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71. 发明申请

US20150305339A1 FUNGICIDAL PYRAZOLES AND THEIR MIXTURES 有权
标题翻译：杀真菌剂及其混合物
公开(公告)号：US20150305339A1
公开(公告)日：2015-10-29
申请号：US14791563
申请日：2015-07-06
申请人： E I DU PONT DE NEMOURS AND COMPANY
发明人： JEFFREY KEITH LONG , Vann Gregory , Steven Gutteridge , Andrew Edmund Taggi , James Francis Bereznak
IPC分类号： A01N43/56 , C07D231/20 , A01N43/42 , A01N43/80 , A01N47/08 , A01N43/50 , A01N43/40 , A01N59/20 , A01N47/28 , A01N43/54 , A01N37/34 , A01N43/90 , A01N43/84 , A01N43/30 , A01N47/12 , A01N37/44 , A01N43/12 , A01N43/26 , A01N43/653 , C07D231/38
CPC分类号： A01N43/56 , A01N37/34 , A01N37/44 , A01N43/12 , A01N43/26 , A01N43/30 , A01N43/40 , A01N43/42 , A01N43/48 , A01N43/50 , A01N43/54 , A01N43/653 , A01N43/78 , A01N43/80 , A01N43/84 , A01N43/90 , A01N47/08 , A01N47/12 , A01N47/28 , A01N59/20 , C07D231/20 , C07D231/38 , A01N37/38 , A01N37/46 , A01N43/36 , A01N45/02 , A01N47/04 , A01N47/14 , A01N47/24 , A01N47/34 , A01N47/38
摘要： Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula 1, N-oxides, and salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined in the disclosure; and (b) at least one additional fungicidal compound. Also disclosed is a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of a compound of Formula 1, an N-oxide, or salt thereof (e.g., as a component in the aforesaid composition). Also disclosed is a composition comprising: (a) at least one compound selected from the compounds of Formula 1 described above, N-oxides, and salts thereof; and at least one invertebrate pest control compound or agent.
摘要翻译：公开了一种杀真菌组合物，其包含（a）至少一种选自式1化合物，N-氧化物及其盐的化合物，其中R 1，R 2，R 3，R 4，R 5和R 6如本公开所定义; 和（b）至少一种另外的杀真菌化合物。还公开了一种用于控制由真菌植物病原体引起的植物病害的方法，包括向植物或其部分或植物种子施用杀真菌有效量的式1，N-氧化物或其盐的化合物（例如，作为上述组合物中的组分）。还公开了一种组合物，其包含：（a）至少一种选自上述式1的化合物，N-氧化物及其盐的化合物; 和至少一种无脊椎害虫防治化合物或药剂。

72. 发明授权

US09040082B2 Compositions and methods for treatment of chronic fatigue 有权
标题翻译：用于治疗慢性疲劳的组合物和方法
公开(公告)号：US09040082B2
公开(公告)日：2015-05-26
申请号：US13530673
申请日：2012-06-22
申请人： Jon D. Kaiser
发明人： Jon D. Kaiser
IPC分类号： A61K9/48 , A01N43/90 , A61K31/522 , A01N43/40 , A61K31/445 , A61K31/44 , A01N43/26 , A61K31/385 , A01N43/04 , A61K31/70 , A61K45/06 , A61K31/4415 , A61K31/4458 , A61K31/714
CPC分类号： A61K31/385 , A61K31/137 , A61K31/138 , A61K31/145 , A61K31/165 , A61K31/185 , A61K31/198 , A61K31/205 , A61K31/4415 , A61K31/4458 , A61K31/522 , A61K31/714 , A61K45/06 , A61K2300/00
摘要： Pharmaceutical compositions and methods for the treatment of chronic fatigue in human patients comprising a central nervous system (CNS) stimulant in a daily low-dosage amount in combination with therapeutically effective daily amounts of micronutrients, comprising acetyl L-carnitine, L-tyrosine, N-acetyl cysteine, and alpha-lipoic acid. The CNS and micronutrient components may be in an oral dosage composition containing a low dosage amount of CNS stimulant such as about 2.5 mg methylphenidate HCl together with about 60-250 mg acetyl L-carnitine, 50-200 mg L-tyrosine, 60-250 mg N-acetyl cysteine, and 25-100 mg alpha-lipoic acid.
摘要翻译：用于治疗人类患者慢性疲劳的药物组合物和方法，其包括每日低剂量量的中枢神经系统（CNS）兴奋剂与治疗有效的每日量的微量营养素组合，包括乙酰基左旋肉碱，L-酪氨酸，N 乙酰半胱氨酸和α-硫辛酸。 CNS和微量营养素组分可以是含有低剂量CNS兴奋剂的口服剂量组合物，例如约2.5mg哌甲酯盐酸盐以及约60-250mg乙酰左旋肉碱，50-200mg L-酪氨酸，60-250 mg N-乙酰半胱氨酸和25-100mgα-硫辛酸。

