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71. 发明申请

US20120308629A1 INJECTABLE BULKING COMPOSITIONS 失效
标题翻译：可注射的组合物
公开(公告)号：US20120308629A1
公开(公告)日：2012-12-06
申请号：US13587159
申请日：2012-08-16
申请人： Jamie Li , Michael Madden
发明人： Jamie Li , Michael Madden
IPC分类号： A61K9/70 , A61K33/42 , A61K33/44 , A61K31/765 , A61K35/12 , A61K8/02 , A61P15/00 , A61K8/19 , A61K8/25 , A61K8/24 , A61K8/81 , A61K8/84 , A61K33/00 , A61K35/34
CPC分类号： A61K9/70 , A61F2/0036 , A61K8/02 , A61K8/0204 , A61K8/027 , A61K8/19 , A61K8/24 , A61K8/25 , A61K8/26 , A61K8/28 , A61K31/765 , A61K33/08 , A61K33/24 , A61K33/34 , A61K33/42 , A61K33/44 , A61K35/12 , A61K35/33 , A61K35/34 , A61K47/32 , A61K2800/91 , A61L27/50 , A61L2400/06 , A61Q19/00 , A61Q90/00
摘要： According to an aspect of the invention, injectable bulking compositions are provided which contain the following: (a) fibers that are configured to prevent migration to locations in the body remote from the injection site, for example, because they have a minimum length that is sufficiently large to prevent migration of the fibers and/or because they have surface features that stimulate host tissue response to lock the fibers in position and (b) a carrier in an amount effective to render the composition injectable.
摘要翻译：根据本发明的一个方面，提供了可注射的填充组合物，其包含以下内容：（a）被配置为防止迁移到远离注射部位的身体中的位置的纤维，例如，因为它们具有最小长度足够大以防止纤维的迁移和/或因为它们具有刺激宿主组织反应以将纤维锁定在其中的表面特征，和（b）有效使组合物可注射的载体。

72. 发明申请

US20120225039A1 TISSUE ENGINEERED CARTILAGE, METHOD OF MAKING SAME, THERAPEUTIC AND COSMETIC SURGICAL APPLICATIONS USING SAME 审中-公开
标题翻译：组织工程化纤维，其制备方法，使用相同的治疗方法和化妆品外科应用
公开(公告)号：US20120225039A1
公开(公告)日：2012-09-06
申请号：US13472173
申请日：2012-05-15
申请人： Wan-Ju Li , Rocky S. Tuan
发明人： Wan-Ju Li , Rocky S. Tuan
IPC分类号： A61K35/32 , A61K47/34 , C12N5/071 , A61P19/04 , B82Y5/00 , B82B1/00 , B82Y99/00
CPC分类号： A61Q90/00 , A61L27/18 , A61L27/3817 , A61L27/3852 , A61L27/3895 , A61L27/56 , A61L2400/12 , A61L2430/06 , C08L67/04
摘要： Cartilage has been constructed using biodegradable electrospun polymeric scaffolds seeded with chondrocytes or adult mesenchymal stem cells. More particularly engineered cartilage has been prepared where the cartilage has a biodegradable and biocompatible nanofibrous polymer support prepared by electrospinning and a plurality of chondocytes or mesenchymal stem cells dispersed in the pores of the support. The tissue engineered cartilages of the invention possess compressive strength properties similar to natural cartilage. Methods of preparing engineered tissues, including tissue engineered cartilages, are provided in which an electrospun nanofibrous polymer support is provided, the support is treated with a cell solution and the polymer-cell mixture cultured in a rotating bioreactor to generate the cartilage. The invention provides for the use of the tissue engineered cartilages in the treatment of cartilage degenerative diseases, reconstructive surgery, and cosmetic surgery.
摘要翻译：软骨已经使用生物降解的电纺聚合物支架构建，该支架用软骨细胞或成体间充质干细胞接种。已经制备了更特别工程化的软骨，其中软骨具有通过静电纺丝制备的可生物降解和生物相容的纳米纤维聚合物载体和分散在载体孔中的多个软骨细胞或间充质干细胞。本发明的组织工程软骨具有类似于天然软骨的抗压强度性质。提供了制备工程组织，包括组织工程软骨的方法，其中提供电纺丝纳米纤维聚合物载体，将载体用细胞溶液处理，并将聚合物 - 细胞混合物在旋转的生物反应器中培养以产生软骨。本发明提供组织工程软骨在治疗软骨退行性疾病，重建手术和整容手术中的应用。

