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81. 发明授权

US09500726B2 NMR probe head with variable RF resonant circuit capacitor which can be adjusted in steps via a piezo-electric actuator 有权
标题翻译： NMR探头具有可变RF谐振电路电容器，可通过压电致动器进行步调
公开(公告)号：US09500726B2
公开(公告)日：2016-11-22
申请号：US14195919
申请日：2014-03-04
申请人： BRUKER BIOSPIN AG
发明人： Daniel Guy Baumann
IPC分类号： G01V3/00 , G01R33/34 , G01R33/30 , G01R33/36
CPC分类号： G01R33/34 , G01R33/30 , G01R33/34092 , G01R33/36 , G01R33/3628
摘要： An NMR probe head has a capacitor with a dielectric (5), which surrounds a cavity (15) in which a capacitor piston (7) is disposed. A sliding bush (9) has a through hole (16) in which a piston operating rod (8) extends. The piston operating rod (8) is connected to a piezo-electric actuator and to the capacitor piston (7) in such a way that it displaces the capacitor piston linearly when a sawtooth voltage is applied to the piezo-electric actuator. The sliding bush thereby applies braking friction to the piston operating rod during linear displacement of the capacitor piston and only allows the piston operating rod to slide through during the steep edges of the sawtooth voltage. This avoids the disadvantages of prior art, wherein the NMR probe head remains compact and the material cost and manufacturing complexity are reduced.
摘要翻译： NMR探针头具有电介质（5）的电容器，其围绕设置有电容器活塞（7）的空腔（15）。滑动衬套（9）具有活塞操作杆（8）延伸的通孔（16）。活塞操作杆（8）连接到压电致动器和电容器活塞（7），使得当锯齿电压施加到压电致动器时，其将电容器活塞线性移位。滑动衬套因此在电容器活塞的线性位移期间对活塞操作杆施加制动摩擦，并且仅允许活塞操作杆在锯齿形电压的陡峭边缘期间滑动。这避免了现有技术的缺点，其中NMR探针头保持紧凑并且降低了材料成本和制造复杂性。

82. 发明授权

US09329246B2 Method for hyperpolarization transfer in the liquid state 有权
标题翻译：在液体状态下超极化转移的方法
公开(公告)号：US09329246B2
公开(公告)日：2016-05-03
申请号：US13633899
申请日：2012-10-03
申请人： Bruker BioSpin AG , Ecole Polytechnique Federale de Lausanne (EPFL)
发明人： Sami Jannin , Joost Lohman , Geoffrey Bodenhausen , Klaes Golman
IPC分类号： G01R33/28 , G01R33/30 , G01R33/381 , G01R33/46
CPC分类号： G01R33/282 , G01R33/307 , G01R33/381 , G01R33/4608
摘要： A method for producing a hyperpolarized sample for use in a magnetic resonance investigation has the following steps: a) providing a solid sample (50), containing long T1 nuclei and short T1 nuclei in the same molecules (51); b) hyperpolarizing the short T1 nuclei in the solid sample (50); c) transforming the solid sample (50) into a liquid sample (52); and d) transferring the polarization of the short T1 nuclei to the long T1 nuclei within the molecules in the liquid sample (52) by Cross Polarization. The method can provide samples with hyperpolarized long T1 nuclei, in particular 13C or 15N, in a simple and efficient way.
摘要翻译：制备用于磁共振研究的超极化样品的方法具有以下步骤：a）提供在相同分子（51）中含有长T1核和短T1核的固体样品（50）; b）在固体样品（50）中超极化短T1核; c）将固体样品（50）转化成液体样品（52）; 和d）通过交叉极化将短T1核的极化转移到液体样品（52）中的分子内的长T1核上。该方法可以以简单有效的方式提供具有超极化长T1核，特别是13C或15N的样品。

