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81. 发明申请

US20120156162A1 PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY 失效
标题翻译： PERHYDROLASE变体提供改进的特定活性
公开(公告)号：US20120156162A1
公开(公告)日：2012-06-21
申请号：US13328418
申请日：2011-12-16
申请人： Robert Dicosimo , Mark Scott Payne , John Edward Gavagan
发明人： Robert Dicosimo , Mark Scott Payne , John Edward Gavagan
IPC分类号： A61L9/01 , C12N9/16 , C12N1/21 , D21H21/32 , A01N37/02 , C07H21/04 , D06L3/00 , C12P7/62 , C12N15/63
CPC分类号： C12N9/18 , C12Y301/01072
摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritime acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
摘要翻译：提供具有过水解活性的乙酰木聚糖酯酶变体，用于从羧酸酯和过氧源产生过氧羧酸。更具体地，使用易错PCR和定点诱变来修饰Thermotoga海洋乙酰木聚糖酯酶基因，以产生特征在于比活性增加的酶催化剂。变体乙酰木聚糖酯酶可用于制备适用于各种用途的过氧羧酸，例如清洁，消毒，消毒，漂白，木浆加工和纸浆加工应用。

82. 发明申请

US20120156160A1 PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY 失效
公开(公告)号：US20120156160A1
公开(公告)日：2012-06-21
申请号：US13328381
申请日：2011-12-16
申请人： Robert DiCosimo , Mark Scott Payne , John Edward Gavagan
发明人： Robert DiCosimo , Mark Scott Payne , John Edward Gavagan
IPC分类号： A61L9/01 , C12N9/16 , C12N1/21 , D21H21/32 , A61K31/22 , C07H21/04 , D06L3/00 , C12P7/40 , C12N15/63
CPC分类号： A61L2/186 , A61L2/22 , A61L2/23 , A61L2202/24 , C12N9/18 , C12Y301/01072
摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.

83. 发明申请

US20120156155A1 PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY 失效
公开(公告)号：US20120156155A1
公开(公告)日：2012-06-21
申请号：US13328305
申请日：2011-12-16
申请人： Robert Dicosimo , Mark Scott Payne , John Edward Gavagan
发明人： Robert Dicosimo , Mark Scott Payne , John Edward Gavagan
IPC分类号： C12N9/18 , C12N15/63 , C12N1/15 , C12N1/19 , C12N1/21 , D06L3/02 , A01N37/16 , A01P1/00 , A61L2/16 , C12M1/40 , D21C9/16 , C12N15/55 , C12P7/40
CPC分类号： C11D3/3945 , C12N9/18 , C12P7/40 , C12P7/54 , C12Y301/01072 , D21C5/005 , D21C9/166
摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.

84. 发明授权

US08168676B2 Production on peracids using an enzyme having perhydrolysis activity 有权
标题翻译：使用具有过水解活性的酶对过酸生产
公开(公告)号：US08168676B2
公开(公告)日：2012-05-01
申请号：US12722288
申请日：2010-03-11
申请人： Robert Dicosimo , John Edward Gavagan , Mark Scott Payne , Frederick B. Cooling, III
发明人： Robert Dicosimo , John Edward Gavagan , Mark Scott Payne , Frederick B. Cooling, III
IPC分类号： A01N37/00 , C12P7/40 , C12N9/14
CPC分类号： A01N37/02 , A01N37/16 , A01N37/36 , A01N59/00 , A61L2/186 , C12P7/40 , C12P7/62 , A01N63/02 , A01N2300/00
摘要： A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided.
摘要翻译：提供了从羧酸酯制备过氧羧酸的方法。更具体地说，羧酸酯与无机过氧化物如过氧化氢在具有过水解活性的酶催化剂存在下反应。基于保守的结构特征，本发明的过水解酶催化剂被分类为碳水化合物酯酶家族7（CE-7）的成员。此外，提供包含通过本文所述方法生产的过酸的消毒剂制剂。

85. 发明授权

US08063008B2 Enzymatic production of peracids using perhydrolytic enzymes 有权
标题翻译：使用过水解酶对过酸的酶促生产
公开(公告)号：US08063008B2
公开(公告)日：2011-11-22
申请号：US12471030
申请日：2009-05-22
申请人： Robert DiCosimo , Mark Scott Payne , Eugenia Costa Hann , Vincent Brian Croud , John Edward Gavagan , Lorraine Winona Wagner
发明人： Robert DiCosimo , Mark Scott Payne , Eugenia Costa Hann , Vincent Brian Croud , John Edward Gavagan , Lorraine Winona Wagner
IPC分类号： C11D7/38 , A01N37/16 , A01P1/00 , C12N9/18
CPC分类号： C11D3/3947 , A61L2/183 , A61L2/186 , A61L2202/18 , A61L2202/24 , A61L2202/26 , C11D3/2093 , C11D3/32 , C11D3/38627 , C11D3/48 , C12P7/00 , C12P7/40
摘要： A process is provided to produce a concentrated aqueous peracid solution in situ using at least one enzyme having perhydrolase activity in the presence of hydrogen peroxide (at a concentration of at least 500 mM) under neutral to acidic reaction conditions from suitable carboxylic acid esters (including glycerides) and/or amides substrates. The concentrated peracid solution produced is sufficient for use in a variety of disinfection and/or bleaching applications.
摘要翻译：提供了一种方法，在中性至酸性反应条件下，使用至少一种在过氧化氢（至少500mM浓度）存在下具有过水解酶活性的酶，从合适的羧酸酯（包括甘油酯）和/或酰胺底物。所生产的浓缩的过酸溶液足以用于各种消毒和/或漂白应用。

