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71. 发明授权

US4892940A Aromatic naphthyl compounds, a process for their preparation and their use in human and veterinary medicine and in cosmetic compositions 失效
标题翻译：芳香族萘基化合物，其制备方法及其在人和兽医学和化妆品组合物中的应用
公开(公告)号：US4892940A
公开(公告)日：1990-01-09
申请号：US52930
申请日：1987-05-22
申请人： Jean Maignan , Gerard Lang , Gerard Malle , Serge Restle , Braham Shroot
发明人： Jean Maignan , Gerard Lang , Gerard Malle , Serge Restle , Braham Shroot
IPC分类号： C07C41/00 , A61K8/00 , A61K8/30 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/49 , A61K31/045 , A61K31/085 , A61K31/12 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/215 , A61P17/00 , A61P29/00 , A61P37/08 , C07C29/143 , C07C33/18 , C07C33/26 , C07C33/28 , C07C33/32 , C07C33/46 , C07C41/18 , C07C43/14 , C07C43/164 , C07C43/20 , C07C43/23 , C07C45/30 , C07C45/46 , C07C47/546 , C07C49/215 , C07C49/76 , C07C49/86 , C07C51/347 , C07C57/44 , C07C59/48 , C07C59/64 , C07C59/84 , C07C59/90 , C07C63/36 , C07C65/24 , C07C65/34 , C07C65/40 , C07C67/00 , C07C69/618 , C07C69/738 , C07C69/76 , C07C231/00 , C07C231/02 , C07C233/11 , C07C233/65 , C07C235/34 , C07C235/66 , C07C235/84 , C07C239/00
CPC分类号： C07C65/40 , C07C43/23 , C07C45/305 , C07C49/86 , C07C59/90 , C07C65/24 , C07C65/34 , Y10S514/844 , Y10S514/859 , Y10S514/88
摘要： An aromatic naphthyl compound of the formula ##STR1## wherein n is 0 or 1,R' is hydrogen, OH, acyloxy, alkoxy or NH.sub.2,R" is hydrogen or lower alkoxy, or R' and R" taken together form an oxo, methano or hydroxy-imino radical,R is --CH.sub.2 OH or --COR.sub.8,R.sub.8 is hydrogen, --OR.sub.9 or ##STR2## R.sub.9 is hydrogen, alkyl having 1-20 carbon atoms, mono or polyhydroxyalkyl, aryl, aralkyl, the residue of a sugar or ##STR3##is 1, 2 or 3,r' and r" each independently represent hydrogen, alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl, benzyl, the residue of amino acid or the residue of aminated sugar, or r' and r" together form a heterocycle,R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent hydrogen, lower alkyl, alkoxy having 1-4 carbon atoms, fluoroalkoxy, CF.sub.3, cycloalkyl, lower acyl, halogen, OH, amino, acylamino or alkoxy carbonyl,R.sub.5, R.sub.6 and R.sub.7 represent hydrogen or methyl or when n=1, R.sub.5 and R.sub.7 taken together can form with the benzene ring a naphthalene ring, and the salts of the compound of formula I or their geometric or optical isomers.These compounds are useful in human and veterinary medicine and in cosmetic compositions.
摘要翻译：式（I）的芳香族萘基化合物，其中n为0或1，R'为氢，OH，酰氧基，烷氧基或NH 2，R“为氢或低级烷氧基，或R'和R”为一起形成氧代，甲醇或羟基亚氨基，R为-CH 2 OH或-COR 8，R 8为氢，-OR 9或R 9为氢，具有1-20个碳原子的烷基，单或多羟基烷基，芳基，芳烷基，糖或“IMAGE”的残基为1,2或3，r'和r“各自独立地表示氢，烷基，单羟基烷基，多羟基烷基，芳基，苄基，氨基酸的残基或胺化糖的残基，或 r'和r“一起形成杂环，R 1，R 2，R 3和R 4表示氢，低级烷基，具有1-4个碳原子的烷氧基，氟烷氧基，CF 3，环烷基，低级酰基，卤素，OH，氨基，酰氨基或烷氧基羰基，R 5，R 6和R 7表示氢或甲基，或当n = 1时，R 5和R 7一起可以与苯环形成萘环，式I化合物或其几何形式的盐 c或光学异构体。这些化合物可用于人和兽医学和化妆品组合物。