73. 发明授权

US08765806B2 Biocidal composition of 2,6-dimethyl-M-dioxane-4-OL acetate and methods of use 有权
标题翻译： 2,6-二甲基-M-二恶烷-4-OL乙酸酯的杀生物组合物及其使用方法
公开(公告)号：US08765806B2
公开(公告)日：2014-07-01
申请号：US12619715
申请日：2009-11-17
申请人： Ioana Annis , Jon B. Raymond , Emerentiana Sianawati
发明人： Ioana Annis , Jon B. Raymond , Emerentiana Sianawati
IPC分类号： A01N43/26 , A01N43/80 , A01N25/00
CPC分类号： A01N43/80 , A01N43/32 , A01N2300/00
摘要： Provided is a biocidal composition comprising 2,6-dimethyl-m-dioxane-4-ol acetate and an isothiazolinone biocidal compound. The composition is useful for controlling microorganisms in aqueous or water containing systems.
摘要翻译：提供了包含2,6-二甲基 - 间二氧杂环己烷-4-醇乙酸酯和异噻唑啉酮杀生物化合物的杀生物组合物。该组合物可用于控制含水或含水体系中的微生物。

74. 发明授权

US08722729B2 Unsaturated fatty acid monoesters and diesters on ascorbic acid and cosmetic uses thereof 失效
标题翻译：抗坏血酸的不饱和脂肪酸单酯和二酯及其化妆品用途
公开(公告)号：US08722729B2
公开(公告)日：2014-05-13
申请号：US13376752
申请日：2010-06-08
申请人： Stéphane Poigny , Sylvie Daunes-Marion , Nathalie Castex Rizzi , Patrick Bogdanowicz
发明人： Stéphane Poigny , Sylvie Daunes-Marion , Nathalie Castex Rizzi , Patrick Bogdanowicz
IPC分类号： A01N43/26 , C07D307/62
CPC分类号： C07D407/04
摘要： The present invention relates to a compound with the following general formula (I): in which: R1 is a hydrocarbon chain of an unsaturated fatty acid from C12 to C24 including at least one unsaturation; and R2 and R3 are, independently or simultaneously: a hydrogen or a C1-C3 alkyl or a phenyl; and R4: a hydrogen atom or COR1′, where R1′ is a hydrocarbon chain of an unsaturated fatty acid from C12 to C24 including at least one unsaturation, advantageously 1 to 6 and preferably 1 to 4.
摘要翻译：本发明涉及具有以下通式（I）的化合物：其中：R1是包含至少一个不饱和键的C12-C24不饱和脂肪酸的烃链; 和R 2和R 3独立地或同时地是氢或C 1 -C 3烷基或苯基; 和R 4：氢原子或COR 1'，其中R 1'是C 12至C 24不饱和脂肪酸的烃链，其包含至少一个不饱和键，有利地为1至6个，优选1至4个。

