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71. 发明授权

US08022238B2 Phosphate surfactants 有权
标题翻译：磷酸盐表面活性剂
公开(公告)号：US08022238B2
公开(公告)日：2011-09-20
申请号：US12408074
申请日：2009-03-20
申请人： Sheng Peng , Allison Mary Yake
发明人： Sheng Peng , Allison Mary Yake
IPC分类号： C07F9/02
CPC分类号： C09D9/04 , B01F17/0035 , B01F17/0064 , C07F9/091 , C09D7/47 , C09G1/04 , C11D1/006
摘要： A compound of Formula 1 Rf-A-OP(O)(O−M+)(OROH) Formula 1 wherein Rf is a C2 to C6 linear or branched perfluoroalkyl optionally interrupted by one, two or three ether oxygen atoms; A is (CH2CF2)m(CH2)n—, (CH2)oSO2N(CH3)(CH2)p—, O(CF2)q(CH2)r—, or OCHFCF2OE-; m is 0 to 4; n, o, p, and r are each independently 2 to 20; q is 2; E is a C2 to C20 linear or branched alkyl group optionally interrupted by oxygen, sulfur, or nitrogen atoms; a cyclic alkyl group, or a C6 to C10 aryl group; M is H or a Group I metal or an ammonium cation (NHxR2y)+ wherein R2 is a C1 to C4 alkyl, x is 0 to 4, y is 0 to 4 and x+y is 4; and R is a C2 to C60 linear or branched alkyl group optionally interrupted by hetero atoms selected from the group consisting of an oxygen, sulfur, or nitrogen atom; a cyclic alkyl; or a C6 to C10 aryl; provided that when R is greater than 8 carbons, the ratio of hetero atoms to carbon atoms is at least 1:2.
摘要翻译：式1的化合物Rf-A-OP（O）（O-M +）（OROH）式1其中Rf是任选被一个，两个或三个醚氧原子间断的C2至C6直链或支链全氟烷基; A是（CH 2 CF 2）m（CH 2）n - ，（CH 2）o SO 2 N（CH 3）（CH 2）p - ，O（CF 2）q（CH 2）r - 或OCHFCF 2 OE-; m为0〜4; n，o，p和r各自独立地为2〜20; q是2; E是任选被氧，硫或氮原子间隔的C2至C20直链或支链烷基; 环状烷基或C6〜C10芳基; M为H或I族金属或铵阳离子（NH x R 2y）+，其中R 2为C 1至C 4烷基，x为0至4，y为0至4，x + y为4; 并且R是任选地被选自氧，硫或氮原子的杂原子中断的C2至C60直链或支链烷基; 环状烷基; 或C 6〜C 10芳基; 条件是当R大于8个碳时，杂原子与碳原子的比例至少为1：2。

72. 发明授权

US08013203B2 System for controlling the reactivity of boronic acids 有权
标题翻译：控制硼酸反应性的体系
公开(公告)号：US08013203B2
公开(公告)日：2011-09-06
申请号：US11937338
申请日：2007-11-08
申请人： Martin D. Burke , Eric P. Gillis , Suk Joong Lee , David M. Knapp , Kaitlyn C. Gray
发明人： Martin D. Burke , Eric P. Gillis , Suk Joong Lee , David M. Knapp , Kaitlyn C. Gray
IPC分类号： C07F5/02 , C07F9/02
CPC分类号： C07F5/025 , C07C45/68 , C07C51/353 , C07C67/343 , C07D213/55 , C07D307/81 , C07F5/02 , C07F5/04 , Y02P20/55
摘要： A protected organoboronic acid includes a boron having an sp3 hybridization, a conformationally rigid protecting group bonded to the boron, and an organic group bonded to the boron through a boron-carbon bond. A method of performing a chemical reaction includes contacting a protected organoboronic acid with a reagent, the protected organoboronic acid including a boron having an sp3 hybridization, a conformationally rigid protecting group bonded to the boron, and an organic group bonded to the boron through a boron-carbon bond. The organic group is chemically transformed, and the boron is not chemically transformed.
摘要翻译：受保护的有机硼酸包括具有sp 3杂交的硼，与硼结合的构象刚性保护基，以及通过硼 - 碳键与硼结合的有机基团。进行化学反应的方法包括使受保护的有机硼酸与试剂接触，被保护的有机硼酸包括具有sp3杂交的硼，与硼结合的构象刚性保护基，和通过硼键合到硼上的有机基团碳键。有机基团被化学转化，并且硼不被化学转化。

