlson
发明人： William C. Lincoln , Gerrard M. Carlson
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61B5/0215 , A61B5/7239 , A61B2562/0219 , A61N1/36578
摘要： This document discusses cardiac rhythm management systems and methods using the MVC-to-AE time between mitral valve closure (“MVC”) and aortic ejection (“AE”) of the same heart contraction, sometimes referred to as the isovolumic contraction time (“ICVT”). In one example, the MVC-to-AE time is used for predicting which patients will respond to cardiac resynchronization therapy (CRT), or other therapy. In another example, the MVC-to-AE time is used as a wellness indicator. In a further example, the MVC-to-AE time is used to select or control a therapy or therapy parameter. In one example, the MVC and AE are obtained using an accelerometer signal, however, plethysmography, tonometry, or other techniques may alternatively be used.
摘要翻译：本文讨论了使用相同心脏收缩的二尖瓣关闭（“MVC”）和主动脉瓣（“AE”）之间的MVC至AE时间的心律管理系统和方法，有时称为等容收缩时间（“ ICVT“）。在一个实例中，MVC至AE时间用于预测哪些患者将对心脏再同步治疗（CRT）或其他治疗作出反应。在另一个例子中，MVC到AE时间用作健康指标。在另一个实例中，使用MVC至AE时间来选择或控制治疗或治疗参数。在一个示例中，使用加速度计信号获得MVC和AE，然而，可以替代地使用体积描记术，眼压计或其他技术。

84. 发明授权

US06665564B2 Cardiac rhythm management system selecting A-V delay based on interval between atrial depolarization and mitral valve closure 有权
公开(公告)号：US06665564B2
公开(公告)日：2003-12-16
申请号：US09862763
申请日：2001-05-21
申请人： William C. Lincoln , Gerrard M. Carlson
发明人： William C. Lincoln , Gerrard M. Carlson
IPC分类号： A61N1365
CPC分类号： A61N1/368
摘要： A cardiac rhythm management system selects an atrioventricular (A-V) delay based on a time-interval between an atrial depolarization and mitral valve closure (MVC). For several different A-V delays, the system measures time intervals between atrial depolarizations (i.e., sensed or paced P-waves) and accelerometer-detected MVCs. Based on this information, the system selects a particular A-V delay for improving cardiac output during subsequent delivery of cardiac rhythm management therapy.

85. 发明授权

US06650940B1 Accelerometer-based heart sound detection for autocapture 有权
标题翻译：基于加速度计的心脏声音检测
公开(公告)号：US06650940B1
公开(公告)日：2003-11-18
申请号：US09496832
申请日：2000-02-02
申请人： Qingsheng Zhu , Julio C. Spinelli , Gerrard M. Carlson
发明人： Qingsheng Zhu , Julio C. Spinelli , Gerrard M. Carlson
IPC分类号： A61N1365
CPC分类号： A61N1/36542 , A61N1/3712
摘要： An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient's heart. The device operates in an automatic capture verification mode, wherein a global accelerometer signal is utilized to identify heart sounds (S1 and S2) of the patient's heart. The presence or absence of one or more of the heart sounds S1 and S2 in the accelerometer signal indicates whether a stimulation pulse evokes a response by the patient's heart. The device may automatically adjust the stimulation output in accordance with a step down stimulation protocol, wherein the presence of a predetermined heart sound indicates capture. Also, the device may suspend the automatic capture verification sequence if the patient's physical activity level exceeds a predetermined threshold.
摘要翻译：一种能够自动检测患者心脏的内在和诱发反应的植入式心律管理装置。该装置以自动捕获验证模式工作，其中使用全局加速度计信号来识别患者心脏的心音（S1和S2）。加速度计信号中存在或不存在一个或多个心音S1和S2表示刺激脉冲是否引起患者心脏的反应。设备可以根据降压刺激协议自动调节刺激输出，其中预定心音的存在指示捕获。此外，如果患者的身体活动水平超过预定阈值，则设备可以暂停自动捕获验证序列。

86. 发明授权

US6026320A Heart rate variability as an indicator of exercise capacity 失效
标题翻译：心率变异性作为运动能力的指标
公开(公告)号：US6026320A
公开(公告)日：2000-02-15
申请号：US93118
申请日：1998-06-08
申请人： Gerrard M. Carlson , Veerichetty A. Kadhiresan , Julio C. Spinelli
发明人： Gerrard M. Carlson , Veerichetty A. Kadhiresan , Julio C. Spinelli
IPC分类号： A61B5/0456 , A61N1/362 , A61N1/365 , A61N1/37
CPC分类号： A61N1/365 , A61N1/3627 , A61N1/36592
摘要： Based upon patient studies indices a high degree of correlation was found between HRV and VO2.sub.max, i.e., the patient's exercise capacity. Based on this finding, a pacing therapy optimization protocol for treating patients with CHF has been devised. The protocol involves first pacing the patient's heart with a pacemaker programmed to operate in a first mode for a predetermined time period and then collecting electrogram data from which a HRV index is derived. The mode is then changed and the steps repeated until all possible modes have been utilized. At that time, a determination is made as to which of the modes is associated with the largest HRV index and the pacemaker is then programmed to function in that mode. Alternatively, the method of the present invention can be applied to changes in drug therapy instead of or in combination with pacing therapy.
摘要翻译：根据患者研究指标，发现HRV和VO2max之间存在高度相关性，即患者的运动能力。基于这一发现，已经设计了用于治疗CHF患者的起搏治疗优化方案。该方案涉及首先用编程为在第一模式中操作预定时间段的起搏器起搏患者的心脏，然后收集从其导出HRV指数的电描记图数据。然后改变模式，重复步骤直到所有可能的模式被使用。此时，确定哪个模式与最大HRV指数相关联，并且起搏器然后被编程为在该模式下起作用。或者，本发明的方法可以应用于药物治疗的变化，而不是起搏治疗或与起搏治疗组合。