75. 发明授权

US08691867B2 Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction 失效
标题翻译：苯并稠合杂环磺酰胺衍生物用于治疗药物滥用和成瘾
公开(公告)号：US08691867B2
公开(公告)日：2014-04-08
申请号：US11612202
申请日：2006-12-18
申请人： Virginia L. Smith-Swintosky , Allen B. Reitz
发明人： Virginia L. Smith-Swintosky , Allen B. Reitz
IPC分类号： A01N43/32 , A61K31/335 , A01N43/26 , A01N43/02 , C07D323/00 , C07D319/12 , C07D317/00 , C07D307/00
CPC分类号： A61K31/353 , A23V2002/00 , A61K31/357 , A23V2200/334
摘要： The present invention is a method for the treatment of alcohol abuse and/or addiction comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and/or formula (II) as herein defined.
摘要翻译：本发明是用于治疗酒精滥用和/或成瘾的方法，包括向有需要的受试者施用治疗有效量的一种或多种式（I）和/或式（II）的新型苯并稠合的杂环磺酰胺衍生物）。

76. 发明授权

US08592466B2 Methods for treating conditions caused by higher-than-normal dopaminergic activity in basal ganglia 有权
标题翻译：治疗由基底神经节高于正常多巴胺能活性引起的病症的方法
公开(公告)号：US08592466B2
公开(公告)日：2013-11-26
申请号：US13552182
申请日：2012-07-18
申请人： Ahmed Elkashef
发明人： Ahmed Elkashef
IPC分类号： A01N43/78 , A61K31/425 , A01N43/26 , A61K31/385 , A01N43/06 , A61K31/38 , A01N47/28 , A61K31/17
CPC分类号： A61K31/426
摘要： Treatment of humans suffering from conditions caused by higher-than-normal dopaminergic activity in basal ganglia includes administering the compound (2S)-2-{3-[3-({[(2R,4R)-4-tert-Butoxycarbonyl-2-(2-fluorophenyl)]-3-thiazolidinyl}carbonylmethyl)ureido]phenyl}propionic acid and its physiological acceptable salts.
摘要翻译：患有由基底神经节高于正常多巴胺能活性引起的病症的人的治疗包括给予化合物（2S）-2- {3- [3 - （{[（2R，4R）-4-叔丁氧基羰基-2 - （2-氟苯基）] - 3-噻唑烷基}羰基甲基）脲基]苯基}丙酸及其生理学上可接受的盐。

77. 发明授权

US08536222B2 Addition compounds of guanidinoacetic acid 有权
标题翻译：胍基乙酸的添加化合物
公开(公告)号：US08536222B2
公开(公告)日：2013-09-17
申请号：US13425893
申请日：2012-03-21
申请人： Thomas Gastner , Hans-Peter Krimmer
发明人： Thomas Gastner , Hans-Peter Krimmer
IPC分类号： A01N43/30 , A01N43/26 , A01N43/16
CPC分类号： C07C65/10 , A23K20/10 , A23K20/147 , A23K20/174 , A23K20/24 , A23K50/20 , A23K50/30 , A23K50/40 , A23K50/75 , A23L33/10 , A23L33/15 , A23L33/16 , A23L33/175 , C07C53/06 , C07C53/10 , C07C55/10 , C07C57/145 , C07C57/15 , C07C59/08 , C07C59/105 , C07C59/19 , C07C59/245 , C07C59/265 , C07C229/10 , C07C229/22 , C07C229/24 , C07C279/14
摘要： The present invention provides new addition compounds of guanidinoacetic acid with malic acid, aspartic acid, ascorbic acid, succinic acid, pyruvic acid, fumaric acid, gluconic acid, alpha-ketoglutaric acid, pyroglutamic acid, 3-nicotinic acid, lactic acid, citric acid, maleic acid, acetic acid, formic acid, 2-hydroxybenzoic acid, L-carnitine, acetyl-L-carnitine, taurine, betaine, choline, methionine and lipoic acid as well as in the form of sodium, potassium or calcium guanidinoacetate. These addition compounds have improved physiological and therapeutic properties and are particularly suitable for use as dietary supplements, as animal feeds and in cosmetic or dermatological preparations in which especially the marked stability and good bioavailability of the addition compounds come to the fore.
摘要翻译：本发明提供胍基乙酸与苹果酸，天冬氨酸，抗坏血酸，琥珀酸，丙酮酸，富马酸，葡萄糖酸，α-酮戊二酸，焦谷氨酸，3-烟酸，乳酸，柠檬酸的新的加成化合物，马来酸，乙酸，甲酸，2-羟基苯甲酸，L-肉毒碱，乙酰基-L-肉碱，牛磺酸，甜菜碱，胆碱，甲硫氨酸和硫辛酸，以及胍，乙酸胍或钙胍。这些加成化合物具有改善的生理和治疗性质，并且特别适合用作作为动物饲料的膳食补充剂和在化妆品或皮肤病学制剂中，特别是添加化合物的显着稳定性和良好的生物利用度出现。

