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81. 发明申请

US20110034536A1 CONTROLLING THE POTENTIAL OF PRIMATE NEURAL STEM CELLS BY REGULATING PAX6 有权
标题翻译：通过调节PAX6控制原始神经干细胞的潜力
公开(公告)号：US20110034536A1
公开(公告)日：2011-02-10
申请号：US12849249
申请日：2010-08-03
申请人： SU-CHUN ZHANG , XIAOQING ZHANG
发明人： SU-CHUN ZHANG , XIAOQING ZHANG
IPC分类号： A61K31/7105 , C12N5/0797 , A61P35/00
CPC分类号： C12N5/0623 , C12N5/0618 , C12N5/0696 , C12N15/86 , C12N2501/40 , C12N2501/60 , C12N2502/99 , C12N2506/02 , C12N2506/08 , C12N2510/00
摘要： A transcription factor both necessary and sufficient for human neuroectoderm specification, Pax6, as well as applications thereof, is disclosed.
摘要翻译：公开了对人神经外胚层规范Pax6所必需的足够的转录因子及其应用。

82. 发明授权

US07862766B2 Method for functionalization of nanoscale fiber films 有权
标题翻译：纳米纤维膜功能化方法
公开(公告)号：US07862766B2
公开(公告)日：2011-01-04
申请号：US11749302
申请日：2007-05-16
申请人： Zhiyong Liang , Ben Wang , Chun Zhang , Shiren Wang
发明人： Zhiyong Liang , Ben Wang , Chun Zhang , Shiren Wang
IPC分类号： H01J37/30 , H05B6/00 , B29C35/08 , B29C35/10 , C01B31/00 , B01J19/08
CPC分类号： D06M10/008 , B82Y30/00 , B82Y40/00 , C01B32/174 , D06M2101/40 , D21H13/50 , D21H15/02 , D21H19/14 , D21H25/04 , Y10S977/742
摘要： Methods are provided for functionalizing a macroscopic film comprised of nanoscale fibers by controlled irradiation. The methods may include the steps of (a) providing a nanoscale fiber film material comprising a plurality of nanoscale fibers (which may include single wall nanotubes, multi-wall nanotubes, carbon nanofibers, or a combination thereof); and (b) irradiating the nanoscale fiber film material with a controlled amount of radiation in the open air or in a controlled atmosphere. The step of irradiating the nanoscale fiber film material is effective to functionalize the plurality of nanoscale fibers. Irradiated nanoscale fiber films are also provided having improved mechanical and electrical conducting properties.
摘要翻译：提供了通过受控照射使由纳米级纤维构成的肉眼膜官能化的方法。所述方法可以包括以下步骤：（a）提供包含多个纳米级纤维（其可以包括单壁纳米管，多壁纳米管，碳纳米纤维或其组合）的纳米级纤维膜材料; 和（b）在露天或受控气氛中用受控量的辐射照射纳米级纤维膜材料。对纳米级纤维膜材料照射的步骤对多个纳米级纤维进行官能化是有效的。还提供了具有改善的机械和导电性能的辐照的纳米级纤维膜。

83. 发明授权

US07818281B2 Computer software for visualizing recombination events in a group of individuals from recombination breakpoints and assignments in high density SNP genotyping data by generating a color-coded view for each individual chromosome and a whole genome view for the group 有权
标题翻译：计算机软件，用于通过为每个单独的染色体生成一个颜色编码的视图和该组的整个基因组视图来显现来自重组断裂点和高密度SNP基因分型数据中的分配的一组个体中的重组事件
公开(公告)号：US07818281B2
公开(公告)日：2010-10-19
申请号：US11674726
申请日：2007-02-14
申请人： Giulia Kennedy , Yaron Turpaz , Chun Zhang
发明人： Giulia Kennedy , Yaron Turpaz , Chun Zhang
IPC分类号： G06F15/00 , G06F3/00
CPC分类号： G06F19/26 , G06F19/18 , G06F19/20
摘要： A computer system for visualizing recombination events in a group of individuals is provided. According to one aspect of the invention, high-density SNP genotype data is obtained from related individuals in a family. A pedigree is created, haplotypes are reconstructed and likely recombination breakpoints are identified with the use of publicly available computer programs. A software tool is then used facilitate the visualization of the recombination events in the family.
摘要翻译：提供了用于在一组个体中可视化重组事件的计算机系统。根据本发明的一个方面，从家族中的相关个体获得高密度SNP基因型数据。创建谱系，单倍型被重建，并且可能使用公共可用的计算机程序识别重组断点。然后使用软件工具来促进家族中重组事件的可视化。

