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81. 发明授权

US08389254B2 Perhydrolase providing improved specific activity 失效
公开(公告)号：US08389254B2
公开(公告)日：2013-03-05
申请号：US13070123
申请日：2011-03-23
申请人： Robert Dicosimo , John Edward Gavagan , Mark Scott Payne
发明人： Robert Dicosimo , John Edward Gavagan , Mark Scott Payne
IPC分类号： C12N9/18
CPC分类号： C12N9/18 , C11D3/38636 , C11D3/3945 , C12P7/40 , D21C5/005 , D21C9/1036
摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.

82. 发明授权

US08329441B2 Production of peracids using an enzyme having perhydrolysis activity 有权
公开(公告)号：US08329441B2
公开(公告)日：2012-12-11
申请号：US13087800
申请日：2011-04-15
申请人： Robert Dicosimo , John Edward Gavagan , Mark Scott Payne , Frederick B. Cooling, III
发明人： Robert Dicosimo , John Edward Gavagan , Mark Scott Payne , Frederick B. Cooling, III
IPC分类号： C12N9/04 , C12N9/18
CPC分类号： C11D3/38636 , A01N37/16 , C11D3/2093 , C11D3/221 , C11D3/226 , C11D3/3947 , C11D3/48 , C12P7/40 , A01N37/02 , A01N37/12 , A01N37/46 , A01N43/16 , A01N59/00 , A01N61/00 , A01N2300/00
摘要： A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided.

83. 发明申请

US20120270580A1 System and Methods for Integrating Short Message Service Messaging with Contact Center Applications 有权
标题翻译：将短消息服务消息与联络中心应用程序集成的系统和方法
公开(公告)号：US20120270580A1
公开(公告)日：2012-10-25
申请号：US13537681
申请日：2012-06-29
申请人： Nikolay Anisimov , Yevgeniy Petrovykh , Sergey B. Belov , Mark Scott
发明人： Nikolay Anisimov , Yevgeniy Petrovykh , Sergey B. Belov , Mark Scott
IPC分类号： H04W4/14
CPC分类号： H04M3/5183 , H04L12/1822 , H04L12/66 , H04L51/04 , H04L51/36 , H04L51/38 , H04L67/02 , H04M3/5141 , H04M3/5191 , H04M3/523 , H04W4/12 , H04W4/14 , H04W40/02 , H04W88/16
摘要： A system for routing short message service (SMS) messages to endpoints in a contact center includes a first node for receiving SMS message streams from multiple sources operating variant protocols and for multiplexing the multiple streams into a single message stream following a universal protocol, a media gateway server connected to the first node for receiving the single message stream and for forwarding individual ones of the messages therein to individual ones of a plurality of connected servers, and a router connected to at least one of the connected servers for routing individual messages represented therein to individual ones of a plurality of network-supported endpoint devices.
摘要翻译：用于将短消息服务（SMS）消息路由到联络中心中的端点的系统包括用于从操作变体协议的多个源接收SMS消息流的第一节点，以及根据通用协议将多个流复用到单个消息流中的媒体网关服务器连接到第一节点，用于接收单个消息流，并将其中的各个消息转发到多个连接的服务器中的个别消息流，以及连接到至少一个连接的服务器的路由器，用于路由其中表示的各个消息到多个网络支持的端点设备中的单个的。

84. 发明授权

US08232892B2 Method and system for operating a well service rig 有权
标题翻译：操作井服务钻机的方法和系统
公开(公告)号：US08232892B2
公开(公告)日：2012-07-31
申请号：US12627457
申请日：2009-11-30
申请人： Mark Overholt , Torrence Cambridge , Mark Scott
发明人： Mark Overholt , Torrence Cambridge , Mark Scott
IPC分类号： G01V3/00
CPC分类号： E21B41/00
摘要： A system for automating service operations at a well includes a service rig having at least one input device, an engine connected to an engine electronic control unit having a engine controller area network, a plurality of crown sheeves, a cable, an output device, a communication infrastructure, and at least one of a computer and an operator station; at least one remote server in electronic communication with the communication infrastructure; and a web portal in electronic communication with the at least one remote server.
摘要翻译：用于在井处自动化服务操作的系统包括具有至少一个输入装置的服务装置，连接到具有发动机控制器区域网络的发动机电子控制单元的发动机，多个冠状罩，电缆，输出装置，通信基础设施，以及计算机和操作员站中的至少一个; 至少一个与所述通信基础设施电子通信的远程服务器; 以及与所述至少一个远程服务器进行电子通信的网络门户。