86. 发明申请

US20110094296A1 Systems and Methods for Measurement and Analysis of Pipeline Contaminants 有权
标题翻译：管道污染物测量与分析系统与方法
公开(公告)号：US20110094296A1
公开(公告)日：2011-04-28
申请号：US12913302
申请日：2010-10-27
申请人： David Burns , Tomas Borjon , Mark Scott
发明人： David Burns , Tomas Borjon , Mark Scott
IPC分类号： G01N1/20
CPC分类号： G01N15/0205 , G01N2001/2223 , G01N2001/225 , G01N2015/1486 , G01N2030/8886
摘要： A system for measurement and analysis of pipeline contaminants is provided. The system includes a first assembly for engaging a pipeline from which a first fluid flow sample may be isokinetically collected for measurement of aerosol contaminants. The system also includes a second assembly for engaging the pipeline from which a second fluid flow sample may be collected for chromatographic analysis of the aerosol contaminants. The system may further include a third assembly for engaging the pipeline from which a fluid flow sample may be obtained for measurement of solid contaminants. Information on aerosol contaminants and solid contaminants can subsequently be used to select an appropriate extraction technology to control the presence of aerosol and solid contaminants within the pipeline. Information from the chromatographic analysis, on the other hand, may be used to identify the origin of the aerosol contaminants, so that corrective measures can be implemented to minimize the presence of aerosol contaminants within the pipeline. A method for measurement and analysis of pipeline contaminants is also provided.
摘要翻译：提供了一种用于管道污染物测量和分析的系统。该系统包括用于接合管道的第一组件，从该管道可以动态地收集第一流体流动样品用于测量气溶胶污染物。该系统还包括用于接合管道的第二组件，从该管道可以收集第二流体流动样品用于气溶胶污染物的色谱分析。该系统还可以包括用于接合管道的第三组件，从该管道可获得用于测量固体污染物的流体流动样本。随后可以使用关于气溶胶污染物和固体污染物的信息来选择适当的提取技术来控制管道内气溶胶和固体污染物的存在。另一方面，来自色谱分析的信息可用于识别气溶胶污染物的来源，以便可以实施纠正措施以最小化管道内气溶胶污染物的存在。还提供了一种测量和分析管道污染物的方法。

87. 发明授权

US07854158B2 Systems and methods for measurement and analysis of pipeline contaminants 有权
标题翻译：管道污染物测量和分析的系统和方法
公开(公告)号：US07854158B2
公开(公告)日：2010-12-21
申请号：US11646846
申请日：2006-12-28
申请人： David Burns , Tomas Borjon , Mark Scott
发明人： David Burns , Tomas Borjon , Mark Scott
IPC分类号： G01N30/02 , G01N30/90
CPC分类号： G01N15/0205 , G01N2001/2223 , G01N2001/225 , G01N2015/1486 , G01N2030/8886
摘要： A system for measurement and analysis of pipeline contaminants is provided. The system includes a first assembly for engaging a pipeline from which a first fluid flow sample may be isokinetically collected for measurement of aerosol contaminants. The system also includes a second assembly for engaging the pipeline from which a second fluid flow sample may be collected for chromatographic analysis of the aerosol contaminants. The system may further include a third assembly for engaging the pipeline from which a fluid flow sample may be obtained for measurement of solid contaminants. Information on aerosol contaminants and solid contaminants can subsequently be used to select an appropriate extraction technology to control the presence of aerosol and solid contaminants within the pipeline. Information from the chromatographic analysis, on the other hand, may be used to identify the origin of the aerosol contaminants, so that corrective measures can be implemented to minimize the presence of aerosol contaminants within the pipeline. A method for measurement and analysis of pipeline contaminants is also provided.
摘要翻译：提供了一种用于管道污染物测量和分析的系统。该系统包括用于接合管道的第一组件，从该管道可以动态地收集第一流体流动样品用于测量气溶胶污染物。该系统还包括用于接合管道的第二组件，从该管道可以收集第二流体流动样品用于气溶胶污染物的色谱分析。该系统还可以包括用于接合管道的第三组件，从该管道可获得用于测量固体污染物的流体流动样本。随后可以使用关于气溶胶污染物和固体污染物的信息来选择适当的提取技术来控制管道内气溶胶和固体污染物的存在。另一方面，来自色谱分析的信息可用于识别气溶胶污染物的来源，以便可以实施纠正措施以最小化管道内气溶胶污染物的存在。还提供了一种测量和分析管道污染物的方法。

