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81. 发明授权

US06210716B1 Controlled release bupropion formulation 失效
标题翻译：受控释放的安非他酮制剂
公开(公告)号：US06210716B1
公开(公告)日：2001-04-03
申请号：US09259133
申请日：1999-02-26
申请人： Chih-Ming Chen , Jianbo Xie , Steve Jan
发明人： Chih-Ming Chen , Jianbo Xie , Steve Jan
IPC分类号： A61K914
CPC分类号： A61K9/2081 , A61K9/5078 , A61K9/5084
摘要： A controlled release dosage form of bupropion hydrochloride which comprises: (a) a first pellet having a core of bupropion hydrochloride and hydroxypropyl methylcellulose at a weight ratio of 10:1 to 30:1 and a coating of a mixture of an acrylic resin which is soluble in acidic media and ethyl cellulose; (b) a second pellet having a core of bupropion hydrochloride and hydroxypropyl methylcellulose at a ratio of 10:1 to 30:1; an inner coating of a mixture of an acrylic resin which is soluble in acidic media and a water insoluble polymer and an outer coating which comprises an enteric coating polymer.
摘要翻译：一种盐酸安非他酮的控释剂型，其包含：（a）具有核心的盐酸安非他酮和羟丙基甲基纤维素的重量比为10:1至30:1的第一颗粒和丙烯酸树脂的混合物的涂层，所述丙烯酸树脂是可溶于酸性介质和乙基纤维素;（b）具有10：1至30：1比例的盐酸安非他酮核心和羟丙基甲基纤维素的第二粒料; 可溶于酸性介质的丙烯酸树脂和水不溶性聚合物的混合物的内涂层和包含肠溶衣聚合物的外涂层。

82. 发明授权

US6106862A Once daily analgesic tablet 失效
标题翻译：每日一次止痛片
公开(公告)号：US6106862A
公开(公告)日：2000-08-22
申请号：US132796
申请日：1998-08-13
申请人： Chih-Ming Chen , Joseph Chou , David Wong
发明人： Chih-Ming Chen , Joseph Chou , David Wong
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22 , A61K9/28 , A61K31/64 , A61K9/30
CPC分类号： A61K9/2886 , A61K31/64 , A61K9/0004 , A61K9/2054 , A61K9/282 , A61K9/2866 , A61K9/2013
摘要： An analgesic controlled release dosage form containing: (a) 40-80 weight percent of an analgesic; (b) 10-30 weight percent of a pharmaceutically acceptable filler; and (c) 10-30 weight percent of a carrier base wherein the carrier base is formed from a high molecular weight hydroxypropyl methylcellulose, a water soluble binder and optionally a water insoluble binder.
摘要翻译：镇痛控释剂型，其含有：（a）40-80重量％的止痛剂; （b）10-30重量％的药学上可接受的填料; 和（c）10-30重量％的载体碱，其中载体碱由高分子量羟丙基甲基纤维素，水溶性粘合剂和任选的水不溶性粘合剂形成。

83. 发明授权

US6103263A Delayed pulse release hydrogel matrix tablet 失效
标题翻译：延迟脉冲释放水凝胶基质片
公开(公告)号：US6103263A
公开(公告)日：2000-08-15
申请号：US341478
申请日：1994-11-17
申请人： Der-Yang Lee , Chih-Ming Chen
发明人： Der-Yang Lee , Chih-Ming Chen
IPC分类号： A61K9/20 , A61K9/22
CPC分类号： A61K9/2054 , A61K9/2018
摘要： The invention provides a delayed-pulse controlled release pharmaceutical tablet having:(a) from 20 to 60 wt. % of a low molecular weight hydroxypropyl cellulose having a number average molecular weight of 70,000 to 90,000;(b) from 4 to 10 wt. % of a high molecular weight hydroxypropyl cellulose having a number average molecular weight of 1,100,000 to 1,200,000;(c) a pharmacologically acceptable amount of a medicament; and(d) an inert solid diluent.
摘要翻译：本发明提供了一种延迟脉冲控释药物片，其具有：（a）20至60重量％％数均分子量为70,000至90,000的低分子量羟丙基纤维素; （b）4-10wt。％数均分子量为1,100,000至1,200,000的高分子量羟丙基纤维素; （c）药理学上可接受量的药物; 和（d）惰性固体稀释剂。

