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71. 发明授权

US09162987B2 Iodo pyrimidine derivatives useful for the treatment of macrophage migration inhibitory factor (MIF)-implicated diseases and conditions 有权
标题翻译：碘代嘧啶衍生物可用于治疗巨噬细胞迁移抑制因子（MIF）的重要疾病和病症
公开(公告)号：US09162987B2
公开(公告)日：2015-10-20
申请号：US13498036
申请日：2010-09-24
申请人： Robert A. Mitchell , John O. Trent , Pooran Chand , Gilles Hugues Tapolsky
发明人： Robert A. Mitchell , John O. Trent , Pooran Chand , Gilles Hugues Tapolsky
IPC分类号： C07D239/02 , A01N43/54 , A61K31/505 , C07D239/30 , C07D239/38 , C07D239/42 , C07D401/04 , C07D405/04 , C07D409/04
CPC分类号： C07D239/30 , C07D239/38 , C07D239/42 , C07D401/04 , C07D405/04 , C07D409/04
摘要： Compounds useful for the inhibition of macrophage migration inhibitory factor (MIF) are provided herein, having the Formula (I): wherein A is selected from the group consisting of aromatic or non-aromatic rings, bicyclic rings, polycyclic rings, alkenes or alkynes; B is H, OH, OR, SR, NH2, NHR, or alkyl; R is H or alkyl, and X and Y are independently N or CH, but one of X and Y must be N. Also provided are pharmaceutical compositions comprising a Formula I compound and methods for the treatment of MIF-implicated diseases or conditions, comprising administering a safe and effective amount of a Formula I compound.
摘要翻译：本文提供了可用于抑制巨噬细胞迁移抑制因子（MIF）的化合物，其具有式（I）：其中A选自芳族或非芳族环，双环，多环，烯烃或炔烃; B是H，OH，OR，SR，NH 2，NHR或烷基; R是H或烷基，X和Y独立地是N或CH，但是X和Y中的一个必须是N.还提供了包含式I化合物的药物组合物和用于治疗MIF牵连的疾病或病症的方法，包括施用安全有效量的式I化合物。

72. 发明授权

US09090874B2 Olfactory epithelial-derived stem cells and methods of use therefor 有权
标题翻译：嗅上皮衍生的干细胞及其使用方法
公开(公告)号：US09090874B2
公开(公告)日：2015-07-28
申请号：US13127142
申请日：2009-11-02
申请人： Fred J. Roisen , Chengliang Lu , Meng Wang , Mengsheng Qiu
发明人： Fred J. Roisen , Chengliang Lu , Meng Wang , Mengsheng Qiu
IPC分类号： C12N5/0793 , A61K35/12
CPC分类号： C12N5/0619 , A61K35/12 , C12N2501/01 , C12N2501/38 , C12N2501/385 , C12N2501/41 , C12N2501/60 , C12N2510/00
摘要： The presently disclosed subject matter provides recombinant dopaminergic neurons and/or recombinant progenitors thereof that include one or more transgenes encoding a nurr-1 polypeptide, a pitx3 polypeptide, an Imxi a polypeptide, a biologically active fragment thereof, a biologically active derivative thereof, and/or any combination thereof. Also provided are methods for producing a recombinant dopaminergic neuron or recombinant progenitor thereof, methods for producing lineage primed cells, methods for ameliorating at least one symptom associated with a neurological disorder, methods for transplantation, methods for inducing growth, repair, ancllor regeneration of a neuron, for delivering a cytokine or a growth factor to the central nervous system, methods for providing a dopaminergic neuron function, and cell cultures that include recombinant olfactory epithelial-derived stem cells and/or a differentiated derivatives thereof.
摘要翻译：目前公开的主题提供了重组多巴胺能神经元和/或其重组祖细胞，其包含编码Nurr-1多肽，pitx3多肽，Imxi一种多肽，其生物活性片段，其生物活性衍生物的一种或多种转基因，和 /或其任何组合。还提供了用于产生重组多巴胺能神经元或其重组祖细胞的方法，用于产生谱系引发细胞的方法，用于改善与神经障碍相关的至少一种症状的方法，用于移植的方法，诱导生长的方法，修复，祖细胞再生用于将细胞因子或生长因子递送至中枢神经系统的神经元，用于提供多巴胺能神经元功能的方法，以及包含重组嗅上皮来源的干细胞和/或其分化衍生物的细胞培养物。

