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1. 发明申请

US20120251399A1 CONVERSION OF NITROGEN DIOXIDE (NO2) TO NITRIC OXIDE (NO) 有权
公开(公告)号：US20120251399A1
公开(公告)日：2012-10-04
申请号：US13436018
申请日：2012-03-30
申请人： David H. Fine , David P. Rounbehler , Gregory Vasquez , Bryan Johnson
发明人： David H. Fine , David P. Rounbehler , Gregory Vasquez , Bryan Johnson
IPC分类号： B01J7/00
CPC分类号： B01J12/007 , A61K33/00 , A61M16/10 , A61M16/122 , A61M2016/1025 , A61M2202/0007 , A61M2202/0078 , A61M2202/0275 , A61M2205/07 , A61M2205/12 , A62B7/08 , C01B21/24
摘要： A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

2. 发明授权

US08187544B2 Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) 有权
标题翻译：二氧化氮（NO2）转化为一氧化氮（NO）
公开(公告)号：US08187544B2
公开(公告)日：2012-05-29
申请号：US13072466
申请日：2011-03-25
申请人： David Fine , Gregory Vasquez , David P. Rounbehler
发明人： David Fine , Gregory Vasquez , David P. Rounbehler
IPC分类号： A62B7/08
CPC分类号： C01B21/32 , A61D7/04 , A61K33/00 , A61M16/0051 , A61M16/0057 , A61M16/009 , A61M16/104 , A61M16/1055 , A61M16/107 , A61M16/1075 , A61M16/12 , A61M16/16 , A61M2016/102 , A61M2202/0275 , C01B21/24 , G01N27/416 , Y10T436/179228
摘要： Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.
摘要翻译：本文公开了各种系统，装置，NO 2吸收剂，NO 2清除剂和用于产生一氧化氮的NO 2还原剂。根据一个实施方案，用于将二氧化氮转化成一氧化氮的装置可以包括容器，其包括入口，出口，涂覆有抗坏血酸水溶液的表面活性材料和吸收剂，其中所述入口构造成接收气体通过表面活性材料和吸收剂流动并流动地将气流传递到出口，使得气流中的二氧化氮转化为一氧化氮。

3. 发明授权

US5472882A Method and system for sampling and determining the presence of salts of ammonia and amines in containers 失效
标题翻译：用于取样和确定容器中氨和胺盐的存在的方法和系统
公开(公告)号：US5472882A
公开(公告)日：1995-12-05
申请号：US320407
申请日：1994-10-03
申请人： David P. Rounbehler , Eugene K. Achter , David H. Fine , Freeman W. Fraim , Stephen J. MacDonald , Helmut W. Klotzsch
发明人： David P. Rounbehler , Eugene K. Achter , David H. Fine , Freeman W. Fraim , Stephen J. MacDonald , Helmut W. Klotzsch
IPC分类号： G01N21/76 , G01N21/90 , G01N33/00 , G01N35/00 , G01N35/04 , G01N35/10 , G01N35/02
CPC分类号： G01N21/9018 , G01N21/76 , G01N21/766 , G01N35/00 , G01N2033/0081 , G01N2035/0484 , G01N35/10 , Y10T436/113332 , Y10T436/17 , Y10T436/173845
摘要： Disclosed is an improved method and system for injecting liquid into containers and for inspecting containers for the presence of certain substances such as potential contaminants such as ammonium salts or amine salts in glass or plastic bottles. A high speed system and method are provided for detecting these contaminants in these bottles. Ammonia and amines can be detected by chemiluminescence of samples of volatiles emitted from the bottles during the high speed inspection process. A solution of Na.sub.2 CO.sub.3 is injected into the bottles in order to enhance the conversion of ammonium or amine salts to free ammonia or amines which are then released as vapors. This enhances the likelihood that a gas-phase detection system such as one using chemiluminescence detection techniques will detect the presence of contaminants containing ammonium salts or amine salts.
摘要翻译：公开了一种改进的方法和系统，用于将液体注入容器中并用于检查容器中是否存在某些物质，例如玻璃或塑料瓶中的诸如铵盐或胺盐的潜在污染物。提供了一种用于检测这些瓶子中这些污染物的高速系统和方法。氨和胺可以通过在高速检查过程中从瓶子发出的挥发物样品的化学发光来检测。将Na 2 CO 3溶液注入瓶中以增强铵盐或胺盐向游离氨或胺的转化，然后将其释放为蒸气。这增强了诸如使用化学发光检测技术的气相检测系统将检测到含有铵盐或胺盐的污染物的存在的可能性。

