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71. 发明申请

US20120264603A1 ATTACHMENT AND RETENTION FORMULATIONS FOR BIOLOGICALLY ACTIVE ORGANIC COMPOUNDS 审中-公开
标题翻译：生物活性有机化合物的附着和保留配方
公开(公告)号：US20120264603A1
公开(公告)日：2012-10-18
申请号：US13267970
申请日：2011-10-07
申请人： David S. Soane , Gangadhar Jogikalmath
发明人： David S. Soane , Gangadhar Jogikalmath
IPC分类号： C08G63/91 , A01N39/04 , A01N37/10 , A01N43/40 , A01N37/22 , A01N47/24 , A01N35/10 , A01N25/10 , A01N25/34 , A01N43/707 , A01N43/50 , A01N47/34 , A01N43/78 , C07C59/70 , C07C59/68 , C07C65/21 , C07D213/83 , C07C233/18 , C07C311/53 , C07C251/52 , A01N25/26 , A01P13/00 , A01P7/04 , A01P3/00 , C08G65/48 , A01N39/02
CPC分类号： A01N25/10 , A01N25/26 , A01N35/10 , A01N37/22 , A01N37/40 , A01N37/46 , A01N39/04 , A01N43/40 , A01N43/653 , A01N43/707 , A01N47/24 , A01N37/26 , A01N43/50 , A01N43/70 , A01N43/78 , A01N43/88 , A01N47/36
摘要： The invention encompasses formulations for increased attachment and retention systems of biologically active organic compounds and methods for the preparation and use thereof.
摘要翻译：本发明包括用于增加生物活性有机化合物的附着和保留系统的制剂及其制备和使用方法。

72. 发明授权

US06939875B2 Compounds that modulate PPAR activity and methods for their preparation 有权
标题翻译：调节PPAR活性的化合物及其制备方法
公开(公告)号：US06939875B2
公开(公告)日：2005-09-06
申请号：US10979617
申请日：2004-11-02
申请人： Bruce J. Auerbach , Larry D. Bratton , Gary F. Filzen , Andrew G. Geyer , Bharat K. Trivedi , Paul C. Unangst
发明人： Bruce J. Auerbach , Larry D. Bratton , Gary F. Filzen , Andrew G. Geyer , Bharat K. Trivedi , Paul C. Unangst
IPC分类号： A61K31/19 , A61K31/192 , A61K31/353 , A61K31/381 , A61K31/404 , A61K31/4168 , A61K31/4178 , A61K31/42 , A61K31/422 , A61K31/4245 , A61K31/44 , A61K31/4402 , A61K31/445 , A61K31/4525 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P35/00 , A61P43/00 , C07C27/02 , C07C51/09 , C07C59/135 , C07C59/70 , C07C59/72 , C07C315/04 , C07C317/22 , C07C319/20 , C07C323/19 , C07C323/20 , C07C323/21 , C07D209/10 , C07D211/14 , C07D211/18 , C07D213/20 , C07D213/30 , C07D213/32 , C07D231/12 , C07D233/68 , C07D235/18 , C07D261/08 , C07D271/06 , C07D271/10 , C07D295/092 , C07D307/79 , C07D311/58 , C07D333/54 , C07D405/06 , C07D405/10 , C07D405/12 , C07D413/04 , C07D413/12 , C07D521/00 , C07D213/02
CPC分类号： C07C323/20 , C07C59/70 , C07C59/72 , C07C317/22 , C07C323/19 , C07C2602/08 , C07C2603/18 , C07D209/10 , C07D211/14 , C07D213/30 , C07D213/32 , C07D231/12 , C07D233/56 , C07D233/68 , C07D235/18 , C07D249/08 , C07D261/08 , C07D271/06 , C07D271/10 , C07D295/088 , C07D307/79 , C07D311/58 , C07D333/54 , C07D405/12 , C07D413/04 , C07D413/12
摘要： This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing disipidemia, hypercholesteremia, obesity, eating disorders, hyperglycemia, atherosclerosis, hypertriglyceridemia, hyperinsulinemia and diabetes in a mammal as well as methods of supressing appetite and modulating leptin levels in a mammal. The present invention also discloses methods for making the disclosed compounds.
摘要翻译：本发明公开了改变PPAR活性的化合物。本发明还公开了化合物的药学上可接受的盐，包含化合物或其盐的药学上可接受的组合物，以及使用它们作为治疗或预防血脂异常，高胆固醇血症，肥胖，进食障碍，高血糖症，动脉粥样硬化，高甘油三酯血症，高胰岛素血症和哺乳动物中的糖尿病以及抑制食欲和调节哺乳动物瘦素水平的方法。本发明还公开了制备所公开的化合物的方法。

