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81. 发明申请

US20050199494A1 Analyte monitoring device and methods of use 有权
标题翻译：分析物监测装置及使用方法
公开(公告)号：US20050199494A1
公开(公告)日：2005-09-15
申请号：US11027423
申请日：2004-12-29
申请人： James Say , Michael Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip Plante , Mark Vreeke , Keith Friedman , Fredric Colman
发明人： James Say , Michael Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip Plante , Mark Vreeke , Keith Friedman , Fredric Colman
IPC分类号： G01N27/30 , A61B5/00 , A61B5/145 , A61B5/1477 , A61B5/1495 , G01N27/416 , G06F19/00 , H01L23/31 , H01L23/495 , G01N27/26
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
摘要翻译：分析物监测器包括传感器，传感器控制单元和显示单元。传感器具有例如基板，形成在基板中的凹陷通道，以及设置在凹陷通道中以形成工作电极的导电材料。传感器控制单元通常具有适于放置在皮肤上并适于接收电化学传感器的一部分的壳体。传感器控制单元还包括设置在壳体上并被配置为耦合到传感器上的两个或更多个接触垫的两个或更多个导电触头。发射器设置在壳体中并且耦合到多个导电接触件，用于传送使用传感器获得的数据。显示单元具有用于接收由传感器控制单元的发送器发送的数据的接收器和耦合到接收器的显示器以显示分析物水平的指示的接收器。分析物监测器还可以是药物递送系统的一部分，以基于使用传感器获得的数据来改变分析物的水平。

82. 发明申请

US20050164322A1 Small volume in vitro analyte sensor 有权
标题翻译：体积小体积分析物传感器
公开(公告)号：US20050164322A1
公开(公告)日：2005-07-28
申请号：US11035131
申请日：2005-01-13
申请人： Adam Heller , Benjamin Feldman , James Say , Mark Vreeke
发明人： Adam Heller , Benjamin Feldman , James Say , Mark Vreeke
IPC分类号： G01N33/483 , A61B5/00 , A61B5/145 , A61B5/1473 , A61B5/1486 , A61B5/15 , A61B5/151 , A61B5/157 , C12M1/34 , C12Q1/00 , G01N21/76 , G01N21/78 , G01N27/28 , G01N27/327 , G01N27/42 , G01N27/49 , G01N33/487 , G01N33/543 , G01N33/66 , C12Q1/54
CPC分类号： G01N27/3272 , A61B5/1411 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/150022 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/15105 , A61B5/15113 , A61B5/15144 , A61B5/157 , A61B2560/0223 , A61B2562/0295 , C12Q1/001 , C12Q1/004 , C12Q1/006 , G01N27/3273 , G01N33/5438 , G01N2333/904
摘要： A sensor designed to determine the amount and concentration of analyte in a sample having a volume of less than about 1 μL. The sensor has a working electrode coated with a non-leachable redox mediator. The redox mediator acts as an electron transfer agent between the analyte and the electrode. In addition, a second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. The redox mediator is typically a redox compound bound to a polymer. The preferred redox mediators are air-oxidizable. The amount of analyte can be determined by coulometry. One particular coulometric technique includes the measurement of the current between the working electrode and a counter or reference electrode at two or more times. The charge passed by this current to or from the analyte is correlated with the amount of analyte in the sample. Other electrochemical detection methods, such as amperometric, voltammetric, and potentiometric techniques, can also be used. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is provided as a second electron transfer agent.
摘要翻译：设计用于确定样品中分析物的量和浓度小于约1μl的传感器。该传感器具有涂覆有不可浸出的氧化还原介体的工作电极。氧化还原介体作为分析物和电极之间的电子转移剂。此外，可以加入第二电子转移剂，例如酶，以促进分析物的电氧化或电还原。氧化还原介体通常是与聚合物结合的氧化还原化合物。优选的氧化还原介体是可空气氧化的。分析物的量可以通过库仑法测定。一种特定的库仑技术包括两次或更多次测量工作电极与计数器或参考电极之间的电流。通过该电流流向或来自分析物的电荷与样品中分析物的量相关。还可以使用其他电化学检测方法，例如电流，伏安和电位技术。本发明可用于测定生物液体如血液或血清中生物分子如葡萄糖或乳酸盐的浓度。提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

