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81. 发明授权

US06774216B2 Antibodies to secreted protein HCEJQ69 有权
标题翻译：分泌蛋白HCEJQ69的抗体
公开(公告)号：US06774216B2
公开(公告)日：2004-08-10
申请号：US10115123
申请日：2002-04-04
申请人： Steven M. Ruben , Craig A. Rosen , David W. LaFleur
发明人： Steven M. Ruben , Craig A. Rosen , David W. LaFleur
IPC分类号： C07K1618
CPC分类号： G01N33/6893 , A61K38/00 , C07K14/47 , G01N2500/20
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

82. 发明授权

US06635482B1 Monoclonal antibodies to membrane neutrokine-&agr; 有权
标题翻译：膜中性粒细胞α的单克隆抗体
公开(公告)号：US06635482B1
公开(公告)日：2003-10-21
申请号：US09589286
申请日：2000-06-08
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
IPC分类号： C12N506
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

83. 发明授权

US06607726B1 Human tumor necrosis factor receptor TR10 失效
标题翻译：人肿瘤坏死因子受体TR10
公开(公告)号：US06607726B1
公开(公告)日：2003-08-19
申请号：US09769402
申请日：2001-01-26
申请人： Jian Ni , Craig A. Rosen
发明人： Jian Ni , Craig A. Rosen
IPC分类号： A61K3900
CPC分类号： C07K14/70578 , A61K38/00 , C12N2799/026
摘要： The present invention relates to a novel protein, TR10, which is a member of the tumor necrosis factor (TNF) receptor superfamily and the TRAIL receptor subfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR10 protein. TR10 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR10 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体超家族和TRAIL受体亚家族成员的新蛋白质TR10。特别地，提供编码人TR10蛋白的分离的核酸分子。还提供TR10多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定TR10活性的激动剂和拮抗剂的筛选方法。

84. 发明授权

US06583270B2 Interleukin-19 有权
标题翻译：白细胞介素-19多肽及其变体
公开(公告)号：US06583270B2
公开(公告)日：2003-06-24
申请号：US09386380
申请日：1999-08-31
申请人： Craig A. Rosen , Joseph J. Kenny
发明人： Craig A. Rosen , Joseph J. Kenny
IPC分类号： C07K1454
CPC分类号： C07K14/54 , A61K38/00 , Y02A50/41
摘要： The present invention concerns a novel human cytokine. In particular, isolated nucleic acid molecules are provided encoding interleukin-19 (IL-19). IL-19 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further concerns therapeutic methods for modulating cytokine production.
摘要翻译：本发明涉及一种新的人细胞因子。特别地，提供编码白细胞介素-19（IL-19）的分离的核酸分子。还提供了IL-19多肽，载体，宿主细胞以及用于制备它们的重组方法。本发明还涉及调节细胞因子产生的治疗方法。

85. 发明授权

US06531447B1 Secreted protein HEMCM42 有权
标题翻译：分泌蛋白HEMCM42
公开(公告)号：US06531447B1
公开(公告)日：2003-03-11
申请号：US09690454
申请日：2000-10-18
申请人： Steven M. Ruben , Craig A. Rosen , Kenneth C. Carter , Patrick J. Dillon , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng
发明人： Steven M. Ruben , Craig A. Rosen , Kenneth C. Carter , Patrick J. Dillon , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng
IPC分类号： C07K1400
CPC分类号： C07K14/47 , A61K38/00 , C07K14/525 , G01N2500/04
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

86. 发明授权

US06521227B1 Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides 失效
标题翻译：编码前列腺生长因子的多核苷酸和产生前列腺生长因子多肽的方法
公开(公告)号：US06521227B1
公开(公告)日：2003-02-18
申请号：US09461418
申请日：1999-12-18
申请人： Peter L. Hudson , Craig A. Rosen , Wei Wu He
发明人： Peter L. Hudson , Craig A. Rosen , Wei Wu He
IPC分类号： A61K3942
CPC分类号： C07K14/575 , A61K39/00 , C07K16/22
摘要： The present invention relates to human PGF polypeptides, DNA (RNA) encoding such polypeptides, and antibodies specifically binding such polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques, and for producing antibodies and antagonist/inhibitors against such polypeptides. Also provided are methods of using the polypeptide therapeutically for treating prostate cancer, promoting tissue regeneration, and facilitating wound healing. Further provided are methods of using such antibodies therapeutically to inhibit the action of PGF polypeptides and for the treatment of PGF-dependent tumors. Also provided is a diagnostic assay to detect prostate cancer and benign prostatic hyperplasia.
摘要翻译：本发明涉及人PGF多肽，编码这种多肽的DNA（RNA）和与这些多肽特异性结合的抗体。还提供了通过重组技术产生这种多肽的方法，以及用于产生抗这种多肽的抗体和拮抗剂/抑制剂。还提供了用于治疗前列腺癌，促进组织再生和促进伤口愈合的方法。进一步提供的是使用这种抗体治疗性地抑制PGF多肽的作用和用于治疗PGF依赖性肿瘤的方法。还提供了用于检测前列腺癌和良性前列腺增生的诊断测定法。