73. 发明授权

US08012916B2 Phosphorus-molybdenum compound, method for producing same and lubricant additive and lubricant composition containing the compound 有权
标题翻译：磷钼化合物，其制备方法和含有该化合物的润滑剂添加剂和润滑剂组合物
公开(公告)号：US08012916B2
公开(公告)日：2011-09-06
申请号：US12311319
申请日：2007-10-26
申请人： Yukiya Moriizumi , Kazuhiro Umehara , Yukio Tatsumi
发明人： Yukiya Moriizumi , Kazuhiro Umehara , Yukio Tatsumi
IPC分类号： C10M137/10 , C07F9/02
CPC分类号： C07F11/005 , C07F9/02 , C10M137/06 , C10M137/08 , C10M2207/026 , C10M2215/064 , C10M2223/041 , C10M2223/042 , C10M2223/043 , C10M2223/045 , C10N2230/10 , C10N2230/42 , C10N2230/45 , C10N2230/72 , C10N2240/10 , C10N2210/06 , C10N2210/02
摘要： A lubricating oil additive capable of providing an antioxidant which enables a lubricating oil composition to have long drain intervals, while reducing specific components such as metals and phosphorus atoms, and a lubricating oil composition containing the lubricating oil additive are provided. A phosphorus molybdenum compound represented by the following general formula (1) where R1, R2, and R3 each independently represent a hydrocarbon group having 1 to 20 carbon atoms is also provided.
摘要翻译：提供能够提供抗氧化剂的润滑油添加剂以及含有润滑油添加剂的润滑油组合物，其能够使润滑油组合物具有较长的排水间隔，同时减少特定组分如金属和磷原子。还提供了由以下通式（1）表示的磷钼化合物，其中R 1，R 2和R 3各自独立地表示具有1至20个碳原子的烃基。

74. 发明授权

US08003816B2 Bisphosphite ligands for hydroformylation catalyzed by transition metals 有权
标题翻译：过渡金属催化加氢甲酰化的二亚磷酸酯配体
公开(公告)号：US08003816B2
公开(公告)日：2011-08-23
申请号：US12515967
申请日：2007-11-13
申请人： Detlef Selent , Armin Boerner , Burkard Kreidler , Dieter Hess , Klaus-Diether Wiese
发明人： Detlef Selent , Armin Boerner , Burkard Kreidler , Dieter Hess , Klaus-Diether Wiese
IPC分类号： C07F15/04 , C07F9/02 , C07C45/50
CPC分类号： C07F9/65746 , C07B41/06
摘要： The invention relates to a bisphosphite of the formula I where X=a divalent substituted or unsubstituted bisalkylene or bisarylene radical, Y=a divalent substituted or unsubstituted bisarylene or bisalkylene radical, Z=oxygen or NR9, and R1, R2, R3, R4 are identical or different, substituted or unsubstituted, linked, unlinked or fused aryl or heteroaryl radicals and R9 is hydrogen or a substituted or unsubstituted alkyl or aryl radical, a process for preparing it and also the use of this phosphite in catalysis in particular in the catalytic hydroformylation of olefins or organic compounds having C—C double bonds.
摘要翻译：本发明涉及式I的双亚磷酸酯，其中X =二价取代或未取代的双亚烷基或双亚芳基，Y =二价取代或未取代的双亚芳基或双亚烷基，Z =氧或NR 9，并且R 1，R 2，R 3，R 4为相同或不同的取代或未取代的连接的，未连接的或稠合的芳基或杂芳基，R 9为氢或取代或未取代的烷基或芳基，其制备方法，以及该亚磷酸酯在催化中的用途，特别是在催化具有C-C双键的烯烃或有机化合物的加氢甲酰化反应。

