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    • 72. 发明授权
    • 2-trifluoromethylquinoxalinedi n oxides
    • 2-三氟甲基氧杂环丁烷氧化物
    • US3752812A
    • 1973-08-14
    • US3752812D
    • 1970-02-05
    • PFIZER
    • ABUSHANAB E
    • C07D241/52C07D51/78
    • C07D241/52
    • NOVEL 2-TRIFLUOROMETHYL-3-SUBSTITUTEDQUINOXALINEDI-N-OXIDES AND 2-TRIFLUOROACETYL-3-SUBSTITUTEDQUINOZALINE-DI-OXIDES HAVING THE FORMULAE

      2-CF3,3-R,1,4-DI(O=),X-QUINOXALINE, 2-(CF3-CO-),3-R2,1,4-

      DI(O=),X-QUINOXALINE, AND 2-CF3,3-(R1-CH(-Z)-),1,4-DI(O=)

      ,X-QUINOXALINE

      WHEREIN X IS A 6- OR A 7-POSITION SUBSTITUENT AND IS HYDROGEN, CHLORO, FLUORO, METHYL, METHOXY, TRIFLUOROMETHYL, SULFONAMIDO, N-METHYLSULFONAMIDEO AND N,N-DIMETHYLSULFONAMIDO; Z IS HYDROGEN, CARBOXY, CARBO(LOWER ALKOXY), CARBAMYL, CHLORO, FLUORO, BROMO, (LOWER ALKYL)THIO, (LOWER ALKYL)SULFINYL, (LOWER ALKYL)SULFONYL, HYDROXY, LOWER ALKOXY, LOWER ALKANOYLOXY, AMINO, MONO(LOWER ALKYL)AMINO, DI(LOWER ALKYL)AMINO, TRIMETHYLAMMONIUM AND NITRO-OXY; R1 IS HYDROGEN AND LOWER ALKYL; R IS HYDROGEN, CARBO(LOWER ALKOXY), CARBAMYL, CHLORO, BROMO, FLUORO, CYANO, LOWER ALKOXY, (LOWER ALKYL)THIO, (LOWER ALKYL)SULFINYL, (LOWER ALKYL)SULFONYL, AMINO, MONO (LOWER ALKYL)AMINO, DI(LOWER ALKYL)AMINO, W,W,W-TRIFLUORO(LOWER ALKYL), TRIFLUOROACETYL, PHENYL, CYCLOALKYL, DI(LOWER ALKYL)AMINOETHYL, -CO-R2, FORMYL AND -CH=N-R5 WHEREIN R5 IS

      (2-(O=)OXAZOLIDIN-3-YL)-, AND (1-(HO-(CH2)2-)PIPERAZIN-

      4-YL)-

      WHEREIN R6 IS LOWER ALKYL, BENZYL AND HYDROXY ALKYL CONTAINING FROM 2 TO 3
      CAR ON ATOMS; R7 IS LOWER ALKYL AND HYDROXY ALKYL CONTAINING FROM 2 TO 4 CARBON ATOMS; R8 IS LOWER ALKYL AND PHENYL; AND R9 IS HYDROGEN AND LOWER ALKYL; AND R2 IS LOWER ALKYL, PHENYL, 2-FURYL, 2-PYRRYL, 2-THIENYL, 2,5-DIMETHYL-3-THIENYL AND 5-SUBSTITUTED-2-THIENYL WHEREIN THE SUBSTITUENT IS METHYL, CHLORO, BROMO AND IODO; THE NON-TOXIC ACID ADDITION SALTS OF THOSE COMPOUNDS WHEREIN Z AND R ARE AMINO, MONO(LOWER ALKYL)AMINO AND DI(LOWER ALKYL)AMINO; AND THE SODIUM AND POTASSIUM SALTS OF THOSE COMPOUNDS WHEREIN Z IS CARBOXY; AND METHODS FOR THEIR PREPARATION ARE DESCRIBED. THE COMPOUNDS ARE USEFUL AS ANTIBACTERIAL AGENTS. MANY OF THEM ARE ALSO USEFUL AS ANIMAL GROWTH PROMOTANTS.