73. 发明授权

US09079976B2 Immunostimulatory compositions and methods 有权
公开(公告)号：US09079976B2
公开(公告)日：2015-07-14
申请号：US13227162
申请日：2011-09-07
申请人： Haval Shirwan , Kutlu G. Elpek , Esma S. Yolcu
发明人： Haval Shirwan , Kutlu G. Elpek , Esma S. Yolcu
IPC分类号： C07K14/70 , A61K39/00 , A61K45/06 , A61K47/48 , C12N5/00 , A61K39/12 , C07K14/705 , B82Y5/00 , A61K38/00
CPC分类号： C07K14/70532 , A61K38/00 , A61K39/0011 , A61K39/12 , A61K45/06 , A61K47/646 , A61K47/665 , A61K2039/5152 , A61K2039/5154 , A61K2039/5158 , A61K2039/55516 , A61K2039/585 , A61K2039/6031 , A61K2039/625 , B82Y5/00 , C07K14/70575 , C12N5/0012 , C12N2710/20034 , C12N2760/16134 , Y02A50/41 , Y02A50/412 , Y02A50/492 , A61K2300/00
摘要： The invention provides conjugates comprising an immune co-stimulatory polypeptide and an antigen or infectious agent. The conjugates are useful for generating or enhancing an immune response against the antigen or infectious agent. The invention also provides immune cells modified with a conjugate that are useful for generating or enhancing an immune response to an antigen or infectious agent. The invention also provides immunostimulatory moieties comprising an immune co-stimulatory polypeptide that are useful for stimulating an immune response. The invention also provides immunotherapy methods and methods of treating or preventing infections.

74. 发明授权

US09068004B2 TWEAK/Fn14 system regulates skeletal muscle atrophy and regeneration 有权
标题翻译： TWEAK / Fn14系统调节骨骼肌萎缩和再生
公开(公告)号：US09068004B2
公开(公告)日：2015-06-30
申请号：US13576838
申请日：2011-02-04
申请人： Ashok Kumar
发明人： Ashok Kumar
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/2875 , C07K2317/76
摘要： The invention provides methods for preventing loss and augmenting regeneration of skeletal muscle by decreasing the activity of the TWEAK/Fn14 system.
摘要翻译：本发明提供了通过降低TWEAK / Fn14系统的活性来防止骨骼肌损失和增强再生的方法。

75. 发明授权

US08999984B2 Macrophage migration inhibitory factor antagonists and methods of using same 有权
标题翻译：巨噬细胞迁移抑制因子拮抗剂及其使用方法
公开(公告)号：US08999984B2
公开(公告)日：2015-04-07
申请号：US12301783
申请日：2007-05-24
申请人： Robert A. Mitchell , John O. Trent , Jason B. Meier
发明人： Robert A. Mitchell , John O. Trent , Jason B. Meier
IPC分类号： A01N43/58 , A61K31/50 , A01N43/60 , A61K31/495 , A01N43/54 , C07D239/42 , C07D401/04 , C07D471/04 , C07D471/22 , C07D487/04 , A01N43/90 , A61K31/517 , A61K31/519 , A61K31/513
CPC分类号： A61K31/513
摘要： Methods of inhibiting one or more biological activities of Macrophage migration inhibitory factor (MIF) polypeptides are provided using an MIF inhibitory compound. The methods include therapeutic methods for treating cancers and inflammatory diseases.
摘要翻译：使用MIF抑制化合物提供抑制巨噬细胞迁移抑制因子（MIF）多肽的一种或多种生物活性的方法。该方法包括治疗癌症和炎性疾病的治疗方法。

