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71. 发明申请

US20060172002A1 Patch containing nonsteroidal antinflammatory and analgesic agent 有权
标题翻译：贴剂含有非甾体抗炎和止痛剂
公开(公告)号：US20060172002A1
公开(公告)日：2006-08-03
申请号：US10549184
申请日：2004-03-18
申请人： Yasunori Takada , Koji Tanaka , Kiyomi Tsuruda
发明人： Yasunori Takada , Koji Tanaka , Kiyomi Tsuruda
IPC分类号： A61K31/192 , A61K9/70
CPC分类号： A61K31/192 , A61K9/7053 , A61K9/7076 , A61K31/196 , A61K31/407
摘要： An adhesive patch containing a non-steroidal anti-inflammatory agent, comprising a support and an adhesive layer laminated on this support, wherein the adhesive layer contains a non-steroidal anti-inflammatory agent having a carboxyl group or its salt, and polyethylene glycol having an average molecular weight of 1000 or more.
摘要翻译：一种含有非甾体抗炎剂的粘合贴剂，其包含层压在该载体上的载体和粘合剂层，其中所述粘合剂层含有具有羧基或其盐的非甾体抗炎剂和具有平均分子量为1000以上。

72. 发明申请

US20060058398A1 Medicinal compositions containing vitamin k's as nerve growth factor potentiator and utilization thereof 审中-公开
标题翻译：含有维生素K作为神经生长因子增强剂及其利用的药物组合物
公开(公告)号：US20060058398A1
公开(公告)日：2006-03-16
申请号：US10502836
申请日：2003-01-24
申请人： Yuto Kamei , Takeshi Goto , Hidenao Fukushima , Kengo Uemura
发明人： Yuto Kamei , Takeshi Goto , Hidenao Fukushima , Kengo Uemura
IPC分类号： A61K31/12
CPC分类号： A61K31/122
摘要： To provide medicinal compositions containing an active ingredient which has a low molecular weight, is free from any side effects and has an effect of potentiating nerve growth factor activity and utilization thereof for treating diseases associated with dementia, medicinal preparations containing an effective amount of vitamin K and/or its derivative showing an effect of potentiating nerve growth factor activity are provided.
摘要翻译：为了提供含有低分子量活性成分的药物组合物，没有任何副作用，并且具有增强神经生长因子活性和用于治疗与痴呆相关的疾病的作用，含有有效量的维生素K的药物制剂和/或其衍生物显示增强神经生长因子活性的作用。

73. 发明申请

US20050266063A1 Adhesive patch 有权
标题翻译：胶贴
公开(公告)号：US20050266063A1
公开(公告)日：2005-12-01
申请号：US11141727
申请日：2005-05-31
申请人： Takashi Yasukochi , Tetsuro Tateishi , Naruhito Higo
发明人： Takashi Yasukochi , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K9/70
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K9/7076
摘要： The present invention relates an adhesive patch comprising a backing layer and an adhesive layer that contains a drug, wherein the adhesive layer contains a mixed adhesive base containing a hydrocarbon rubber and a silicon-containing polymer. The adhesive patch of the invention shows extremely superior skin absorbability of a drug in a preparation, reduced skin irritation, and excellent aging stability of the drug in the preparation, and can achieve easiness of drug-taking methods and improvement in compliance.
摘要翻译：本发明涉及包含背衬层和含有药物的粘合剂层的粘合贴剂，其中粘合剂层含有含有烃橡胶和含硅聚合物的混合粘合剂基料。本发明的贴剂在制剂中显示出极好的药物在皮肤吸收性，皮肤刺激性降低，以及药物优良的老化稳定性，并且可以实现药物吸收方法的容易性和依从性的提高。

74. 发明申请

US20050113738A1 Iontophoresis electrode device 审中-公开
标题翻译：离子电渗电极装置
公开(公告)号：US20050113738A1
公开(公告)日：2005-05-26
申请号：US10500537
申请日：2003-01-09
申请人： Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi , Takuji Oikawa , Shuji Sato , Naruhito Higo , Hiroyuki Maeda , Kenji Mori
发明人： Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi , Takuji Oikawa , Shuji Sato , Naruhito Higo , Hiroyuki Maeda , Kenji Mori
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/044
摘要： There is provided an electrode device for iontophoresis capable of retaining a drug in a gel state with a force just enough so as not to disturb the treatment. In order to retain the gel (70), a sheet member (50) composed of a nonwoven fabric is laminated on a base film (20) including an electrode layer (30) so as to be integrated with the base film (20). The sheet member (50) has a property for allowing the gel (70) to permeate therein. Owing to this feature, the gel (70) loaded on the sheet member (50) is retained thereon with at least a part of the gel (70) permeated therein.
摘要翻译：提供了一种用于离子电渗疗法的电极装置，其能够以刚好足够的力将药物保持在凝胶状态，以免扰乱治疗。为了保持凝胶（70），将由非织造织物构成的片材（50）层叠在包含电极层（30）的基膜（20）上以与基膜（20）一体化。片材（50）具有使凝胶（70）渗透到其中的性质。由于这个特征，装载在片材（50）上的凝胶（70）保留在其上，凝胶（70）的至少一部分渗入其中。

