专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明申请

US20120219577A1 HIV-1 CLADE A CONSENSUS SEQUENCES, ANTIGENS, AND TRANSGENES 有权
标题翻译： HIV-1 CLADE A CONSENSUS序列，抗原和转移物
公开(公告)号：US20120219577A1
公开(公告)日：2012-08-30
申请号：US13398897
申请日：2012-02-17
申请人： Kalpana GUPTA , Nicholas Jackson
发明人： Kalpana GUPTA , Nicholas Jackson
IPC分类号： A61K39/21 , C12P21/00 , A61P37/02 , C07H21/04 , A61K31/711
CPC分类号： C12Q1/703 , A61K39/00 , A61K2039/53 , C07K14/005 , C12N2710/10343 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322
摘要： The present invention relates to consensus nucleotide and protein sequences for HIV-1 Clade A antigens, and to nucleotide and protein sequences for Clade A antigens from circulating HIV-1 field isolates wherein the antigen sequences are closely related to the these consensus sequences. Advantageously, the present invention relates to HIV-1 Clade A transgenes that are derived from such sequences, and that encode either HIV-1 Clade A Gag, Pol (RT and Int), and Nef (collectively “GRIN”), HIV-1 Clade A Gag, RT, and Nef (collectively “GRN”), or HIV-1 Clade A Env. The invention also relates to vectors containing such transgenes, including adenovirus vectors containing such transgenes. The invention also relates to immunogenic compositions comprising the HIV-1 Clade A antigens, nucleotide sequences, vectors, or transgenes of the invention, and to methods of generating an immune response against HIV in a subject by administering an effective amount of such immunogenic compositions.
摘要翻译：本发明涉及用于HIV-1进化枝A抗原的共有核苷酸和蛋白质序列，以及来自循环HIV-1场分离株的克隆A抗原的核苷酸和蛋白质序列，其中所述抗原序列与这些共有序列密切相关。有利地，本发明涉及从这样的序列衍生的编码HIV-1分子A Gag，Pol（RT和Int）和Nef（统称为“GRIN”）的HIV-1进化枝A转基因，HIV-1 Clade A Gag，RT和Nef（统称为“GRN”）或HIV-1 Clade A Env。本发明还涉及含有这种转基因的载体，包括含有这种转基因的腺病毒载体。本发明还涉及包含本发明的HIV-1进化枝A抗原，核苷酸序列，载体或转基因的免疫原性组合物，以及通过施用有效量的这种免疫原性组合物在受试者中产生针对HIV的免疫应答的方法。

72. 发明申请

US20120213811A1 CHIMERIC HIV FUSION PROTEINS AS VACCINES 有权
标题翻译： CHIMERIC艾滋病毒融合蛋白作为疫苗
公开(公告)号：US20120213811A1
公开(公告)日：2012-08-23
申请号：US13452358
申请日：2012-04-20
申请人： CHAO-WEI LIAO , HSIU-KANG CHANG
发明人： CHAO-WEI LIAO , HSIU-KANG CHANG
IPC分类号： A61K39/104 , A61P37/04 , A61P31/18 , C07K14/21
CPC分类号： C07K14/21 , A61K39/12 , A61K39/21 , A61K2039/5254 , A61K2039/54 , A61K2039/545 , A61K2039/55566 , A61K2039/57 , C07K14/005 , C07K2319/00 , C07K2319/10 , C07K2319/40 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334
摘要： A method for treating HIV infection is disclosed. The method comprises administering to a patient in need thereof a therapeutically effective amount of a fusion protein comprising: a) a Pseudomonas Exotoxin A (PE) peptide comprising a binding domain and a PE translocation domain, the PE peptide being devoid of cytotoxic domain III; b) optionally gag24, being fused to the PE peptide; c) a fragment of gp120 C1 domain, being fused to the PE peptide or fused to the gag24 if the gag24 is present; d) a fragment of gp 120 C5 domain, being fused to the fragment of gp120 C1 domain; e) a fragment of gp41 amino acid sequence, being fused to the fragment of gp 120 C5 domain, and f) optionally an endoplasmic reticulum retention sequence, being fused to the C-terminus of the fragment of gp41.
摘要翻译：公开了一种治疗HIV感染的方法。所述方法包括向有需要的患者施用治疗有效量的融合蛋白，其包含：a）包含结合结构域和PE易位结构域的假单胞菌素外毒素A（PE）肽，所述PE肽缺乏细胞毒性结构域III; b）任选的gag24，与PE肽融合; c）gp120 C1结构域的片段，如果存在gag24，则与PE肽融合或融合至gag24; d）gp120C5结构域的片段，与gp120 C1结构域的片段融合; e）gp41氨基酸序列的片段，与gp120C5结构域的片段融合，以及f）任选的内质网保留序列，其与gp41片段的C末端融合。