85. 发明申请

US20120179064A1 SURGICAL INSTRUMENT 审中-公开
标题翻译：手术器械
公开(公告)号：US20120179064A1
公开(公告)日：2012-07-12
申请号：US13262124
申请日：2010-03-31
申请人： Richard Mark Scott , Stephen Addison Hall
发明人： Richard Mark Scott , Stephen Addison Hall
IPC分类号： A61B10/02
CPC分类号： A61B10/0266 , A61B10/0291 , A61B10/06 , A61B2010/0208 , A61B2017/2927 , A61B2017/32004
摘要： A surgical instrument (10) for removing a sample (50, 82) from a body of tissue (80) comprises a support structure (30) and a knife (32) arranged to cut into the body of tissue (80). The knife (32) has at least a first blade (36a), a second blade (36b) and a third blade (36c), and each blade has two cutting edges (42a, 44a; 42b, 44b; 42c, 44c) defining an apex. The knife (32) is movable between a first configuration in which the blades (36a, 36b, 36c) are substantially aligned along the longitudinal axis (X) of the support structure (30), and a second configuration in which the blades (36a, 36b, 36c) define the walls of a pyramidal enclosure for containing the sample (50, 82). In one embodiment, the instrument (10) further comprises a biasing member (52a, 52b, 52c) arranged to urge each blade (36a, 36b, 36c) towards the central axis (X) of the support structure (30). In another embodiment, the instrument (10) further comprises a plunger (72) disposed in, and being axially movable in a longitudinal direction along, the support structure (30). The plunger (72) is arranged to move the knife (32) between the first configuration and the second configuration.
摘要翻译：用于从组织体（80）移除样品（50,82）的外科器械（10）包括支撑结构（30）和布置成切入组织体（80）的刀（32）。刀具（32）具有至少第一刀片（36a），第二刀片（36b）和第三刀片（36c），并且每个刀片具有两个切割边缘（42a，44a; 42b，44b; 42c，44c）一个顶点所述刀（32）可在其中所述刀片（36a，36b，36c）沿着所述支撑结构（30）的纵向轴线（X）基本上对准的第一构造和第二构造（第二构造，其中所述刀片，36b，36c）限定用于容纳样品（50,82）的金字塔形外壳的壁。在一个实施例中，仪器（10）还包括偏置构件（52a，52b，52c），该偏置构件（52a，52b，52c）朝着支撑结构（30）的中心轴线（X）推动每个叶片（36a，36b，36c）。在另一个实施例中，仪器（10）还包括柱塞（72），该柱塞（72）沿着支撑结构（30）沿着纵向方向设置并且可轴向移动。柱塞72设置成在第一配置和第二配置之间移动刀具32。

86. 发明申请

US20120156161A1 PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY 失效
公开(公告)号：US20120156161A1
公开(公告)日：2012-06-21
申请号：US13328390
申请日：2011-12-16
申请人： Robert DiCosimo , Mark Scott Payne , John Edward Gavagan
发明人： Robert DiCosimo , Mark Scott Payne , John Edward Gavagan
IPC分类号： A61L9/01 , C12N15/63 , C12N1/21 , D21H21/32 , C12P7/62 , A61K31/22 , D06L3/00 , C07H21/04 , C12N9/16
CPC分类号： C12N9/18 , C12Y301/01072
摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.

87. 发明申请

US20120156158A1 PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY 失效
公开(公告)号：US20120156158A1
公开(公告)日：2012-06-21
申请号：US13328350
申请日：2011-12-16
申请人： Robert DiCosimo , Mark Scott Payne , John Edward Gavagan
发明人： Robert DiCosimo , Mark Scott Payne , John Edward Gavagan
IPC分类号： C12P7/40 , C12N15/63 , C12N9/18 , C12M1/40 , C12N1/15 , D21C9/16 , C12N1/21 , A01N37/16 , D06L3/02 , A61L2/16 , A01P1/00 , C12N15/55 , C12N1/19
CPC分类号： C11D3/38636 , C11D3/2093 , C11D3/3942 , C11D3/3947 , C12N9/18 , C12P7/40 , C12Y301/01072 , D21C9/166
摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.