72. 发明授权

US4814497A Dehalogenation process 失效
标题翻译：脱卤过程
公开(公告)号：US4814497A
公开(公告)日：1989-03-21
申请号：US861934
申请日：1986-05-12
申请人： K. Pushpananda A. Senaratne
发明人： K. Pushpananda A. Senaratne
IPC分类号： C07B35/06 , C07B31/00 , C07B63/02 , C07C51/00 , C07C51/377 , C07C51/487 , C07C63/70 , C07C65/21 , C07C65/24 , C07C67/00 , C07C67/317 , C07C69/76 , C07C233/81 , C07C235/66 , C07C253/00 , C07C255/52 , C07C255/53 , C07C255/54 , C07C325/00 , C07C327/48 , C07C63/34
CPC分类号： C07C51/377
摘要： Particulate aluminum is intimately mixed with an aromatic material that contains at least one ar-halo substituent having an atomic number above 20 and at least one side-chain halo substituent having an atomic number below 20 in the presence of an aqueous alkali or alkaline earth metal hydroxide so as to effect selective removal of the ar-halo substituent.
摘要翻译：颗粒铝与含有至少一个原子数大于20的卤素取代基和至少一个原子序数低于20的侧链卤代基取代基在碱金属或碱土金属水溶液的芳族材料上充分混合氢氧化物，以便实现选择性除去芳卤基取代基。

73. 发明授权

US4783487A N-(1-carboxy-2-hydroxy-5-phenyl)-2-(6-methoxy-2-naphthyl)propionamide and anti-inflammatory use thereof 失效
标题翻译： N-（1-羧基-2-羟基-5-苯基）-2-（6-甲氧基-2-萘基）丙酰胺及其抗炎用途
公开(公告)号：US4783487A
公开(公告)日：1988-11-08
申请号：US839255
申请日：1986-03-13
申请人： Kay Brune
发明人： Kay Brune
IPC分类号： C07C233/55 , A61K31/35 , A61K31/351 , A61K31/38 , A61K31/381 , A61K31/44 , A61P29/00 , C07C233/81 , C07C235/38 , C07C235/56 , C07C235/66 , C07C237/20 , C07C237/40 , C07D209/42 , C07D213/00 , C07D213/56 , C07D213/81 , C07D309/00 , C07D309/32 , C07D333/24 , C07C101/74 , A61K31/05
CPC分类号： C07D209/42
摘要： Amide derivatives of non-steroidal anti-inflammatory carboxylic acids which have anti-inflammatory activity in their own right as well as being effective as pro-drugs of the carboxylic acids.
摘要翻译：具有自身抗炎活性的非甾体抗炎羧酸的酰胺衍生物，以及作为羧酸的前药有效。

74. 发明授权

US4604406A N-[6-methoxy-5-(perfluoroalkyl)-1-naphtholyl]-N-methylglycines and their thionaphthoyl analogs 失效
标题翻译： N- [6-甲氧基-5-（全氟烷基）-1-萘酚基] -N-甲基甘氨酸及其硫代肉豆蔻酯类似物
公开(公告)号：US4604406A
公开(公告)日：1986-08-05
申请号：US672015
申请日：1984-11-16
申请人： Francesco Bellini , Kazimir Sestanj
发明人： Francesco Bellini , Kazimir Sestanj
IPC分类号： A61K31/195 , A61P3/08 , A61P3/10 , A61P13/02 , A61P15/00 , A61P25/18 , A61P27/02 , A61P27/12 , C07C67/00 , C07C233/64 , C07C233/83 , C07C235/66 , C07C325/00 , C07C327/48 , A61K31/19 , C07C103/84 , C07C153/063
CPC分类号： C07C233/83
摘要： Disclosed herein are new aldose reductase inhibitors of the formula ##STR1## wherein n is an integer from 1 to 5 and X is a chalcogen, and methods of preparation. The derivatives are useful for treating or preventing diabetic complications.
摘要翻译：本文公开的是新的式IMAF的醛糖还原酶抑制剂，其中n是1至5的整数，X是硫属元素，以及制备方法。该衍生物可用于治疗或预防糖尿病并发症。

