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    • 75. 发明申请
    • Methods and Compositions for Promoting Glucose Homeostasis
    • 促进葡萄糖稳态的方法和组合
    • US20140363416A1
    • 2014-12-11
    • US14342432
    • 2012-08-30
    • Umut OzcanJaemin Lee
    • Umut OzcanJaemin Lee
    • A61K38/45G01N33/573
    • A61K38/45A61K31/66C12Y207/12002G01N33/502G01N33/573G01N2333/4703G01N2440/14G01N2800/042
    • A method of reducing blood glucose in a subject has been developed. In preferred embodiments, the method involves administering to the subject a specific activator of endogenous mitogen-activated protein kinase kinase 6 (MKK3), mitogen-activated protein kinase kinase 6 (MKK4), mitogen-activated protein kinase kinase 6 (MKK6), p38 mitogen-activated protein kinase (p38MAPK), mitogen-activated kinase-activated protein kinase 2 (MK2), or a combination thereof, in an effective amount to reduce blood glucose in a subject. In other embodiments, the method involves administering to the subject a specific activator to increase X-box binding protein 1 (XBP1) phosphorylation on Thr48 and Ser61 in an effective amount to reduce blood glucose in the subject. Methods of identifying agents for reducing blood glucose in a subject are also provided.
    • 已经开发了降低受试者血糖的方法。 在优选的实施方案中,该方法包括向受试者施用内源丝裂原活化蛋白激酶6(MKK3),丝裂原活化蛋白激酶6(MKK4),丝裂原活化蛋白激酶6(MKK6),p38 丝裂原活化蛋白激酶(p38MAPK),丝裂原活化激酶激活蛋白激酶2(MK2)或其组合,以有效量降低受试者的血糖。 在其他实施方案中,该方法涉及向受试者施用特异性活化剂以有效量增加Thr48和Ser61上的X盒结合蛋白1(XBP1)磷酸化以降低受试者的血糖。 还提供了鉴定用于降低受试者血糖的药剂的方法。