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71. 发明授权

US09492428B2 Compounds, compositions, pharmaceutical compositions, and methods of use 有权
标题翻译：化合物，组合物，药物组合物和使用方法
公开(公告)号：US09492428B2
公开(公告)日：2016-11-15
申请号：US14358731
申请日：2012-11-16
申请人： University of Louisville Research Foundation, Inc. , Cayetano Heredia University
发明人： Gerald B. Hammond , Zhuang Jin , Paula J. Bates , Elsa Merit Reyes-Reyes , Abraham Vaisberg
IPC分类号： A61K31/366 , A61K36/81
CPC分类号： A61K31/366 , A61K36/81
摘要： Certain embodiments of the invention include compositions comprising a compound of Formula (I), and salts, isomers, and derivatives thereof. Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I), and salts, isomers, and derivatives thereof. Other embodiments of this invention include methods for treating disease (e.g., cancer) and methods for administering a compound of Formula (I), and salts, isomers, and derivatives thereof.
摘要翻译：本发明的某些实施方案包括包含式（I）化合物及其盐，异构体及其衍生物的组合物。本发明一些实施方案的药物组合物包含式（I）化合物及其盐，异构体及其衍生物。本发明的其它实施方案包括治疗疾病（例如癌症）的方法和给予式（I）化合物及其盐，异构体及其衍生物的方法。

72. 发明授权

US09463019B2 Trocar site closure assembly 有权
标题翻译：套管针座闭合装配
公开(公告)号：US09463019B2
公开(公告)日：2016-10-11
申请号：US14279765
申请日：2014-05-16
申请人： University of Louisville Research Foundation, Inc.
发明人： Daniel S. Metzinger , Robert S. Keynton , Scott D. Cambron
IPC分类号： A61B17/08 , A61D1/00 , A61B17/00
CPC分类号： A61B17/08 , A61B17/0057 , A61B2017/00592 , A61B2017/00619 , A61B2017/00623 , A61B2017/00637 , A61B2017/081
摘要： Embodiments of this invention relate to trocar site closures including a head with a plurality of arm receiving passages therethrough, an arm received by each of the passages, each passage having a discontinuity which allows each arm to be pulled inward but deters outward movement, and each arm having a grappling portion. The head and arms are inserted into a patient wound, such as a trocar site. The arms engage with tissue surrounding the wound. A pulling force is exerted on the arm proximal ends, drawing the distal ends of the arms toward the head and at least partially closing the wound. The head and at least a portion of the arms remain in the patient, and are preferably made of a biocompatible material. Embodiments of this invention also relate to an insertion device used to insert the closure into the wound and at least partially close the wound.
摘要翻译：本发明的实施例涉及套管针位置闭合，其包括具有多个臂接收通道的头部，由每个通道接收的臂，每个通道具有不连续性，其允许每个臂向内拉动但阻止向外移动，并且每个臂具有抓钩部分。头部和手臂插入患者伤口，如套管针部位。手臂与伤口周围的组织接合。牵引力作用在臂的近端，将臂的远端朝头部拉出并且至少部分地闭合伤口。头部和至少一部分臂保持在患者体内，并且优选地由生物相容性材料制成。本发明的实施例还涉及用于将闭合件插入伤口并且至少部分地闭合伤口的插入装置。

73. 发明授权

US09386960B2 Multimodal cardiac phantom for imaging 有权
标题翻译：用于成像的多峰心脏模型
公开(公告)号：US09386960B2
公开(公告)日：2016-07-12
申请号：US14021756
申请日：2013-09-09
申请人： University of Louisville Research Foundation, Inc.
发明人： Vahid Tavakoli , Amir A. Amini
IPC分类号： G09B23/28 , A61B6/00 , A61B5/055 , A61B8/00 , G01R33/58 , A61B5/00
CPC分类号： A61B6/583 , A61B5/0044 , A61B5/055 , A61B5/7285 , A61B8/587 , G01R33/58
摘要： A multimodal cardiac phantom has a body structure with a shape and properties that mimic the elasticity, ultrasound, and magnetic properties of cardiac tissue. The multimodal cardiac phantom is advantageously produced from a polymer such as polyvinyl alcohol. The polyvinyl alcohol may include magnetic resonance imaging (MRI) markers and ultrasound markers. The multimodal cardiac phantom can be used to evaluate and to configure apparatuses for imagining cardiac tissue.
摘要翻译：多峰心脏体模具有体模结构，具有模拟心脏组织的弹性，超声和磁性的形状和性质。多峰心脏模型有利地由聚合物如聚乙烯醇制成。聚乙烯醇可以包括磁共振成像（MRI）标记物和超声标记物。多模态心脏模型可用于评估和配置用于想象心脏组织的装置。