83. 发明授权

US09086465B2 Fourier tickling for homonuclear decoupling in NMR 有权
标题翻译： NMR中的同核去耦的傅立叶痒
公开(公告)号：US09086465B2
公开(公告)日：2015-07-21
申请号：US13545995
申请日：2012-07-11
申请人： Geoffrey Bodenhausen , Diego Carnevale
发明人： Geoffrey Bodenhausen , Diego Carnevale
IPC分类号： G01V3/00 , G01R33/46 , G01R33/58
CPC分类号： G01R33/4608 , G01R33/583
摘要： A method for high resolution NMR (=nuclear magnetic resonance) measurements using the application of excitation pulses and the acquisition of data points, whereby a dwell time Δt separates the acquisition of two consecutive data points, which is characterized in that one or more tickling rf (=radio frequency) pulses of duration τp are applied within each dwell time Δt, and that the average rf field amplitude of each of the tickling rf pulses approximately fulfills the condition ω1=ω1τp/Δt=πJ wherein J is the scalar J-coupling constant and ω1=γB1 with γ being the gyromagnetic ratio and B1 being the strength of the magnetic component of each tickling rf pulse. This method is effective in decoupling homonuclear couplings.
摘要翻译：使用激励脉冲的应用和采集数据点的高分辨率NMR（=核磁共振）测量的方法，其中驻留时间＆Dgr; t分离两个连续数据点的获取，其特征在于一个或多个在每个停留时间＆Dgr; t内施加持续时间τp的脉动rf（=射频）脉冲，并且每个痒痒脉冲脉冲的平均rf场幅近似满足条件ω1=ω1τp/＆Dgr; t =＆pgr; J 其中J是标量J耦合常数，ω1=γB1，其中γ是回旋磁比，B1是每个挠曲rf脉冲的磁分量的强度。这种方法在去耦合同核耦合方面是有效的。

84. 发明授权

US09012366B2 Device and method for the densification of filaments in a long superconductive wire 有权
标题翻译：用于在长超导丝中细丝致密化的装置和方法
公开(公告)号：US09012366B2
公开(公告)日：2015-04-21
申请号：US13398865
申请日：2012-02-17
申请人： René Flükiger , Florin Buta , Carmine Senatore
发明人： René Flükiger , Florin Buta , Carmine Senatore
IPC分类号： H01L39/24 , H01B13/00 , B30B7/04
CPC分类号： H01L39/2487 , B30B7/04 , H01L39/24 , H01L39/2409 , H01L39/2412 , Y10T29/49014
摘要： A device for the high pressure densification of superconducting wire from compacted superconductor material or superconductor precursor powder particles, has four hard metal anvils (5, 6, 7, 8) with a total length (L2) parallel to the superconducting wire, the hard metal anvils borne in external independent pressure blocks (9, 10, 11), which are in turn either fixed or connected to high pressure devices, preferably hydraulic presses. At least one of the hard metal anvils is a free moving anvil (6) having clearances of at least 0.01 mm up to 0.2 mm towards the neighboring hard metal anvils (5, 8), so that no wall friction occurs between the free moving anvil and the neighboring anvils. This allows for high critical current densities Jc at reduced pressure applied to the hard metal anvils.
摘要翻译：用于从压实的超导体材料或超导体前体粉末颗粒的超导线的高压致密化的装置具有四个硬金属砧座（5,6,7,8），其总长度（L2）与超导线平行，硬质金属砧座承载在外部独立的压力块（9,10,11）中，它们又固定或连接到高压装置，优选液压机。硬质金属砧座中的至少一个是自由移动的砧座（6），其相对于相邻的硬质金属砧座（5,8）具有至少0.01mm至0.2mm的间隙，使得在自由移动砧座之间不发生壁摩擦和邻近的砧座。这允许在施加到硬金属砧座上的减压下的高临界电流密度Jc。