84. 发明申请

US20100005077A1 METHODS AND SYSTEMS FOR GENERATING QUERY PLANS THAT ARE COMPATIBLE FOR EXECUTION IN HARDWARE 审中-公开
标题翻译：用于产生兼容硬件执行的查询计划的方法和系统
公开(公告)号：US20100005077A1
公开(公告)日：2010-01-07
申请号：US12168821
申请日：2008-07-07
申请人： Ravi Krishnamurthy , Chi-Young Ku , James Shau , Chun Zhang , Kapil Surlaker , Jeremy Branscome , Michael Corwin , Joseph I. Chamdani
发明人： Ravi Krishnamurthy , Chi-Young Ku , James Shau , Chun Zhang , Kapil Surlaker , Jeremy Branscome , Michael Corwin , Joseph I. Chamdani
IPC分类号： G06F17/30
CPC分类号： G06F16/24542
摘要： Embodiments of the present invention generate and optimize query plans that are at least partially executable in hardware. Upon receiving a query, the query is rewritten and optimized with a bias for hardware execution of fragments of the query. A template-based algorithm may be employed for transforming a query into fragments and then into query tasks. The various query tasks can then be routed to either a hardware accelerator, a software module, or sent back to a database management system for execution. For those tasks routed to the hardware accelerator, the query tasks are compiled into machine code database instructions. In order to optimize query execution, query tasks may be broken into subtasks, rearranged based on available resources of the hardware, pipelined, or branched conditionally
摘要翻译：本发明的实施例生成和优化在硬件中至少部分可执行的查询计划。在接收到查询后，查询将被重写和优化，以便查询的片段的硬件执行偏差。可以采用基于模板的算法将查询转换成片段，然后转换为查询任务。然后可以将各种查询任务路由到硬件加速器，软件模块，或者发送回数据库管理系统以执行。对于路由到硬件加速器的任务，将查询任务编译为机器码数据库指令。为了优化查询执行，查询任务可能被分解为子任务，根据硬件的可用资源，流水线或有条件的分支进行重新排列

85. 发明申请

US20080263001A1 SYSTEM AND METHOD FOR AUTOMATING DATA PARTITIONING IN A PARALLEL DATABASE 失效
标题翻译：用于在并行数据库中自动数据分区的系统和方法
公开(公告)号：US20080263001A1
公开(公告)日：2008-10-23
申请号：US12110674
申请日：2008-04-28
申请人： GUY MARING LOHMAN , Nimrod Megiddo , Jun Rao , Chun Zhang
发明人： GUY MARING LOHMAN , Nimrod Megiddo , Jun Rao , Chun Zhang
IPC分类号： G06F17/30
CPC分类号： G06F17/30584 , G06F17/30445 , Y10S707/99943 , Y10S707/99953
摘要： A system for automating data partitioning in a parallel database includes plural nodes connected in parallel. Each node includes a database server and two databases connected thereto. Each database server includes a query optimizer. Moreover, a partitioning advisor communicates with the database server and the query optimizer. The query optimizer and the partitioning advisor include a program for recommending and evaluating data table partitions that are useful for processing a workload of query statements. The data table partitions are recommended and evaluated without requiring the data tables to be physically repartitioned.
摘要翻译：用于在并行数据库中自动化数据划分的系统包括并行连接的多个节点。每个节点包括一个数据库服务器和两个连接到其上的数据库。每个数据库服务器都包含一个查询优化器。此外，分区顾问与数据库服务器和查询优化器进行通信。查询优化器和分区顾问程序包括一个用于推荐和评估对处理查询语句的工作负载有用的数据表分区的程序。建议和评估数据表分区，而不需要物理重新分区数据表。