83. 发明授权

US06623501B2 Reusable ceramic skin-piercing device 有权
标题翻译：可重复使用的陶瓷皮肤穿刺装置
公开(公告)号：US06623501B2
公开(公告)日：2003-09-23
申请号：US09827109
申请日：2001-04-05
申请人： Adam Heller , James L. Say , Jeffery V. Funderburk
发明人： Adam Heller , James L. Say , Jeffery V. Funderburk
IPC分类号： A61B1732
CPC分类号： A61B5/15032 , A61B5/150022 , A61B5/150328 , A61B5/150458 , A61B5/150633 , A61B5/150702 , A61B5/15105
摘要： A reusable ceramic skin-piercing device. The skin-piercing device is capable of piercing the skin so as to make a sample of biological fluid available for an assay. In one embodiment, the skin-piercing device includes a skin-piercing element which is heated prior to use to a sufficiently high temperature to kill or deactivate pathogenic microorganisms. The device is heat-sterilized, being heated by passing an electrical current through a resistive element in thermal contact with the heat-conducting ceramic piercer. In another embodiment, the skin-piercing device includes a sleeve of elastomeric material with a sterilizing agent disposed in contact with the skin-piercing element. The sterilizing agent sterilizes the skin-piercing element after use. The skin-piercing element is made of a hard refractory ceramic material. The ceramic material is optionally a composite, for example, a composite of a ceramic material and a metal, or multiple ceramic materials.
摘要翻译：一种可重复使用的陶瓷皮肤刺穿装置。皮肤穿刺装置能够穿透皮肤，以便制备可用于测定的生物流体样品。在一个实施方案中，皮肤刺穿装置包括穿刺元件，其在使用前被加热到足够高的温度以杀死或失活致病微生物。该装置被热灭菌，通过使电流通过与导热陶瓷穿孔器热接触的电阻元件来加热。在另一个实施例中，皮肤穿孔装置包括弹性体材料的套筒，其中设置有与皮肤刺穿元件接触的灭菌剂。消毒剂在使用后对穿刺元件进行消毒。皮肤刺穿元件由硬质耐火陶瓷材料制成。陶瓷材料可选地是复合材料，例如陶瓷材料和金属的复合材料，或多种陶瓷材料。

84. 发明授权

US06576461B2 Electrochemical affinity assay 有权
标题翻译：电化学亲和力测定
公开(公告)号：US06576461B2
公开(公告)日：2003-06-10
申请号：US09883591
申请日：2001-06-18
申请人： Adam Heller , Charles N. Campbell
发明人： Adam Heller , Charles N. Campbell
IPC分类号： C12M140
CPC分类号： G01N33/543 , C12Q1/002 , C12Q1/005 , G01N33/5438 , Y10S435/817 , Y10S436/806
摘要： An electrochemical affinity assay system for detection of ligand—ligand receptor binding.
摘要翻译：用于检测配体 - 配体受体结合的电化学亲和力测定系统。

85. 发明授权

US06537635B1 Pseudo-reflective read inhibitor for optical storage media 失效
标题翻译：用于光学存储介质的伪反射读取抑制剂
公开(公告)号：US06537635B1
公开(公告)日：2003-03-25
申请号：US09507224
申请日：2000-02-18
申请人： Yannis Bakos , Erik Brynjolfsson , Adam Heller , Ephraim Heller
发明人： Yannis Bakos , Erik Brynjolfsson , Adam Heller , Ephraim Heller
IPC分类号： B32B302
CPC分类号： G11B7/253 , G11B7/0037 , G11B7/0052 , G11B7/252 , G11B7/2534 , G11B7/2542 , G11B7/258 , G11B7/2585 , G11B7/259 , G11B7/2595 , G11B23/0021 , G11B23/282 , Y10T428/21
摘要： Systems and methods are described for inhibiting the readability of an optical media due to changes in a pseudo-reflective material that composes the optical media after the optical media has been exposed to air for a predetermined time. An optical media includes a data encoded component. At least a fraction of the data encoded component transforms from a substantially optically reflective state to a substantially optically non-reflective state as at-least-in-part a function of time from an initializing event. The systems and methods provide advantages because of low cost, limited content lifetime, avoidance of rental returns and minimum changes to existing manufacturing precesses.
摘要翻译：描述了系统和方法，用于在光学介质已经暴露于空气中预定时间之后，由于构成光学介质的伪反射材料的变化而抑制光学介质的可读性。光学介质包括数据编码部件。数据编码分量的至少一部分从基本上光学反射状态转换为基本上光学上不反射的状态，作为从初始化事件的时间的函数的至少部分变换。这些系统和方法由于成本低，内容寿命有限，避免租金回报以及现有制造过程的最小变化而提供了优势。

86. 发明授权

US06514718B2 Subcutaneous glucose electrode 失效
公开(公告)号：US06514718B2
公开(公告)日：2003-02-04
申请号：US09997808
申请日：2001-11-29
申请人： Adam Heller , Michael V. Pishko
发明人： Adam Heller , Michael V. Pishko
IPC分类号： C12Q154
CPC分类号： C12Q1/54 , C12Q1/006 , Y10S435/817 , Y10S435/917 , Y10S435/962
摘要： A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.