76. 发明授权

US08965069B2 Three dimensional minutiae extraction in three dimensional scans 有权
标题翻译：三维细节提取三维扫描
公开(公告)号：US08965069B2
公开(公告)日：2015-02-24
申请号：US13631041
申请日：2012-09-28
申请人： University of Louisville Research Foundation, Inc.
发明人： Tamer Inanc , Sara Shafaei
IPC分类号： G06K9/00 , G06K9/54
CPC分类号： G06K9/00073 , G06K9/036
摘要： A system and method extract a plurality of three dimensional identification minutiae from a three dimensional image of a biometric identification feature. The extracted three dimensional identification minutiae from the three dimensional image may be compared to one or more sets of three dimensional identification minutiae to determine an identification and/or confirm an identification. In a preferred embodiment, the system and method extract three dimensional identification minutiae from a three dimensional image of a fingerprint, and compare the extracted three dimensional identification minutiae from the fingerprint to one or more sets of three dimensional identification minutiae associated with previously classified fingerprints to determine and/or confirm an identification.
摘要翻译：系统和方法从生物识别特征的三维图像中提取多个三维识别细节。可以将来自三维图像的提取的三维识别细节与一组或多组三维识别细节进行比较，以确定识别和/或确认识别。在优选实施例中，系统和方法从指纹的三维图像中提取三维识别细节，并将提取的三维识别细节与指纹相关联的一组或多组三维识别细节与先前分类的指纹相关联确定和/或确认识别。

77. 发明申请

US20140343603A1 TROCAR SITE CLOSURE ASSEMBLY 有权
公开(公告)号：US20140343603A1
公开(公告)日：2014-11-20
申请号：US14279765
申请日：2014-05-16
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
发明人： Daniel S. Metzinger , Robert S. Keynton , Scott D. Cambron
IPC分类号： A61B17/08
CPC分类号： A61B17/08 , A61B17/0057 , A61B2017/00592 , A61B2017/00619 , A61B2017/00623 , A61B2017/00637 , A61B2017/081
摘要： Disclosed herein are trocar site closures, comprising a head with a plurality of arm receiving passages therethrough, an arm received by each of the passages, each passage having a discontinuity which allows each arm to be pulled inward but deters outward movement, and each arm having a grappling portion. The head and arms are inserted into a patient wound, such as a trocar site. The arms engage with tissue surrounding the wound. A pulling force is exerted on the arm proximal ends, drawing the distal ends of the arms toward the head and at least partially closing the wound. The head and at least a portion of the arms remain in the patient, and are preferably made of a biocompatible material. Also disclosed herein is an insertion device used to insert the closure into the wound and at least partially close the wound.
摘要翻译：本文公开了一种套管针关闭装置，其包括具有穿过其中的多个臂接收通道的头部，由每个通道容纳的臂，每个通道具有允许每个臂向内拉以阻止向外运动的不连续性，并且每个臂具有抓钩部分。头部和手臂插入患者伤口，如套管针部位。手臂与伤口周围的组织接合。牵引力作用在臂的近端，将臂的远端朝头部拉出并且至少部分地闭合伤口。头部和至少一部分臂保持在患者体内，并且优选地由生物相容性材料制成。本文还公开了用于将闭合件插入伤口并且至少部分地闭合伤口的插入装置。