73. 发明申请

US20050113440A1 Compounds that modulate PPAR activity and methods for their preparation 失效
公开(公告)号：US20050113440A1
公开(公告)日：2005-05-26
申请号：US10979629
申请日：2004-11-02
申请人： Bruce Auerbach , Larry Bratton , Gary Filzen , Andrew Geyer , Bharat Trivedi , Paul Unangst
发明人： Bruce Auerbach , Larry Bratton , Gary Filzen , Andrew Geyer , Bharat Trivedi , Paul Unangst
IPC分类号： A61K31/19 , A61K31/192 , A61K31/353 , A61K31/381 , A61K31/404 , A61K31/4168 , A61K31/4178 , A61K31/42 , A61K31/422 , A61K31/4245 , A61K31/44 , A61K31/4402 , A61K31/445 , A61K31/4525 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P35/00 , A61P43/00 , C07C27/02 , C07C51/09 , C07C59/135 , C07C59/70 , C07C59/72 , C07C315/04 , C07C317/22 , C07C319/20 , C07C323/19 , C07C323/20 , C07C323/21 , C07D209/10 , C07D211/14 , C07D211/18 , C07D213/20 , C07D213/30 , C07D213/32 , C07D231/12 , C07D233/68 , C07D235/18 , C07D261/08 , C07D271/06 , C07D271/10 , C07D295/092 , C07D307/79 , C07D311/58 , C07D333/54 , C07D405/06 , C07D405/10 , C07D405/12 , C07D413/04 , C07D413/12 , C07D521/00 , A61K31/195 , A61K31/277 , C07D333/24
CPC分类号： C07C323/20 , C07C59/70 , C07C59/72 , C07C317/22 , C07C323/19 , C07C2602/08 , C07C2603/18 , C07D209/10 , C07D211/14 , C07D213/30 , C07D213/32 , C07D231/12 , C07D233/56 , C07D233/68 , C07D235/18 , C07D249/08 , C07D261/08 , C07D271/06 , C07D271/10 , C07D295/088 , C07D307/79 , C07D311/58 , C07D333/54 , C07D405/12 , C07D413/04 , C07D413/12
摘要： This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing disipidemia, hypercholesteremia, obesity, eating disorders, hyperglycemia, atherosclerosis, hypertriglyceridemia, hyperinsulinemia and diabetes in a mammal as well as methods of supressing appetite and modulating leptin levels in a mammal. The present invention also discloses methods for making the disclosed compounds.

74. 发明授权

US5663413A Biphenyl iodinated derivatives and their diagnostic use 失效
标题翻译：联苯碘化衍生物及其诊断用途
公开(公告)号：US5663413A
公开(公告)日：1997-09-02
申请号：US448750
申请日：1995-05-24
申请人： Fulvio Uggeri , Pier Lucio Anelli , Marino Brocchetta , Massimo Visigalli
发明人： Fulvio Uggeri , Pier Lucio Anelli , Marino Brocchetta , Massimo Visigalli
IPC分类号： A61K49/04 , C07C39/367 , C07C43/225 , C07C59/70 , C07C69/708 , C07C233/65 , C07C233/69 , C07C235/06 , C07C235/08 , C07C235/16 , C07C235/20 , C07C235/46 , C07C235/48 , C07C69/76 , C07C17/00 , C07C233/11
CPC分类号： C07C235/20 , A61K49/0433 , C07C233/65 , C07C233/69 , C07C235/06 , C07C235/16 , C07C235/46 , C07C235/48 , C07C43/225 , C07C59/70 , C07C69/708
摘要： The invention relates to novel contrast media particularly useful for X-ray diagnostic investigations of human and animal body.
摘要翻译：本发明涉及对人体和动物体的X射线诊断研究特别有用的新型造影剂。