87. 发明授权

US06518404B1 Human endothelin-bombesin receptor antibodies 有权
标题翻译：人内皮素 - 铃蟾肽受体抗体
公开(公告)号：US06518404B1
公开(公告)日：2003-02-11
申请号：US09520210
申请日：2000-03-07
申请人： Yi Li , Craig A. Rosen , Chandrika Kumar
发明人： Yi Li , Craig A. Rosen , Chandrika Kumar
IPC分类号： C07K1628
CPC分类号： C07K14/70571 , A61K38/00 , C07K14/72 , C07K14/723 , C12N2799/026
摘要： A human endothelin-bombesin receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for disclosed. Also disclosed are methods for utilizing such polypeptide for identifying agonists and antagonists to such polypeptide. Agonists to the endothelin-bombesin receptor polypeptide of the present invention may be used to treat asthma, Parkinson's Disease, acute heart failure, hypotension and osteoporosis. Antagonists against such polypeptides may be used therapeutically to treat hypertension, ulcerigenesis, subarachnoid hemorrhage, asthma, tumors, ciclosporin toxicity, cancer and septic shock. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.
摘要翻译：人内皮素 - 铃蟾肽受体多肽和编码这种多肽的DNA（RNA）和用于公开的方法。还公开了利用这种多肽识别这种多肽的激动剂和拮抗剂的方法。本发明的内皮素 - 铃蟾肽受体多肽的激动剂可用于治疗哮喘，帕金森病，急性心力衰竭，低血压和骨质疏松症。抗这种多肽的拮抗剂可以治疗性地用于治疗高血压，溃疡发生，蛛网膜下腔出血，哮喘，肿瘤，环孢菌素毒性，癌症和败血性休克。还公开了用于检测本发明的多核苷酸中的突变并用于检测衍生自宿主的样品中可溶性多肽的水平的诊断方法。

88. 发明授权

US06495519B1 Interleukin-1 &bgr; converting enzyme like apoptosis protease-3 and 4 失效
标题翻译：白细胞介素-1β转换酶如凋亡蛋白酶-3和4
公开(公告)号：US06495519B1
公开(公告)日：2002-12-17
申请号：US09124934
申请日：1998-07-28
申请人： Wei Wu He , Craig A. Rosen , Peter L. Hudson , Gregg A. Hastings
发明人： Wei Wu He , Craig A. Rosen , Peter L. Hudson , Gregg A. Hastings
IPC分类号： A61K3848
CPC分类号： C12N9/6475 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： Disclosed are human interleukin-1 &bgr; converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury.
摘要翻译：公开了人白细胞介素-1β转换酶如凋亡蛋白酶-3和4以及编码这种多肽的DNA（RNA）。还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。还提供了使用多肽例如抗肿瘤剂和抗病毒剂的方法，以及抗这种多肽的抗体和拮抗剂，例如用于治疗阿尔茨海默病，帕金森病，类风湿性关节炎和头部损伤。

89. 发明授权

US06461823B1 Death domain containing receptor-4 antibodies 有权
标题翻译：含有受体-4抗体的死亡域
公开(公告)号：US06461823B1
公开(公告)日：2002-10-08
申请号：US09448868
申请日：1999-11-24
申请人： Jian Ni , Craig A. Rosen , James G. Pan , Reiner L. Gentz , Vishva M. Dixit
发明人： Jian Ni , Craig A. Rosen , James G. Pan , Reiner L. Gentz , Vishva M. Dixit
IPC分类号： G01N33567
CPC分类号： C07K14/70578
摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。特别地，提供编码人DR4蛋白的分离的核酸分子。还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法。

90. 发明授权

US06451577B1 Human uridine disphosphate galactose-4-epimerase 失效
标题翻译：人尿苷磷酸半乳糖-4-差向异构酶
公开(公告)号：US06451577B1
公开(公告)日：2002-09-17
申请号：US09624183
申请日：2000-07-24
申请人： Hongjun Ji , Craig A. Rosen
发明人： Hongjun Ji , Craig A. Rosen
IPC分类号： C12N990
CPC分类号： C12N9/90
摘要： A human UDP galactose-4-epimerase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of galactosemia. Also disclosed are diagnostic assays for the detection of mutations in the nucleic acid sequencing encoding human UDP galactose-4-epimerase protein and for detecting an altered level of human UDP galactose-4-epimerase protein in a sample derived from a host.
摘要翻译：公开了人类UDP半乳糖-4-差向异构酶多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。还公开了利用这种多肽治疗半乳糖血症的方法。还公开了用于检测编码人UDP半乳糖-4-差向异构酶蛋白的核酸测序中的突变的诊断测定，并用于检测源自宿主的样品中人UDP半乳糖-4-差向异构酶蛋白的水平的变化。

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