75. 发明申请

US20110201707A1 ISOCYANATE TRIMERISATION CATALYST SYSTEM, A PRECURSOR FORMULATION, A PROCESS FOR TRIMERISING ISOCYANATES, RIGID POLYISOCYANURATE/POLYURETHANE FOAMS MADE THEREFROM, AND A PROCESS FOR MAKING SUCH FOAMS 审中-公开
标题翻译：异氰酸酯三聚体催化剂体系，前体配方，异构体三元共聚物的方法，刚性聚异氰酸酯/聚氨酯泡沫体的制备方法以及制备此类方法的方法
公开(公告)号：US20110201707A1
公开(公告)日：2011-08-18
申请号：US13125481
申请日：2009-11-09
申请人： Phillip S. Athey , Nathan Wilmot , Richard Keaton , David A. Babb , Cecile Boyer , Timothy Morley
发明人： Phillip S. Athey , Nathan Wilmot , Richard Keaton , David A. Babb , Cecile Boyer , Timothy Morley
IPC分类号： C08J9/00 , C07F9/02
CPC分类号： C08G18/022 , C08G18/092 , C08G18/166 , C08G18/168 , C08G18/1875 , C08G2101/0025 , C08G2105/02
摘要： The instant invention provides an isocyanate trimerisation catalyst system, a precursor formulation, a process for trimerising isocyanates, rigid foams made therefrom, and a process for making such foams. The trimerisation catalyst system comprises: (a) a phosphatrane cation; and (b) an isocyanate-trimer inducing anion; wherein said trimerisation catalyst system has a trimerisation activation temperature in the range of equal to or less than 73 C.
摘要翻译：本发明提供了异氰酸酯三聚催化剂体系，前体制剂，异氰酸三甲酯的方法，由其制备的硬质泡沫以及制备这种泡沫的方法。三聚催化剂体系包括：（a）磷酸盐阳离子; 和（b）异氰酸酯 - 三聚体诱导阴离子; 其中所述三聚催化剂体系具有等于或小于73℃的三聚活化温度。

76. 发明申请

US20110195028A1 MAGNETIC RESONANCE IMAGING AND/OR SPECTROSCOPY CONTRAST AGENTS AND METHODS OF USE THEREOF 有权
标题翻译：磁共振成像和/或光谱对比剂及其使用方法
公开(公告)号：US20110195028A1
公开(公告)日：2011-08-11
申请号：US13056795
申请日：2009-07-31
申请人： Warren S. Warren
发明人： Warren S. Warren
IPC分类号： A61K49/06 , A61K49/18 , C07C49/12 , C07C209/68 , C08G73/10 , C07C67/00 , C07D213/60 , C07C29/00 , C07C45/00 , B01J19/12 , C07F9/02 , C12P7/26
CPC分类号： A61K49/08 , A61K49/18 , A61K49/1812 , C07C49/12 , G01R33/282 , G01R33/5601 , G01R33/5605
摘要： The presently disclosed subject matter demonstrates that a spin state which has zero magnetic resonance signal, but an extremely long lifetime, can be used to store magnetization, which can then be recovered into an observable transition. Coupled with hyper-polarization techniques, this permits the preparation of a wide range of contrast agent molecules for use in magnetic resonance imaging (MRI) techniques that have long effective relaxation time.
摘要翻译：目前公开的主题表明，具有零磁共振信号但具有极长寿命的自旋状态可以用于存储磁化，然后可以将其恢复到可观察的转变中。结合超极化技术，这允许制备用于具有长效有效弛豫时间的磁共振成像（MRI）技术的大范围造影剂分子。

77. 发明授权

US07973191B2 Method for the production of dibenz[c,e] [1,2]-oxaphosphorin derivatives, amino-dibenz[c,e] [1,2]-oxaphosphorin and also use thereof 失效
标题翻译：生产二苯并[c，e] [1,2] - 氧代磷酸衍生物，氨基 - 二苯并[c，e] [1,2] - 氧磷磷酸酯的方法及其用途
公开(公告)号：US07973191B2
公开(公告)日：2011-07-05
申请号：US12539972
申请日：2009-08-12
申请人： Manfred Döring , Brigitte Lindner , Andreas Kaplan
发明人： Manfred Döring , Brigitte Lindner , Andreas Kaplan
IPC分类号： C07F9/02
CPC分类号： C07F9/65719 , C08K5/5377 , C08K5/5399
摘要： The invention relates to general syntheses of (6H)-dibenz[c,e] [1,2]-oxaphosphorins which are substituted with nitrogen compounds on the phosphorus atom and comprising commercially available 6H-dibenz[c,e] [1,2]-oxaphosphorin-6-oxides. These nitrogen-containing (6H)-dibenz[c,e] [1,2]-oxaphosphorins can be used as reactive starting substances for further syntheses or as flameproofing agents or as stabilisers.
摘要翻译：本发明涉及在磷原子上被氮化合物取代的（6H） - 二苯并[c，e] [1,2] - 氧代磷杂环己烷的一般合成，并且包含市售的6H-二苯并[c，e] [1,2 ] - 氧磷脂-6-氧化物。这些含氮（6H） - 二苯并[c，e] [1,2] - 氧磷杂菁可用作进一步合成的反应性起始物质或作为防火剂或稳定剂。