75. 发明授权

US5565485A Biphenyl compounds useful or endothelin antagonists 失效
标题翻译：联苯化合物有用或内皮素拮抗剂
公开(公告)号：US5565485A
公开(公告)日：1996-10-15
申请号：US294232
申请日：1994-08-22
申请人： Scott W. Bagley , Theodore P. Broten , Prasun K. Chakravarty , Daljit S. Dhanoa , Kenneth J. Fitch , William J. Greenlee , Nancy J. Kevin , Douglas J. Pettibone , Ralph A. Rivero , Thomas F. Walsh , David L. Williams, Jr. , Richard B. Toupence , Jay M. Matthews
发明人： Scott W. Bagley , Theodore P. Broten , Prasun K. Chakravarty , Daljit S. Dhanoa , Kenneth J. Fitch , William J. Greenlee , Nancy J. Kevin , Douglas J. Pettibone , Ralph A. Rivero , Thomas F. Walsh , David L. Williams, Jr. , Richard B. Toupence , Jay M. Matthews
IPC分类号： C07C59/70 , C07C65/24 , C07C311/51 , C07D257/04 , C07D317/60 , C07D317/64 , C07D319/18 , C07D405/12 , C07D409/12 , A61K31/335 , A61K31/535 , C07D265/30 , C07D319/08
CPC分类号： C07D257/04 , C07C311/51 , C07C59/70 , C07C65/24 , C07D317/60 , C07D317/64 , C07D319/18 , C07D405/12 , C07D409/12 , Y10S514/869
摘要： Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.
摘要翻译：苯氧基苯基乙酸和一般结构式I的衍生物具有内皮素拮抗剂活性，可用于治疗心血管疾病，如高血压，缺血性肾衰竭，血管痉挛，脑和心脏缺血，心肌梗死，内毒素性休克，良性前列腺增生，包括雷诺氏病和哮喘的炎性疾病。

76. 发明授权

US5527945A Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom 失效
标题翻译：二苯基杂烷基衍生物，其制备方法和由其制备的药物和化妆品
公开(公告)号：US5527945A
公开(公告)日：1996-06-18
申请号：US297537
申请日：1994-08-31
申请人： Bernd Janssen , Hans-Heiner Wuest
发明人： Bernd Janssen , Hans-Heiner Wuest
IPC分类号： A61K8/33 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/67 , A61K31/195 , A61Q19/00 , C07C37/11 , C07C39/17 , C07C43/20 , C07C43/205 , C07C43/21 , C07C43/23 , C07C45/44 , C07C47/575 , C07C51/367 , C07C59/70 , C07C65/21 , C07C65/24 , C07C65/26 , C07C69/76 , C07C69/92 , C07C205/06 , C07C205/34 , C07C205/35 , C07C205/37 , C07C211/60 , C07C217/48 , C07C217/58 , C07C217/76 , C07C217/86 , C07C223/06 , C07C229/38 , C07C229/60 , C07C233/18 , C07C233/25 , C07C233/43 , C07C233/47 , C07C233/48 , C07C233/75 , C07C235/42 , C07C255/51 , C07C255/54 , C07C259/10 , C07C309/42 , C07C317/22 , C07C317/32 , C07C317/44 , C07C323/16 , C07C323/19 , C07C323/20 , C07C323/32 , C07C323/34 , C07C323/36 , C07C323/41 , C07C323/56 , C07C323/62 , C07C327/30 , C07D263/58 , C07D311/72 , C07F9/38 , C07F9/40 , C07C255/49 , A61K31/275 , C07C69/02
CPC分类号： A61K8/46 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/411 , A61K8/42 , A61K8/445 , A61K8/671 , A61Q19/00 , C07C205/06 , C07C205/34 , C07C205/35 , C07C205/37 , C07C211/60 , C07C217/48 , C07C217/58 , C07C217/76 , C07C217/86 , C07C223/06 , C07C229/38 , C07C229/60 , C07C233/18 , C07C233/25 , C07C233/43 , C07C233/47 , C07C233/48 , C07C233/75 , C07C235/42 , C07C255/54 , C07C259/10 , C07C309/42 , C07C317/22 , C07C317/32 , C07C317/44 , C07C323/16 , C07C323/19 , C07C323/20 , C07C323/32 , C07C323/34 , C07C323/36 , C07C323/41 , C07C323/56 , C07C323/62 , C07C327/30 , C07C37/18 , C07C39/17 , C07C41/26 , C07C43/202 , C07C43/2055 , C07C43/21 , C07C43/23 , C07C45/44 , C07C47/575 , C07C51/367 , C07C65/24 , C07C65/26 , C07C69/76 , C07C69/92 , C07D263/58 , C07D311/58 , C07D311/70 , C07D311/72 , C07D317/22 , C07F9/3834 , C07F9/4021 , C07C2102/10
摘要： Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R.sup.1 -R.sup.6 have the meanings specified in the description, and the preparation thereof are described.The substances are suitable for controlling diseases and as cosmetic agents.
摘要翻译：描述了其中A和R 1 -R 6具有说明书中规定的含义的式I的（I）的二苯基杂烷基衍生物及其制备。该物质适用于控制疾病和化妆品。