78. 发明申请

US20140308212A1 EDIBLE PLANT-DERIVED MICROVESICLE COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF DISEASE 审中-公开
标题翻译：食用植物衍生的微波组合物，用于诊断和治疗疾病
公开(公告)号：US20140308212A1
公开(公告)日：2014-10-16
申请号：US14356853
申请日：2012-09-20
申请人： University of Louisville Research Foundation, Inc.
发明人： Huang-Ge Zhang
IPC分类号： A61K9/48 , A61K47/46 , A61K45/06 , A61K31/713 , A61K31/519 , A61K31/337 , A61K49/00 , A61K31/12
CPC分类号： A61K9/4816 , A61K31/12 , A61K31/337 , A61K31/519 , A61K31/713 , A61K36/752 , A61K36/81 , A61K36/87 , A61K45/06 , A61K47/46 , A61K49/0004 , A61K49/005
摘要： Compositions comprising a therapeutic agent encapsulated by an edible plant-derived microvesicle are provided. Methods of treating an inflammatory disorder and methods of treating a cancer are further provided and include administering an effective amount of a composition comprising a therapeutic agent encapsulated by an edible plant-derived microvesicle to a subject. Further provided are methods of diagnosing a colon cancer that include the steps of administering an edible plant-derived microvesicle incorporating a detectable label to a subject and then determining an amount of the detectable label in an intestine of the subject.
摘要翻译：提供了包含由食用植物衍生的微泡包封的治疗剂的组合物。进一步提供治疗炎性疾病的方法和治疗癌症的方法，包括向受试者施用有效量的包含由食用植物来源的微囊包封的治疗剂的组合物。进一步提供了诊断结肠癌的方法，其包括向受试者施用掺有可检测标记的可食用植物来源的微泡，然后确定受试者肠中可检测标记的量。

79. 发明授权

US08858995B2 Methods and compositions for controlled delivery of phytochemical agents 有权
标题翻译：用于控制输送植物化学试剂的方法和组合物
公开(公告)号：US08858995B2
公开(公告)日：2014-10-14
申请号：US13429601
申请日：2012-03-26
申请人： Ramesh C. Gupta , Manicka V. Vadhanam , Farrukh Aqil
发明人： Ramesh C. Gupta , Manicka V. Vadhanam , Farrukh Aqil
IPC分类号： A61K9/26 , A61K47/40 , A61K45/06 , A61K31/121 , A61K9/00 , A61K36/82 , A61K31/05 , A61K31/366 , A61K36/235 , A61K47/10 , A61K47/34 , A61K31/404 , A61K31/01 , A61K36/9066 , A61K31/497
CPC分类号： A61K9/0036 , A61K9/0024 , A61K31/01 , A61K31/05 , A61K31/121 , A61K31/366 , A61K31/404 , A61K31/497 , A61K36/235 , A61K36/82 , A61K36/9066 , A61K45/06 , A61K47/10 , A61K47/34 , A61K47/40 , A61K2300/00
摘要： Compositions are provided that comprises a biocompatible polymeric matrix incorporating an effective amount of a phytochemical agent, a combination of phytochemical agents, or a phytochemical agent and one or more additional therapeutic agents. Methods of treating a cancer using the compositions are further provided.
摘要翻译：提供了组合物，其包含结合有效量的植物化学试剂，植物化学试剂或植物化学试剂和一种或多种另外的治疗剂的组合的生物相容性聚合物基质。进一步提供使用该组合物治疗癌症的方法。

80. 发明申请

US20140303170A1 COMPOUNDS FOR TREATING DISEASE, FOR ADMINISTERING, AND FOR PHARMACEUTICAL COMPOSITIONS 有权
标题翻译：用于治疗疾病，管理和药物组合物的化合物
公开(公告)号：US20140303170A1
公开(公告)日：2014-10-09
申请号：US14289712
申请日：2014-05-29
申请人： University of Louisville Research Foundation, Inc.
发明人： John O. Trent , Jason B. Meier , Kelby B. Napier
IPC分类号： C07D403/12 , C07D217/24
CPC分类号： C07D403/12 , A61K31/132 , A61K31/335 , A61K31/4015 , A61K31/4045 , A61K31/41 , A61K31/4184 , A61K31/4188 , A61K31/4196 , A61K31/454 , A61K31/47 , A61K31/472 , A61K31/473 , A61K31/4965 , A61K31/498 , A61K31/4985 , C07D217/24
摘要： Some embodiments of this invention include methods for treating disease and methods for administering a compound of Formula (I). In some aspects of the invention, diseases can be treated by administration of compositions comprising a compound of Formula (I). Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I).
摘要翻译：本发明的一些实施方案包括治疗疾病的方法和给予式（I）化合物的方法。在本发明的一些方面，可以通过给予包含式（I）化合物的组合物来治疗疾病。本发明一些实施方案的药物组合物包含式（I）的化合物。

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