73. 发明申请

US20120177676A1 ALPHABODIES FOR HIV ENTRY INHIBITION 审中-公开
标题翻译：用于艾滋病毒入侵抑制的字体
公开(公告)号：US20120177676A1
公开(公告)日：2012-07-12
申请号：US13382647
申请日：2010-07-07
申请人： Johan Desmet , Ignace Joseph Isabella Lasters , Sophie Vanwetswinkel
发明人： Johan Desmet , Ignace Joseph Isabella Lasters , Sophie Vanwetswinkel
IPC分类号： A61K39/12 , C12Q1/70 , A61K38/16 , C12N5/10 , C12N15/13 , A61P37/00 , C12N1/19 , C12N1/21 , C07K14/00 , A61P31/18
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K16/1063 , C07K2318/20 , C12N2740/16122 , G01N33/56988 , G01N2333/162 , G01N2500/00
摘要： The present invention relates to HIV-1 gp41-binding single-chain 3-stranded alpha-helical coiled coil molecules, denoted “Alphabodies”, nucleic acids encoding said Alphabodies, host cells comprising said nucleic acids, as well as pharmaceutical compositions comprising said Alphabodies, and methods for the treatment, prevention and diagnosis of HIV infection using said Alphabodies.
摘要翻译：本发明涉及表示为“Alphabodies”的编码所述Alphabody的核酸，包含所述核酸的宿主细胞以及包含所述Alphabody的药物组合物的HIV-1 gp41结合单链3链α-螺旋卷曲螺旋分子以及使用所述Alphabody来治疗，预防和诊断HIV感染的方法。

74. 发明申请

US20120149120A1 CHIMERIC PROTEIN, METHOD FOR MANUFACTURING THE SAME, NANO-SENSOR IN WHICH THE CHIMERIC PROTEIN IS FIXED, AND APPLICATION THEREOF 有权
标题翻译：重要蛋白质，其制备方法，固定蛋白质的纳米传感器及其应用
公开(公告)号：US20120149120A1
公开(公告)日：2012-06-14
申请号：US13225088
申请日：2011-09-02
申请人： Jee Won Lee , Young Keun Kim , Moon Kyu Cho , Jin Seung Park , Eun Jung Lee
发明人： Jee Won Lee , Young Keun Kim , Moon Kyu Cho , Jin Seung Park , Eun Jung Lee
IPC分类号： G01N21/64 , C12P21/00 , C07K2/00 , C07K17/08 , B82Y15/00
CPC分类号： G01N27/327 , B82Y30/00 , C07K14/005 , C07K14/31 , C12N2730/10122 , C12N2740/16122 , C25D5/022
摘要： There is provided a chimeric protein of capsid protein of Hepatitis B virus (HBV) and B domain of Staphylococcal protein A (SPAB); a method for fabricating the same; the substrate and nanosensor immobilized with HBV-derived chimeric protein; and the use of the above nanosensor.
摘要翻译：提供乙型肝炎病毒（HBV）衣壳蛋白和葡萄球菌蛋白A（SPAB）B结构域的嵌合蛋白; 其制造方法; 固定有HBV衍生嵌合蛋白的底物和纳米传感器; 并使用上述纳米传感器。

75. 发明申请

US20120129772A1 SOLUBLE IGF RECEPTORS AS ANTI-ANGIOGENIC AGENTS 审中-公开
标题翻译：可溶性IGF受体作为抗血管生成剂
公开(公告)号：US20120129772A1
公开(公告)日：2012-05-24
申请号：US13056360
申请日：2009-07-28
申请人： Pnina Brodt , Zhipeng You
发明人： Pnina Brodt , Zhipeng You
IPC分类号： A61K38/30 , A61P35/00 , A61P35/04 , A61P9/00
CPC分类号： C07K14/005 , A61K35/35 , A61K38/30 , A61K48/00 , C12N2740/16122
摘要： There is disclosed a method of inhibiting angiogenesis in a patient having an angiogenic associated disorder comprising administering to said patient a therapeutically effective amount of a soluble IGF-IR protein. The use of such soluble IGF-IR protein for inhibiting angiogenesis in a patient is also disclosed.
摘要翻译：公开了一种在具有血管生成相关病症的患者中抑制血管发生的方法，包括向所述患者施用治疗有效量的可溶性IGF-1R蛋白。还公开了这种可溶性IGF-1R蛋白用于抑制患者血管生成的用途。

