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71. 发明申请

US20100019658A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE EMPLOYING THE SAME 有权
标题翻译：有机化合物和有机电致发光器件
公开(公告)号：US20100019658A1
公开(公告)日：2010-01-28
申请号：US12340145
申请日：2008-12-19
申请人： Chi-Jen LIN , Heh-Lung HUANG , Jin-Sheng LIN , Chien-Hong CHENG , Mei-Rurng TSENG
发明人： Chi-Jen LIN , Heh-Lung HUANG , Jin-Sheng LIN , Chien-Hong CHENG , Mei-Rurng TSENG
IPC分类号： H01J1/63 , C07D219/00
CPC分类号： C07D401/14 , C07D219/14 , C09K11/06 , C09K2211/1007 , C09K2211/1029 , H01J29/20 , Y10S428/917
摘要： Organic compounds and organic electroluminescence devices employing the same are provided. The organic compound has a chemical structure represented as follows: wherein, R1 and R2 are independent and can be aryl, heteroaryl, cycloalkyl, hetero-cycloalkyl, or a cycloaliphatic group, or R1 and R2 link together with the carbon atoms to which they are attached to form a fused aryl, heteroaryl, cycloalkyl, hetero-cycloalkyl, or a cycloaliphatic group, and R3, R4, and R5 are independent and can be H, C1-8 alkyl, C1-8 alkoxy, C1-8 halo-alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, or a cycloaliphatic group.
摘要翻译：提供了使用其的有机化合物和有机电致发光器件。有机化合物具有如下的化学结构：其中，R 1和R 2是独立的，可以是芳基，杂芳基，环烷基，杂环烷基或脂环族基团，或者R 1和R 2与它们所在的碳原子一起连接连接以形成稠合芳基，杂芳基，环烷基，杂环烷基或脂环族基团，并且R 3，R 4和R 5是独立的，可以是H，C 1-8烷基，C 1-8烷氧基，C 1-8卤代烷基，芳基，杂芳基，环烷基，杂环烷基或脂环族基团。

72. 发明申请

US20090318627A1 SOLID PHASE SYNTHESIS OF ACRIDINIUM DERIVATIVES 审中-公开
标题翻译：茜素衍生物的固相合成
公开(公告)号：US20090318627A1
公开(公告)日：2009-12-24
申请号：US12278621
申请日：2007-02-06
申请人： Anand Natrajan , David Sharpe , Jim Costello , Qingping Jiang
发明人： Anand Natrajan , David Sharpe , Jim Costello , Qingping Jiang
IPC分类号： C08G63/91 , C07D219/00 , C07J43/00 , C07K2/00 , C07H21/00
CPC分类号： C07D219/04
摘要： Acridinium-functionalized solid-phase supports and methods for making acridinium-functionalized solid-phase supports are disclosed. The acridinium-functionalized solid-phase supports comprise a solid phase support linked to a chemiluminescent substituted acridinium compound through a linker group covalently attached to the nitrogen atom of the acridinium nucleus and the solid phase support as exemplified in FIG. 1.
摘要翻译：公开了吖啶鎓官能化固相载体和制备吖啶酮官能化固相载体的方法。吖啶酮官能化的固相载体包括通过共价连接到吖啶核的氮原子的连接基团和固相载体连接到化学发光的取代的吖啶鎓化合物的固相载体，如图1所示。 1。