73. 发明申请

US20120130098A1 Skin Treatments Containing Carboxylic Acid-Substituted Idebenone Derivatives and Methods of Preparation and Use Thereof 有权
标题翻译：包含羧酸取代的艾地苯醌衍生物的皮肤处理及其制备和使用方法
公开(公告)号：US20120130098A1
公开(公告)日：2012-05-24
申请号：US13349651
申请日：2012-01-13
申请人： Falko Diedrich , Joseph A. Lewis, II , Joseph C. DiNardo , Birgit Neudecker , Eberhard Weiland
发明人： Falko Diedrich , Joseph A. Lewis, II , Joseph C. DiNardo , Birgit Neudecker , Eberhard Weiland
IPC分类号： C07C69/95
CPC分类号： A61K8/37 , A61K8/375 , A61K8/67 , A61K8/671 , A61K8/673 , A61K8/676 , A61K8/678 , A61K8/97 , A61Q17/04 , A61Q19/004 , A61Q19/007 , A61Q19/02 , A61Q19/06 , A61Q19/08 , A61Q19/10 , A61Q90/00 , C07C67/08 , C07C67/14 , C07C67/28 , C07C67/31 , C07C69/67 , C07C69/95 , C07C2601/16 , C07C69/28 , C07C69/675
摘要： The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted idebenone derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.
摘要翻译：本发明涉及新的羧酸取代的艾地苯醌衍生物，含有这些羧酸取代的艾地苯醌衍生物的皮肤处理组合物，通过局部施用这些羧酸取代的艾地苯醌衍生物来治疗皮肤变化的方法及其合成方法。本发明的羧酸取代的艾地苯醌衍生物在治疗皮肤方面是意想不到的，特别是在皮肤耐受性方面。当包含在局部组合物中时，本发明的羧酸取代的艾地苯醌衍生物具有可用于治疗皮肤变化的抗氧化作用。

74. 发明授权

US08066956B2 Delivery of an odor control agent through the use of a presaturated wipe 有权
标题翻译：通过使用预饱和擦拭物来递送气味控制剂
公开(公告)号：US08066956B2
公开(公告)日：2011-11-29
申请号：US11640115
申请日：2006-12-15
申请人： Bao Trong Do , John Gavin MacDonald , Stephanie Michelle Martin , Duane G. Uitenbroek
发明人： Bao Trong Do , John Gavin MacDonald , Stephanie Michelle Martin , Duane G. Uitenbroek
IPC分类号： A61L2/00 , A61L9/00 , C11D17/00
CPC分类号： A61L9/014 , A61K8/0208 , A61K8/19 , A61K8/25 , A61K8/26 , A61K8/28 , A61K8/355 , A61L15/18 , A61L15/46 , A61L2300/102 , A61L2300/108 , A61L2300/216 , A61L2300/802 , A61Q15/00 , A61Q90/00
摘要： A wiping product is disclosed containing an odor control agent. In one embodiment, the wipe may comprise a pre-moistened wipe containing a wiping solution. The wiping solution can contain the odor control agent. The odor control agent may comprise inorganic oxide particles, quinone compounds, or activated carbon particles. The odor control agent can be present in the wipe and can be configured to transfer to an opposing surface. In one embodiment, the pre-moistened wipe can be used during diaper changing to reduce malodors given off by the diaper after being discarded.
摘要翻译：公开了一种含有气味控制剂的擦拭产品。在一个实施例中，擦拭物可以包括含有擦拭溶液的预润湿擦拭物。擦拭液可以含有气味控制剂。气味控制剂可以包含无机氧化物颗粒，醌化合物或活性炭颗粒。气味控制剂可以存在于擦拭物中，并且可以构造成转移到相对的表面。在一个实施例中，可以在尿布更换期间使用预先润湿的擦拭巾，以便在丢弃之后减少由尿布排出的恶臭。

75. 发明申请

US20100061962A1 Tissue Engineered Cartilage, Method of Making Same, Therapeutic and Cosmetic Surgical Applications Using Same 失效
标题翻译：组织工程软骨，相同方法，治疗和美容外科应用使用相同
公开(公告)号：US20100061962A1
公开(公告)日：2010-03-11
申请号：US11922251
申请日：2006-06-15
申请人： Wan-Ju Li
发明人： Wan-Ju Li
IPC分类号： A61L27/38
CPC分类号： A61Q90/00 , A61L27/18 , A61L27/3817 , A61L27/3852 , A61L27/3895 , A61L27/56 , A61L2400/12 , A61L2430/06 , C08L67/04
摘要： Cartilage has been constructed using biodegradable electrospun polymeric scaffolds seeded with chondrocytes or adult mesenchymal stem cells. More particularly engineered cartilage has been prepared where the cartilage has a biodegradable and biocompatible nanofibrous polymer support prepared by electrospinning and a plurality of chondocytes or mesenchymal stem cells dispersed in the pores of the support. The tissue engineered cartilages of the invention possess compressive strength properties similar to natural cartilage. Methods of preparing engineered tissues, including tissue engineered cartilages, are provided in which an electrospun nanofibrous polymer support is provided, the support is treated with a cell solution and the polymer-cell mixture cultured in a rotating bioreactor to generate the cartilage. The invention provides for the use of the tissue engineered cartilages in the treatment of cartilage degenerative diseases, reconstructive surgery, and cosmetic surgery.
摘要翻译：软骨已经使用生物降解的电纺聚合物支架构建，该支架用软骨细胞或成体间充质干细胞接种。已经制备了更特别工程化的软骨，其中软骨具有通过静电纺丝制备的可生物降解和生物相容的纳米纤维聚合物载体和分散在载体孔中的多个软骨细胞或间充质干细胞。本发明的组织工程软骨具有类似于天然软骨的抗压强度性质。提供了制备工程组织，包括组织工程软骨的方法，其中提供电纺丝纳米纤维聚合物载体，将载体用细胞溶液处理，并将聚合物 - 细胞混合物在旋转的生物反应器中培养以产生软骨。本发明提供组织工程软骨在治疗软骨退行性疾病，重建手术和整容手术中的应用。