75. 发明授权

US3947516A Novel aromatic aldehydes and process for preparing them 失效
标题翻译：新型芳香醛及其制备方法
公开(公告)号：US3947516A
公开(公告)日：1976-03-30
申请号：US489538
申请日：1974-07-18
申请人： Klaus Hunger , Theodor Papenfuhs
发明人： Klaus Hunger , Theodor Papenfuhs
IPC分类号： C07D209/48 , C07C67/00 , C07C231/00 , C07C231/12 , C07C235/66 , C07C255/60 , C07C311/46 , C07C313/00 , C07C315/04 , C07C317/40 , C07D235/02 , C07D235/26 , C07D237/30 , C07D239/72 , C07D241/40 , C09B55/00 , C07C103/26
CPC分类号： C09B55/00
摘要： Aldehydes of a 2-hydroxy-naphthalene-3-carboxylic acid arylide of the general formula ##SPC1##In which X represents a hydrogen, chlorine or bromine atom, and Ar represents a naphthyl group, a benzimidazolone, chlorobenzimidazoline, quinazolone, quinoxaline, phthalimide, phthalazine group or a phenyl group which may carry 1 to 3 lower alkyl, lower alkoxy, lower alkylsulfonyl, lower carboalkoxy, halogen, trifluoromethyl, nitro, cyano, lower alkanoylamino, benzoylamino, carboxamido or sulfonamido groups and a process for their preparation wherein the corresponding 2-hydroxynaphthalene-3-carboxylic acid arylide is reacted in a lower aliphatic carboxylic acid with hexamethylene tetramine and a mineral acid.These aldehydes are valuable intermediate products for the synthesis of optical brighteners, pharmaceuticals and, in particular, of azamethine pigments which are obtained by condensation of these aldehydes with suitable amines. The pigments thus obtained are distinguished by good fastness properties and are especially suitable for the printing of paper and the coloring of lacquers, varnishes and plastics.
摘要翻译：通式为I的2-羟基 - 萘-3-羧酸芳基化物的醛，其中X表示氢，氯或溴原子，Ar表示萘基，苯并咪唑啉酮，氯代苯并咪唑啉，喹唑酮，喹喔啉，邻苯二甲酰亚胺，酞嗪基或可以带有1-3个低级烷基，低级烷氧基，低级烷基磺酰基，低级烷氧羰基，卤素，三氟甲基，硝基，氰基，低级烷酰基氨基，苯甲酰基氨基，甲酰氨基或亚磺酰氨基的苯基和其制备方法，羟基萘-3-羧酸芳基化物在低级脂族羧酸与六亚甲基四胺和无机酸反应。

76. 发明授权

US3881931A Method for developing black diazotype photographic light-sensitive materials 失效
标题翻译：黑色二极体照相感光材料的开发方法
公开(公告)号：US3881931A
公开(公告)日：1975-05-06
申请号：US36272273
申请日：1973-05-22
申请人： FUJI PHOTO FILM CO LTD
发明人： TSUBOTA MOTOHIKO , NISHIMURA TAIICHI , OHKUBO KINJI
IPC分类号： G03C1/52 , C07C67/00 , C07C231/00 , C07C235/66 , C07C301/00 , C07C309/72 , C07C313/00 , C07C317/22 , C07C323/20 , C07C325/00 , C07C335/00 , G03C1/58 , G03C5/18 , G03C1/54 , G03C5/34
CPC分类号： G03C1/58
摘要： WHEREIN R7 represents a hydrogen atom, an alkyl group having 1-4 alkyl group or

(WHEREIN N REPRESENTS 1 OR 2), AS A COUPLER (Component B) capable of coupling with said light-sensitive diazonium compound (Component A) to form a blue dye; and, as a coupler (Component C1) capable of forming a yellow dye, at least one compound selected from the compounds represented by the general formula;

(WHEREIN N REPRESENTS 1 OR 2) OR FROM THE COMPOUNDS REPRESENTED BY THE GENERAL FORMULA;

(WHEREIN R4 and R5 each represents a hydrogen atom, a halogen atom or an alkyl group having 1-4 carbon atoms), -COR6 (wherein R6 represents an alkyl group having 1-4 carbon atoms, or a substituted or unsubstituted phenyl group or

WHEREIN R3 represents

WHEREIN R1 and R2 each represents an alkyl group having 1-6 carbon atoms or a cycloalkyl group having 5-6 carbon atoms, and X represents an anion, which comprises developing the lightsensitive material in the presence of: at least one compound selected from the compounds represented by the general formula;

A method for developing a diazo-type photographic lightsensitive material containing at least one light-sensitive diazonium compound (Component A) selected from the compounds represented by the general formula;

WHEREIN R8 and R10 each represents an alkyl group having 1-4 carbon atom, and R9 and R11 each represents a hydrogen atom or a halogen atom.

D R A W I N G
摘要翻译：含有至少一种选自通式所表示的化合物的感光性重氮化合物（成分A）的重氮型照相感光材料的制造方法; 其中R1和R2各自表示具有1-6个碳原子的烷基或具有5-6个碳原子的环烷基，X表示阴离子，其包括在以下存在下显影感光材料：选择至少一种化合物由通式表示的化合物; 其中R 3表示（其中R 4和R 5各自表示氢原子，卤素原子或具有1-4个碳原子的烷基），-COR 6（其中R 6表示具有1-4个碳原子的烷基或取代或未取代的苯基或（其中N代表1或2）或由通式所表示的化合物;其中R7表示氢原子，具有1-4个烷基的烷基或（代替1或2个），作为偶联剂（成分B），能够与所述感光性重氮化合物（A成分）偶联而形成蓝色染料;作为能够形成黄色染料的成色剂（成分C1），可以使用选自由通式R8和R 10各自表示具有1-4个碳原子的烷基，R 9和R 11各自表示氢原子或卤素原子。