88. 发明申请

US20120156157A1 PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY 失效
公开(公告)号：US20120156157A1
公开(公告)日：2012-06-21
申请号：US13328336
申请日：2011-12-16
申请人： Robert DiCosimo , Mark Scott Payne , John Edward Gavagan
发明人： Robert DiCosimo , Mark Scott Payne , John Edward Gavagan
IPC分类号： C12N9/18 , C12N15/63 , C12N1/15 , C12N1/19 , C12N1/21 , D21C9/16 , A01N37/16 , A01P1/00 , A61L2/16 , C12M1/40 , D06L3/02 , C12N15/55 , C12P7/40
CPC分类号： C11D3/38636 , C11D3/3945 , C12N9/18 , C12P7/40 , C12Y301/01072
摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.

89. 发明授权

US08163801B2 Enzymatic production of peracids using perhydrolytic enzymes 有权
标题翻译：使用过水解酶对过酸的酶促生产
公开(公告)号：US08163801B2
公开(公告)日：2012-04-24
申请号：US12565419
申请日：2009-09-23
申请人： Robert DiCosimo , Mark Scott Payne , Eugenia Costa Hann , Vincent Brian Croud , John Edward Gavagan , Lorraine Winona Wagner
发明人： Robert DiCosimo , Mark Scott Payne , Eugenia Costa Hann , Vincent Brian Croud , John Edward Gavagan , Lorraine Winona Wagner
IPC分类号： A61K31/19 , A01N37/02 , A01N37/16 , C11D7/38 , C12N9/18
CPC分类号： A61L2/186 , A61L2/183 , A61L2202/18 , A61L2202/24 , A61L2202/26 , C11D1/521 , C11D3/2093 , C11D3/32 , C11D3/386 , C11D3/3947 , C11D3/48 , C12P7/00 , C12P7/40
摘要： A process is provided to produce a concentrated aqueous peracid solution in situ using at least one enzyme having perhydrolase activity in the presence of hydrogen peroxide (at a concentration of at least 500 mM) under neutral to acidic reaction conditions from suitable carboxylic acid esters (including glycerides) and/or amides substrates. The concentrated peracid solution produced is sufficient for use in a variety of disinfection and/or bleaching applications.
摘要翻译：提供了一种方法，在中性至酸性反应条件下，使用至少一种在过氧化氢（至少500mM浓度）存在下具有过水解酶活性的酶，从合适的羧酸酯（包括甘油酯）和/或酰胺底物。所生产的浓缩的过酸溶液足以用于各种消毒和/或漂白应用。

90. 发明授权

US08117538B2 Method for dynamically converting voice XML scripts into other compatible markup language scripts based on required modality 有权
标题翻译：基于所需模式将语音XML脚本动态转换为其他兼容标记语言脚本的方法
公开(公告)号：US08117538B2
公开(公告)日：2012-02-14
申请号：US12339904
申请日：2008-12-19
申请人： Nikolay Anisimov , Petr Makagon , Andriy Ryabchun , Mark Scott
发明人： Nikolay Anisimov , Petr Makagon , Andriy Ryabchun , Mark Scott
IPC分类号： G06F17/00
CPC分类号： H04M3/5183 , H04M3/4938
摘要： In a contact center, a routing interface for enabling redirection of interactions from one scripted resource type to another includes a language transformation engine executable from a browser application resident on a digital medium installed on or accessible to a computing appliance, and an interactive panel accessible through the browser application the panel containing selectable modality options. The language transformation engine has network access to a language server, and a routing strategy server, and wherein VXML scripts downloaded to the browser are transformed into scripts expressed in another markup language for presentation and wherein the transformed scripts are used at an end resource that the interaction is redirected to.
摘要翻译：在联络中心中，用于使得从一个脚本化资源类型到另一个脚本资源类型的交互重定向的路由接口包括可以从驻留在安装在计算设备上或可访问的数字媒体上的浏览器应用程序执行的语言转换引擎，以及可通过浏览器应用程序面板包含可选择的模式选项。语言转换引擎具有对语言服务器和路由策略服务器的网络访问，并且其中下载到浏览器的VXML脚本被转换成以另一种标记语言表示的脚本用于呈现，并且其中转换的脚本在最终资源处被使用，互动被重定向到。

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