84. 发明授权

US6057202A Method for manufacturing an inductor with resonant frequency and Q value increased in semiconductor process 失效
标题翻译：在半导体工艺中制造具有谐振频率和Q值的电感器的方法增加
公开(公告)号：US6057202A
公开(公告)日：2000-05-02
申请号：US034947
申请日：1998-03-05
申请人： Tzong-Liang Chen , Kuan-Ting Chen , Chih-Ming Chen , Hao-Chien Yung
发明人： Tzong-Liang Chen , Kuan-Ting Chen , Chih-Ming Chen , Hao-Chien Yung
IPC分类号： H01L21/02 , H01L23/522 , H01L27/08 , H01L21/20
CPC分类号： H01L28/10 , H01L23/5227 , H01L27/08 , H01L2924/0002
摘要： A method for manufacturing an inductor with resonant frequency and Q value increased in semiconductor process can reduce substrate coupling effect, because (an) air layer(s) is/are formed just under a spiral metal layer which functions as an inductor. In addition, part of the substrate material still remains around the air layer(s), which can be used as a support for the spiral metal layer. Therefore, a problem causing the above-mentioned spiral metal layer to collapse will never occur.
摘要翻译：在半导体工艺中增加谐振频率和Q值增加的电感器的制造方法可以减少衬底耦合效应，因为（a）空气层正好形成在用作电感器的螺旋金属层下方。此外，一部分基底材料仍然保留在空气层周围，空气层可用作螺旋金属层的支撑体。因此，不会发生导致上述螺旋状金属层崩溃的问题。

85. 发明授权

US6026028A Hot carrier injection programming and negative gate voltage channel erase flash EEPROM structure 失效
标题翻译：热载波注入编程和负栅极电压通道擦除闪存EEPROM结构
公开(公告)号：US6026028A
公开(公告)日：2000-02-15
申请号：US123305
申请日：1998-07-28
申请人： Chen-Hsi Lin , Chih-Ming Chen , Ling-Sung Wang , Horng-Ming Lee , Ko-Hsing Chang
发明人： Chen-Hsi Lin , Chih-Ming Chen , Ling-Sung Wang , Horng-Ming Lee , Ko-Hsing Chang
IPC分类号： G11C16/04 , H01L21/8247 , H01L27/115 , H01L29/788 , H01L29/792 , G11C13/00
CPC分类号： H01L29/7885
摘要： A flash electrical erasable programmable read only memory structure that utilizes hot carrier injection for programming and negative gate voltage to carry out channel erase operations. Characteristic of the memory structure includes a triple well structure having a P-well and an N-well located within a P-type substrate, wherein the N-well isolated the P-well from the P-type substrate. Therefore, an independently isolated triple well structure is established during memory erase operation.
摘要翻译：闪存电可擦除可编程只读存储器结构，其利用热载流子注入用于编程和负栅极电压来执行通道擦除操作。存储器结构的特征包括具有P阱和位于P型衬底内的N阱的三阱结构，其中N阱从P型衬底隔离P阱。因此，在存储器擦除操作期间建立独立隔离的三重阱结构。