4. 发明授权

US5470754A Method and system for sampling and determining the presence of compounds 失效
标题翻译：用于取样和确定化合物存在的方法和系统
公开(公告)号：US5470754A
公开(公告)日：1995-11-28
申请号：US20804
申请日：1993-02-22
申请人： David P. Rounbehler , David H. Fine , Eugene K. Achter , Stephen J. MacDonald , Daniel B. Dennison
发明人： David P. Rounbehler , David H. Fine , Eugene K. Achter , Stephen J. MacDonald , Daniel B. Dennison
IPC分类号： B07C5/34 , B08B9/46 , B29B17/00 , B29B17/02 , G01N1/00 , G01N1/22 , G01N1/24 , G01N21/64 , G01N21/76 , G01N21/90 , G01N33/00 , G01N33/44
CPC分类号： B07C5/34 , B07C5/3408 , B08B9/46 , B29B17/00 , B29B17/02 , G01N1/2226 , G01N21/64 , G01N21/766 , G01N21/9018 , B08B2203/005 , B29B2017/0275 , G01N1/2202 , G01N1/24 , G01N2001/2223 , G01N2001/2229 , G01N2033/0081 , G01N21/76 , Y02W30/62 , Y02W30/622 , Y10T436/113332 , Y10T436/17 , Y10T436/206664 , Y10T436/21
摘要： A system and method are provided for minimizing the effects of background signals in masking signals indicating the presence of substances to be detected such as contaminants in materials moving rapidly along a conveyor. The contaminants detected may include nitrogen containing compounds and hydrocarbons. The system and method of the present invention minimize during detection of the presence or absence of such substances, the number of falsely positive indications of the presence of such substances due to background signals and changes in background signals. The substances detected are divided into first and second sample portions and the respective portions are heated. The first heated portion is mixed with ozone to cause a chemical reaction therewith in order to generate radiation by chemiluminescence having characteristic wavelengths related to substances in the first portion. The second portion heated is also mixed with ozone to cause a chemical reaction therewith in order to generate radiation by chemiluminescence having characteristic wavelengths related to substances in the second portion. The radiation of the respective first and second portions is selectively detected. The heating and detecting steps are performed in a manner so as to yield a higher level of detected radiation from one of the portions of the sample then the other for at least some of the selected compounds being detected. Electrical signals from the respective first and second portions are generated and compared in order to determine the presence or absence of selected compounds in the sample. Appropriate reject signals for a bottle sorting system are generated accordingly.
摘要翻译：提供了一种系统和方法，用于最小化背景信号在屏蔽指示待检测物质的存在的信号中的影响，例如沿着传送器快速移动的材料中的污染物。检测到的污染物可能包括含氮化合物和碳氢化合物。本发明的系统和方法在检测到这种物质的存在或不存在期间最小化了由于背景信号和背景信号的变化而导致的这种物质的存在的错误的阳性迹象的数量。所检测的物质被分成第一和第二样品部分，并且各个部分被加热。将第一加热部分与臭氧混合以引起与其的化学反应，以通过具有与第一部分中的物质相关的特征波长的化学发光来产生辐射。加热的第二部分也与臭氧混合以引起与其的化学反应，以通过具有与第二部分中的物质相关的特征波长的化学发光产生辐射。选择性地检测相应的第一和第二部分的辐射。加热和检测步骤以这样的方式进行，以便从样品的一个部分产生更高水平的检测到的辐射，然后对于检测到的至少一些所选化合物产生另一个。产生并比较来自相应的第一和第二部分的电信号，以确定样品中选定化合物的存在或不存在。相应地生成用于瓶分选系统的适当拒绝信号。