78. 发明申请

US20120316066A1 Chiral Diacylhydrazine Ligands for Modulating the Expression of Exogenous Genes via an Ecdysone Receptor Complex 有权
标题翻译：用于通过蜕皮激素受体复合物调节外源基因表达的手性二酰肼配体
公开(公告)号：US20120316066A1
公开(公告)日：2012-12-13
申请号：US13309918
申请日：2011-12-02
申请人： Robert Eugene HORMANN , Bing Li
发明人： Robert Eugene HORMANN , Bing Li
IPC分类号： A61K31/166 , C07D317/68 , C07D319/18 , C07D333/38 , C07D213/56 , C07D307/68 , C12N5/00 , C12N15/87 , C12P21/00 , A61K31/357 , A61K31/381 , A61K31/341 , A61K31/44 , A61P35/00 , A01N37/18 , A01N43/26 , A01N43/32 , A01N43/10 , A01N43/08 , A01N43/40 , A01P13/00 , A01P21/00 , C07C241/02
CPC分类号： C07D333/38 , A01N37/18 , A01N43/08 , A01N43/10 , A01N43/30 , A01N43/32 , A01N43/40 , A61K48/00 , C07B2200/07 , C07C241/04 , C07C243/38 , C07C269/06 , C07C271/08 , C07C281/02 , C07C2601/14 , C07D213/82 , C07D217/24 , C07D307/68 , C07D317/68 , C07D319/18 , C12N15/8217 , C12N15/8238
摘要： The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful for applications such as gene therapy, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable. An advantage of the present invention is that it provides a means to regulate gene expression and to tailor expression levels to suit the user's requirements.
摘要翻译：本发明提供了与基于蜕皮激素受体的诱导型基因表达系统一起使用的二酰肼配体和手性二酰基肼配体。因此，本发明可用于基因治疗，大规模生产蛋白质和抗体，基于细胞的筛选测定，功能基因组学，蛋白质组学，代谢组学和转基因生物体中性状的调控，其中基因表达水平的控制是合意。本发明的优点在于它提供了调节基因表达和调整表达水平以适应用户要求的手段。