74. 发明授权

US09383364B2 Predictive marker of DNMT1 inhibitor therapeutic efficacy and methods of using the marker 有权
标题翻译： DNMT1抑制剂的预测标记治疗效果及使用标记的方法
公开(公告)号：US09383364B2
公开(公告)日：2016-07-05
申请号：US14003714
申请日：2012-03-07
申请人： Paula J. Bates , Mohammad Tariq Malik , Francesca R. Salipur
发明人： Paula J. Bates , Mohammad Tariq Malik , Francesca R. Salipur
IPC分类号： A61K31/215 , A61K31/22 , G01N33/574 , C12Q1/68 , A61K31/045 , C07K16/18 , G01N33/53
CPC分类号： G01N33/5748 , A61K31/045 , C07K16/18 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/53
摘要： Provided herein are methods for predicting efficacy of a DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibitor treatment in a subject having a cancer, methods of identifying a subject having a cancer that is more likely to respond to a DNMT1 inhibitor treatment, and methods of selecting a treatment for a subject having a cancer that include determining a level of SOX9 in a sample containing cells from a subject having a cancer. Also provided are methods of treating a subject having a cancer that include selectively administering a DNMT1 inhibitor to a subject having cancer determined to have an elevated level of SOX9 in a sample containing cells from the subject compared to a reference level. Also provided are antibodies and antigen-binding antibody fragments that specifically bind to SOX9, and nucleic acid sequences that contain at least 10 nucleotides complementary to a contiguous sequence present in a SOX9 nucleic acid for use in these methods.
摘要翻译：本文提供了用于预测患有癌症的受试者中DNA（胞嘧啶-5） - 甲基转移酶1（DNMT1）抑制剂治疗的功效的方法，鉴定具有更可能对DNMT1抑制剂治疗有反应的癌症的受试者的方法，以及选择具有癌症的受试者的治疗方法，所述方法包括测定含有患有癌症的受试者的细胞的样品中的SOX9的水平。还提供了治疗患有癌症的受试者的方法，所述方法包括在与参考水平相比的含有来自所述受试者的细胞的样品中确定具有升高的SOX9水平的患者中选择性施用DNMT1抑制剂。还提供了特异性结合SOX9的抗体和抗原结合抗体片段，以及与SOX9核酸中存在的连续序列互补的至少10个核苷酸的核酸序列，用于这些方法。

75. 发明授权

US09230320B2 Computer aided diagnostic system incorporating shape analysis for diagnosing malignant lung nodules 有权
标题翻译：计算机辅助诊断系统，结合形状分析诊断恶性肺结节
公开(公告)号：US09230320B2
公开(公告)日：2016-01-05
申请号：US13833333
申请日：2013-03-15
申请人： University of Louisville Research Foundation, Inc.
发明人： Ayman S. El-Baz , Matthew Nitzken
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T2207/10081 , G06T2207/20081 , G06T2207/30064
摘要： A computer aided diagnostic system and automated method diagnose lung cancer through modeling and analyzing the shape of pulmonary nodules. A model used in such analysis describes the shape of pulmonary nodules in terms of spherical harmonics required to delineate a unit sphere corresponding to the pulmonary nodule to a model of the pulmonary nodule.
摘要翻译：计算机辅助诊断系统和自动化方法通过建模和分析肺结节的形状来诊断肺癌。在这种分析中使用的模型将肺结节的形状描述为将对应于肺结节的单位球划定为肺结节模型所需的球谐函数。