88. 发明授权

US07767792B2 Antibodies to EGF receptor epitope peptides 有权
标题翻译： EGF受体表位肽的抗体
公开(公告)号：US07767792B2
公开(公告)日：2010-08-03
申请号：US11060646
申请日：2005-02-17
申请人： Terrance Grant Johns , Andrew Mark Scott , Antony Wilks Burgess , Lloyd J. Old , Timothy E. Adams , K. Dane Wittrup , Ginger Chao , Peter Anthony Hoyne
发明人： Terrance Grant Johns , Andrew Mark Scott , Antony Wilks Burgess , Lloyd J. Old , Timothy E. Adams , K. Dane Wittrup , Ginger Chao , Peter Anthony Hoyne
IPC分类号： C12P21/08 , C07K17/00 , C07K14/00
CPC分类号： C07K14/71 , A61K39/00
摘要： The present invention relates generally to growth factor receptor epitope peptides, particularly EGF family receptor epitope peptides. The invention also relates to the use of the receptor peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against the receptor peptides. Methods for generating an immune response and for treatment of tumors and cancer are also provided.
摘要翻译：本发明一般涉及生长因子受体表位肽，特别是EGF家族受体表位肽。本发明还涉及受体肽在产生具有抗肿瘤或抗癌活性或刺激免疫应答的抗体中的用途。本发明还涉及特异性针对受体肽的抗体。还提供了产生免疫应答和治疗肿瘤和癌症的方法。

89. 发明授权

US07665671B2 Thermostatic mixing valve 有权
标题翻译：恒温混合阀
公开(公告)号：US07665671B2
公开(公告)日：2010-02-23
申请号：US10559975
申请日：2004-06-04
申请人： Aaron Christian Cunningham , Tony Mark Scott
发明人： Aaron Christian Cunningham , Tony Mark Scott
IPC分类号： G05D23/185 , G05D23/13 , G05D23/12 , G05D23/08 , F23N5/10
CPC分类号： G05D23/134
摘要： Thermostatic mixing valve has a valve body, a cold fluid inlet, a hot fluid inlet, and a fluid outlet. Mixing chamber is located between the respective fluid inlets and the fluid outlet. Thermostatic element is located in or adjacent to the mixing chamber and is arranged to contact a piston at one end and via a mixing tube the valve body at the other end. Piston regulates flow through the fluid inlets into the mixing chamber. The piston is can move due to continued expansion of the thermostatic element after the piston has closed off the second fluid inlet. Valve body has an internal thread with which a thread on mixing tube permits adjustment of the relative position of the thermostatic element within the valve body and hence the set temperature of the thermostatic mixing valve.
摘要翻译：恒温混合阀具有阀体，冷流体入口，热流体入口和流体出口。混合室位于相应的流体入口和流体出口之间。恒温元件位于或邻近混合室，并且被布置成在一端接触活塞并且经由混合管与另一端的阀体接触。活塞调节通过流体进入混合室的流量。活塞可以在活塞已经关闭第二流体入口之后由于恒温元件的继续膨胀而移动。阀体具有内螺纹，混合管上的螺纹可以调节恒温元件在阀体内的相对位置，从而调节恒温混合阀的设定温度。

90. 发明申请

US20090312627A1 Radio-labeled ingestible capsule 审中-公开
标题翻译：放射标记的摄入胶囊
公开(公告)号：US20090312627A1
公开(公告)日：2009-12-17
申请号：US12456093
申请日：2009-06-11
申请人： Laura A. Matott , John R. Semler , Mark Scott
发明人： Laura A. Matott , John R. Semler , Mark Scott
IPC分类号： A61B6/12
CPC分类号： A61B6/12 , A61B5/036 , A61B5/06 , A61B5/064 , A61B5/14539 , A61B5/6861 , A61B6/4258 , A61J3/071
摘要： A method of determining the location of an ingested capsule comprising the steps of providing an ingestible capsule (15) having a shell (16) and a flexible fluid retaining sleeve (17) affixed to the sleeve and defining a chamber (19) between the shell and the sleeve, the fluid retaining sleeve having a fill port (30), providing a radioactive material (22) contained in a filling device (31) having an output port (32) adapted to engage the fill port of the sleeve, engaging the output port of the filling device with the fill port of the sleeve, moving the radioactive material through the output port and into the chamber of the sleeve through the sleeve fill port, sealing the fill port to provide a radio-labeled ingestible capsule, having a subject ingest the radio-labeled capsule, and screening the subject by gamma imagining to determine location of the radio-labeled capsule within the subject.
摘要翻译：一种确定摄取的胶囊的位置的方法，包括以下步骤：提供具有壳体（16）和固定到所述套筒上的柔性流体保持套筒（17）的可摄取胶囊（15），并在所述壳体和所述套筒，所述流体保持套筒具有填充口（30），提供容纳在填充装置（31）中的放射性材料（22），所述放射性材料具有适于接合所述套筒的填充口的输出端口（32）所述填充装置的输出端口具有所述套筒的填充端口，通过所述套筒填充口移动所述放射性材料通过所述输出端口并进入所述套筒的腔室，密封所述填充口以提供放射性标签的可摄取胶囊，摄取放射性标签胶囊，并通过伽玛想象筛选受试者以确定受试者内的放射性标签胶囊的位置。

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