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71. 发明申请

US20090011510A1 Device and method for biolistic transformation of cells 审中-公开
标题翻译：细胞的生物弹性转化的装置和方法
公开(公告)号：US20090011510A1
公开(公告)日：2009-01-08
申请号：US12134906
申请日：2008-06-06
申请人： Shiv D. Kale , Brett M. Tyler
发明人： Shiv D. Kale , Brett M. Tyler
IPC分类号： C12N15/87 , C12M1/00
CPC分类号： C12N15/895 , C12M35/00
摘要： The present invention provides a device and method for biolistic bombardment of cells. In a preferred embodiment, the device comprises a hollow tube or cylinder that attaches to a standard biolistic transformation apparatus, and focuses the nucleic acids at cells and tissue sections. In a typical configuration, the device has two barrels that deliver equal or substantially equal amounts of nucleic acids to cells of a tissue, such as a plant leaf.
摘要翻译：本发明提供了用于细胞的生物射弹轰击的装置和方法。在优选实施例中，该装置包括连接到标准生物弹性变换装置的中空管或圆筒，并将核酸聚焦在细胞和组织切片处。在典型的配置中，该装置具有两个桶，其将等量或基本相等量的核酸递送到组织细胞如植物叶。

72. 发明申请

US20080299647A1 Cell capturing plate, microinjection apparatus, and method of producing cell capturing plate 审中-公开
标题翻译：细胞捕获板，显微注射装置和细胞捕获板的制造方法
公开(公告)号：US20080299647A1
公开(公告)日：2008-12-04
申请号：US12155003
申请日：2008-05-28
申请人： Akio Ito , Akihiko Yabuki , Daisuke Uchida , Satoru Sakai , Sachihiro Youoku
发明人： Akio Ito , Akihiko Yabuki , Daisuke Uchida , Satoru Sakai , Sachihiro Youoku
IPC分类号： C12M1/00 , B44C1/22
CPC分类号： C12M35/00 , C12M23/12 , C12M25/06
摘要： A cell capturing plate has a flat surface, an opening formed in one surface of the flat surface and supporting the cell therein, and a through-hole penetrating from the opening to the other surface of the flat surface and having a cross section parallel to the flat surface smaller than that of the opening.
摘要翻译：细胞捕获板具有平坦表面，形成在平坦表面的一个表面中并且将细胞支撑在其中的开口以及从开口延伸到平坦表面的另一个表面的通孔，并且具有与平面比开口小。

73. 发明授权

US07339090B2 Microinjection devices and methods of use 有权
标题翻译：显微注射装置和使用方法
公开(公告)号：US07339090B2
公开(公告)日：2008-03-04
申请号：US11159973
申请日：2005-06-23
申请人： Leandro Christmann
发明人： Leandro Christmann
IPC分类号： A01K67/027 , C12N15/00 , A61M1/00 , A61M5/00
CPC分类号： A01K67/0275 , A01K2217/05 , A61M37/00 , C12M35/00 , G02B21/32
摘要： The present invention provides for microinjection devices comprising a needle and a viewing instrument wherein the viewing instrument provides magnified viewing of an object to an operator from an angle other than a right angle to the object.
摘要翻译：本发明提供了一种显微注射装置，其包括针和观察仪器，其中观察仪器从与该物体的直角不同的角度向操作者提供物体的放大观察。

74. 发明申请

US20080002868A1 Microinjection apparatus and automatic focal point adjustment method 有权
标题翻译：显微注射装置和自动焦点调整方法
公开(公告)号：US20080002868A1
公开(公告)日：2008-01-03
申请号：US11600815
申请日：2006-11-17
申请人： Moritoshi Ando , Sachihiro Youoku
发明人： Moritoshi Ando , Sachihiro Youoku
IPC分类号： G06K9/00
CPC分类号： C12M35/00
摘要： A microinjection apparatus, which injects an object into a cell with a needle, includes an image acquiring unit that acquires a first image that is an image of the cell at a first focal position and a second image that is an image of the cell at a second focal position; and a state deciding unit that decides a state of the cell based on a difference image obtained from the first image and the second image.
摘要翻译：一种用针将物体注射到细胞中的显微注射装置包括图像获取单元，其获取作为第一焦点位置处的细胞的图像的第一图像和作为细胞的图像的第二图像，第二焦点; 以及状态判定单元，其基于从所述第一图像和所述第二图像获得的差分图像来决定所述单元的状态。