86. 发明授权

US06887706B2 Method of in vitro differentiation of transplantable neural precursor cells from primate embryonic stem cells 有权
标题翻译：从灵长类动物胚胎干细胞体外分化可移植神经前体细胞的方法
公开(公告)号：US06887706B2
公开(公告)日：2005-05-03
申请号：US09970382
申请日：2001-10-03
申请人： Su-Chun Zhang , James A. Thomson , Ian David Duncan
发明人： Su-Chun Zhang , James A. Thomson , Ian David Duncan
IPC分类号： A61K35/12 , C12N5/02 , C12N5/0797 , C12N5/00 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0623 , A61K35/12 , C12N2500/25 , C12N2501/115 , C12N2501/392 , C12N2501/91 , C12N2502/13 , C12N2506/02
摘要： A method of differentiating embryonic stem cells into neural precursor cells is disclosed. In one embodiment the method comprises the steps of (a) obtaining an embryonic stem cell culture, (b) propagating the stem cells, (c) forming embryoid bodies from the stem cells, and (d) culturing the embryoid bodies in a medium containing an effective amount of fibroblast growth factor 2, wherein neural precursor cells will be generated and isolated.
摘要翻译：公开了将胚胎干细胞分化成神经前体细胞的方法。在一个实施方案中，该方法包括以下步骤：（a）获得胚胎干细胞培养物，（b）扩增干细胞，（c）从干细胞形成胚状体，和（d）在含有有效量的成纤维细胞生长因子2，其中将产生和分离神经前体细胞。

87. 发明授权

US06809515B1 Passive solid-state magnetic field sensors and applications therefor 失效
标题翻译：被动固态磁场传感器及其应用
公开(公告)号：US06809515B1
公开(公告)日：2004-10-26
申请号：US09358177
申请日：1999-07-20
申请人： Yi-Qun Li , Robert C. O'Handley , Gerald F. Dionne , Chun Zhang
发明人： Yi-Qun Li , Robert C. O'Handley , Gerald F. Dionne , Chun Zhang
IPC分类号： G01R3300
CPC分类号： G01R33/18 , G01R33/02
摘要： Passive solid-state magnetic sensors are based on the combination of magnetorestrictive materials and piezoelectric materials. Sensors have applications in rotor speed detection, magnetic field detection, read heads, and MRAM, for example.
摘要翻译：被动固态磁传感器基于磁致伸缩材料和压电材料的组合。传感器在转子速度检测，磁场检测，读取头和MRAM方面有应用。

88. 发明授权

US09475806B2 Complement factor B inhibitors and uses there of 有权
标题翻译：补体因子B抑制剂及其用途
公开(公告)号：US09475806B2
公开(公告)日：2016-10-25
申请号：US14774430
申请日：2014-03-13
申请人： Christopher Michael Adams , Charles Babu , Michael Paul Capparelli , Jian Ding , Takeru Ehara , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Liang Xue , Nello Mainolfi , James J. Powers , Michael H. Serrano-Wu , Chun Zhang
发明人： Christopher Michael Adams , Charles Babu , Michael Paul Capparelli , Jian Ding , Takeru Ehara , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Liang Xue , Nello Mainolfi , James J. Powers , Michael H. Serrano-Wu , Chun Zhang
IPC分类号： C07D401/14 , A61K31/4353 , A61K31/437 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as Factor B inhibitors for the treatment of conditions and diseases associated with complement alternative pathway activation such as age-related macular degeneration, diabetic retinopathy and related ophthalmic diseases. The present invention further provides pharmaceutical compositions and combinations of pharmacologically active agents.