86. 发明授权

US5998262A Method for manufacturing ETOX cell having damage-free source region 失效
标题翻译：制造具有无损源区的ETOX电池的方法
公开(公告)号：US5998262A
公开(公告)日：1999-12-07
申请号：US65369
申请日：1998-04-23
申请人： Chih-Ming Chen
发明人： Chih-Ming Chen
IPC分类号： H01L21/8247 , H01L21/336
CPC分类号： H01L27/11521
摘要： A method for manufacturing EPROM tunnel oxide cell having a damage-free source region. The method comprises the step of providing a substrate having a device region formed thereon, and then forming an ion-implanted region in the device area. Next, a gate oxide layer is formed over the substrate. Subsequently, a floating gate, a dielectric layer, a control gate and an oxide layer are sequentially formed above the substrate. This invention utilizes the implantation of a moderately heavy dose of ions into a device area prior to the formation of the gate oxide layer, so that a thicker gate oxide layer is formed above the source region. Hence, when the first polysilicon layer is etched in a subsequent self-aligned etching operation to establish the common source region, the thicker gate oxide layer can serve as a protective layer for the source region.
摘要翻译：一种具有无损源区的EPROM隧道氧化物电池的制造方法。该方法包括提供其上形成有器件区域的衬底，然后在器件区域中形成离子注入区域的步骤。接下来，在衬底上形成栅氧化层。随后，在衬底上方依次形成浮置栅极，电介质层，控制栅极和氧化物层。本发明利用在形成栅极氧化层之前将中等重量的离子注入器件区域，从而在源极区域上方形成较厚的栅极氧化物层。因此，当在随后的自对准蚀刻操作中蚀刻第一多晶硅层以建立公共源极区域时，较厚的栅极氧化物层可以用作源极区域的保护层。

87. 发明授权

US5834023A Diltiazem controlled release formulation 失效
公开(公告)号：US5834023A
公开(公告)日：1998-11-10
申请号：US677072
申请日：1996-07-09
申请人： Chih-Ming Chen
发明人： Chih-Ming Chen
IPC分类号： A61K9/52 , A61K9/50 , A61K9/58 , A61K31/55 , A61K31/554 , A61K47/30 , A61K9/14 , A61K9/22
CPC分类号： A61K9/5084 , A61K31/554 , A61K9/5078 , Y10S514/963
摘要： A once-a-day controlled release diltiazem formulation is described which includes: (a) from 20 to 50% by weight of enteric polymeric membrane coated pellets comprising a polymer membrane coated core which comprises a biologically inert core which is coated with a first layer which consists essentially of diltiazem and a polymeric binder; and a second layer which comprises a membrane comprising a pH dependent polymeric material; and (b) from 50% to 80% by weight of delayed pulse polymeric membrane coated pellets comprising a polymeric membrane coated core which comprises a biologically inert core which is coated with a first layer which consists essentially of diltiazem and a polymeric binder and a second layer which comprises a polymeric membrane which will substantially maintain its integrity in the varying pH conditions of the gastrointestinal tract but is permeable to diltiazem; and (c) a unit dose containment system.

88. 发明授权

US5756392A Method of formation of polycide in a semiconductor IC device 失效
标题翻译：在半导体IC器件中形成多硅化物的方法
公开(公告)号：US5756392A
公开(公告)日：1998-05-26
申请号：US787194
申请日：1997-01-22
申请人： Hsiang-Fan Lu , Jhon-Jhy Liaw , Chih-Ming Chen , Bu-Fang Chen
发明人： Hsiang-Fan Lu , Jhon-Jhy Liaw , Chih-Ming Chen , Bu-Fang Chen
IPC分类号： H01L21/28 , H01L21/768 , H01L29/49 , H01L21/283 , H01L21/324
CPC分类号： H01L21/76889 , H01L21/28061 , H01L21/28176 , H01L29/4933 , H01L21/28194
摘要： An method for the formation of polycide used for the gate electrode or interconnection metallization in semiconductor integrated circuit devices has been developed. The polycide is formed from doped amorphous silicon deposited from SiH.sub.4 and PH.sub.3 and tungsten silicide deposited from dichlorosilane (SiH.sub.2 Cl.sub.2 and WF.sub.6, followed by conventional RIE patterning. The key feature, annealing of the polycide structure by a combination of RTA (Rapid Thermal Anneal) in a nitrogen ambient, and then a furnace anneal in an oxygen ambient prevents deleterious sidewall growth on the polycide structure and results in a highly manufacturable process having high yield.
摘要翻译：已经开发了用于形成用于半导体集成电路器件中的栅电极或互连金属化的多晶硅化物的方法。聚硅氧烷由SiH4和PH3沉积的掺杂非晶硅和由二氯硅烷沉积的硅化钨（SiH2Cl2和WF6，然后是常规RIE图案化）形成，关键特征是通过RTA（快速热退火）的组合退火多晶硅化物结构氮环境，然后在氧环境中进行炉退火，可防止多晶硅结构上的有害的侧壁生长，并导致高产率的高度可制造的工艺。