73. 发明申请

US20090240026A1 Novel Fluorescent Amino Acid Derivative and Production Method Of The Same 失效
标题翻译：新型荧光氨基酸衍生物及其制备方法
公开(公告)号：US20090240026A1
公开(公告)日：2009-09-24
申请号：US12306784
申请日：2007-07-03
申请人： Masumi Taki , Masahiko Sisido
发明人： Masumi Taki , Masahiko Sisido
IPC分类号： C07K2/00 , C07D219/00
CPC分类号： C07D219/06 , C09K11/06 , C09K2211/1029
摘要： An object of the present invention is to provide a novel fluorescent amino acid derivative which can be synthesized by simple steps, can be excited particularly by a blue laser ray region of visible light, and has an improved light stability. Another object is to provide a production method of the fluorescent amino acid derivative. These objects can be achieved by a fluorescent amino acid derivative which is an acridone derivative substituted with an amino acid to comprise an electrophilic substituent group between the amino acid and the acridone derivative. Instead of a conventional strategy that aminophenylalanine is used as a starting material to form a fluorescent group through a coupling reaction and an intramolecular cyclization reaction, a fluorescent acridone derivative is used as a starting material to furnish the material to a reactive group by a position-specific electrophilic substitution reaction, and then the acridone derivative having the reactive group is allowed to couple with an amino acid derivative.
摘要翻译：本发明的目的是提供可以通过简单的步骤合成的新的荧光氨基酸衍生物，特别可以通过可见光的蓝色激光射线区域被激发，并且具有改善的光稳定性。另一个目的是提供荧光氨基酸衍生物的制备方法。这些目的可以通过荧光氨基酸衍生物来实现，其是由氨基酸取代的吖啶酮衍生物，其在氨基酸和吖啶酮衍生物之间包含亲电取代基。代替使用氨基苯丙氨酸作为通过偶联反应和分子内环化反应形成荧光基团的起始材料的常规策略，使用荧光吖啶酮衍生物作为原料，通过位置 - 取代基将该材料提供给反应性基团，特异性亲电取代反应，然后使具有反应性基团的吖啶酮衍生物与氨基酸衍生物偶联。

74. 发明授权

US07485737B2 Colorant compounds 有权
标题翻译：着色剂化合物
公开(公告)号：US07485737B2
公开(公告)日：2009-02-03
申请号：US11702757
申请日：2007-02-06
申请人： Jeffrey H. Banning
发明人： Jeffrey H. Banning
IPC分类号： C07C45/27 , C07D219/00
CPC分类号： C09B11/02 , C09B11/24 , C09B11/28 , C09D11/34
摘要： A compound of the formula wherein R1, R2, R3, R4, R5, R6, R′, R″, Y, CA+, and A− each, independently of the others are as defined herein.
摘要翻译：下式化合物其中R1，R2，R3，R4，R5，R6，R'，R“，Y，CA +和A各自独立地如本文所定义。

75. 发明申请

US20080308770A1 MONO AND BIS-ESTER DERIVATIVES OF PYRIDINIUM AND QUINOLINIUM COMPOUNDS AS ENVIRONMENTALLY FRIENDLY CORROSION INHIBITORS 审中-公开
标题翻译：吡啶鎓和喹啉鎓化合物的单体和双酚A衍生物作为环境友好的腐蚀抑制剂
公开(公告)号：US20080308770A1
公开(公告)日：2008-12-18
申请号：US11763006
申请日：2007-06-14
申请人： Laxmikant Tiwari
发明人： Laxmikant Tiwari
IPC分类号： C23F11/14 , C07D211/82 , C07D215/00 , C07D219/00 , C07D237/02 , C07D237/28 , C23F11/16 , C07D239/20 , C07D239/72 , C07D263/32 , C07D263/52 , C07D277/22
CPC分类号： C07D213/04 , C07D215/10 , C23F11/149
摘要： A quaternary nitrogen-containing corrosion inhibitor of formula wherein is an aromatic, nitrogen-containing ring of 5 to 14 ring atoms, optionally containing an additional N, O or S ring atom and optionally substituted with one or more alkyl, alkenyl, aryl, arylalkyl, cycloalkyl, amino, aminoalkyl, alkoxy, hydroxylalkyl, or cyano groups, or a mixture thereof, Y is a group of formula —OC(O)R1 or —C(O)R1; L is C1-C10 alkyl, C2-C10 alkenyl or a group of formula CH2CH(OR2)CH2—; R1 is C8-C20 alkyl or C8-C20 alkenyl; R2 is H or C(O)R1; R3 and R4 are independently selected from H, alkyl, alkenyl, amino, alkoxy, hydroxylalkyl and cyano; and X is Br, Cl or I is particularly useful for inhibiting corrosion in oil and gas field applications.
摘要翻译：含季氮含腐蚀抑制剂，其中是含有5至14个环原子的芳族含氮环，任选地含有另外的N，O或S环原子，并任选被一个或多个烷基，烯基，芳基，芳烷基，环烷基，氨基，氨基烷基，烷氧基，羟基烷基或氰基或其混合物，Y是式-OC（O）R 1或-C（O）R 1的基团; L是C 1 -C 10烷基，C 2 -C 10烯基或式CH 2 CH（OR 2）CH 2 - 的基团; R1是C8-C20烷基或C8-C20烯基; R2是H或C（O）R1; R 3和R 4独立地选自H，烷基，烯基，氨基，烷氧基，羟基烷基和氰基; X为Br，Cl或I特别适用于抑制油气田应用中的腐蚀。