5. 发明授权

US5300758A Vapor detection with high speed gas chromatography 失效
标题翻译：用高速气相色谱法进行气相检测
公开(公告)号：US5300758A
公开(公告)日：1994-04-05
申请号：US825368
申请日：1992-01-24
申请人： David P. Rounbehler , David P. Lieb , Eugene K. Achter , David B. Gernes , Abdul Tafreshi
发明人： David P. Rounbehler , David P. Lieb , Eugene K. Achter , David B. Gernes , Abdul Tafreshi
IPC分类号： G01N1/22 , G01N21/76 , G01N30/46 , G01N30/62 , G01N30/74 , G01N30/84 , H05B1/02
CPC分类号： G01N30/62 , G01N30/84 , G01N2030/623 , G01N2030/8405 , G01N21/76 , G01N30/461 , G01N30/74
摘要： Disclosed are a method and apparatus for high speed, selective detection of vapors of specific compounds, particularly nitrogen-containing compounds, utilizing a bypass branch and high speed gas chromatography for improved selectivity and sensitivity of detection. A system with two gas chromatographs (GC's) alternating in series with two pyrolyzers provides two time intervals of detection in a downstream detector, with the second time interval containing signals delayed and further separated relative to signals from the first time interval. The bypass branch, in diverting a portion of the flow of gas samples from passage through the second gas chromatograph and second pyrolyzer, avoids interferences in the first time interval of detection from non-GC-retained compounds decomposed in the second pyrolyzer. Also disclosed is an arrangement for rapid, precise heating of vapor concentrator tubes in which vapors are rapidly focussed and then injected into a GC, and for rapid, precise heating of the GC's.
摘要翻译：公开了一种利用旁路分支和高速气相色谱法对特定化合物，特别是含氮化合物的蒸气进行高速，选择性检测的方法和装置，以提高检测的选择性和灵敏度。具有与两个热解器串联交替的两个气相色谱仪（GC）的系统在下游检测器中提供两个检测时间间隔，其中第二时间间隔包含相对于来自第一时间间隔的信号延迟和进一步分离的信号。旁路分支在将一部分气体样品从通过第二气相色谱仪和第二热解器的过程中转移时，避免了在第二次热解器中分解的非GC保留化合物的第一时间间隔内的干扰。还公开了一种用于快速精确加热蒸汽浓缩管的装置，其中蒸气快速聚焦，然后注入GC，并快速，精确地加热GC。

6. 发明授权

US5092219A Selective decomposition of nitrite esters and nitramines 失效
标题翻译：亚硝酸酯和硝胺的选择性分解
公开(公告)号：US5092219A
公开(公告)日：1992-03-03
申请号：US81967
申请日：1987-07-08
申请人： David P. Rounbehler , David H. Fine
发明人： David P. Rounbehler , David H. Fine
IPC分类号： G01N1/00 , G01N1/02 , G01N1/22 , G01N1/28 , G01N1/40 , G01N21/76 , G01N27/417 , G01N30/02 , G01N30/06 , G01N30/08 , G01N30/12 , G01N30/14 , G01N30/16 , G01N30/30 , G01N30/40 , G01N30/46 , G01N30/62 , G01N30/64 , G01N30/72 , G01N30/84 , G01N31/12 , G01N33/00 , G01N33/22 , G01V9/00
CPC分类号： G01N30/461 , G01N1/02 , G01N30/08 , G01N30/12 , G01N30/84 , G01N33/0057 , G01V9/007 , G01N1/2214 , G01N1/2226 , G01N1/28 , G01N1/40 , G01N2001/022 , G01N2001/028 , G01N2030/025 , G01N2030/065 , G01N2030/085 , G01N2030/121 , G01N2030/122 , G01N2030/123 , G01N2030/125 , G01N2030/126 , G01N2030/143 , G01N2030/167 , G01N2030/3007 , G01N2030/3046 , G01N2030/3053 , G01N2030/3061 , G01N2030/3069 , G01N2030/3076 , G01N2030/3084 , G01N2030/626 , G01N2030/642 , G01N2030/8405 , G01N21/76 , G01N30/14 , G01N30/40 , G01N30/62 , G01N30/72
摘要： A highly selective, sensitive, fast detection system and method are disclosed for detecting vapors of specific compounds in air. Vapors emanating from compounds such as explosives, or stripped from surfaces using heat and suction from a hand-held sample gun, are collected on surfaces coated with gas chromatograph (GC) material which trap explosives vapors but repel nitric oxide, then are desorbed and concentrated in one or more cold spot concentrators. A high speed gas chromatograph (GC) separates the vapors, after which specific vapors are decomposed in two pyrolyzers arranged in parallel and the resulting nitric oxide is detected. A low temperature pyrolyzer with silver produces NO from nitramines or nitrite esters; a high temperature pyrolyzer decomposes all explosives vapors to permit detetion of the remaining explosives. Also disclosed is a series arrangement of pyrolyzers and gas chromatographs and an NO detector to time-shift detection of certain vapors and facilitate very fast GC analyses. The use of hydrogen as a carrier gas, plus unique collectors and concentrators, high speed heaters, NO detectors, and very fast, temperature-programmable GC's enhance selectivity, sensitivity and speed of detection.
摘要翻译：公开了一种高选择性，灵敏，快速的检测系统和方法，用于检测空气中特定化合物的蒸气。从化合物如爆炸物或从手持式样品枪吸取热量从表面剥离的蒸气被收集在涂有气相色谱（GC）材料的表面上，该气相色谱（GC）材料捕获爆炸物蒸气但排斥一氧化氮，然后被解吸和浓缩在一个或多个冷点浓缩器中。高速气相色谱仪（GC）分离蒸汽，之后特定的蒸汽在平行排列的两个热解器中分解，并检测到所产生的一氧化氮。含有银的低温热解器由硝胺或亚硝酸酯产生NO; 高温热解器分解所有爆炸物蒸汽，以允许其他爆炸物的爆破。还公开了热解器和气相色谱仪的串联布置和用于某些蒸气的时移检测的NO检测器，并且促进非常快速的GC分析。使用氢气作为载气，加上独特的收集器和浓缩器，高速加热器，NO检测器和非常快速的温度可编程GC增强了选择性，灵敏度和检测速度。