87. 发明授权

US08805503B2 Method and apparatus for optimizing electrical stimulation parameters using heart rate variability 有权
标题翻译：使用心率变异优化电刺激参数的方法和装置
公开(公告)号：US08805503B2
公开(公告)日：2014-08-12
申请号：US12699457
申请日：2010-02-03
申请人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
发明人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
IPC分类号： A61N1/362
CPC分类号： A61N1/36592 , A61B5/02405 , A61B5/4035 , A61N1/36114 , A61N1/368
摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to evaluate a plurality of parameter values for selecting an approximately optimal parameter value.
摘要翻译：心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。在一个实施例中，HRV参数用于评估用于选择近似最佳参数值的多个参数值。

88. 发明授权

US08463380B2 Automatic adaptation of A-V delay and HR for heart failure using beat to beat measures 有权
标题翻译：自动适应心律失常的A-V延迟和人力资源
公开(公告)号：US08463380B2
公开(公告)日：2013-06-11
申请号：US13357259
申请日：2012-01-24
申请人： Donald Hopper , Yinghong Yu , Allan C. Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey E. Stahmann
发明人： Donald Hopper , Yinghong Yu , Allan C. Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey E. Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： Methods and systems to modulate timing intervals for pacing therapy are described. For each cardiac cycle, one or both of an atrioventricular (A-V) timing interval and an atrial (A-A) timing interval are modulated to oppose beat-to-beat ventricular (V-V) timing variability. Pacing therapy is delivered using the modulated timing intervals.
摘要翻译：描述了调节起搏治疗时间间隔的方法和系统。对于每个心动周期，房室（A-V）定时间隔和心房（A-A）定时间隔中的一个或两个被调制以抵抗搏动到心室（V-V）的时间变异性。使用调制的定时间隔来提供起搏治疗。

89. 发明申请

US20110230926A1 MAXIMUM PACING RATE LIMITER SYSTEM 失效
标题翻译：最大速率限制系统
公开(公告)号：US20110230926A1
公开(公告)日：2011-09-22
申请号：US13115825
申请日：2011-05-25
申请人： Douglas R. Daum , Geng Zhang , Qingsheng Zhu , Gerrard M. Carlson , Julio C. Spinelli
发明人： Douglas R. Daum , Geng Zhang , Qingsheng Zhu , Gerrard M. Carlson , Julio C. Spinelli
IPC分类号： A61N1/365
CPC分类号： A61N1/365
摘要： A maximum pacing rate limiter for use in adaptive rate pacing in conjunction with a cardiac rhythm management system for a heart. The maximum pacing rate limiter may function to measure an interval, termed the ERT interval, between a paced ventricular evoked response and a T-wave. The maximum pacing rate limiter may further function to maintain the ERT interval at less than a certain percentage of the total cardiac cycle. In one disclosed embodiment, a maximum pacing rate limiter calculates an ERT rate based on the detected paced ventricular evoked response and the T-wave, and the pacing rate limiter module further communicates the minimum of the ERT rate and an adaptive-rate sensor indicated rate to a pacemaker.
摘要翻译：与心脏心律管理系统结合使用的适应性起搏速度的最大起搏速率限制器。最大起搏速率限制器可以用于测量在起搏心室诱发反应和T波之间的称为ERT间期的间隔。最大起搏速率限制器可进一步起作用以将ERT间期维持在小于总心律周期的一定百分比。在一个公开的实施例中，最大起搏速率限制器基于检测到的起搏心室诱发反应和T波计算ERT率，并且起搏速率限制器模块进一步传达最小ERT率和自适应速率传感器指示率到起搏器。

90. 发明授权

US07953484B2 Method and apparatus for optimization of cardiac resynchronization therapy using heart sounds 有权
标题翻译：使用心脏声音优化心脏再同步治疗的方法和装置
公开(公告)号：US07953484B2
公开(公告)日：2011-05-31
申请号：US11687812
申请日：2007-03-19
申请人： Marina Brockway , William C. Lincoln , Gerrard M. Carlson
发明人： Marina Brockway , William C. Lincoln , Gerrard M. Carlson
IPC分类号： A61N1/00
CPC分类号： A61B5/0538 , A61B5/0809 , A61B5/113 , A61B5/7203 , A61B5/726 , A61B7/00 , A61N1/36514 , G06K9/00496
摘要： A cardiac rhythm management system provides for assessment of cardiac mechanical dyssynchrony based on heart sound morphology and optimization of pacing parameters based on the effect of pacing on the cardiac mechanical dyssynchrony assessment. A degree of cardiac mechanical dyssynchrony is measured by the time delay between tricuspid valve closure and mitral valve closure and/or the time delay between pulmonary valve closure and aortic valve closure. A cardiac resynchronization therapy is optimized by determining therapy parameters to provide an approximately minimum degree of cardiac mechanical dyssynchrony by cardiac pacing.
摘要翻译：心脏节律管理系统基于心脏机械不同步评估的起搏效果，提供基于心脏声音形态和起搏参数优化的心脏机械不同步的评估。通过三尖瓣关闭和二尖瓣关闭之间的时间延迟和/或肺动脉瓣关闭与主动脉瓣闭合之间的时间延迟来测量心脏机械不同步程度。通过确定治疗参数来优化心脏再同步治疗，以通过心脏起搏提供心脏机械不同步的近似程度。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式