85. 发明授权

US08975896B2 Cryogenic probehead cooler in a nuclear magnetic resonance apparatus 有权
标题翻译：核磁共振装置中的低温探针头冷却器
公开(公告)号：US08975896B2
公开(公告)日：2015-03-10
申请号：US13407819
申请日：2012-02-29
申请人： Oskar Schett , Daniel Guy Baumann , Marc Schnell , Cengiz Cetrefli , Daniel Marek , Klemens Kessler , Philippe Stauffenegger
发明人： Oskar Schett , Daniel Guy Baumann , Marc Schnell , Cengiz Cetrefli , Daniel Marek , Klemens Kessler , Philippe Stauffenegger
IPC分类号： G01R33/34
CPC分类号： G01R33/3403
摘要： An NMR (nuclear magnetic resonance) apparatus has a magnet system disposed in a cryostat (1), the cryostat having at least one nitrogen tank (3b) for receiving liquid nitrogen (5b) and a room temperature bore (7) for receiving an NMR probehead (8), wherein part(s) of the probehead or the overall probehead can be cooled to cryogenic temperatures by supplying liquid nitrogen (5b) via a supply line (14). The nitrogen tank (3b) of the cryostat (1) is connected to the NMR probehead (8) by means of a supply line (14) in such a fashion that liquid nitrogen (5b) is removed from the nitrogen tank (3b) and guided to the NMR probehead (8). The overall apparatus is therefore more compact, the operating comfort of the apparatus is increased, and the costs for acquisition, operation and maintenance are considerably reduced compared to previous comparable devices.
摘要翻译： NMR（核磁共振）装置具有设置在低温恒温器（1）中的磁体系统，低温恒温器具有用于接收液氮的至少一个氮气罐（3b）和用于接收NMR的室温孔（7）探头（8），其中通过经由供应管线（14）供应液氮（5b），探针头或整个探针头的部分可被冷却至低温。低温恒温器（1）的氮气罐（3b）借助于供应管线（14）与NMR探针头（8）连接，使氮气（5b）从氮气罐（3b）中取出，引导到NMR探针头（8）。因此，整体装置更紧凑，装置的操作舒适性增加，并且与先前的可比装置相比，采集，操作和维护的成本大大降低。

86. 发明授权

US08847595B2 Temperature control device for an NMR sample tube 有权
公开(公告)号：US08847595B2
公开(公告)日：2014-09-30
申请号：US13104071
申请日：2011-05-10
申请人： Beat Grossniklaus , Federico Raffa , Markus Mayer , Dirk Wilhelm
发明人： Beat Grossniklaus , Federico Raffa , Markus Mayer , Dirk Wilhelm
IPC分类号： G01V3/00
CPC分类号： G01R33/31
摘要： Temperature control device (20) for an NMR sample tube (22), wherein multiple interleaved, concentric flow channels (28, 31; 40, 41, 42; 50, 51) for temperature control fluid extending coaxially with respect to a cylindrical interior space (21) for holding the NMR sample tube are constituted around said interior space (21), wherein said temperature control device is constituted such that it is closed toward the interior space in an axial end region (26) and, an axial end region (23) at the opposite end thereto, open to the interior space for inserting the NMR sample tube into said interior space (21), wherein, in a counter flow region (GB), adjacent flow channels (28, 31; 40, 41, 42; 51) are interconnected through a fluid passage (34, 43, 44) at one axial end in such a way that the direction of a fluid flow in the flow channels of the counter flow region is reversed with respect to the corresponding adjacent flow channel in the counter flow region, wherein the outermost flow channel (28; 51) of the counter flow region has a fluid inlet (32) at one axial end, and wherein the innermost flow channel (31; 42) of the counter flow region has a fluid passage (36) to the interior space at one axial end that faces toward the axial end region that is closed, is characterized in that at least one of the flow channels, in particular, the outermost flow channel (28; 50) of the temperature control device and/or the next outermost flow channel (31; 40; 50) of the temperature control device has a fluid outlet (35) at one axial end, through which at least part (MS) of the temperature-controlling fluid flow that is conveyed along the outermost flow channel (28; 50) of the temperature control device can escape from the temperature control device without passing through all of the flow channels of the counter-low region. With this invention, temperature control of an NMR sample tube can be ensured with low temperature gradients, while achieving a high temperature control performance.