77. 发明授权

US5217981A LTB4 synthesis inhibitors 失效
标题翻译： LTB4合成抑制剂
公开(公告)号：US5217981A
公开(公告)日：1993-06-08
申请号：US967296
申请日：1992-10-27
申请人： Stevan W. Djuric , Richard A. Haack , Julie M. Miyashiro
发明人： Stevan W. Djuric , Richard A. Haack , Julie M. Miyashiro
IPC分类号： C07C59/70 , C07C59/74 , C07C65/19 , C07C65/30 , C07C65/38 , C07C311/51 , C07D213/79 , C07D257/04 , C07D307/68 , C07D333/38
CPC分类号： C07D213/79 , C07C311/51 , C07C59/70 , C07C59/74 , C07C65/19 , C07C65/30 , C07C65/38 , C07D257/04 , C07D307/68 , C07D333/38
摘要： This invention relates to a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, --CH.dbd.CH--or --CH.dbd.N--; wherein R.sub.1 is alkyl, alkenyl or alkynyl of about 1 to 20 carbon atoms; wherein R is --CO.sub.2 R.sup.2, tetrazole, methylsulfonamide or benzenesulfonamide, wherein R.sup.2 is hydrogen, alkyl of 1 to 6 carbon atoms or a pharmaceutically acceptable cation and R.sup.3 is hydroxyl or halogen, having utility as LTB.sub.4 synthesis inhibitors.
摘要翻译：本发明涉及式IMA的化合物或其药学上可接受的盐，其中X是氧，硫，-CH = CH-或-CH = N-; 其中R1是约1-20个碳原子的烷基，烯基或炔基; 其中R为-CO 2 R 2，四唑，甲基磺酰胺或苯磺酰胺，其中R 2为氢，1至6个碳原子的烷基或药学上可接受的阳离子，R 3为羟基或卤素，可用作LTB4合成抑制剂。

