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    • 71. 发明申请
    • Crosslinked hydrogel copolymers
    • 交联水凝胶共聚物
    • US20050020734A1
    • 2005-01-27
    • US10922964
    • 2004-08-23
    • Firouz AsgarzadehHenry Costantino
    • Firouz AsgarzadehHenry Costantino
    • C08G63/664C08G65/14C08G65/332C08J3/16C08L67/00C08L71/02C08L63/00
    • C08J3/16C08G63/664C08G65/14C08G65/3324C08G2650/34C08G2650/58C08L67/00C08L71/02C08L2666/18
    • The present invention relates to crosslinked polymers, synthesized through ring-opening polymerization of ethylenically unsaturated epoxides, in combination with α-hydroxy acids using a hydrophilic macroinitiator, such as poly(ethylene glycol), to form substituted copolymers having ethylenically unsaturated functionality randomly distributed along the polyester polymer backbone. That copolymer is subsequently crosslinked to form a hydrogel network. More particularly, the present invention relates to the synthesis of biodegradable poly(α-hydroxy acid-co-glycidyl methacrylate)-block-poly(ethylene glycol)-block-poly(α-hydroxy acid-co-glycidyl methacrylate) copolymers, which are subsequently crosslinked to form hydrogel networks. The invention also relates to the use of these hydrogel networks in various applications, in particular, for the controlled release of drugs and proteins.
    • 本发明涉及通过使用亲水性大分子引发剂如聚(乙二醇)与烯键式不饱和环氧化物的开环聚合合成的交联聚合物,与α-羟基酸组合形成具有随机分布的烯属不饱和官能团的取代共聚物 聚酯聚合物骨架。 随后将该共聚物交联以形成水凝胶网络。 更具体地说,本发明涉及可生物降解的聚(α-羟基酸 - 共缩水甘油基甲基丙烯酸酯) - 嵌段 - 聚(乙二醇) - 嵌段 - 聚(α-羟基酸 - 共 - 缩水甘油基甲基丙烯酸酯)共聚物的合成,其中 随后交联以形成水凝胶网络。 本发明还涉及这些水凝胶网络在各种应用中的用途,特别是用于药物和蛋白质的控制释放。
    • 73. 发明授权
    • Crosslinked hydrogel copolymers
    • 交联水凝胶共聚物
    • US06800663B2
    • 2004-10-05
    • US10273365
    • 2002-10-18
    • Firouz AsgarzadehHenry R. Costantino
    • Firouz AsgarzadehHenry R. Costantino
    • B01J1318
    • C08J3/16C08G63/664C08G65/14C08G65/3324C08G2650/34C08G2650/58C08L67/00C08L71/02C08L2666/18
    • The present invention relates to crosslinked polymers, synthesized through ring-opening polymerization of ethylenically unsaturated epoxides, in combination with &agr;-hydroxy acids using a hydrophilic macroinitiator, such as poly(ethylene glycol), to form substituted copolymers having ethylenically unsaturated functionality randomly distributed along the polyester polymer backbone. That copolymer is subsequently crosslinked to form a hydrogel network. More particularly, the present invention relates to the synthesis of biodegradable poly(&agr;-hydroxy acid-co-glycidyl methacrylate)-block-poly(ethylene glycol)-block-poly(&agr;-hydroxy acid-co-glycidyl methacrylate) copolymers, which are subsequently crosslinked to form hydrogel networks. The invention also relates to the use of these hydrogel networks in various applications, in particular, for the controlled release of drugs and proteins.
    • 本发明涉及通过使用亲水性大分子引发剂如聚(乙二醇)与烯键式不饱和环氧化物的开环聚合合成的交联聚合物,与α-羟基酸组合形成具有随机分布的烯属不饱和官能团的取代共聚物 聚酯聚合物骨架。 随后将该共聚物交联以形成水凝胶网络。 更具体地说,本发明涉及可生物降解的聚(α-羟基酸 - 共缩水甘油基甲基丙烯酸酯) - 嵌段 - 聚(乙二醇) - 嵌段 - 聚(α-羟基酸 - 共 - 缩水甘油基甲基丙烯酸酯)共聚物的合成,其中 随后交联以形成水凝胶网络。 本发明还涉及这些水凝胶网络在各种应用中的用途,特别是用于药物和蛋白质的控制释放。