79. 发明授权

US08232276B2 Anhydrous topical skin preparations 有权
标题翻译：无水局部皮肤制剂
公开(公告)号：US08232276B2
公开(公告)日：2012-07-31
申请号：US10722134
申请日：2003-11-26
申请人： Katherine M. Burnett , Ellen S. Kurtz
发明人： Katherine M. Burnett , Ellen S. Kurtz
IPC分类号： A01N43/58 , A01N43/60 , A01N43/52 , A01N43/26 , A01N25/34 , A61K31/50 , A61K31/495 , A61K31/415 , A61K31/335
CPC分类号： A61K9/0014 , A61K47/10 , A61K47/32 , A61K47/38 , Y10S514/944
摘要： The present invention provides anhydrous compositions for topical delivery of a medicament comprising (A) a penetration enhancer/solvent selected from the group consisting of alcohol, propylene glycol, or a combination thereof; (B) a humectant/solvent selected from the group consisting of polyethylene glycol, glycerin, sorbitol, xylitol, or any combination of any of the foregoing; and (C) an anhydrous vehicle. In an alternate embodiment, the present invention provides anhydrous compositions for topical delivery of a medicament which comprise (A) a penetration enhancer/solvent selected from the group consisting of alcohol, propylene glycol, or a combination thereof; (B) a humectant/solvent selected from the group consisting of polyethylene glycol, glycerin, sorbitol, xylitol or any combination of any of the foregoing; (C) an anhydrous vehicle; and (D) a medicament. Also provided are methods for topically delivering a medicament to an animal, such as a mammal or a human patient, in need of the medicament by topically administering to the animal the compositions of the present invention.
摘要翻译：本发明提供了用于局部递送药物的无水组合物，其包含（A）渗透促进剂/选自醇，丙二醇或其组合的溶剂; （B）选自聚乙二醇，甘油，山梨糖醇，木糖醇或任何上述任何组合的保湿剂/溶剂; 和（C）无水载体。在一个替代实施方案中，本发明提供用于局部递送药物的无水组合物，其包含（A）渗透促进剂/选自醇，丙二醇或其组合的溶剂; （B）选自聚乙二醇，甘油，山梨糖醇，木糖醇或任何上述任何组合的湿润剂/溶剂; （C）无水车辆; 和（D）药物。还提供了通过向动物局部施用本发明的组合物来将药物局部递送给需要该药物的动物例如哺乳动物或人类患者的方法。

80. 发明授权

US08153685B2 Salts, addition compounds and complex compounds of guinadinoacetic acid 有权
标题翻译：盐，加成化合物和瓜氨酰乙酸的络合物
公开(公告)号：US08153685B2
公开(公告)日：2012-04-10
申请号：US11885375
申请日：2006-03-02
申请人： Thomas Gastner , Hans-Peter Krimmer
发明人： Thomas Gastner , Hans-Peter Krimmer
IPC分类号： A01N43/30 , A01N43/26 , A01N43/16
CPC分类号： A61Q19/08 , A23L33/10 , A61K8/43 , A61K8/44 , A61K31/19 , A61K31/205 , A61Q19/00 , A61Q19/005
摘要： The present invention provides new salts and/or addition compounds and/or complex compounds of guanidinoacetic acid with malic acid, aspartic acid, ascorbic acid, succinic acid, pyruvic acid, fumaric acid, gluconic acid, α-ketoglutaric acid, oxalic acid, pyroglutamic acid, 3-nicotinic acid, lactic acid, citric acid, maleic acid, sulfuric acid, acetic acid, formic acid, 2-hydroxybenzoic acid, L-carnitine, acetyl-L-carnitine, taurine, betaine, choline, methionine and lipoic acid as well as in the form of sodium, potassium or calcium guanidinoacetate. These salts have improved physiological and therapeutic properties and are particularly suitable for use as dietary supplements, as animal feeds and in cosmetic or dermatological preparations in which especially the marked stability and good bioavailability of the salts come to the fore.
摘要翻译：本发明提供新的盐和/或加成化合物和/或胍基乙酸与苹果酸，天冬氨酸，抗坏血酸，琥珀酸，丙酮酸，富马酸，葡糖酸，α-酮戊二酸，草酸，焦谷氨酸酸，3-烟酸，乳酸，柠檬酸，马来酸，硫酸，乙酸，甲酸，2-羟基苯甲酸，L-肉毒碱，乙酰基-L-肉碱，牛磺酸，甜菜碱，胆碱，甲硫氨酸和硫辛酸以及胍盐酸钠，钾或钙的形式。这些盐具有改善的生理和治疗性质，并且特别适合用作作为动物饲料的膳食补充剂和在化妆品或皮肤病学制剂中，其中特别是盐的显着稳定性和良好的生物利用度出现。

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