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81. 发明申请

US20180028314A1 APPARATUS AND METHODS FOR DELIVERY, REPOSITIONING, AND RETRIEVAL OF TRANSCATHETER PROSTHETIC VALVES 审中-公开
公开(公告)号：US20180028314A1
公开(公告)日：2018-02-01
申请号：US15730148
申请日：2017-10-11
申请人： Tendyne Holdings, Inc.
发明人： Craig A. EKVALL , Khoi LE , John F. OTTE , Zachary J. TEGELS , Robert M. VIDLUND
IPC分类号： A61F2/24 , A61M25/01
摘要： Apparatus and methods are described herein for use in the delivery and deployment of a prosthetic mitral valve into a heart. In some embodiments, an apparatus includes a catheter assembly, a valve holding tube and a handle assembly. The valve holding tube is releasably couplable to a proximal end portion of the catheter assembly and to a distal end portion of the handle assembly. The handle assembly includes a housing and a delivery rod. The delivery rod is configured to be actuated to move distally relative to the housing to move a prosthetic heart valve disposed within the valve holding tube out of the valve holding tube and distally within a lumen of the elongate sheath of the catheter assembly. The catheter assembly is configured to be actuated to move proximally relative to the housing such that the prosthetic valve is disposed outside of the lumen of the elongate sheath.

82. 发明申请

US20170319333A1 APPARATUS AND METHODS FOR ANTERIOR VALVE LEAFLET MANAGEMENT 审中-公开
公开(公告)号：US20170319333A1
公开(公告)日：2017-11-09
申请号：US15499129
申请日：2017-04-27
申请人： Tendyne Holdings, Inc.
发明人： Zachary J. TEGELS , Michael J. URICK
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61B17/0401 , A61B18/1492 , A61B2017/0417 , A61B2017/0649 , A61B2018/00369 , A61B2018/00619 , A61F2/2418 , A61F2/2427 , A61F2/2445 , A61F2/2457 , A61F2250/0006 , A61F2250/001 , A61F2250/0063
摘要： In some embodiments, a method includes delivering to a native valve annulus (e.g., a native mitral valve annulus) of a heart a prosthetic heart valve having a body expandable from a collapsed, delivery configuration to an expanded, deployed configuration. The method can further include, after the delivering, causing the prosthetic heart valve to move from the delivery configuration to the deployed configuration. With the prosthetic heart valve in its deployed configuration, an anchor can be delivered and secured to at least one of a fibrous trigone of the heart or an anterior native leaflet of the native valve. With the prosthetic heart valve disposed in the native valve annulus and in its deployed configuration, an anchoring tether can extending from the anchor can be secured to a wall of the heart to urge the anterior native leaflet towards the body of the prosthetic heart valve.

83. 发明申请

US20170312077A1 EXPANDABLE EPICARDIAL PADS AND DEVICES AND METHODS FOR DELIVERY OF SAME 审中-公开
公开(公告)号：US20170312077A1
公开(公告)日：2017-11-02
申请号：US15654374
申请日：2017-07-19
申请人： Tendyne Holdings, Inc.
发明人： Robert M. VIDLUND , Igor KOVALSKY , Zachary J. TEGELS , Craig A. EKVALL
IPC分类号： A61F2/24 , A61B17/34
CPC分类号： A61F2/2418 , A61B17/0401 , A61B2017/0443 , A61B2017/3425 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2/2457 , A61F2220/0016 , A61F2220/0041 , A61F2220/0075 , A61F2220/0083 , A61F2230/0093 , A61F2250/0039 , A61F2250/0063 , A61F2250/0098
摘要： Apparatus and methods are described herein for use in the delivery of a prosthetic mitral valve. In some embodiments, an apparatus includes an epicardial pad configured to engage an outside surface of a heart to secure a prosthetic heart valve in position within the heart. The epicardial pad defines a lumen configured to receive therethrough a tether extending from the prosthetic valve. The epicardial pad is movable between a first configuration in which the epicardial pad has a first outer perimeter and is configured to be disposed within a lumen of a delivery sheath and a second configuration in which the epicardial pad has a second outer perimeter greater than the first outer perimeter. The epicardial pad can be disposed against the outside surface of the heart when in the second configuration to secure the prosthetic valve and tether in a desired position within the heart.

84. 发明申请

US20170266001A1 DELIVERY SYSTEMS AND METHODS FOR TRANSCATHETER PROSTHETIC VALVES 审中-公开
公开(公告)号：US20170266001A1
公开(公告)日：2017-09-21
申请号：US15477715
申请日：2017-04-03
申请人： Tendyne Holdings, Inc.
发明人： Robert VIDLUND , Kemal SCHANKERELI
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2412 , A61F2/2439 , A61F2220/0008
摘要： This invention relates to a delivery apparatus and method for deployment of a mitral valve replacement.