76. 发明申请

US20090238787A1 ODOUR-REDUCING SUBSTANCES 有权
标题翻译：减少气味的物质
公开(公告)号：US20090238787A1
公开(公告)日：2009-09-24
申请号：US12405730
申请日：2009-03-17
申请人： Anja Finke , Erich Dilk
发明人： Anja Finke , Erich Dilk
IPC分类号： A61K8/37 , A61L11/00 , A61L9/01 , A61Q13/00 , A61Q15/00 , A61K8/34
CPC分类号： A61L9/01 , A61K8/34 , A61K8/375 , A61Q13/00 , A61Q90/00 , C11B9/0019 , D06M13/005 , D06M23/06 , D06M23/12
摘要： The use is described (i)(a) of a single alcohol of formula (1) or (i)(b) of a mixture comprising or consisting of two or more different alcohols of formula (1), wherein in each case one of the two radicals Ra or Rb represents hydrogen and in each case the other radical Ra or Rb represents an acyl radical having 2 to 6 C atoms, for reducing an odour or as an auxiliary for reducing an odour.
摘要翻译：所述用途描述了由式（1）或（i）（b）的单一醇组成或由两种或更多种不同的式（1）的醇组成的混合物，其中在每种情况下为两个基团R a或R b表示氢，并且在每种情况下，另一个基团R a或R b表示具有2至6个C原子的酰基，用于降低气味或作为用于降低气味的辅助剂。

77. 发明申请

US20080280865A1 WATER-IN-OIL TYPE EMULSIFIED COMPOSITION 有权
标题翻译：油 - 油型乳化组合物
公开(公告)号：US20080280865A1
公开(公告)日：2008-11-13
申请号：US12101234
申请日：2008-04-11
申请人： Kazuhiko Tobita
发明人： Kazuhiko Tobita
IPC分类号： A61K8/06 , A61K8/63 , A61Q99/00
CPC分类号： A61K8/44 , A61K8/06 , A61K8/585 , A61Q17/04 , A61Q90/00
摘要： Water-in-oil type emulsified compositions with a high silicone oil content which are excellent in emulsification stability and whose sticky feeling has been improved may be obtained by incorporating a specific (A) N-long chain acyl neutral amino acid ester, (B) a silicone oil, and (C) water therein.
摘要翻译：通过掺入特定的（A）N-长链酰基中性氨基酸酯，（B）可以得到具有优异的乳化稳定性和粘度感改善的高含油量的油包水型乳化组合物，硅油，（C）水。

78. 发明申请

US20080193489A1 Personal Lubricant Compositions That Are Free Of Glycerin and Parabens 审中-公开
标题翻译：不含甘油和对羟基苯甲酸酯的个人润滑剂组合物
公开(公告)号：US20080193489A1
公开(公告)日：2008-08-14
申请号：US11674617
申请日：2007-02-13
申请人： Robert De Armond , Michael B. Halsdorff , Daniel X. Wray
发明人： Robert De Armond , Michael B. Halsdorff , Daniel X. Wray
IPC分类号： A61K31/70 , A61P17/00
CPC分类号： A61K9/0014 , A61K9/0034 , A61K31/047 , A61K31/70 , A61Q90/00
摘要： A stable personal lubricant composition comprising xylitol and excluding glycerin and parabens is provided. In one embodiment, the composition comprises from about 1% to about 15% by weight xylitol; from about 10% to about 35% by weight butylene glycol; from about 5% to about 20% by weight propylene glycol;from about 0.1% to about 1.0% by weight polyquaternium; and from about 50% to about 70% by weight water. Also provided are methods of making and using the personal lubricant compositions comprising xylitol. Packaged kits of the compositions and articles of manufacture including the personal lubricant compositions comprising xylitol also are provided.
摘要翻译：提供了包含木糖醇并且不包括甘油和对羟基苯甲酸酯的稳定的个人润滑剂组合物。在一个实施方案中，组合物包含约1重量％至约15重量％的木糖醇; 约10重量％至约35重量％的丁二醇; 约5％至约20％重量的丙二醇; 约0.1％至约1.0％重量的聚季铵盐; 和约50％至约70％重量的水。还提供了制备和使用包含木糖醇的个人润滑剂组合物的方法。还提供了包含包含木糖醇的个人润滑剂组合物的组合物和制品的包装试剂盒。

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