专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明授权

US08372422B2 Hydroxyapatite-targeting poly(ethylene glycol) and related polymers 有权
标题翻译：羟基磷灰石靶向聚（乙二醇）和相关聚合物
公开(公告)号：US08372422B2
公开(公告)日：2013-02-12
申请号：US12899521
申请日：2010-10-06
申请人： Antoni Kozlowski , Michael J. Roberts
发明人： Antoni Kozlowski , Michael J. Roberts
IPC分类号： A61F2/00 , A61K31/74 , A61K31/00 , A61K47/48 , A61K31/79
CPC分类号： A61K47/18 , A61K31/715 , A61K47/24 , A61K47/60 , C08G65/329 , C08G65/3353 , C08L2203/02
摘要： Isolatable, hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are provided. The polymeric structure includes a linear or branched water-soluble and non-peptidic polymer backbone, such as a PEG backbone, having at least two termini, a first terminus being covalently bonded to a hydroxyapatite-targeting moiety, such as a bisphosphonate, and a second terminus covalently bonded to a chemically reactive group, wherein said chemically reactive group is protected or unprotected. Methods of preparing and using hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are also provided.
摘要翻译：提供可分离的羟基磷灰石靶向聚合物结构及其生物活性缀合物。聚合物结构包括直链或支链的水溶性和非肽聚合物主链，例如具有至少两个末端的PEG主链，第一个末端与羟基磷灰石靶向部分如二膦酸共价键合，和第二末端共价键合到化学反应基团，其中所述化学反应基团被保护或未被保护。还提供了制备和使用羟基磷灰石靶向聚合物结构及其生物活性缀合物的方法。

72. 发明授权

US08338545B2 Multi-arm block copolymers as drug delivery vehicles 有权
标题翻译：多臂嵌段共聚物作为药物输送载体
公开(公告)号：US08338545B2
公开(公告)日：2012-12-25
申请号：US13287852
申请日：2011-11-02
申请人： Xuan Zhao
发明人： Xuan Zhao
IPC分类号： C08F283/00 , C08G63/91
CPC分类号： C08G63/914 , A61K31/724 , A61K31/74 , A61K31/77 , A61K47/593 , A61K47/60 , A61K47/6949 , B82Y5/00 , C08G65/2609 , C08G81/00 , C08G2650/24 , C08L71/02 , C08L2205/05 , C08L2666/18
摘要： The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.
摘要翻译：本发明提供了制备用作药物递送载体的共聚物和多臂嵌段共聚物的方法。多臂嵌段共聚物包括中心核心分子，例如多元醇的残基，以及共价连接到中心核心分子上的至少三个共聚物臂，每个共聚物臂包含共价连接到中心核心分子上的内部疏水性聚合物链段和共价连接到疏水性聚合物链段上的外部亲水性聚合物链段，其中中心核心分子和疏水聚合物链段限定疏水核心区域。疏水性生物活性剂的溶解度可以通过在嵌段共聚物的疏水核心区域内捕获来改善。本发明还包括药物组合物，包括这种嵌段共聚物，药物组合物和使用嵌段共聚物作为药物递送载体的方法。

73. 发明申请

US20120244597A1 POLYMER FACTOR VIII MOIETY CONJUGATES 有权
标题翻译：聚合物因子VIII MOIETY CONJUGATES
公开(公告)号：US20120244597A1
公开(公告)日：2012-09-27
申请号：US13431872
申请日：2012-03-27
申请人： Mary J. Bossard , Michael D. Bentley , Ping Zhang
发明人： Mary J. Bossard , Michael D. Bentley , Ping Zhang
IPC分类号： C12N9/96
CPC分类号： A61K38/37 , A61K47/10 , A61K47/60
摘要： Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.
摘要翻译：提供因子VIII部分和一种或多种水溶性聚合物的共轭物。通常，水溶性聚合物是聚（乙二醇）或其衍生物。还提供了包含缀合物的组合物，制备缀合物的方法，以及向患者施用包含缀合物的组合物的方法。

74. 发明授权

US08273339B2 Polymer-based compositions and conjugates of antimicrobial agents 有权
标题翻译：基于聚合物的组合物和抗微生物剂的共轭物
公开(公告)号：US08273339B2
公开(公告)日：2012-09-25
申请号：US11402641
申请日：2006-04-11
申请人： Mary J. Bossard , Stacy Mitchell
发明人： Mary J. Bossard , Stacy Mitchell
IPC分类号： A61K31/74
CPC分类号： A61K47/48215 , A61K38/00 , A61K47/60 , C12N9/52
摘要： Provided herein are water-soluble polymer conjugates and polymer-based compositions of antimicrobial agents. Also provided are methods for synthesizing and administering such conjugates and compositions.
摘要翻译：本文提供的是水溶性聚合物共轭物和抗微生物剂的基于聚合物的组合物。还提供了用于合成和施用这种缀合物和组合物的方法。

75. 发明授权

US08273330B2 Particulate materials 有权
标题翻译：颗粒材料
公开(公告)号：US08273330B2
公开(公告)日：2012-09-25
申请号：US10422342
申请日：2003-04-24
申请人： Peter York , Boris Yu Shekunov , Mahboob Ur Rehman , Jane Catherine Feeley
发明人： Peter York , Boris Yu Shekunov , Mahboob Ur Rehman , Jane Catherine Feeley
IPC分类号： A61K9/14 , A61K9/16 , A61M38/00 , A61M38/28
CPC分类号： A61K9/0075 , A61K9/0043 , A61K9/1688
摘要： The present invention relates to active substances in particulate form, to methods for preparing them and to their uses. The present invention provides particulate powders, such as might be of use for delivery using a dry powder inhaler (DPI) or similar delivery device, having properties which may be beneficial to the DPI delivery process.
摘要翻译：本发明涉及颗粒形式的活性物质，其制备方法和用途。本发明提供了颗粒粉末，例如可能用于使用可能有益于DPI递送过程的性质的干粉吸入器（DPI）或类似递送装置的递送。