76. 发明授权

US09227002B1 Systems and methods for providing cavopulmonary support 有权
标题翻译：用于提供肺肺支持的系统和方法
公开(公告)号：US09227002B1
公开(公告)日：2016-01-05
申请号：US14304614
申请日：2014-06-13
申请人： University of Louisville Research Foundation, Inc.
发明人： Guruprasad A. Giridharan , Steven C. Koenig , Michael A. Sobieski , Palaniappan Sethu , Mark D. Rodefeld
IPC分类号： A61N1/362 , A61M1/12
CPC分类号： A61M1/122 , A61M1/1005 , A61M1/1039 , A61M1/106 , A61M1/1067 , A61M1/107 , A61M1/1086 , A61M1/12 , A61M2205/3334
摘要： Systems and methods for providing cavopulmonary support to a subject are provided that include and make use of a first inflatable extravascular cuff configured to be placed around a superior vena cava in the subject and a second inflatable extravascular cuff configured to be placed around an inferior vena cava in the subject. The system further includes a pump that is operably connected to both the first inflatable extravascular cuff and the second inflatable extravascular cuff, as well as a controller that is in communication with the pump. The controller receives one or more user-defined parameters and, in response to the user-defined parameters, independently controls the inflation and deflation of the first inflatable extravascular cuff and the second inflatable extravascular cuff to provide cavopulmonary support.
摘要翻译：提供了用于向受试者提供气肺支持的系统和方法，其包括并利用构造成围绕受试者的上腔静脉放置的第一可充气血管外套，以及构造成围绕下腔静脉放置的第二可充气血管外套在主题。该系统还包括可操作地连接到第一可充气血管外箍和第二可膨胀血管外套的泵以及与泵连通的控制器。所述控制器接收一个或多个用户定义的参数，并且响应于所述用户定义的参数，独立地控制所述第一可膨胀血管外套和所述第二可膨胀血管外套的充气和放气以提供空气肺支持。

77. 发明申请

US20150361241A1 STIMULI-RESPONSIVE POLYMER COMPOSITES 审中-公开
标题翻译：刺激性聚合物复合材料
公开(公告)号：US20150361241A1
公开(公告)日：2015-12-17
申请号：US14766612
申请日：2014-02-07
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
发明人： James Loomis , Balaji Panchapakesan
IPC分类号： C08J9/228 , H01C7/00 , H05K1/02 , H05K1/16
CPC分类号： C08J9/228 , C08J2203/22 , C08J2333/20 , C08J2383/04 , C08K3/01 , C08K7/22 , C08K7/24 , C08K9/10 , C08K2201/011 , C08L83/04 , H01C7/008 , H05K1/028 , H05K1/0283 , H05K1/167
摘要： A polymer composite is provided that includes a plurality of heat-absorbing nanomaterials, a plurality of thermally-expanding microspheres, and an elastomeric matrix. In the polymer composite, the heat-absorbing nanomaterials and the thermally-expanding microspheres are dispersed within the elastomeric matrix such that the thermally-expanding microspheres expand and stretch the matrix upon exposure to a thermal stimulus. Methods of forming a thermally-expanding polymer composite are also provided and include the steps of dispersing a plurality of heat-absorbing nanomaterials in an evaporative solvent; combining the dispersion with an amount of an elastomeric material to create a mixture; adding an amount of thermally-expanding microspheres to the mixture; and polymerizing the mixture. Circuits including resistors comprised of the polymer composites are further provided.
摘要翻译：提供了一种聚合物复合材料，其包括多个吸热纳米材料，多个热膨胀微球体和弹性体基体。在聚合物复合材料中，吸热纳米材料和热膨胀微球分散在弹性体基体内，使得热膨胀微球在暴露于热刺激时膨胀和拉伸基体。还提供了形成热膨胀聚合物复合材料的方法，包括将多种吸热纳米材料分散在蒸发溶剂中的步骤; 将分散体与一定量的弹性体材料组合以产生混合物; 向混合物中加入一定量的热膨胀微球; 并使该混合物聚合。还提供了包括由聚合物复合材料组成的电阻器的电路。

78. 发明授权

US09181586B2 Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms 有权
标题翻译：使用串联单核苷酸多态性检测胎儿染色体异常
公开(公告)号：US09181586B2
公开(公告)日：2015-11-10
申请号：US13714242
申请日：2012-12-13
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION
发明人： Aoy Tomita Mitchell , Michael Mitchell
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172 , Y10T436/143333
摘要： The invention provides tandem single nucleotide polymorphisms and methods for their use, for example, in diagnosing Down Syndrome.
摘要翻译：本发明提供串联单核苷酸多态性及其使用方法，例如诊断唐氏综合征。