7. 发明授权

US4775633A Detection of hydrazine compounds in gaseous samples by their conversion to nitric oxide-yielding derivatives 失效
标题翻译：通过将其转化为产生一氧化氮的衍生物，检测气态样品中的肼化合物
公开(公告)号：US4775633A
公开(公告)日：1988-10-04
申请号：US4237
申请日：1987-01-05
申请人： David P. Rounbehler
发明人： David P. Rounbehler
IPC分类号： G01N21/76 , G01N31/00 , G01N33/00 , G01N31/12
CPC分类号： G01N33/0047 , G01N21/766 , G01N31/00 , Y10T436/17 , Y10T436/173845 , Y10T436/200833
摘要： Disclosed is a method and apparatus for detecting hydrazine, monomethylhydrazine (MMH), and unsymmetrical dimethylhydrazine (UDMH) in a gaseous sample. The hydrazine compound detector includes a sample converter wherein vapors of an aldehyde such as acetaldehyde or a ketone such as acetone are mixed with a sample in gaseous form, and the mixture is allowed to react to form azine and hydrazone derivatives of the aldehyde or ketone. The derivatives may be transported long distances and then analyzed, as by heating in the presence of an oxidant in a pyrolyzer containing a nickel surface to produce nitric oxide (NO), followed by measurement of the NO in a NO detector such as a chemiluminescent analyzer.
摘要翻译：公开了一种在气态样品中检测肼，单甲基肼（MMH）和不对称二甲基肼（UDMH）的方法和装置。肼化合物检测器包括样品转化器，其中醛（例如乙醛或酮如丙酮）的蒸气与气体形式的样品混合，并使混合物反应形成醛或酮的吖嗪和腙衍生物。衍生物可以长距离运输，然后通过在含有镍表面的热解器中的氧化剂存在下加热来分析，以产生一氧化氮（NO），随后在NO检测器（例如化学发光分析仪）中测量NO 。

