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71. 发明授权

US07122083B2 Apparatus and process used in growing crystals 有权
标题翻译：用于生长晶体的装置和工艺
公开(公告)号：US07122083B2
公开(公告)日：2006-10-17
申请号：US10405436
申请日：2003-04-02
申请人： Daniel Albert Green
发明人： Daniel Albert Green
IPC分类号： C30B7/08
CPC分类号： B82Y30/00 , B01D9/0013 , B01D9/0018 , B01D9/005 , B01D9/0081 , C30B7/00 , C30B29/54
摘要： This invention relates to a novel system for making uniform crystals. The system, by virtue of the nature of its crystal product, is useful in various chemical, pharmaceutical, agricultural, and biotechnology applications. The invention features physically separated and controlled crystal nucleation and growth zones useful in industrially scaled crystallization processes. The invention also provides a method to preferentially nucleate and crystallize a desired category of crystal structure (enantiomer, solvate, polymorph) of non-chiral and chiral compounds.
摘要翻译：本发明涉及一种制备均匀晶体的新系统。该系统凭借其晶体产品的性质，可用于各种化学，制药，农业和生物技术应用。本发明具有物理分离和控制的晶体成核和生长区域，其可用于工业规模结晶过程。本发明还提供了优选使非手性和手性化合物的所需类型的晶体结构（对映异构体，溶剂合物，多晶型物）成核并结晶的方法。

72. 发明授权

US06960256B2 Formation of small crystals 失效
标题翻译：形成小晶体
公开(公告)号：US06960256B2
公开(公告)日：2005-11-01
申请号：US10476156
申请日：2002-05-02
申请人： Michael Joseph Bowe , John William Stairmand , Linda Jane McCausland
发明人： Michael Joseph Bowe , John William Stairmand , Linda Jane McCausland
IPC分类号： A61K9/14 , A61K9/16 , A61K31/43 , B01D9/00 , B01D9/02 , B01F5/00 , B01F11/02 , B01F13/10 , C30B7/00 , C30B7/08
CPC分类号： C30B7/00 , A61K9/1688 , B01D9/0027 , B01D9/005 , B01D9/0059 , B01D9/0081 , B01F5/0057 , B01F11/0258 , B01F11/0266 , B01F13/1025
摘要： Small crystals are made by mixing a solution of a desired substance with an anti-solvent in a fluidic vortex mixer in which the residence time is less than 1 s, for example 10 ms. The liquid within the fluidic vortex mixer (12) is subjected to high intensity ultrasound from a transducer (20, 22) in or on the wall of the mixer, or coupled to a pipe supplying liquid to the mixer. The solution very rapidly becomes supersaturated, and the ultrasound can induce a very large number of nuclei for crystal growth. Small crystals, for example less than 5 μm, are formed that may be of a suitable size for use in inhalers.
摘要翻译：通过将所需物质与抗溶剂的溶液在其中停留时间小于1秒，例如10ms的流体涡旋混合器中混合来制备小晶体。流体涡流混合器（12）内的液体经受来自混合器壁上或其上的换能器（20,22）的高强度超声波，或耦合到向混合器供应液体的管道。溶液非常迅速地变得过饱和，并且超声可以诱导非常大量的用于晶体生长的核。形成小晶体，例如小于5μm，其可以具有适合用于吸入器的尺寸。

73. 发明申请

US20050188913A1 Production of crystalline materials by using high intensity ultrasound 有权
标题翻译：通过使用高强度超声波生产结晶材料
公开(公告)号：US20050188913A1
公开(公告)日：2005-09-01
申请号：US10514883
申请日：2003-05-13
申请人： Linda McCausland , John Perkins
发明人： Linda McCausland , John Perkins
IPC分类号： C07H3/02 , B01D9/00 , B01D9/02 , C07K5/072 , C30B1/00
CPC分类号： B01D9/0013 , B01D9/0036 , B01D9/0063 , B01D9/0081 , C07K5/0613 , Y10T117/1024 , Y10T117/1028
摘要： A crystalline material sufficiently pure for use in pharmaceuticals may be made by forming a saturated solution of the material, changing the temperature of the solution so it becomes supersaturated, and subjecting the solution to irradiation by high intensity ultrasound, the frequency of the ultrasound being scanned over a range of frequencies. For example the ultrasound may be varied between 19.5 and 20.5 kHz, and this variation may be sinusoidal. Preferably the ultrasound is provided only briefly, say for less than 5 s, before allowing the solution to cool gradually without further irradiation. The ultrasound may be applied using a vessel with an array of ultrasonic transducers attached to a wall, so each transducer radiates no more than 3 W/cm2 yet the power dissipation within the vessel is between 25 and 150 W/litre. This method can reduce the metastable zone width to less than 10 K. It is applicable in particular to aspartame.
摘要翻译：可以通过形成饱和的材料溶液，改变溶液的温度，使其变得过饱和，并通过高强度超声波对该溶液进行照射，使超声频率被扫描，可以制备足够纯的用于药物的结晶物质在一个频率范围内。例如，超声可以在19.5和20.5kHz之间变化，并且该变化可以是正弦的。优选地，在允许溶液逐渐冷却而不进一步照射之前，仅提供超声波，例如少于5秒。可以使用具有附接到壁的超声波换能器阵列的血管来应用超声波，因此每个换能器辐射不超过3W / cm 2，但是容器内的功率耗散在25和150之间 W /升。该方法可将亚稳区宽度减小到10K以下。特别适用于阿斯巴甜。

