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    • 81. 发明授权
    • Resorption-controllable medical implants
    • 吸收可控医用植入物
    • US07608101B2
    • 2009-10-27
    • US11897016
    • 2007-08-28
    • Barry N. GellmanJianmin Li
    • Barry N. GellmanJianmin Li
    • A61F2/06A61F2/02
    • A61L29/085A61L27/34A61L27/44A61L27/58A61L29/126A61L29/148A61L29/18A61L31/10A61L31/125A61L31/148A61L31/18A61M25/0045
    • Bioresorbable medical implants are designed to have different resorption rates over time or over the topography of the implants. The resorption of the medical implants are controlled by including layers having differing resorption rates. The layers resorb sequentially over time through sequential exposure to body fluids. A resorption-controllable medical implant includes a series of two or more layers. The first layer includes a first bioresorbable material. The second layer includes a second bioresorbable material and resorbable particles of a first kind dispersed within the second bioresorbable material. Additional layers of bioresorbable material alone or including resorbable particles may be added to slow or speed resorption and achieve desired control over the resorption of the implant. Resorbable particles can be added in differing amounts or kinds in various segments of the implant to provide topographically differing resorption rates.
    • 生物可吸收的医疗植入物被设计为具有不同的吸收速率随时间或超过植入物的形貌。 医疗植入物的吸收通过包括具有不同吸收速率的层来控制。 随着时间的推移,这些层依次暴露于体液。 吸收可控医用植入物包括一系列两层或多层。 第一层包括第一生物可吸收材料。 第二层包括分散在第二生物可吸收材料内的第一种可再吸收材料和可再吸收的第一种颗粒。 可添加单独的或包含可吸收颗粒的生物再吸收材料的附加层以减缓或加速吸收并实现对植入物吸收的期望控制。 可以在植入物的各个部分中以不同的量或种类加入可再吸收的颗粒以提供形貌上不同的再吸收速率。
    • 84. 发明授权
    • Resorption-controllable medical implants
    • 吸收可控医用植入物
    • US07261734B2
    • 2007-08-28
    • US10128214
    • 2002-04-23
    • Barry N. GellmanJianmin Li
    • Barry N. GellmanJianmin Li
    • A61F2/06A61F2/02
    • A61L29/085A61L27/34A61L27/44A61L27/58A61L29/126A61L29/148A61L29/18A61L31/10A61L31/125A61L31/148A61L31/18A61M25/0045
    • Bioresorbable medical implants are designed to have different resorption rates over time or over the topography of the implants. The resorption of the medical implants are controlled by including layers having differing resorption rates. The layers resorb sequentially over time through sequential exposure to body fluids. A resorption-controllable medical implant includes a series of two or more layers. The first layer includes a first bioresorbable material. The second layer includes a second bioresorbable material and resorbable particles of a first kind dispersed within the second bioresorbable material. Additional layers of bioresorbable material alone or including resorbable particles may be added to slow or speed resorption and achieve desired control over the resorption of the implant. Resorbable particles can be added in differing amounts or kinds in various segments of the implant to provide topographically differing resorption rates.
    • 生物可吸收的医疗植入物被设计为具有不同的吸收速率随时间或超过植入物的形貌。 医疗植入物的吸收通过包括具有不同吸收速率的层来控制。 随着时间的推移,这些层依次暴露于体液。 吸收可控医用植入物包括一系列两层或多层。 第一层包括第一生物可吸收材料。 第二层包括分散在第二生物可吸收材料内的第一种可再吸收材料和可再吸收的第一种颗粒。 可添加单独的或包含可吸收颗粒的生物再吸收材料的附加层以减缓或加速吸收并实现对植入物吸收的期望控制。 可以在植入物的各个部分中以不同的量或种类加入可再吸收的颗粒以提供形貌上不同的再吸收速率。
    • 88. 发明授权
    • Shear-sensitive injectable delivery system
    • 剪切敏感的注射输送系统
    • US06699214B2
    • 2004-03-02
    • US09487436
    • 2000-01-19
    • Barry N. Gellman
    • Barry N. Gellman
    • A61M3700
    • A61M5/2066A61M5/31596A61M2005/3139
    • A delivery system for delivering a shear-sensitive injectable material into the body of a mammal, such as a human being, acts as a mechanical feed that continuously mixes a shear-sensitive injectable material as it delivers the shear-sensitive injectable material to a target tissue, or to a site adjacent a target tissue. In one embodiment of the invention, the delivery system comprises an injector system including a rotatable mixing member coupled to a driving system. The injector system comprises a housing defining a lumen and having an output end and a driving system connection end and includes a rotatable mixing member for coupling to the driving system and for mixing and delivering the shear-sensitive injectable material. The driving system comprises a drive mechanism, an actuator capable of actuating the drive mechanism, and an interfacing member coupled to the drive mechanism for coupling with the mixing member to rotate the mixing member when the interfacing member is driven by the drive mechanism.
    • 用于将剪切敏感的可注射材料递送到哺乳动物(例如人)的体内的输送系统用作机械进料,其将剪切敏感的可注射材料连续混合,因为其将剪切敏感的可注射材料输送到靶 组织或邻近靶组织的部位。 在本发明的一个实施例中,输送系统包括喷射器系统,其包括联接到驱动系统的可旋转的混合部件。 注射器系统包括限定内腔并具有输出端和驱动系统连接端的壳体,并且包括用于联接到驱动系统并用于混合和输送剪切敏感的可注射材料的可旋转的混合构件。 所述驱动系统包括驱动机构,能够致动所述驱动机构的致动器,以及联接到所述驱动机构的接合构件,用于在所述接合构件被所述驱动机构驱动时与所述混合构件联接以旋转所述混合构件。
    • 90. 发明授权
    • Drainage devices and methods
    • 排水装置和方法
    • US06676624B2
    • 2004-01-13
    • US10028208
    • 2001-12-20
    • Barry N. Gellman
    • Barry N. Gellman
    • A61M500
    • A61M27/008A61M25/0017
    • A ureteral drainage stent is designed to be placed in a patient's ureter and extend into a patient's bladder. An elongated tubular segment includes a distal retention structure for placement in the renal cavity, and a proximal retention structure constructed at least partly from a foam material and for placement in a urinary bladder. A central lumen connects at least one opening in the distal retention structure to the foam proximal retention structure. The foam proximal retention structure typically extends along at least a lower part of the ureter, across the ureteral-vesical junction, and into the bladder, to provide drainage through multiple networked channels.
    • 输尿管引流支架被设计为放置在患者的输尿管中并延伸到患者的膀胱中。 细长管状部分包括用于放置在肾腔中的远端保持结构,以及至少部分地由泡沫材料构造并用于放置在膀胱中的近端保持结构。 中心腔将远端保持结构中的至少一个开口连接到泡沫近端保持结构。 泡沫近端保持结构通常沿着输尿管的至少一部分,穿过输尿管 - 囊泡,并进入膀胱,以通过多个联网通道提供排水。