76. 发明授权

US08227555B2 Hydrolytically stable maleimide-terminated polymers 有权
标题翻译：水解稳定的马来酰亚胺封端的聚合物
公开(公告)号：US08227555B2
公开(公告)日：2012-07-24
申请号：US13336886
申请日：2011-12-23
申请人： Antoni Kozlowski , Remy F. Gross, III , Samuel P. McManus
发明人： Antoni Kozlowski , Remy F. Gross, III , Samuel P. McManus
IPC分类号： C08F8/30 , C08F8/32 , C08F8/34 , C08G65/325 , C08G65/326 , A61K47/48
CPC分类号： C08G65/33396 , A61K47/48215 , A61K47/60 , C08G65/33337 , C08L63/10 , C08L2203/02
摘要： The present invention is directed to conjugates of hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.
摘要翻译：本发明涉及水解稳定的马来酰亚胺官能化水溶性聚合物的共轭物，以及制备和利用这些聚合物及其前体的方法。

77. 发明申请

US20120142594A1 Von Willebrand Factor- and Factor VIII-Polymer Conjugates Having a Releasable Linkage 有权
标题翻译： Von Willebrand因子和因子VIII-聚合物缀合物具有可释放的连接
公开(公告)号：US20120142594A1
公开(公告)日：2012-06-07
申请号：US13371275
申请日：2012-02-10
申请人： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
发明人： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
IPC分类号： C07K14/755 , C07K14/745 , C07K17/08
CPC分类号： C07K14/755 , A61K47/60
摘要： The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
摘要翻译：本发明提供了von Willebrand因子 - 聚合物共轭物和因子VIII-聚合物缀合物，其各自具有可释放的连接。还提供了制备缀合物的方法，用于施用缀合物的方法。

78. 发明授权

US08183376B2 Stereoselective reduction of a morphinone 有权
标题翻译：吗啡酮的立体选择性还原
公开(公告)号：US08183376B2
公开(公告)日：2012-05-22
申请号：US12297632
申请日：2007-04-19
申请人： Lin Cheng , Michael D. Bentley
发明人： Lin Cheng , Michael D. Bentley
IPC分类号： C07D489/02
CPC分类号： C07D489/02 , Y02P20/55
摘要： A synthetic method is provided, wherein the method comprises stereoselectively reducing a ketone of a morphinone to form a reduced morphinone and optionally covalently attaching a water soluble polymer to the reduced morphinone.
摘要翻译：提供了一种合成方法，其中所述方法包括立体选择性还原吗啡酮的酮以形成还原的吗啡酮并且任选地将水溶性聚合物共价连接到还原的吗啡酮上。

79. 发明授权

US08183338B2 Sterically hindered poly(ethylene glycol) alkanoic acids and derivatives thereof 有权
标题翻译：受阻的聚（乙二醇）链烷酸及其衍生物
公开(公告)号：US08183338B2
公开(公告)日：2012-05-22
申请号：US13099965
申请日：2011-05-03
申请人： Michael D. Bentley , Xuan Zhao , Xiaoming Shen , Lihong Guo
发明人： Michael D. Bentley , Xuan Zhao , Xiaoming Shen , Lihong Guo
IPC分类号： C08F6/14 , C08G65/34 , C08G65/324 , C08G65/329 , C08G65/332
CPC分类号： C08G65/324 , A61K47/60 , C08G65/32 , C08G65/329 , C08G65/332 , C08G65/3322 , C08G65/333
摘要： The invention provides a sterically hindered polymers and conjugates formed therefrom that comprise a water-soluble and non-peptidic polymer backbone having at least one terminus covalently bonded to an alkanoic acid or alkanoic acid derivative prior to conjugation, wherein the carbon adjacent to the carbonyl group of the acid or acid derivative group has an alkyl or aryl group pendent thereto. The steric effects of the alkyl or aryl group allow greater control of the hydrolytic stability of polymer derivatives. The polymer backbone may be poly(ethylene glycol).
摘要翻译：本发明提供一种空间位阻聚合物和由其形成的共轭物，其包含水溶性和非肽性聚合物主链，其在共轭之前具有至少一个与链烷酸或链烷酸衍生物共价结合的末端，其中与羰基相邻的碳的酸或酸衍生物基团具有与其相邻的烷基或芳基。烷基或芳基的空间效应可以更好地控制聚合物衍生物的水解稳定性。聚合物主链可以是聚（乙二醇）。

80. 发明申请

US20120094998A1 Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates 审中-公开
公开(公告)号：US20120094998A1
公开(公告)日：2012-04-19
申请号：US13264662
申请日：2010-04-19
申请人： Jennifer Riggs-Sauthier , Wen Zhang
发明人： Jennifer Riggs-Sauthier , Wen Zhang
IPC分类号： A61K31/5377 , C07D239/94 , C07D213/68 , C07D209/34 , A61P35/02 , A61K31/517 , A61K31/44 , A61K31/404 , A61K31/502 , A61P35/00 , C07D413/12 , C07D237/34
CPC分类号： A61K47/60
摘要： The invention relates to (among other things) oligomer-PTK inhibitor conjugates and related compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over PTK inhibitor compounds lacking a water soluble, non peptidic oligomer.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式