75. 发明申请

US20070175758A1 Solution filling apparatus 有权
标题翻译：解决方案灌装设备
公开(公告)号：US20070175758A1
公开(公告)日：2007-08-02
申请号：US11399626
申请日：2006-04-07
申请人： Jun Sasaki , Kazuo Tamamushi
发明人： Jun Sasaki , Kazuo Tamamushi
IPC分类号： C07K1/26
CPC分类号： B01L3/022 , B01L3/0275 , B01L2200/0684 , C12M35/00 , Y10T436/11 , Y10T436/2575
摘要： A solution filling apparatus fills a capillary with solution of a substance to be introduced into a cell. A capillary holding unit holds the capillary. An injection-tube holding unit holds an injection tube to be injected into the capillary. A solution ejecting unit ejects the solution from the injection tube into the capillary. A guiding unit guides the injection tube into the capillary. A capillary oscillating unit oscillates the injection-tube holding unit and the solution ejecting unit.
摘要翻译：溶液填充装置用待引入物质的溶液填充毛细管。毛细管保持单元保持毛细管。注射管保持单元保持要注入毛细管的注射管。溶液喷射单元将溶液从注射管喷射到毛细管中。引导单元引导注射管进入毛细管。毛细管振荡单元使注射管保持单元和溶液排出单元振荡。

76. 发明申请

US20070087436A1 Microinjection method and device 审中-公开
标题翻译：显微注射法和装置
公开(公告)号：US20070087436A1
公开(公告)日：2007-04-19
申请号：US10552923
申请日：2004-04-09
申请人： Atsushi Miyawaki , Hiroyuki Imabayashi , Sachiko Karaki
发明人： Atsushi Miyawaki , Hiroyuki Imabayashi , Sachiko Karaki
IPC分类号： C12N15/00 , C12M1/00
CPC分类号： B82Y30/00 , C12M35/00
摘要： An object of the present invention is to provide a method for introducing a physiologically active substance such as a gene into a cell, which introduces a physiologically active substance such as any given gene into any given cell in a view under a microscope, while significantly reducing invasiveness to the cell, and a device used for the above method. The present invention provides a method for introducing a physiologically active substance into a cell, which comprises: allowing a physiologically active substance to attach around a needle having a diameter of 500 nm or less, provided that it is able to be inserted into a cell; and inserting the above-described needle into the cell; and a microinjection device for carrying out the aforementioned method.
摘要翻译：本发明的目的是提供一种将生物活性物质如基因导入细胞的方法，该细胞在显微镜下以任何给定的基因引入任何给定基因的生理活性物质，同时显着降低对细胞的侵袭性，以及用于上述方法的装置。本发明提供了一种将生理活性物质引入细胞的方法，其包括：使生理活性物质附着在直径为500nm以下的针上，只要其能够插入细胞中即可。并将上述针插入细胞中; 以及用于实施上述方法的显微注射装置。

77. 发明申请

US20060183215A1 Substance injecting apparatus 审中-公开
标题翻译：物质注入装置
公开(公告)号：US20060183215A1
公开(公告)日：2006-08-17
申请号：US11335612
申请日：2006-01-20
申请人： Sachihiro Youoku , Moritoshi Ando , Akio Ito
发明人： Sachihiro Youoku , Moritoshi Ando , Akio Ito
IPC分类号： C12M1/34
CPC分类号： A61K48/0075 , C12M35/00
摘要： A particle fixing unit fixes a particle. A needle is arranged in such a manner that an angle between a surface on a side of the particle fixing unit on which the particle is fixed and a longitudinal center axis of the needle becomes equal to or more than 45 degrees and equal to or less than 135 degrees. An image forming unit forms, when observing at least one of the particle and the needle across the particle fixing unit, at least one of an image of the particle and an image of the needle, based on a light transmitted through the particle fixing unit.
摘要翻译：颗粒固定单元固定颗粒。针以这样的方式配置，使得固定有颗粒的颗粒固定单元的一侧表面与针的纵向中心轴之间的角度等于或大于45度并且等于或小于 135度。当通过颗粒固定单元观察至少一个颗粒和针时，图像形成单元基于透过颗粒固定单元的光来形成颗粒的图像和针的图像中的至少一个。