87. 发明授权

US06294281B1 Biological fuel cell and method 失效
标题翻译：生物燃料电池及方法
公开(公告)号：US06294281B1
公开(公告)日：2001-09-25
申请号：US09203227
申请日：1998-11-30
申请人： Adam Heller
发明人： Adam Heller
IPC分类号： H01M816
CPC分类号： H01M8/16 , H01M4/9008 , H01M2250/30 , Y02B90/18 , Y02E60/527
摘要： A fuel cell has an anode and a cathode with anode enzyme disposed on the anode and cathode enzyme is disposed on the cathode. The anode is configured and arranged to electrooxidize an anode reductant in the presence of the anode enzyme. Likewise, the cathode is configured and arranged to electroreduce a cathode oxidant in the presence of the cathode enzyme. In addition, anode redox hydrogel may be disposed on the anode to transduce a current between the anode and the anode enzyme and cathode redox hydrogel may be disposed on the cathode to transduce a current between the cathode and the cathode enzyme.
摘要翻译：燃料电池具有阳极和阴极，阳极酶设置在阳极上，阴极酶设置在阴极上。阳极配置和布置成在阳极酶存在下使阳极还原剂电氧化。同样，阴极被配置和布置成在阴极酶的存在下电解还原阴极氧化剂。此外，阳极氧化还原水凝胶可以设置在阳极上以在阳极和阳极酶之间转换电流，并且阴极氧化还原水凝胶可以设置在阴极上以转换阴极和阴极酶之间的电流。

88. 发明授权

US06281006B1 Electrochemical affinity assay 有权
标题翻译：电化学亲和力测定
公开(公告)号：US06281006B1
公开(公告)日：2001-08-28
申请号：US09138888
申请日：1998-08-24
申请人： Adam Heller , Charles N. Campbell
发明人： Adam Heller , Charles N. Campbell
IPC分类号： C12M140
CPC分类号： G01N33/543 , C12Q1/002 , C12Q1/005 , G01N33/5438 , Y10S435/817 , Y10S436/806
摘要： An electrochemical affinity assay system for detection of ligand—ligand receptor binding.
摘要翻译：用于检测配体 - 配体受体结合的电化学亲和力测定系统

89. 发明授权

US06251260B1 Potentiometric sensors for analytic determination 有权
标题翻译：用于分析物测定的电位传感器
公开(公告)号：US06251260B1
公开(公告)日：2001-06-26
申请号：US09158973
申请日：1998-08-24
申请人： Adam Heller , Chaim Yarnitzky
发明人： Adam Heller , Chaim Yarnitzky
IPC分类号： G01N2726
CPC分类号： G01N27/3271
摘要： A potentiometric electrode and method for the determination of an analyte in a sample by linearly correlating potential at the electrode with the concentration of the analyte in the sample.
摘要翻译：一种电位电极和方法，用于通过将电极上的电位与样品中的分析物的浓度线性相关来测定样品中的分析物。

90. 发明授权

US06175752B1 Analyte monitoring device and methods of use 失效
标题翻译：分析物监测装置及使用方法
公开(公告)号：US06175752B1
公开(公告)日：2001-01-16
申请号：US09070677
申请日：1998-04-30
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B505
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
摘要翻译：分析物监测器包括传感器，传感器控制单元和显示单元。传感器具有例如基板，形成在基板中的凹陷通道，以及设置在凹陷通道中以形成工作电极的导电材料。传感器控制单元通常具有适于放置在皮肤上并适于接收电化学传感器的一部分的壳体。传感器控制单元还包括设置在壳体上并被配置为耦合到传感器上的两个或更多个接触垫的两个或更多个导电触头。发射器设置在壳体中并且耦合到多个导电接触件，用于传送使用传感器获得的数据。显示单元具有用于接收由传感器控制单元的发送器发送的数据的接收器和耦合到接收器的显示器，用于显示分析物水平的指示。分析物监测器还可以是药物递送系统的一部分，以基于使用传感器获得的数据来改变分析物的水平。

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