89. 发明授权

US5654005A Controlled release formulation having a preformed passageway 失效
标题翻译：具有预制通道的控制释放制剂
公开(公告)号：US5654005A
公开(公告)日：1997-08-05
申请号：US476455
申请日：1995-06-07
申请人： Chih-Ming Chen , Der-Yang Lee , Jianbo Xie , Aurelio Rodriguez
发明人： Chih-Ming Chen , Der-Yang Lee , Jianbo Xie , Aurelio Rodriguez
IPC分类号： A61K9/00 , A61K9/22 , A61K9/36
CPC分类号： A61K9/0004
摘要： A controlled release pharmaceutical tablet having at least one passageway, said tablet having:(a) a compressed core which comprises:(i) a medicament;(ii) an amount of a water soluble osmotic agent which is effective to cause the medicament to be delivered from said passageway in the presence of aqueous media;(iii) a water-swellable pharmaceutically acceptable polymer; and(b) a membrane coating around said core tablet which comprises a water insoluble pharmaceutically acceptable polymer.
摘要翻译：一种具有至少一个通道的控释药物片剂，所述片剂具有：（a）压缩芯，其包含：（i）药物; （ii）一定量的水溶性渗透剂，其有效地引起药物在水介质存在下从所述通道递送; （iii）水溶胀性药学上可接受的聚合物; 和（b）围绕所述芯片的膜包衣，其包含水不溶性的药学上可接受的聚合物。

90. 发明授权

US5567441A Diltiazem controlled release formulation 失效
标题翻译：地尔硫卓控释制剂
公开(公告)号：US5567441A
公开(公告)日：1996-10-22
申请号：US409449
申请日：1995-03-24
申请人： Chih-Ming Chen
发明人： Chih-Ming Chen
IPC分类号： A61K9/52 , A61K9/50 , A61K9/58 , A61K31/55 , A61K31/554 , A61K47/30 , A61K9/60 , A61K9/62
CPC分类号： A61K9/5084 , A61K31/554 , A61K9/5078 , Y10S514/963
摘要： A once-a-day controlled release diltiazem formulation is described which includes:(a) from 20 to 50% by weight of enteric polymeric membrane coated pellets comprising a polymer membrane coated core which comprises a biologically inert core which is coated with a first layer which consists essentially of diltiazem and a polymeric binder; and a second layer which comprises a membrane comprising a pH dependent polymeric material; and(b) from 50% to 80% by weight of delayed pulse polymeric membrane coated pellets comprising a polymeric membrane coated core which comprises a biologically inert core which is coated with a first layer which consists essentially of diltiazem and a polymeric binder and a second layer which comprises a polymeric membrane which will substantially maintain its integrity in the varying pH conditions of the gastrointestinal tract but is permeable to diltiazem; and(c) a unit dose containment system.
摘要翻译：描述了一种一日一次的控释地尔硫卓制剂，其包括：（a）20至50重量％的包含聚合物膜包衣的核心的肠溶性聚合物膜包衣的丸剂，其包含生物惰性的芯，其涂覆有第一层其基本上由地尔硫卓和聚合物粘合剂组成; 以及第二层，其包括包含pH依赖性聚合物材料的膜; 和（b）50％至80％重量的延迟脉冲聚合物膜包衣的丸剂，其包含聚合物膜包衣芯，其包含生物惰性芯，其涂覆有基本上由地尔硫卓和聚合物粘合剂组成的第一层，其包含聚合物膜，其将在胃肠道的变化的pH条件下基本上保持其完整性，但是可渗透地尔硫卓; 和（c）单位剂量遏制系统。

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