8. 发明授权

US4249904A Method and apparatus for extraction of airborne N-nitroso compounds without artifact formation 失效
标题翻译：用于提取无人造物形成的空气中N-亚硝基化合物的方法和装置
公开(公告)号：US4249904A
公开(公告)日：1981-02-10
申请号：US61554
申请日：1979-07-27
申请人： David P. Rounbehler , John W. Reisch
发明人： David P. Rounbehler , John W. Reisch
IPC分类号： B01D53/54 , B01D53/02 , B01D53/04 , B01J20/281 , G01N1/22 , G01N31/00 , G01N31/22 , G01N33/00 , C01G28/00 , G01N27/62
CPC分类号： G01N33/0047 , B01D53/02 , G01N31/224 , G01N33/0013 , Y10T436/170769 , Y10T436/255
摘要： A method and apparatus are disclosed for extracting N-nitroso compounds from air samples without artifact formation of nitrosamines from precursors in the sample. The apparatus includes a cartridge having two zones between a first port and a second port. The first zone, closest to the first port, contains an air pervious packing of a granular, solid phase amine complexing agent. The second zone, closest to the second port, contains an air pervious packing of a mixture of a granular, solid phase amine complexing agent and a particulate sorbent adapted to extract and concentrate N-nitroso compounds from air. The method includes a first step of driving an air sample through the first and second contiguous zones of the cartridge in succession, and a second step of driving an eluent through the second and first zones in succession, or backflushing the cartridge. To extract N-nitroso compounds, the eluent is a polar, or nitrogenous based, solvent for both N-nitroso compounds and the amine complexing agent in the second zone of the cartridge. The method may contain the further step of determining the N-nitroso compound concentration of at least a portion of the eluate which passes from the first zone following the second step of the method.
摘要翻译：公开了一种用于从空气样品中提取N-亚硝基化合物的方法和装置，该样品中的前体不产生亚硝胺的伪影。该装置包括在第一端口和第二端口之间具有两个区域的盒。最靠近第一口的第一区包含颗粒状固相胺络合剂的透气性填料。最靠近第二口的第二区包含颗粒状固相胺络合剂和适于从空气中提取和浓缩N-亚硝基化合物的颗粒状吸附剂的混合物的透气填料。该方法包括第一步骤，其连续地驱动空气样品通过盒的第一和第二连续区域;以及第二步骤，连续驱动洗脱液通过第二和第一区域或反冲洗墨盒。为了提取N-亚硝基化合物，洗脱液是两种N-亚硝基化合物的极性或含氮基溶剂，以及药筒第二区中的胺络合剂。该方法可以包含在该方法的第二步骤之后测定从第一区域通过的至少一部分洗脱液的N-亚硝基化合物浓度的进一步步骤。

9. 发明授权

US07947227B2 Kit for the conversion of nitrogen dioxide (NO2) to nitric oxide (NO) 有权
标题翻译：将二氧化氮（NO2）转化为一氧化氮（NO）的试剂盒
公开(公告)号：US07947227B2
公开(公告)日：2011-05-24
申请号：US12076723
申请日：2008-03-21
申请人： David H. Fine , David P. Rounbehler , Greg Vasquez
发明人： David H. Fine , David P. Rounbehler , Greg Vasquez
IPC分类号： A62B7/08 , A61M15/00
CPC分类号： A61M16/10 , A61M2016/1025 , A61M2202/0275 , C01B21/24
摘要： A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.
摘要翻译：包括在空气中具有二氧化氮的气瓶的一氧化氮输送系统将二氧化氮转化为一氧化氮，并使用涂覆有抗氧化剂水溶液如抗坏血酸的表面活性物质如硅胶。一氧化氮递送系统可用于产生治疗气体，包括用于将治疗气体递送至哺乳动物的一氧化氮。

10. 发明申请

US20100104667A1 Conversation of nitrogen dioxide (NO2) to nitric oxide (NO) 有权
公开(公告)号：US20100104667A1
公开(公告)日：2010-04-29
申请号：US12563662
申请日：2009-09-21
申请人： David H. Fine , David P. Rounbehler , Gregory Vasquez
发明人： David H. Fine , David P. Rounbehler , Gregory Vasquez
IPC分类号： A61K33/00 , A61M16/12
CPC分类号： B01J12/007 , A61K33/00 , A61M16/10 , A61M16/122 , A61M2016/1025 , A61M2202/0007 , A61M2202/0078 , A61M2202/0275 , A61M2205/07 , A61M2205/12 , A62B7/08 , C01B21/24
摘要： A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

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