78. 发明授权

US5140046A Phenylene derivatives, compositions and use 失效
标题翻译：苯衍生物，组合物和用途
公开(公告)号：US5140046A
公开(公告)日：1992-08-18
申请号：US567159
申请日：1990-08-13
申请人： Toshiyasu Mase , Kiyoshi Murase , Hiromu Hara , Kenichi Tomioka
发明人： Toshiyasu Mase , Kiyoshi Murase , Hiromu Hara , Kenichi Tomioka
IPC分类号： A61K31/195 , C07C45/71 , C07C47/575 , C07C59/70 , C07C59/72 , C07C65/21 , C07C65/24 , C07C69/712 , C07C69/734 , C07C233/81 , C07C235/56 , C07C235/64 , C07C255/60 , C07C271/28 , C07C275/40 , C07D257/04 , C07D285/12 , C07D285/125 , C07D285/135
CPC分类号： C07D257/04 , C07C235/56 , C07C235/64 , C07C255/00 , C07C255/60 , C07C271/28 , C07C275/40 , C07C45/71 , C07C47/575 , C07C59/70 , C07C59/72 , C07C65/21 , C07C65/24 , C07C69/712 , C07C69/734 , C07D285/125 , C07D285/135
摘要： Novel phenylene derivatives shown by the general formula ##STR1## where A represents a hydrogen atom, a phenyl group or a phenoxy group, n represents an integer of 3 to 10, R.sub.1 represents a hydrogen atom or a lower alkoxy group, X.sub.1 represents --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CONH--, B represents ##STR2## wherein R.sub.2 represents a hydrogen atom, a halogen atom, a nitro group, etc.), ##STR3## (wherein R.sub.3 represents a hydrogen atom, a hydroxyl group or a lower alkoxy group), X.sub.2 represents --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, etc. and D represents a carboxy group, a lower alkoxycarbonyl group or ##STR4## which are useful as drugs, particularly SRS-A(slow reacting substance of anaphylaxis) antagonist, i.e. they are useful as prophylaxis and treatment for various allergic diseases (e.g. bronchial asthma, allergic rhinitis, urticaria) or, ischemic heart diseases, inflammation, etc. induced by SRS-A.
摘要翻译：其中A表示氢原子，苯基或苯氧基，n表示3〜10的整数，R 1表示氢原子或低级烷氧基，X 1表示-CH 2 CH 2的通式[IMAGE]所示的新型亚苯基衍生物 - ， - CH = CH-，-CONH-，+ E，crc / B /表示其中R2表示氢原子，卤素原子，硝基等），其中R3表示氢原子，羟基或低级烷氧基），X2表示-CH = CH-，-CH2CH2-等，D表示可用作药物的羧基，低级烷氧基羰基或“IMAGE”，特别是SRS -A（过敏反应缓慢反应物质）拮抗剂，即可用作预防和治疗由SRS-A引起的各种过敏性疾病（如支气管哮喘，过敏性鼻炎，荨麻疹）或缺血性心脏病，炎症等。

79. 发明授权

US4994479A Phenylene derivatives and anti-allergic use thereof 失效
标题翻译：苯衍生物及其抗过敏用途
公开(公告)号：US4994479A
公开(公告)日：1991-02-19
申请号：US899218
申请日：1986-08-15
申请人： Toshiyasu Mase , Kiyoshi Murase , Hiromu Hara , Kenichi Tomioka
发明人： Toshiyasu Mase , Kiyoshi Murase , Hiromu Hara , Kenichi Tomioka
IPC分类号： A61K31/195 , C07C45/71 , C07C47/575 , C07C59/70 , C07C59/72 , C07C59/90 , C07C65/21 , C07C65/24 , C07C69/712 , C07C69/734 , C07C233/12 , C07C235/56 , C07C235/64 , C07C255/59 , C07C255/60 , C07C271/28 , C07C275/40 , C07D257/04 , C07D285/12 , C07D285/125 , C07D285/135
CPC分类号： C07D257/04 , C07C235/56 , C07C235/64 , C07C255/00 , C07C255/60 , C07C271/28 , C07C275/40 , C07C45/71 , C07C47/575 , C07C59/70 , C07C59/72 , C07C65/21 , C07C65/24 , C07C69/712 , C07C69/734 , C07D285/125 , C07D285/135
摘要： Novel phenylene derivatives shown by the general formula ##STR1## wherein A represents a hydrogen atom, a phenyl group or a phenoxy group, n represents an integer of 3 to 10, R.sub.1 represents a hydrogen atom or a lower alkoxy group, X.sub.1 represents --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CONH--, .circle.B represents ##STR2## (wherein R.sub.2 represents a hydrogen atom, a halogen atom, a nitro group, etc.), ##STR3## (wherein R.sub.3 represents a hydrogen atom, a hydroxyl group or a lower alkoxy group), X.sub.2 represents --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, etc. and D represents a carboxy group, a lower alkoxycarbonyl group or ##STR4## which are useful as drugs, particularly SRS-A (slow reacting substance of anaphylaxis) antagonist, i.e. they are useful as prophylaxis and treatment for various allergic diseases (e.g. bronchial asthma, allergic rhinitis, urticaria) or, ischemic heart diseases, inflammation, etc. induced by SRS-A.
摘要翻译： PCT No.PCT / JP86 / 00155 Sec。 371日期1986年8月15日 102（e）日期1986年8月15日PCT提交1986年3月31日PCT公布。公开号WO86 / 05779 日期：1986年10月9日。通式[IMAGE]所示的新型亚苯基衍生物，其中A表示氢原子，苯基或苯氧基，n表示3〜10的整数，R1表示氢原子或低级烷氧基，X 1表示-CH 2 CH 2 - ， - CH = CH - ， - CONH - ，＆C＆B表示＆lt; IMAGE＆gt;（其中R 2表示氢原子，卤素原子，硝基等）， R3表示氢原子，羟基或低级烷氧基），X2表示-CH = CH-，-CH2CH2-等，D表示可用作药物的羧基，低级烷氧基羰基或特别是SRS-A（过敏反应缓慢反应物质）拮抗剂，即它们可用作预防和治疗SRS-诱导的各种过敏性疾病（如支气管哮喘，过敏性鼻炎，荨麻疹）或缺血性心脏病，炎症等。一个。