78. 发明申请

US20060166377A1 Particle for magnetically induced membrane transport 审中-公开
标题翻译：磁性膜运输用颗粒
公开(公告)号：US20060166377A1
公开(公告)日：2006-07-27
申请号：US10526901
申请日：2003-09-11
申请人： Sarah Fredriksson , Dario Kriz
发明人： Sarah Fredriksson , Dario Kriz
IPC分类号： G01N33/553
CPC分类号： C12N15/87 , A61N2/00 , C12M35/00
摘要： The present invention relates to particles, for use in transport of substances through biological membranes, the particle being characterised in that it contains at least one magnetically inducible material and at least one difunctional molecule with at least one binding site for said substance and at least one binding site for said biological membrane. Moreover the invention concerns both production of the same particles and applications thereof.
摘要翻译：本发明涉及用于通过生物膜运输物质的颗粒，该颗粒的特征在于其含有至少一种磁诱导材料和至少一种具有至少一个所述物质结合位点的二官能分子和至少一个所述生物膜的结合位点。此外，本发明涉及相同颗粒的生产和其应用。

79. 发明申请

US20060134600A1 Method and devices for non-traumatic movement of a probe through biological cell material 有权
标题翻译：探针通过生物细胞材料非创伤运动的方法和装置
公开(公告)号：US20060134600A1
公开(公告)日：2006-06-22
申请号：US10546023
申请日：2003-12-02
申请人： Gunter Fuhr , Heiko Zimmermann
发明人： Gunter Fuhr , Heiko Zimmermann
IPC分类号： C12Q1/00
CPC分类号： B01L3/021 , A61B10/0233 , A61B10/0283 , A61B2010/0208 , B01L2200/0647 , B01L2300/0838 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , C12M33/02 , C12M35/00 , G01N1/286 , G01N15/12 , G01N15/14 , G01N2015/1486 , G01N2015/1493
摘要： A method for moving a probe (10, 91) through a cell material (20), which is formed from biological cells (21), is described, the probe (10) displacing the cells (21) without injury. A probe (10, 91) for performing the method and a cell manipulator, which is equipped with at least one probe of this type, are also described.
摘要翻译：描述了通过由生物细胞（21）形成的细胞材料（20）移动探针（10,91）的方法，探针（10）不损伤地移动细胞（21）。还描述了用于执行该方法的探针（10,91）和装备有这种类型的至少一个探针的细胞操纵器。

80. 发明申请

US20060018941A1 System and method for injecting liquid drug containing biological material 审中-公开
标题翻译：用于注射含药物的生物材料的系统和方法
公开(公告)号：US20060018941A1
公开(公告)日：2006-01-26
申请号：US10954639
申请日：2004-09-30
申请人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shin Kawamata , Shigeru Miyagawa , Emi Maeno , Yoshiho Toyota , Shinji Ozawa
发明人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shin Kawamata , Shigeru Miyagawa , Emi Maeno , Yoshiho Toyota , Shinji Ozawa
IPC分类号： A61F13/00
CPC分类号： A61M5/1456 , A61M5/14566 , A61M5/14593 , A61M5/482 , A61M5/488 , A61M2005/14513 , C12M35/00
摘要： A method for injecting a liquid drug containing a biological material is provided, which comprises the step of injecting the liquid drug containing the biological material contained in an injector into a subject at a predetermined range of velocity.
摘要翻译：提供了一种用于注射含有生物材料的液体药物的方法，其包括将包含在注射器中的生物材料的液体药物以预定的速度范围注射到受试者中的步骤。

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