75. 发明授权

US06844372B2 Crosslinked anion-exchange resin or salt thereof and phosphorus adsorbent comprising the same 失效
标题翻译：交联阴离子交换树脂或其盐和含有它们的磷吸附剂
公开(公告)号：US06844372B2
公开(公告)日：2005-01-18
申请号：US10220781
申请日：2001-03-09
申请人： Takeshi Goto , Kazuhisa Yoshitake , Kazuteru Moriyama , Shuichi Toriya , Tsutomu Yuasa , Hideyuki Nishibayashi
发明人： Takeshi Goto , Kazuhisa Yoshitake , Kazuteru Moriyama , Shuichi Toriya , Tsutomu Yuasa , Hideyuki Nishibayashi
IPC分类号： A61K31/785 , A61P3/12 , B01J20/26 , B01J41/12 , B01J41/14 , C08F8/00
CPC分类号： B01J41/12 , A61K31/785 , B01J20/26 , B01J41/13 , B01J41/14
摘要： An cross-linked anion exchange resin or a salt thereof obtained by reacting a polymer (A) having amino and/or imino groups in the total number of two or more per molecule with a compound (B) having two or more functional groups capable of reacting with amino and/or imino group contained in the polymer (A). The resin or salt has a water absorption ratio of 4.0 or lower.
摘要翻译：通过使具有氨基和/或亚氨基的聚合物（A）每分子总数为两个以上而得到的交联阴离子交换树脂或其盐与具有两个以上官能团的化合物（B）反应，与聚合物（A）中所含的氨基和/或亚氨基反应。树脂或盐的吸水率为4.0以下。

76. 发明授权

US06841716B1 Patch 有权
标题翻译：补丁
公开(公告)号：US06841716B1
公开(公告)日：2005-01-11
申请号：US09959928
申请日：2000-04-27
申请人： Nobuo Tsutsumi
发明人： Nobuo Tsutsumi
IPC分类号： A61F13/00 , A61F13/02 , A61K9/70
CPC分类号： A61K9/703 , A61F13/0256 , A61F13/0259 , A61F2013/008 , A61K9/7038
摘要： According to the invention, a patch provided with a support 1, an adhesive layer 2 laminated on one side of the support, and a release film 4 attached in a releasable manner to the adhesive layer and having a slit 42 running from one edge to the opposite edge, is characterized in that the shape of the slit in the release film is a wave shape such that, by simply bending the support slightly along the slit while the exposed side of the adhesive layer which has been exposed by peeling off part of the release film along the slit is attached to the attachment site, the edge 44 of the slit of the remaining release film can promptly protrude outward from between the attachment site and the adhesive layer.
摘要翻译：根据本发明，设置有支撑体1，层压在支撑体的一侧上的粘合剂层2的贴片和以可释放的方式附着到粘合剂层的剥离膜4，并且具有从一个边缘到其特征在于，剥离膜中的狭缝的形状是波形，通过简单地将支撑件沿着狭缝弯曲，同时通过剥离部分暴露的粘合剂层的暴露侧沿着狭缝的剥离膜附着到附着位置，剩余的剥离膜的狭缝的边缘44可以从附着位置和粘合剂层之间迅速地向外突出。

77. 发明申请

US20040142024A1 Patch formulation for external use 审中-公开
标题翻译：补丁配方外用
公开(公告)号：US20040142024A1
公开(公告)日：2004-07-22
申请号：US10754592
申请日：2004-01-12
申请人： Hisamitsu Pharmaceutical Co., Inc.
发明人： Hideharu Chono , Toshiro Yamaguchi , Hisakazu Kurita , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K009/70
CPC分类号： A61K9/7053 , A61K47/12
摘要： A patch formulation for external use where a basic drug, an organic acid and an organic acid salt are combined as essential components is disclosed. The basic drug is preferably in the form of its acid addition salt. The organic acid is preferably a carboxylic acid having carbon atoms of 2 to 7, and more preferably at least one acid selected from the group consisting of acetic, lactic, tartaric, citric, malic, benzoic and salicylic acids. The organic acid salt is preferably a metal salt of a carboxylic acid, and more preferably sodium acetate.
摘要翻译：公开了将碱性药物，有机酸和有机酸盐组合为必需成分的外用贴剂。碱性药物优选为其酸加成盐的形式。有机酸优选为碳原子数为2〜7的羧酸，更优选为选自乙酸，乳酸，酒石酸，柠檬酸，苹果酸，苯甲酸和水杨酸中的至少一种酸。有机酸盐优选为羧酸的金属盐，更优选为乙酸钠。