78. 发明授权

US07968607B2 Skin pore minimizers and skin elasticity improvers 有权
标题翻译：皮肤孔隙最小化和皮肤弹性改良剂
公开(公告)号：US07968607B2
公开(公告)日：2011-06-28
申请号：US12130160
申请日：2008-05-30
申请人： Takafumi Nishijima , Shinya Amano , Tsutomu Fujimura
发明人： Takafumi Nishijima , Shinya Amano , Tsutomu Fujimura
IPC分类号： A01N31/14 , A61K31/08 , C07F9/02
CPC分类号： C07F9/091 , A61K8/463 , A61K8/55 , A61K8/602 , A61K8/604 , A61Q19/00 , A61Q19/08 , C07C279/14
摘要： This invention relates to skin pore tighteners each of which comprises, as an active ingredient, a compound represented by the following formula: R1—OG (1) wherein R1 represents an alkyl or alkenyl group having 8 to 32 carbon atoms, and OG represents a residual group obtained by removing a hydrogen atom from a hydroxyl group of a polyhydric alcohol, monosaccharide or oligosaccharide at least one hydroxyl group of which has been sulfated or phosphatized, or a salt thereof, and also to skin elasticity improvers each of which comprises, as an active ingredient, a glyceryl ether derivative represented by the following formula: wherein R1 represents the same group as defined above, and X1 and X2 each independently represents a hydrogen atom, —SO3OH or —PO(OH)2 with the proviso that X1 and X2 are not hydrogen atoms at the same time, or a salt thereof.
摘要翻译：本发明涉及一种皮肤紧密剂，它们各自包含作为活性成分的由下式表示的化合物：R1-OG（1）其中R1表示碳原子数为8〜32的烷基或烯基，OG表示通过从至少一个羟基被硫酸化或磷酸化的多元醇，单糖或寡糖的羟基除去氢原子而获得的残基，或其盐，以及皮肤弹性改进剂，其各自包含作为活性成分，由下式表示的甘油醚衍生物：其中R1表示与上述相同的基团，X1和X2各自独立地表示氢原子，-SO3OH或-PO（OH）2，条件是X1和 X2不同时为氢原子或其盐。

79. 发明授权

US07951789B2 Compounds and pharmaceutical compositions for the treatment of viral infections 有权
公开(公告)号：US07951789B2
公开(公告)日：2011-05-31
申请号：US12005937
申请日：2007-12-27
申请人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
发明人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
IPC分类号： A61K31/70 , C07F9/02
CPC分类号： C07H17/02 , A61K31/675 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07F9/65586 , C07F9/65616 , C07H19/00
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

80. 再颁专利

USRE42275E1 Peptidomimetic inhibitors of PSMA, compounds comprising them, and methods of use 有权
标题翻译： PSMA的拟肽抑制剂，包含它们的化合物和使用方法
公开(公告)号：USRE42275E1
公开(公告)日：2011-04-05
申请号：US12835257
申请日：2010-07-13
申请人： Clifford E. Berkman
发明人： Clifford E. Berkman
IPC分类号： A61K31/66 , C07F9/02
CPC分类号： C07F9/4006 , C07F9/091 , C07F9/222 , C07F9/2408 , C07F9/2416 , C07F9/2429 , C07F9/2458 , C07F9/65522 , C07F9/6561
摘要： Compounds of the formula, A—L—B, wherein A is glutamate or a glutamate analog; L is a phosphoramidate or a phosphoramidate analog; and B is serine or a serine analog are described which are potent inhibitors of prostate-specific membrane antigen (PMSA). Such compounds are useful in treatment of prostate cancer; and when chemically attached to a fluorescent dye, can efficiently and selectively label prostate cancer cells for fluorescent imaging.
摘要翻译：式A-L-B的化合物，其中A是谷氨酸或谷氨酸类似物; L是氨基磷酸酯或氨基磷酸酯类似物; 并且B是丝氨酸或丝氨酸类似物，其是前列腺特异性膜抗原（PMSA）的有效抑制剂。这些化合物可用于治疗前列腺癌; 当化学连接到荧光染料上时，可以有效地选择性地标记前列腺癌细胞进行荧光成像。

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