85. 发明授权

US09675454B2 Delivery systems and methods for transcatheter prosthetic valves 有权
公开(公告)号：US09675454B2
公开(公告)日：2017-06-13
申请号：US14418130
申请日：2012-08-14
申请人： Robert Vidlund , Kemal Schankereli
发明人： Robert Vidlund , Kemal Schankereli
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2412 , A61F2/2439 , A61F2220/0008
摘要： This invention relates to a delivery apparatus and method for deployment of a mitral valve replacement.

86. 发明申请

US20170128208A1 PROSTHETIC HEART VALVE AND SYSTEMS AND METHODS FOR DELIVERING THE SAME 审中-公开
公开(公告)号：US20170128208A1
公开(公告)日：2017-05-11
申请号：US15416353
申请日：2017-01-26
申请人： Tendyne Holdings, Inc.
发明人： Mark CHRISTIANSON , Zachary J. TEGELS , Craig A. EKVALL , Robert M. VIDLUND
IPC分类号： A61F2/24 , A61B17/122 , A61B17/128
CPC分类号： A61F2/2439 , A61B17/00234 , A61B17/0644 , A61B17/068 , A61B17/1227 , A61B17/1285 , A61B2017/00243 , A61B2017/00867 , A61F2/2418 , A61F2/2457 , A61F2/2487 , A61F2210/0014 , A61F2220/0016 , A61F2230/005
摘要： A prosthetic heart valve includes a self-expanding wire frame body, a valve disposed in the body, a leaflet clip coupled to the body, and a control element operably coupled to the leaflet clip. The body has a proximal end and a distal end. The leaflet clip is configured to be transitioned between a first configuration in which the prosthetic valve can be inserted into a heart, and a second configuration in which the leaflet clip is disposed to capture a native valve leaflet between the leaflet clip and the wire frame body when the body is disposed in a native annulus of an atrioventricular valve of a heart. The control element extends from the leaflet clip through a ventricle of the heart and out a wall of the ventricle to allow a user to transition the leaflet clip from its first configuration to its second configuration.

87. 发明授权

US09610159B2 Structural members for prosthetic mitral valves 有权
公开(公告)号：US09610159B2
公开(公告)日：2017-04-04
申请号：US14950656
申请日：2015-11-24
申请人： Tendyne Holdings, Inc.
发明人： Mark Christianson , Chad Perrin , Zachary Tegels , Craig Ekvall , Robert Vidlund
IPC分类号： A61F2/24 , A61L27/06 , A61L27/14 , A61L27/34 , A61L27/36 , A61L27/54 , A61L33/00
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2409 , A61F2/2457 , A61F2210/0014 , A61F2220/0016 , A61F2220/0041 , A61F2220/0075 , A61F2220/0083 , A61F2230/0019 , A61F2230/0093 , A61F2250/0039 , A61F2250/0063 , A61F2250/0098 , A61L27/06 , A61L27/14 , A61L27/34 , A61L27/3629 , A61L27/50 , A61L27/54 , A61L33/0011 , A61L2300/236 , A61L2400/16 , A61L2430/20
摘要： A self-expanding wire frame for a pre-configured compressible transcatheter prosthetic cardiovascular valve, a combined inner frame/outer frame support structure for a prosthetic valve, and methods for deploying such a valve for treatment of a patient in need thereof, are disclosed.

88. 发明申请

US20160367368A1 DEVICES AND METHODS FOR POSITIONING AND MONITORING TETHER LOAD FOR PROSTHETIC MITRAL VALVE 审中-公开
标题翻译：用于定位和监测预制阀门的负载的装置和方法
公开(公告)号：US20160367368A1
公开(公告)日：2016-12-22
申请号：US15251269
申请日：2016-08-30
申请人： Tendyne Holdings, Inc.
发明人： Robert M. VIDLUND , Craig A. EKVALL
IPC分类号： A61F2/24 , A61B90/00
摘要： Apparatus and methods are described herein for positioning an epicardial anchor device and measuring the load of a tether extending from a prosthetic heart valve and coupled to the epicardial anchor device. In some embodiments, an apparatus includes a handle assembly coupled to an elongate member and a docking member coupled to a distal end of the elongate member. The docking member can be releasably coupled to an epicardial anchor device configured to secure a tether extending from a prosthetic heart valve implanted with a heart at a location on an exterior of a ventricular wall of the heart. A force sensor device is coupled to the handle assembly and can measure a force exerted on the force sensor device. The force is associated with a tension of the tether extending through the elongate member and handle assembly.
摘要翻译：本文描述了用于定位心外膜锚装置并测量从假体心脏瓣膜延伸并联接到心外膜锚定装置的系绳的负载的装置和方法。在一些实施例中，装置包括联接到细长构件的手柄组件和联接到细长构件的远端的对接构件。对接构件可以可释放地联接到心外膜锚定装置，所述心外膜锚定装置构造成将从植入心脏的假体心脏瓣膜延伸的系绳固定在心脏心室壁外部位置处。力传感器装置联接到手柄组件并且可以测量施加在力传感器装置上的力。该力与通过细长构件和手柄组件延伸的系绳的张力相关联。