76. 发明授权

US08183354B2 Virus coat protein/receptor chimeras and methods of use 有权
标题翻译：病毒外壳蛋白/受体嵌合体和使用方法
公开(公告)号：US08183354B2
公开(公告)日：2012-05-22
申请号：US11940445
申请日：2007-11-15
申请人： Anthony L. DeVico , Timothy R. Fouts , Robert G. Tuskan
发明人： Anthony L. DeVico , Timothy R. Fouts , Robert G. Tuskan
IPC分类号： C07H23/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/70514 , C07K16/1063 , C07K16/2812 , C07K2317/34 , C07K2319/00 , C07K2319/30 , C07K2319/32 , C07K2319/40 , C07K2319/41 , C07K2319/735 , C12N15/62 , C12N2740/16122 , G01N33/56983 , G01N33/56988 , G01N2500/00
摘要： The invention relates to chimeric molecules comprising a virus coat sequence and a receptor sequence that can inter-act with each other to form a complex that is capable of binding a co-receptor. Such chimeric molecules therefore exhibit functional properties characteristic of a receptor-coat protein complex and are useful as agents that inhibit virus infection of cells due to occn-panty of co-receptor present on the cell, for example. In particular aspects, the chimeric polypeptide includes an immunodeficiency virus envelope polypeptide, such as that of HIV, SIV, FIV, FeLV, FPV and herpes virus. Receptor sequences suitable for use in a chimeric polypeptide include, for example, CCR5 and CXCR4 sequences.
摘要翻译：本发明涉及包含能够相互作用以形成能够结合共受体的复合物的病毒外壳序列和受体序列的嵌合分子。因此，这样的嵌合分子显示出受体外壳蛋白复合物特征的功能特性，并且可用作例如抑制细胞上存在的共 - 受体的隐窝的细胞的病毒感染的试剂。在具体方面，嵌合多肽包括免疫缺陷病毒包膜多肽，例如HIV，SIV，FIV，FeLV，FPV和疱疹病毒的多肽。适用于嵌合多肽的受体序列包括例如CCR5和CXCR4序列。

77. 发明授权

US08168418B2 Expression of HIV polypeptides and production of virus-like particles 有权
标题翻译： HIV多肽的表达和病毒样颗粒的产生
公开(公告)号：US08168418B2
公开(公告)日：2012-05-01
申请号：US12770905
申请日：2010-04-30
申请人： Susan W Barnett , Jan Zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
发明人： Susan W Barnett , Jan Zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
IPC分类号： C12N7/00 , A61K39/21
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.
摘要翻译：本发明涉及HIV多肽在各种细胞类型中的有效表达，包括但不限于哺乳动物，昆虫和植物细胞。描述了编码含有HIV Gag的多肽的合成表达盒，以及包括DNA免疫，产生包装细胞系以及产生含有Env，tat或Gag的蛋白质的应用中的表达盒的用途。本发明提供了生产病毒样颗粒（VLP）的方法，以及VLP的使用，包括但不限于用于呈递抗体的媒介物和在施用VLP的受试者中刺激免疫应答。

78. 发明授权

US6114148C1 High level expression of proteins 失效
标题翻译：蛋白质的高水平表达
公开(公告)号：US6114148C1
公开(公告)日：2012-05-01
申请号：US71729496
申请日：1996-09-20
申请人： GEN HOSPITAL CORP
发明人： SEED BRIAN , HAAS JURGEN
IPC分类号： C12N15/09 , C07K14/16 , C07K14/435 , C07K14/755 , C12N5/07 , C12N5/10 , C12N15/33 , C12N15/67 , C12N15/85 , C12P21/02 , C12R1/91
CPC分类号： C07K14/005 , C07K14/43595 , C07K14/755 , C07K2319/00 , C12N15/67 , C12N2740/16122 , C12P21/02

79. 发明授权

US5786464C1 Overexpression of mammalian and viral proteins 失效
标题翻译：哺乳动物和病毒蛋白的过表达
公开(公告)号：US5786464C1
公开(公告)日：2012-04-24
申请号：US32424394
申请日：1994-09-19
申请人： GEN HOSPITAL CORP
发明人： SEED BRIAN , HAAS JUERGEN
IPC分类号： C12N15/09 , C07K14/16 , C07K14/435 , C07K14/705 , C12N15/67 , C12N15/85
CPC分类号： C07K14/005 , C07K14/43595 , C07K14/70503 , C12N15/67 , C12N15/85 , C12N2740/16122

80. 发明授权

US08133494B2 Expression cassettes endcoding HIV-1 south african subtype C modified ENV proteins with deletions in V1 and V2 有权
标题翻译：表达盒在V1和V2中以缺失形式编码HIV-1南非亚型C修饰的ENV蛋白
公开(公告)号：US08133494B2
公开(公告)日：2012-03-13
申请号：US11724050
申请日：2007-03-13
申请人： Jan zur Megede , Susan Barnett , Ying Lian , Susan Engelbrecht , Estrelita Janse van Rensburg , Thomas J. Scriba
发明人： Jan zur Megede , Susan Barnett , Ying Lian , Susan Engelbrecht , Estrelita Janse van Rensburg , Thomas J. Scriba
IPC分类号： A61K39/21 , C07H21/04 , C12N15/00 , C12P21/06
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , C12N15/86 , C12N2720/00034 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2799/027 , C12N2800/108 , C12N2830/42 , C12N2840/203
摘要： The invention relates to polynucleotides encoding modified immunogenic HIV-1 South African subtype C Env polypeptides. The modifications to the Env polypeptides include deletions of V1, V2 and the stem region. The expression cassettes may be used, for example, to express the encoded polypeptide. A recombinant expression system for use in a selected host cell comprising an expression cassette encoding for the modified HIV-1 Env polypeptide is also described.
摘要翻译：本发明涉及编码经修饰的免疫原性HIV-1南非亚型C Env多肽的多核苷酸。对Env多肽的修饰包括缺失V1，V2和茎区。表达盒可以用于例如表达编码的多肽。还描述了用于选择的宿主细胞中的重组表达系统，其包含编码经修饰的HIV-1 Env多肽的表达盒。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式