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    • 76. 发明授权
    • Antimicrobial composition for medical articles
    • 医疗用品的抗微生物组合物
    • US07381751B2
    • 2008-06-03
    • US10925631
    • 2004-08-25
    • Shantha Sarangapani
    • Shantha Sarangapani
    • A61K47/30A61K33/42A61K33/38A61K33/34A61K33/00A61K31/28A01N59/26A01N59/16A01N59/20A01N59/02
    • A61K45/06A61K31/555A61K33/38Y10S514/836A61K2300/00
    • An antimicrobial composition is formed from about 5 to about 25 wt % of an antimicrobial formulation and about 75 to about 95 wt % of a silicone resin. The antimicrobial formulation is formed from about 60 to about 95 wt % of an antimicrobial material, about 1 to about 30 wt % calcium chelator, about 0.001 to about 0.25 wt % pigment, and about 0.5 to about 3.5 wt % lubricant. The silicone resin may be a dispersion of about 40 to about 60 w/v % of an RTV silicone resin in a solvent, a liquid silicone resin, or a solid silicone resin. An antimicrobial coating may be formed on the surface of an article by applying an antimicrobial composition to the article and permitting the solvent to evaporate. It may also be formed by making a mixture of about 5 to about 12 wt % of an antimicrobial formulation and about 88 to about 95 wt % of a liquid or solid silicone resin and molding, overmolding, or extruding the article from the compounded mixture.
    • 抗微生物组合物由约5至约25重量%的抗微生物制剂和约75至约95重量%的有机硅树脂形成。 抗微生物制剂由约60至约95重量%的抗微生物材料,约1至约30重量%的钙螯合剂,约0.001至约0.25重量%的颜料和约0.5至约3.5重量%的润滑剂形成。 有机硅树脂可以是溶剂中的约40至约60w / v%的RTV硅树脂的分散体,液体硅树脂或固体有机硅树脂。 通过将抗微生物组合物施用于制品并允许溶剂蒸发,可以在制品的表面上形成抗微生物涂层。 还可以通过制备约5至约12重量%的抗微生物制剂和约88至约95重量%的液体或固体有机硅树脂的混合物并从混合的混合物中模制,包覆成型或挤出制品而形成。