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    • 71. 发明授权
    • Preparation and maintenance of sensors
    • 传感器的准备和维护
    • US08834703B2
    • 2014-09-16
    • US13430492
    • 2012-03-26
    • Michael HigginsMark KonnoTodd Fjield
    • Michael HigginsMark KonnoTodd Fjield
    • G01F1/64C12Q1/00G01N27/26G01N33/50G01N33/487G01N27/327A61B5/1486A61B5/145A61B5/1495
    • G01N27/416A61B5/14532A61B5/1486A61B5/1495A61B2562/242G01N27/327G01N33/4875
    • Apparatus and methods are described for preparing, maintaining, and stabilizing sensors. The apparatus and methods for preparing sensors for use are utilized in advance of the sensor being removed from a sealed, sterilized package. The apparatus include packaging materials having electrical circuits capable of stabilizing a sensor to prepare the sensor for use. The methods for preparing a sensor for use includes methods of providing a solution to a sterilized packaging that contains a sensor connected to a sensor activating circuit, activating the circuit, and allowing the sensor to stabilize. These methods can be performed without compromising the packaging. The apparatus for stabilizing a sensor that is in use include a circuit connectable to the sensor that provides a signal to the sensor that prevents the sensor from becoming destabilized when disconnected from a monitoring device.
    • 描述了用于制备,维护和稳定传感器的装置和方法。 在将传感器从密封的无菌包装中取出之前,使用用于制备用于制备传感器的装置和方法。 该装置包括具有能够稳定传感器以制备传感器以供使用的电路的封装材料。 制备用于使用的传感器的方法包括向包括连接到传感器启动电路的传感器,激活电路并允许传感器稳定的灭菌包装提供解决方案。 这些方法可以在不损害包装的情况下进行。 用于稳定正在使用的传感器的装置包括可连接到传感器的电路,该传感器向传感器提供信号,以防止当与监视装置断开时传感器变得不稳定。
    • 74. 发明授权
    • Method for determining analyte concentration based on complex index functions
    • 基于复杂指数函数确定分析物浓度的方法
    • US08744776B2
    • 2014-06-03
    • US13153793
    • 2011-06-06
    • Huan-Ping WuSung-Kwon Jung
    • Huan-Ping WuSung-Kwon Jung
    • G01N33/48
    • G01N27/3273G01N27/3274G01N27/416
    • A biosensor system determines analyte concentration from an output signal generated from a light-identifiable species or a redox reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals or determined analyte concentrations with one or more complex index function extracted from the output signals or from other sources. The complex index functions determine at least one slope deviation value, ΔS, or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias.
    • 生物传感器系统从分析物的光可识别物质或氧化还原反应产生的输出信号中确定分析物浓度。 生物传感器系统通过从输出信号或其他来源提取的一个或多个复杂索引函数调整用于从输出信号或确定的分析物浓度确定分析物浓度的相关性。 复杂索引函数确定至少一个斜率偏差值,&Dgr; S或从一个或多个误差参数归一化的斜率偏差。 可以使用分析物浓度和输出信号之间的斜率调整的相关性来确定包括归因于偏压的成分的输出信号具有改进的精度和/或精度的分析物浓度。
    • 75. 发明申请
    • SYSTEMS AND METHODS FOR MULTIPLE ANALYTE ANALYSIS
    • 多分析分析的系统与方法
    • US20140124384A1
    • 2014-05-08
    • US13667154
    • 2012-11-02
    • ROCHE DIAGNOSTICS OPERATIONS, INC.
    • Martin T. GerberEric R. Diebold
    • G01N27/26
    • G01N27/307A61B5/0002A61B5/14532A61B5/1486A61B2562/0295C12Q1/54G01N27/327G01N27/3272G01N27/3273G01N27/416G01N33/492G01N33/66
    • Systems and methods for multiple analyte analysis are provided. In one embodiment, a method includes determining concentrations of first and second analytes in a sample. The first and second analytes may be, for example, glucose and hydroxybutyrate. In this form, an indication related to the measured concentration of hydroxybutyrate is provided in response to determining that the concentration of hydroxybutyrate is above a predetermined value. In a further aspect of this form, a quantitative indication representative of the measured glucose concentration is automatically provided regardless of the value of the measured glucose concentration. In another embodiment, a system includes a meter configured to interact with a test element to assess first and second analytes in a sample. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description and drawings.
    • 提供了多个分析物分析的系统和方法。 在一个实施方案中,一种方法包括确定样品中第一和第二分析物的浓度。 第一和第二分析物可以是例如葡萄糖和羟基丁酸酯。 在这种形式中,响应于确定羟基丁酸酯的浓度高于预定值而提供与所测量的羟基丁酸酯浓度相关的指示。 在该形式的另一方面,自动提供代表测量的葡萄糖浓度的定量指示,而与所测量的葡萄糖浓度的值无关。 在另一个实施方案中,系统包括配置成与测试元件相互作用以评估样品中的第一和第二分析物的仪表。 进一步的实施例,形式,对象,特征,优点,方面和优点将从描述和附图中变得显而易见。
    • 76. 发明申请
    • SYSTEMS, DEVICES AND METHODS FOR IMPROVING ACCURACY OF BIOSENSORS USING FILL TIME
    • 用于提高使用时间的生物传感器精度的系统,设备和方法
    • US20140097097A1
    • 2014-04-10
    • US14090693
    • 2013-11-26
    • LifeScan, Inc.
    • Ronald C. ChatelierAlastair M. Hodges
    • G01N27/416
    • G01N27/416C12Q1/006G01N27/3273
    • Methods for determining a concentration of an analyte in a sample, and the devices and systems used in conjunction with the same, are provided herein. In one exemplary embodiment of a method for determining a concentration of an analyte in a sample, the method includes detecting a presence of a sample in an electrochemical sensor including two electrodes. A fill time of the sample is determined with the two electrodes and a correction factor is calculated in view of at least the fill time. The method also includes reacting an analyte that causes a physical transformation of the analyte between the two electrodes. A concentration of the analyte can then be determined in view of the correction factor with the same two electrodes. Systems and devices that take advantage of the fill time to make analyte concentration determinations are also provided.
    • 本文提供了用于确定样品中分析物浓度的方法以及与其一起使用的装置和系统。 在用于确定样品中分析物浓度的方法的一个示例性实施方案中,该方法包括检测包含两个电极的电化学传感器中样品的存在。 用两个电极确定样品的填充时间,并根据至少填充时间计算校正因子。 该方法还包括使分析物在两个电极之间导致分析物的物理转化的反应。 考虑到相同的两个电极的校正因子,可以确定分析物的浓度。 还提供了利用填充时间进行分析物浓度测定的系统和设备。