77. 发明授权

US12103902B2 Bicyclic compounds 有权
公开(公告)号：US12103902B2
公开(公告)日：2024-10-01
申请号：US17752649
申请日：2022-05-24
申请人： Vivace Therapeutics, Inc.
发明人： Andrei W. Konradi , Tracy Tzu-Ling Tang Lin
IPC分类号： C07C235/66 , C07C255/24 , C07C311/51 , C07D213/40 , C07D213/61 , C07D213/73 , C07D217/24 , C07D217/26 , C07D233/64 , C07D241/12 , C07D257/04 , C07D305/06 , C07D305/08 , C07D333/70 , C07D401/12
CPC分类号： C07C235/66 , C07C255/24 , C07C311/51 , C07D213/40 , C07D213/61 , C07D213/73 , C07D217/24 , C07D217/26 , C07D233/64 , C07D241/12 , C07D257/04 , C07D305/06 , C07D305/08 , C07D333/70 , C07D401/12 , C07C2601/02 , C07C2601/04
摘要： Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating diseases, such as cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

78. 发明授权

US11866431B2 Bicyclic compounds 有权
公开(公告)号：US11866431B2
公开(公告)日：2024-01-09
申请号：US17291765
申请日：2019-11-07
申请人： Vivace Therapeutics, Inc.
发明人： Andrei W. Konradi , Tracy Tzu-Ling Tang Lin
IPC分类号： C07D471/04 , C07C233/65 , C07C233/69 , C07C235/66 , C07C237/48 , C07C271/16 , C07C307/06 , C07C311/16 , C07C311/51 , C07C317/32 , C07D205/04 , C07D213/40 , C07D213/61 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D215/54 , C07D217/18 , C07D231/56 , C07D233/64 , C07D235/06 , C07D239/26 , C07D239/28 , C07D241/12 , C07D241/44 , C07D257/04 , C07D261/12 , C07D263/56 , C07D271/12 , C07D277/82 , C07D285/08 , C07D295/13 , C07D305/06 , C07D307/22 , C07D333/58 , C07D401/12 , C07D413/12
CPC分类号： C07D471/04 , C07C233/65 , C07C233/69 , C07C235/66 , C07C237/48 , C07C271/16 , C07C307/06 , C07C311/16 , C07C311/51 , C07C317/32 , C07D205/04 , C07D213/40 , C07D213/61 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D215/54 , C07D217/18 , C07D231/56 , C07D233/64 , C07D235/06 , C07D239/26 , C07D239/28 , C07D241/12 , C07D241/44 , C07D257/04 , C07D261/12 , C07D263/56 , C07D271/12 , C07D277/82 , C07D285/08 , C07D295/13 , C07D305/06 , C07D307/22 , C07D333/58 , C07D401/12 , C07D413/12
摘要： Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

79. 发明申请

US20230061429A1 BICYCLIC COMPOUNDS 有权
公开(公告)号：US20230061429A1
公开(公告)日：2023-03-02
申请号：US17291765
申请日：2019-11-07
申请人： Vivace Therapeutics, Inc.
发明人： Andrei W. KONRADI , Tracy Tzu-Ling Tang LIN
IPC分类号： C07D471/04 , C07C311/16 , C07D295/13 , C07D233/64 , C07D261/12 , C07C235/66 , C07D213/61 , C07D217/18 , C07D307/22 , C07D413/12 , C07C311/51 , C07D231/56 , C07D401/12 , C07D239/26 , C07D241/44 , C07D271/12 , C07D285/08 , C07C233/65 , C07C237/48 , C07D213/74 , C07D215/54 , C07D333/58 , C07C271/16 , C07D215/48 , C07D239/28 , C07D257/04 , C07D277/82 , C07C307/06 , C07D213/40 , C07D213/84 , C07D305/06 , C07C233/69 , C07C317/32 , C07D205/04 , C07D235/06 , C07D241/12 , C07D263/56 , C07D213/73
摘要： Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

80. 发明授权

US11278025B2 Antibiotic compounds 有权
公开(公告)号：US11278025B2
公开(公告)日：2022-03-22
申请号：US16614251
申请日：2018-05-17
申请人： The General Hospital Corporation , Rhode Island Hospital, A Lifespan-Partner , Temple University-Of The Commonwealth System Of Higher Education
发明人： Frederick M. Ausubel , Wooseong Kim , Eleftherios Mylonakis , William M. Wuest
IPC分类号： C07C65/11 , C07C65/17 , A61P31/04 , A01N31/08 , C07C39/17 , C07C235/66 , A61K45/06
摘要： The present application provides compounds and methods of treating bacterial infection, including bacterial infection caused by P. acnes.

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