79. 发明授权

US09162987B2 Iodo pyrimidine derivatives useful for the treatment of macrophage migration inhibitory factor (MIF)-implicated diseases and conditions 有权
标题翻译：碘代嘧啶衍生物可用于治疗巨噬细胞迁移抑制因子（MIF）的重要疾病和病症
公开(公告)号：US09162987B2
公开(公告)日：2015-10-20
申请号：US13498036
申请日：2010-09-24
申请人： Robert A. Mitchell , John O. Trent , Pooran Chand , Gilles Hugues Tapolsky
发明人： Robert A. Mitchell , John O. Trent , Pooran Chand , Gilles Hugues Tapolsky
IPC分类号： C07D239/02 , A01N43/54 , A61K31/505 , C07D239/30 , C07D239/38 , C07D239/42 , C07D401/04 , C07D405/04 , C07D409/04
CPC分类号： C07D239/30 , C07D239/38 , C07D239/42 , C07D401/04 , C07D405/04 , C07D409/04
摘要： Compounds useful for the inhibition of macrophage migration inhibitory factor (MIF) are provided herein, having the Formula (I): wherein A is selected from the group consisting of aromatic or non-aromatic rings, bicyclic rings, polycyclic rings, alkenes or alkynes; B is H, OH, OR, SR, NH2, NHR, or alkyl; R is H or alkyl, and X and Y are independently N or CH, but one of X and Y must be N. Also provided are pharmaceutical compositions comprising a Formula I compound and methods for the treatment of MIF-implicated diseases or conditions, comprising administering a safe and effective amount of a Formula I compound.
摘要翻译：本文提供了可用于抑制巨噬细胞迁移抑制因子（MIF）的化合物，其具有式（I）：其中A选自芳族或非芳族环，双环，多环，烯烃或炔烃; B是H，OH，OR，SR，NH 2，NHR或烷基; R是H或烷基，X和Y独立地是N或CH，但是X和Y中的一个必须是N.还提供了包含式I化合物的药物组合物和用于治疗MIF牵连的疾病或病症的方法，包括施用安全有效量的式I化合物。

80. 发明授权

US09090874B2 Olfactory epithelial-derived stem cells and methods of use therefor 有权
标题翻译：嗅上皮衍生的干细胞及其使用方法
公开(公告)号：US09090874B2
公开(公告)日：2015-07-28
申请号：US13127142
申请日：2009-11-02
申请人： Fred J. Roisen , Chengliang Lu , Meng Wang , Mengsheng Qiu
发明人： Fred J. Roisen , Chengliang Lu , Meng Wang , Mengsheng Qiu
IPC分类号： C12N5/0793 , A61K35/12
CPC分类号： C12N5/0619 , A61K35/12 , C12N2501/01 , C12N2501/38 , C12N2501/385 , C12N2501/41 , C12N2501/60 , C12N2510/00
摘要： The presently disclosed subject matter provides recombinant dopaminergic neurons and/or recombinant progenitors thereof that include one or more transgenes encoding a nurr-1 polypeptide, a pitx3 polypeptide, an Imxi a polypeptide, a biologically active fragment thereof, a biologically active derivative thereof, and/or any combination thereof. Also provided are methods for producing a recombinant dopaminergic neuron or recombinant progenitor thereof, methods for producing lineage primed cells, methods for ameliorating at least one symptom associated with a neurological disorder, methods for transplantation, methods for inducing growth, repair, ancllor regeneration of a neuron, for delivering a cytokine or a growth factor to the central nervous system, methods for providing a dopaminergic neuron function, and cell cultures that include recombinant olfactory epithelial-derived stem cells and/or a differentiated derivatives thereof.
摘要翻译：目前公开的主题提供了重组多巴胺能神经元和/或其重组祖细胞，其包含编码Nurr-1多肽，pitx3多肽，Imxi一种多肽，其生物活性片段，其生物活性衍生物的一种或多种转基因，和 /或其任何组合。还提供了用于产生重组多巴胺能神经元或其重组祖细胞的方法，用于产生谱系引发细胞的方法，用于改善与神经障碍相关的至少一种症状的方法，用于移植的方法，诱导生长的方法，修复，祖细胞再生用于将细胞因子或生长因子递送至中枢神经系统的神经元，用于提供多巴胺能神经元功能的方法，以及包含重组嗅上皮来源的干细胞和/或其分化衍生物的细胞培养物。

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