78. 发明申请

US20040052780A1 Immunosuppresants 审中-公开
标题翻译：免疫抑制剂
公开(公告)号：US20040052780A1
公开(公告)日：2004-03-18
申请号：US10378089
申请日：2003-03-04
申请人： Hisamitsu Pharmaceutical Co., Inc.
发明人： Kazuhisa Ono , Seiji Kawamoto , Takeshi Goto , Shuji Sato , Sigeru Goto
IPC分类号： A61K039/395
CPC分类号： C07K16/18 , A61K2039/505
摘要： There are provided immunosuppressants with few side effects that can be used to suppress rejection involving organ transplantation, and the immunosuppressants comprising antibodies against histone H1 which specifically recognize antigenic proteins may be used to suppress immunity in mammals for treatment or prevention of rejection involving organ transplantation.
摘要翻译：提供了具有很少副作用的免疫抑制剂，其可用于抑制涉及器官移植的排斥反应，并且包含特异性识别抗原蛋白的组蛋白H1的抗体的免疫抑制剂可用于抑制哺乳动物的免疫以治疗或预防涉及器官移植的排斥反应。

79. 发明授权

US5998384A Endoscopic administration of an HSV-tk gene to treat digestive organ cancer 失效
标题翻译：内镜下施用HSV-tk基因治疗消化器官癌
公开(公告)号：US5998384A
公开(公告)日：1999-12-07
申请号：US949137
申请日：1997-10-10
申请人： Takashi Shimada , Norio Matsukura , Osamu Iijima , Katsuhiko Akiyama , Takeshi Goto
发明人： Takashi Shimada , Norio Matsukura , Osamu Iijima , Katsuhiko Akiyama , Takeshi Goto
IPC分类号： A61K48/00 , A61P35/00 , C12N5/00 , C12N15/00
CPC分类号： A61K48/00
摘要： A therapy for a disease, e.g., gastric cancer, comprising endoscopic local administration of a vector having a gene for treatment or cells producing the vector to a lesion to transduce the gene into target cells. The direct in vivo transduction of a gene for treatment into the affected site is expected to produce therapeutic effects specific on the lesion. Since the gene is introduced also into lymph nodes which may have developed a metastatic lesion, both the primary lesion and the metastatic lesion in the surrounding lymph nodes can be treated simultaneously.
摘要翻译：用于疾病例如胃癌的治疗方法，包括内窥镜局部施用具有用于治疗的基因的载体或产生所述载体的细胞以将所述基因转导入靶细胞。用于治疗受影响部位的基因的直接体内转导预期产生对病变特异性的治疗效果。由于该基因也被引入可能已经发展为转移性病变的淋巴结，所以可以同时治疗周围淋巴结中的原发性病变和转移性病变。

80. 发明授权

US5891920A Medicinal adjuvants consisting of N-subsitituted-o-toluidine derivatives, and percutaneously absorbable preparations comprising the adjuvants 失效
标题翻译：由N-取代的邻甲苯胺衍生物组成的药用佐剂和包含佐剂的经皮吸收制剂
公开(公告)号：US5891920A
公开(公告)日：1999-04-06
申请号：US809812
申请日：1997-03-31
申请人： Munehiko Hirano , Mitsuru Kuribayashi , Mitsuhiko Kido
发明人： Munehiko Hirano , Mitsuru Kuribayashi , Mitsuhiko Kido
IPC分类号： A61K9/70 , A61K47/18 , A61K31/165 , A61K47/16
CPC分类号： A61K9/7053 , A61K47/18 , A61K9/7061 , A61K9/7076
摘要： A drug solubilizer or drug-absorption accelerator of Formula I is disclosed wherein R.sub.1 and R.sub.2 are herein defined ##STR1##
摘要翻译： PCT No.PCT / JP95 / 02033 Sec。 371日期1997年3月31日 102（e）1997年3月31日PCT PCT 1995年10月4日PCT公布。出版物WO96 / 日本1996年4月18日公开了式I的药物增溶剂或药物吸收促进剂，其中R1和R2在本文中定义。

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