89. 发明授权

US09193967B2 Pegylated analogue protein or canine urate oxidase, preparation method and use thereof 有权
标题翻译：聚乙二醇化类似蛋白或犬尿酸氧化酶，其制备方法和用途
公开(公告)号：US09193967B2
公开(公告)日：2015-11-24
申请号：US13985273
申请日：2012-02-14
申请人： Chun Zhang , Kai Fan , Xuefeng Ma , Li Yang , Chunlan Hu , Hua Luo , Xiang Mei
发明人： Chun Zhang , Kai Fan , Xuefeng Ma , Li Yang , Chunlan Hu , Hua Luo , Xiang Mei
IPC分类号： A61K48/00 , C12N9/96 , A61K47/48 , C12N9/06 , A61K38/00
CPC分类号： C12N9/96 , A61K38/00 , A61K47/60 , C12N9/0048 , C12Y107/03003
摘要： Provided are a PEGylated analogue protein of canine urate oxidase, preparation method and use thereof. The analogue protein of canine urate oxidase is a canine urate oxidase, or a chimeric protein comprising part of the amino acid sequence of a canine urate oxidase and part of the amino acid sequence of a human urate oxidase, or a mutant protein thereof. The PEGylated analogue protein of canine urate oxidase and pharmaceutical compositions thereof according to the present invention can be used for the prevention and/or treatment of hyperuricemia and chronic gout.
摘要翻译：提供犬尿酸氧化酶的聚乙二醇化类似蛋白，其制备方法和用途。犬尿酸氧化酶的类似蛋白是犬尿酸氧化酶，或包含犬尿酸氧化酶的部分氨基酸序列和人尿酸氧化酶的部分氨基酸序列的嵌合蛋白或其突变蛋白。犬尿酸氧化酶的聚乙二醇化类似物蛋白及其药物组合物可用于预防和/或治疗高尿酸血症和慢性痛风。

90. 发明申请

US20150107982A1 APPARATUS AND METHOD FOR PYROLYZING COAL WITH WIDE PARTICLE SIZE DISTRIBUTION 有权
标题翻译：用于颗粒大小分布的热解炉的设备和方法
公开(公告)号：US20150107982A1
公开(公告)日：2015-04-23
申请号：US14384940
申请日：2012-03-16
申请人： Goangwen Xu , Jiangze Han , Rongcheng Wu , Chun Zhang , Shiqiu Gao , Juwei Zhang
发明人： Goangwen Xu , Jiangze Han , Rongcheng Wu , Chun Zhang , Shiqiu Gao , Juwei Zhang
IPC分类号： C10B53/04
CPC分类号： C10B53/04 , C10B5/10 , C10B27/02 , C10B47/02 , C10B47/16
摘要： A carbonization apparatus for coal with wide particle size distribution, a carbonization apparatus unit, and a carbonization method based on the apparatus. The apparatus comprises a char discharge outlet (1), a combustion heating chamber (3), a coal feeding inlet (5), and a pyrolysis gas exhausting pipe (4). Wherein, two partition plates between which a pyrolysis gas channel (2) is formed are further provided in the carbonization apparatus, and orifices are provided on the partition plates to form a gas flow path from the fuel bed to the pyrolysis gas channel (2). Further, another internal having good heat transfer performance and made of a material resistant to high temperature, is provided in this coal carbonization apparatus to enhance the heat transfer from the heated wall of the apparatus to the fuel bed inside the apparatus. With the pyrolysis gas channel in the carbonization reaction apparatus, the gaseous products generated from coal pyrolysis are enabled to flow out timely. Through providing the internals, it greatly improves the effects of heat and mass transfer and reduces the secondary reactions to increase the tar yield and quality.
摘要翻译：一种具有宽粒度分布的煤的碳化装置，碳化装置单元和基于该装置的碳化方法。该装置包括炭排出口（1），燃烧加热室（3），送煤口（5）和热解气排气管（4）。其中，在碳化装置中还设置有形成热解气体通道（2）的两个隔板，并且在隔板上设置有孔，以形成从燃料床到热解气体通道（2）的气体流路，。此外，在该煤炭化装置中设置有具有良好的传热性能并且由耐高温材料制成的另一内部，以增强从设备的加热壁到设备内的燃料床的热传递。通过碳化反应装置中的热解气体通道，由煤热分解产生的气态产物能够及时流出。通过提供内件，大大提高了热和质量传递的效果，减少了二次反应，提高焦油产量和质量。

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