80. 发明授权

US4748272A Phenoxyphenylacetates for use as potential modulators of arichidonic acid pathways 失效
标题翻译：苯氧基苯乙酸盐用作亚硝酸途径的潜在调节剂
公开(公告)号：US4748272A
公开(公告)日：1988-05-31
申请号：US891846
申请日：1986-08-01
申请人： Raymond D. Youssefyeh
发明人： Raymond D. Youssefyeh
IPC分类号： C07C59/70 , C07C59/90 , A61K31/19 , A61K31/22
CPC分类号： C07C59/90 , C07C59/70
摘要： This invention relates to new lipoxygenase inhibitors possessing anti-inflammatory and anti-allergic properties. The present new compounds are of the formula: ##STR1## and salts thereof; whereinAr is phenyl, naphthyl or sulfur, oxygen or nitrogen heterocyclic;X is O, S, NR.sub.5, or a chemical bond;R is H, lower alkoxy, aryloxy, hydroxy, lower alkyl, aryl or lower aralkyl;R.sub.1 and R.sub.2 are independently hydrogen, hydroxy, lower alkoxy, lower alkyl, aryl, aryloxy, lower aralkyl, lower aralkoxy, formyl, lower alkanoyl, benzoyl, and lower aralkanoyl;R.sub.3 and R.sub.4 are independently hydrogen, halogen, hydroxy, lower alkoxy, aryloxy, lower aralkoxy, trifluoromethyl, lower carbalkoxy, carboxy, cyano, nitro, lower alkyl, lower alkenyl, lower alkynyl, aryl or lower aralkyl;R.sub.5 is H, lower alkyl, lower aralkyl or aryl;R.sub.6 is hydroxy or hydroxy-substituted lower alkyl;n and m are independently 0, 1, 2 or 3.
摘要翻译：本发明涉及具有抗炎和抗过敏性质的新的脂氧合酶抑制剂。本发明的新化合物具有以下结构式：其中：其中Ar为苯基，萘基或硫，氧或氮杂环; X是O，S，NR5或化学键; R为H，低级烷氧基，芳氧基，羟基，低级烷基，芳基或低级芳烷基; R 1和R 2独立地是氢，羟基，低级烷氧基，低级烷基，芳基，芳氧基，低级芳烷基，低级芳烷氧基，甲酰基，低级烷酰基，苯甲酰基和低级芳烷酰基。 R3和R4独立地是氢，卤素，羟基，低级烷氧基，芳氧基，低级芳烷氧基，三氟甲基，低级烷氧羰基，羧基，氰基，硝基，低级烷基，低级烯基，低级炔基，芳基或低级芳烷基。 R5是H，低级烷基，低级芳烷基或芳基; R6是羟基或羟基取代的低级烷基; n和m独立地为0,1,2或3。

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