74. 发明申请

US20050152981A1 Process for making sterile aripiprazole of desired mean particle size 审中-公开
标题翻译：制备所需平均粒径的无菌阿立哌唑的方法
公开(公告)号：US20050152981A1
公开(公告)日：2005-07-14
申请号：US10968481
申请日：2004-10-19
申请人： Margaret Gleeson , Soojin Kim , Donald Kientzler , San Kiang
发明人： Margaret Gleeson , Soojin Kim , Donald Kientzler , San Kiang
IPC分类号： B01D9/00 , C07D215/22 , C07D215/227 , A61K9/14
CPC分类号： A61J3/02 , B01D9/0009 , B01D9/005 , B01D9/0054 , B01D9/0063 , B01D9/0081 , B01J2/06 , C07D215/227
摘要： A process is provided for making sterile aripiprazole having an average particle size less than 100 microns but preferably greater than 25 microns employing an impinging jet crystallization procedure. The resulting bulk aripiprazole of desired particle size may be used to form a sterile freeze-dried aripiprazole formulation, which upon constitution with water and intramuscular injection releases aripiprazole over a period of at least about one week and up to about eight weeks.
摘要翻译：提供了一种制备平均粒径小于100微米但优选大于25微米的无菌阿立哌唑的方法，其采用冲击射流结晶方法。所得粒度的阿立哌唑可用于形成无菌冷冻干燥的阿立哌唑制剂，其在用水和肌内注射后，在至少约一周至多达八周的时间内释放阿立哌唑。

75. 发明申请

US20040005255A1 Appartus and process used in growing crystals 有权
标题翻译：用于生长晶体的Appartus和工艺
公开(公告)号：US20040005255A1
公开(公告)日：2004-01-08
申请号：US10405436
申请日：2003-04-02
发明人： Daniel Albert Green
IPC分类号： B01D009/00
CPC分类号： B82Y30/00 , B01D9/0013 , B01D9/0018 , B01D9/005 , B01D9/0081 , C30B7/00 , C30B29/54
摘要： This invention relates to a novel system for making uniform crystals. The system, by virtue of the nature of its crystal product, is useful in various chemical, pharmaceutical, agricultural, and biotechnology applications. The invention features physically separated and controlled crystal nucleation and growth zones useful in industrially scaled crystallization processes. The invention also provides a method to preferentially nucleate and crystallize a desired category of crystal structure (enantiomer, solvate, polymorph) of non-chiral and chiral compounds.
摘要翻译：本发明涉及一种制备均匀晶体的新系统。该系统凭借其晶体产品的性质，可用于各种化学，制药，农业和生物技术应用。本发明具有物理分离和控制的晶体成核和生长区域，其可用于工业规模结晶过程。本发明还提供了优选使非手性和手性化合物的所需类型的晶体结构（对映异构体，溶剂合物，多晶型物）成核并结晶的方法。

76. 发明申请

US20030051659A1 Small particle-adjustment crystallization process 失效
标题翻译：小粒子调整结晶过程
公开(公告)号：US20030051659A1
公开(公告)日：2003-03-20
申请号：US10197444
申请日：2002-07-18
发明人： Matthias Rauls , Richard van Gelder , Katrin Wagner , Harald Bernard
IPC分类号： C30B007/00 , C30B021/02 , C30B028/06
CPC分类号： B01D9/0004 , B01D9/005 , B01D9/0081 , C30B7/00
摘要： The present invention relates to a process for crystallizing small particles with a narrow particle size distribution. The crystals of the invention are obtained by introducing ultrasound into a solution or suspension of the substance to be crystallized while simultaneously adjusting a particular specific stirring power.
摘要翻译：本发明涉及一种使粒径分布窄的小颗粒结晶的方法。通过将超声波引入待结晶物质的溶液或悬浮液中同时调节特定的搅拌功率而获得本发明的晶体。

77. 发明申请

US20020031577A1 Crystallisation process using ultrasound 失效
标题翻译：使用超声波的结晶过程
公开(公告)号：US20020031577A1
公开(公告)日：2002-03-14
申请号：US09902288
申请日：2001-07-10
申请人： Lipton, Division of Conopco, Inc.
发明人： Berend Jan Arends , Renoo Avinash Blindt , Jo Janssen , Maria Patrick
IPC分类号： A23D009/00 , A23D007/00
CPC分类号： C11B15/00 , A23D7/001 , A23D7/05 , A61K8/28 , A61K8/585 , A61K8/922 , A61K2800/82 , A61Q15/00 , B01D9/0004 , B01D9/005 , B01D9/0081
摘要： The present invention relates to a process for the crystallisation of a solid phase from a liquid, characterized in that the liquid during crystallization is subjected to ultrasound in the absence of transient cavitation. In particular the liquid is sonicated under such conditions of time and frequency that nucleation of stable crystals in the liquid is induced without exceeding the cavitation threshold and the occurrence of transient cavitation and the accompagnying flavor deterioration is avoided. The liquid preferably is a triglyceride oil such as a vegetable oil or animal fat, e.g. liquefied milk fat.
摘要翻译：本发明涉及一种从液体中结晶固相的方法，其特征在于，在不存在瞬时空化的情况下，结晶过程中的液体经受超声波。特别地，在这样的时间和频率的条件下，液体被超声处理，使液体中的稳定晶体的成核被诱导而不超过空化阈值，并且避免了瞬时气穴的发生，并避免了伴随的风味变差。液体优选为甘油三酯油，例如植物油或动物脂肪，例如，液化乳脂肪。

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