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    • 71. 发明申请
    • METHODS AND DEVICES FOR TREATING PRIMARY HEADACHE
    • 用于治疗原发性耳鼻喉科的方法和装置
    • US20160121116A1
    • 2016-05-05
    • US14992921
    • 2016-01-11
    • ElectroCore, LLC
    • Bruce J. SimonJoseph P. ErricoJohn T. Raffle
    • A61N1/36A61N1/04
    • A61N1/36021A61N1/0456A61N1/36075A61N1/40A61N2/006A61N2/008A61N2/02
    • Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.
    • 公开了非侵入性电神经刺激装置和磁刺激装置,以及使用由这种装置非侵入性地输送的能量来治疗医学病症的方法。 这些疾病包括偏头痛和其他原发性头痛,例如丛集性头痛,包括类似于免疫介导的反应(“窦”头痛)的窦性症状,而不管这些症状是否由与头痛并发的过敏引起。 所公开的方法还可以用于治疗可能与偏头痛如焦虑症一起并发的其它疾病。 在所公开的方法的优选实施例中,患者的迷走神经中的一个或两个被非侵入性地刺激。 在其它实施方案中,刺激部分交感神经系统和/或肾上腺。
    • 72. 发明授权
    • Automatic anode and cathode fractional control and location to selectively avoid dorsal root stimulation
    • 自动阳极和阴极分数控制和位置选择性地避免背根刺激
    • US09327128B2
    • 2016-05-03
    • US14526031
    • 2014-10-28
    • Boston Scientific Neuromodulation Corporation
    • Emarit A. S. Ranu
    • A61N1/00A61N1/36A61N1/372A61N1/05A61N1/34
    • A61N1/36185A61N1/0553A61N1/36021A61N1/3605A61N1/36071A61N1/37247A61N2001/34
    • A therapeutic neurostimulation system configured for providing therapy to a patient. The neurostimulation system comprises a neurostimulation lead having an array of electrodes arranged along a longitudinal axis configured for being implanted along a spinal cord of a patient, a neurostimulation device configured for delivering electrical stimulation energy to active ones of the electrode array, and control/processing circuitry for instructing the neurostimulation device to configure an active electrode as a cathode, and two active electrodes longitudinally flanking and laterally offset from the cathode as anodes, selecting a ratio of stimulation amplitude values for the two anodes based on a known longitudinal location of the implanted neurostimulation lead relative to the spinal cord, and instructing the neurostimulation device to distribute the electrical stimulation energy between the two anodes in accordance with the selected stimulation amplitude value ratio.
    • 治疗性神经刺激系统,被配置为向患者提供治疗。 神经刺激系统包括神经刺激引线,其具有沿着构造用于沿着患者的脊髓植入的纵向轴线布置的电极阵列,被配置为将电刺激能量传递到电极阵列中的有效参数的神经刺激装置,以及控制/处理 用于指示神经刺激装置将活性电极配置为阴极的电路,以及作为阳极纵向侧向和横向偏离阴极的两个活性电极,基于植入的已知纵向位置选择两个阳极的刺激振幅值的比率 神经刺激导联相对于脊髓,并且指示神经刺激装置根据所选择的刺激振幅值比在两个阳极之间分配电刺激能量。
    • 73. 发明申请
    • MEDICAL ELECTRONIC DEVICE
    • 医疗电子设备
    • US20160096023A1
    • 2016-04-07
    • US14873032
    • 2015-10-01
    • GiMer Medical Co., Ltd.
    • Jian-Hao PANChi-Heng CHANG
    • A61N1/36A61N1/378A61N1/05A61N1/372H02J7/02H02J7/04
    • A61N1/36071A61N1/0551A61N1/36021A61N1/37247A61N1/378A61N1/3787H02J7/025H02J7/04
    • A medical electronic device comprises at least a battery module, a detector for detecting the remaining battery of the battery module to generate a detection signal, a processor generating a first status information according to the detection signal, a transceiver and a function circuit. The processor transmits and receives the first status information and the control signal by the transceiver. The function circuit is electrically connected to the processor and at least an electrode. The electrode extends outward from the medical electronic device. According to the control signal, the processor controls the function circuit to output an electrical stimulation signal with default stimulation frequency, stimulation cycle and stimulation intensity to the electrode. The voltage of the electrical stimulation signal ranges from −10V to −1V and from 1V to 10V, and the frequency of the electrical stimulation signal is between 200 KHz and 800 KHz.
    • 医疗电子设备至少包括电池模块,用于检测电池模块的剩余电池以产生检测信号的检测器,根据检测信号产生第一状态信息的处理器,收发器和功能电路。 处理器通过收发器发送和接收第一状态信息和控制信号。 功能电路电连接到处理器和至少一个电极。 电极从医疗电子设备向外延伸。 根据控制信号,处理器控制功能电路输出具有默认刺激频率,刺激周期和对电极的刺激强度的电刺激信号。 电刺激信号的电压范围为-10V至-1V,1V至10V,电刺激信号的频率为200KHz至800KHz。
    • 80. 发明授权
    • Systems and methods for the treatment of pain through neural fiber stimulation
    • 通过神经纤维刺激治疗疼痛的系统和方法
    • US09248289B2
    • 2016-02-02
    • US14336586
    • 2014-07-21
    • SPR Therapeutics, LLC
    • Maria E. BennettJoseph W. Boggs, IIWarren M. GrillJohn Chae
    • A61N1/34A61N1/36
    • A61N1/36071A61N1/36003A61N1/36017A61N1/36021A61N1/36057A61N1/36139
    • Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.
    • 本发明的实施方案提供了通过激活选择性神经纤维来治疗疼痛的系统和方法。 神经纤维可以包含一个或多个传入神经纤维和/或一个或多个传出神经纤维。 如果传入纤维被单独或与传出纤维组合刺激,则施用治疗有效量的电刺激以以接近自然传入活性的方式激活传入途径。 传入纤维可能与肌肉锭,高尔基体腱器官,肌肉锭子的次要受体,关节受体,触觉受体和其他类型的机械感受器和/或本体感受器的主要受体相关联。 如果传出纤维被单独或与传入纤维组合刺激,则施加治疗有效量的电刺激以激活内部和/或外部肌肉纤维,这导致与其相关联的传入纤维的间接活化。