76. 发明申请

US20080015172A1 CASPASE INHIBITORS AND USES THEREOF 失效
标题翻译： CASPASE抑制剂及其用途
公开(公告)号：US20080015172A1
公开(公告)日：2008-01-17
申请号：US11770093
申请日：2007-06-28
申请人： Michael Mortimore , Andrew Miller , John Studley , Jean-Damien Charrier
发明人： Michael Mortimore , Andrew Miller , John Studley , Jean-Damien Charrier
IPC分类号： A61K31/403 , A61K31/404 , A61K31/407 , A61K31/437 , A61K31/495 , A61K31/502 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K31/58 , A61P1/00 , A61P11/00 , A61P13/12 , A61P17/00 , A61P19/02 , A61P25/00 , A61P3/10 , A61P31/00 , A61P35/00 , A61P37/00 , A61P43/00 , A61P9/00 , C07D209/04 , C07D209/82 , C07D219/00 , C07D221/02 , C07D221/12 , C07D223/14 , C07D237/26 , C07D241/36 , C07D279/18 , C07D295/00 , C07J43/00
CPC分类号： A61K31/55 , A61K31/4015 , A61K31/403 , A61K31/407 , A61K31/435 , A61K31/45 , A61K31/498 , A61K31/5025 , A61K31/538 , A61K31/54 , Y02A50/385 , Y02A50/387 , Y02A50/389
摘要： This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1 is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; between R3 and R4 represents a single or double bond; Y is an electronegative leaving group; R2 is CO2H, CH2CO2H, or esters, amides or isosteres thereof; R3is a group capable of fitting into the S2 subsite of a caspase enzyme; R4 is a hydrogen or C1-6 alkyl or R3 and R4 taken together form a ring; Ring A and Ring B are each heterocyclic rings, and R and R5 are as described in the specification. The compounds are effective inhibitors of apoptosis and IL-1β secretion.
摘要翻译：本发明提供了式I的半胱天冬酶抑制剂：其中Z是氧或硫; R 1是氢，-CHN 2，R 2，CH 2 OR，CH 2 SR或-CH 2 Y; R 3和R 4之间代表单键或双键; Y是电负离子团; R 2是CO 2 H，CH 2 CO 2 H，或它们的酯，酰胺或等体醇; R 3是能够适应半胱天冬酶的S2亚位点的基团; R 4是氢或C 1-6烷基或R 3和R 4合在一起形成环 ; 环A和环B各自是杂环，R和R 5如说明书中所述。这些化合物是凋亡和IL-1β分泌的有效抑制剂。

77. 发明授权

US07319041B2 Applications of acridinium compounds and derivatives in homogeneous assays 有权
标题翻译：吖啶鎓化合物和衍生物在均相测定中的应用
公开(公告)号：US07319041B2
公开(公告)日：2008-01-15
申请号：US10260504
申请日：2002-09-27
申请人： Anand Natrajan , Todd Sells , Hartmut Schroeder , Guohan Yang , David Sharpe , Qingping Jiang , Hana Lukinsky , Say-Jong Law
发明人： Anand Natrajan , Todd Sells , Hartmut Schroeder , Guohan Yang , David Sharpe , Qingping Jiang , Hana Lukinsky , Say-Jong Law
IPC分类号： G01N33/533 , G01N33/536 , G01N33/53 , C07D219/00
CPC分类号： C07D219/04 , B82Y15/00 , G01N33/533 , G01N33/542 , G01N33/588 , Y10S435/968 , Y10S436/80
摘要： Chemiluminescent acridinium compounds are used in homogeneous assays to determine the concentration of an analyte in a sample without strong acid or strong base treatment. The chemiluminescent acridinium compounds include acridinium esters with electron donating functional groups at the C2 and/or C7 position on the acridinium nucleus to inhibit pseudo-base formation, or acridinium sulfonamides with or without electron donating functional groups at the C2 and/or C7 position on the acridinium nucleus.
摘要翻译：化学发光吖啶鎓化合物用于均相测定以确定样品中分析物的浓度，而不需要强酸或强碱处理。化学发光的吖啶鎓化合物包括在吖啶鎓核上的C2和/或C7位上具有给电子官能团的吖啶酯以抑制假碱形成，或在C2和/或C7位置具有或不具有给电子官能团的吖啶鎓磺酰胺， ium核。