87. 发明授权

US08564288B2 Method for NMR spectroscopy or MRI measurements using dissolution dynamic nuclear polarization (DNP) with scavenging of free radicals 有权
标题翻译：使用自由基清除的溶解动态核极化（DNP）的NMR光谱或MRI测量方法
公开(公告)号：US08564288B2
公开(公告)日：2013-10-22
申请号：US12929264
申请日：2011-01-12
申请人： Sami Jannin , Pascal Mieville , Geoffrey Bodenhausen
发明人： Sami Jannin , Pascal Mieville , Geoffrey Bodenhausen
IPC分类号： G01V3/00
CPC分类号： G01R33/282 , G01R33/5601 , G01R33/5605
摘要： A method for sample preparation for magnetic resonance measurements using Hyperpolarization by Dissolution Dynamic Nuclear Polarization, involves preparation of frozen beads of a first kind containing paramagnetic substances in addition to the solute under investigation; insertion of the frozen beads into a polarizing magnet; creation of enhanced polarization of nuclei in a magnetic field; heating of the sample to room temperature; transfer of the sample to an MR magnet; and carrying out an MR measurement. In addition, frozen beads of a second kind containing a reducing agent are prepared and inserted into the polarization magnet together with the frozen beads of the first kind. By this method, longitudinal and transverse relaxation times in NMR are extended and free radicals in hyperpolarized solutions are eliminated.
摘要翻译：通过溶解动力学核极化使用超极化进行磁共振测量的样品制备方法涉及除正在研究的溶质之外还制备含有顺磁性物质的第一类冷冻珠粒; 将冷冻珠插入极化磁体中; 在磁场中产生增强的核的极化; 将样品加热至室温; 将样品转移到MR磁体; 并进行MR测量。此外，制备含有还原剂的第二种冷冻珠，并与第一种冷冻珠一起插入到极化磁体中。通过这种方法，NMR中的纵向和横向弛豫时间延长，并且消除了超极化溶液中的自由基。

88. 发明申请

US20130229182A1 Gradient coil with correction windings and method for production thereof 有权
标题翻译：具有矫正绕组的梯度线圈及其制造方法
公开(公告)号：US20130229182A1
公开(公告)日：2013-09-05
申请号：US13771107
申请日：2013-02-20
申请人： BRUKER BIOSPIN AG
发明人： Schimun Denoth , Silvia Buttazzoni , Thomas Speck , Dirk Wilhelm
IPC分类号： G01R33/385
CPC分类号： G01R33/385 , G01R33/3858 , G01R33/4215 , G01R33/56518 , Y10T29/49004
摘要： In a coil arrangement for nuclear magnetic resonance comprising a main coil (13), a shielding coil (14), and at least one correction coil (41), the function of which consists in forming a magnetic field gradient with eddy current properties which are as good as possible, the main coil (13) and the shielding coil (14) are electrically connected in series with the correction coil (41). The deviations of the residual field from the desired design generated by production tolerances are thereby modified by the correction coil in such a fashion that the long-lasting eddy currents are suppressed. This either reduces the waiting time that must lapse after a gradient pulse before a predetermined field homogeneity is achieved or e.g. the deviations from the desired field are minimized in imaging applications.
摘要翻译：在用于核磁共振的线圈装置中，包括主线圈（13），屏蔽线圈（14）和至少一个校正线圈（41），其功能在于形成具有涡流特性的磁场梯度尽可能地，主线圈（13）和屏蔽线圈（14）与校正线圈（41）串联电连接。由制造公差产生的期望设计的残留磁场的偏差因此被校正线圈修正，使得持续的涡流受到抑制。这可以减少在达到预定的场均匀性之前在梯度脉冲之后必须经过的等待时间，在成像应用中，与期望场的偏差最小化。