89. 发明授权

US09480559B2 Prosthetic valves and related inventions 有权
标题翻译：假体瓣膜及相关发明
公开(公告)号：US09480559B2
公开(公告)日：2016-11-01
申请号：US14237023
申请日：2012-08-13
申请人： Robert Vidlund , Kemal Schankereli , Lucian Lozonschi , Georg Lutter
发明人： Robert Vidlund , Kemal Schankereli , Lucian Lozonschi , Georg Lutter
IPC分类号： A61F2/24 , A61L27/34 , A61L27/36 , A61L33/00 , A61B17/04 , A61B17/064
CPC分类号： A61F2/2412 , A61B17/0401 , A61B17/064 , A61B17/0644 , A61B2017/0404 , A61F2/2409 , A61F2/2418 , A61F2/2427 , A61F2/2436 , A61F2/2457 , A61F2210/0004 , A61F2210/0014 , A61F2220/0008 , A61F2220/005 , A61F2220/0058 , A61F2220/0091 , A61F2230/0013 , A61F2230/0034 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0091 , A61F2310/00023 , A61F2310/00077 , A61L27/34 , A61L27/3625 , A61L27/3629 , A61L33/0011 , A61L2400/16 , A61L2430/20 , C08L67/04
摘要： This invention relates to the design and function of a compressible valve replacement prosthesis, collared or uncollared, which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.
摘要翻译：本发明涉及一种可压缩瓣膜置换假体的设计和功能，可以使用经导管输送系统部署到搏动的心脏而不需要体外循环。所讨论的设计重点是通过微创方式部署装置，并且作为一个例子考虑了一种微创外科手术，优选利用用于瓣膜引入的肋间或副脊柱空间。为了实现这一点，阀以这样的方式形成，使得其可以被压缩以配合在输送系统内，并且二次从输送系统喷射到诸如二尖瓣或三尖瓣的目标瓣膜的环中。

90. 发明申请

US20160206280A1 APPARATUS AND METHODS FOR ALIGNMENT AND DEPLOYMENT OF INTRACARDIAC DEVICES 审中-公开
标题翻译：装置和方法用于对准和分配内脏器官
公开(公告)号：US20160206280A1
公开(公告)日：2016-07-21
申请号：US15085229
申请日：2016-03-30
申请人： Tendyne Holdings, Inc.
发明人： Robert M. VIDLUND , Craig A. EKVALL
IPC分类号： A61B8/08 , A61F2/24 , A61B17/04 , A61B8/12 , A61B8/00
CPC分类号： A61B8/0841 , A61B8/0883 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B8/483 , A61B8/488 , A61B17/0469 , A61B17/3403 , A61B17/3468 , A61B2017/00247 , A61B2017/00783 , A61B2017/3413 , A61F2/2427 , A61F2/2457
摘要： Apparatus and methods are described herein for use in the alignment and deployment of a prosthetic heart valve, such as a mitral valve. In some embodiments, an apparatus includes a tube assembly and a needle assembly configured to be received through a lumen of an outer tube member of the tube assembly. The needle assembly includes an elongate needle having a distal tip configured to be inserted through the epicardial surface of a heart. An imaging probe is coupled to a coupling member and includes an imaging element. The imaging probe is configured to provide image data associated with a location of a commissural-commissural (C-C) plane and a location of the anterior-posterior (A-P) plane of the mitral valve and the annular region of the heart such that a prosthetic mitral valve can be positioned within the heart based at least in part on the C-C plane and the A-P plane.
摘要翻译：本文描述了用于在诸如二尖瓣的假体心脏瓣膜的对准和展开中使用的装置和方法。在一些实施例中，一种装置包括管组件和针组件，其构造成通过管组件的外管构件的内腔容纳。针组件包括细长针，其具有构造成插入穿过心脏的心外膜表面的远侧末端。成像探针耦合到耦合构件并且包括成像元件。成像探针被配置为提供与连合联合（CC）平面的位置以及二尖瓣的前后（AP）平面和心脏的环形区域的位置相关联的图像数据，使得假体二尖瓣阀可以至少部分地基于CC平面和AP平面定位在心脏内。

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