78. 发明申请

US20070299093A1 Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation 审中-公开
标题翻译：用于治疗阿尔茨海默病的有机化合物及其用途和制备方法
公开(公告)号：US20070299093A1
公开(公告)日：2007-12-27
申请号：US10591515
申请日：2006-01-27
申请人： Michela Rosini , Vincenza Andrisano , Manuela Bartolini , Carlo Melchiorre
发明人： Michela Rosini , Vincenza Andrisano , Manuela Bartolini , Carlo Melchiorre
IPC分类号： A61K31/517 , A61K31/38 , A61K31/385 , C07D219/00 , C07D333/00 , C07D239/72 , A61P25/00 , A61K31/44
CPC分类号： C07D409/12 , C07D339/04
摘要： Compounds identified by the general formula (I) are used for the treatment of Alzheimer's disease.
摘要翻译：由通式（I）鉴定的化合物用于治疗阿尔茨海默氏病。

79. 发明授权

US07223865B2 Chromogenic compounds, and use thereof as enzyme substrates 有权
标题翻译：显色化合物及其作为酶底物的用途
公开(公告)号：US07223865B2
公开(公告)日：2007-05-29
申请号：US10541490
申请日：2004-01-26
申请人： Arthur James , Annette Rigby
发明人： Arthur James , Annette Rigby
IPC分类号： C07D219/00 , C12Q1/37
CPC分类号： C12Q1/04 , C07D219/02 , C12Q1/37
摘要： The present invention relates to novel chromogenic substrates which are used to detect aminopeptidase activity in microorganisms or to determine whether at least one bacterium belongs to the Gram-positive group or to the Gram-negative group according to the color thereof. The invention also relates to culture media containing such substrates, to the use of the substrates or media for the detection of aminopeptidase activities and/or the differentiation of Gram-positive bacteria from Gram-negative bacteria and to methods of use.The aforementioned novel substrates have the formula below: in which: R1 is nothing or an alkyl, allyl or aryl group, R2 consists of at least one amino acid, preferably alanine, R3, R4, R5 and R6 consist, independently of one another, of H— or —O-alkyl, preferably —O—CH3, R7 consists of H, O—CH3, alkyl or halogen, R8 consists of H or Cl, and n is an integer corresponding to 0 or 1. The invention is particularly suitable for use in the field of diagnostics.
摘要翻译：本发明涉及用于检测微生物中氨基肽酶活性的新型显色底物，或根据其颜色确定至少一种细菌是否属于革兰氏阴性组或革兰氏阴性组。本发明还涉及含有这种底物的培养基，使用底物或培养基来检测革兰氏阴性细菌中革兰氏阳性菌的氨基肽酶活性和/或分化以及使用方法。上述新型底物具有下式：其中：R 1不是或烷基，烯丙基或芳基，R 2 2由至少一个氨基酸组成，优选丙氨酸，R 3，R 4，R 5和R 6各自独立地为H - 或-O-烷基，优选-O-CH 3，R 7由H，O-CH 3，烷基或卤素组成， R 8由H或Cl组成，n是对应于0或1的整数。本发明特别适用于诊断领域。

80. 发明申请

US20060040900A1 R(-)-11-hydroxyaporphine derivatives and uses thereof 有权
标题翻译： R（ - ） - 11-羟基吗啡衍生物及其用途
公开(公告)号：US20060040900A1
公开(公告)日：2006-02-23
申请号：US11105024
申请日：2005-04-13
申请人： John Neumeyer , Ross Baldessarini
发明人： John Neumeyer , Ross Baldessarini
IPC分类号： A61K31/473 , C07D219/00 , C07D221/18
CPC分类号： C07D491/10 , A61K31/4436 , C07D221/18
摘要： The invention features derivatives of R(—)-11-hydroxyaporphines and methods of treating Parkinson's disease, sexual dysfunction, and depressive disorders therewith.
摘要翻译：本发明的特征在于R（ - ） - 11-羟基蒽环的衍生物及其治疗帕金森病，性功能障碍和抑郁障碍的方法。

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