89. 发明授权

US08482278B2 Method of positioning and aligning with precision, a small animal in order to conduct and perform MRI measurements 有权
标题翻译：定位和精确对准的方法，小动物，以进行和进行MRI测量
公开(公告)号：US08482278B2
公开(公告)日：2013-07-09
申请号：US12585671
申请日：2009-09-22
申请人： Dietmar Wolke , Daniel Schmidig
发明人： Dietmar Wolke , Daniel Schmidig
IPC分类号： G01R33/30 , G01R33/307
CPC分类号： G01R33/30 , G01R33/307 , G01R33/543
摘要： A device used in performing imaging magnetic resonance measurements (=MRI) in a Region of Interest (ROI) (9) of a small animal (3) with an MRI magnet system (7), with a cradle (5) on which the small animal (3) is lying, and with a radio-frequency (=RF) antenna (6), wherein the RF antenna (6) and the small animal (3) can be positioned relative to each other, characterized in that the device comprises a slide (1) on which the cradle together with the small animal immobilized thereupon can be moved both outside and inside the MRI magnet system, and characterized in that the RF antenna is rigidly fixed on the slide. This results in a device for the relative positioning of the small animal with respect to the RF antenna for an MRI measurement, which is easy to retrofit on existing tomography equipment, with which this positioning can be implemented both inside and outside the MRI magnet by simple handling and without great additional technical effort.
摘要翻译：用于在具有MRI磁体系统（7）的小型动物（3）的感兴趣区域（ROI）（9）中进行成像磁共振测量（= MRI）的装置，其中支架（5）上具有小的动物（3）躺着，并且使用射频（= RF）天线（6），其中RF天线（6）和小动物（3）可以相对于彼此定位，其特征在于，所述装置包括其中支架上与其上固定的小动物一起的滑块（1）可以在MRI磁体系统的外部和内部移动，并且其特征在于，RF天线刚性地固定在滑块上。这导致用于小动物相对于用于MRI测量的RF天线的相对定位的装置，其易于在现有的断层摄影设备上进行改型，通过该方法可以通过简单的方式在MRI磁体内部和外部实现该定位处理和没有很多额外的技术努力。

90. 发明授权

US08153084B2 Reduction in eddy current losses in electrically conducting sample materials with the assistance of special NMR sample tubes 有权
标题翻译：借助特殊的NMR样品管，减少导电样品中的涡流损耗
公开(公告)号：US08153084B2
公开(公告)日：2012-04-10
申请号：US11603882
申请日：2006-11-24
申请人： Philippe Stauffenegger , Oskar Schett
发明人： Philippe Stauffenegger , Oskar Schett
IPC分类号： B01L3/00 , B01L99/00 , G01V3/00
CPC分类号： G01R33/30 , B01L3/5082 , B01L2300/0858
摘要： A sample tube for an NMR probe head, which extends along a z axis and has an internal cavity that extends in an axial direction of the z axis, is open to the outside at the axially upper end, is closed at the axially lower end and contains a liquid NMR sample substance during operation, wherein the cross-sectional surface of this cavity extending perpendicularly to the z axis and parallel to the xy coordinate plane has an elongated shape in the direction of the x axis with maximum dimensions a in the y direction and b in the x direction, wherein a
摘要翻译：用于NMR探针头的样品管沿着z轴延伸并且具有在z轴的轴向方向上延伸的内腔，在轴向上端处向外部开口，在轴向下端处封闭，并且包含在操作期间的液体NMR样品物质，其中该空腔的垂直于z轴延伸并且平行于xy坐标平面的横截面在x轴的方向上具有细长形状，并且在y方向具有最大尺寸a， b在x方向上，其中a

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