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71. 发明申请

US20090170829A1 Carboxamide, Sulfonamide and Amine Compounds and Methods for Using The Same 有权
标题翻译：甲酰胺，磺酰胺和胺化合物及其使用方法
公开(公告)号：US20090170829A1
公开(公告)日：2009-07-02
申请号：US12272581
申请日：2008-11-17
申请人： Hui Hong , Xiang Xu , Jiaxin Yu , Rajinder Singh , Ihab S. Darwish , Sambaiah Thota
发明人： Hui Hong , Xiang Xu , Jiaxin Yu , Rajinder Singh , Ihab S. Darwish , Sambaiah Thota
IPC分类号： A61K31/4545 , C07D401/14 , C07D413/14 , C07D405/14 , C07D409/14 , A61K31/5377 , A61K31/506 , A61P3/10
CPC分类号： C07D401/14 , C07D211/46 , C07D211/58 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Disclosed are carboxamide, sulfonamide and amine compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R1, R2, R4, E, T, n and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.
摘要翻译：公开了羧酰胺，磺酰胺和胺化合物，以及药物组合物和使用方法。一个实施方案是具有其中R 1，R 2，R 4，E，T，n和x如本文所述的结构的化合物。在某些实施方案中，本文公开的化合物激活AMPK途径，并且可用于治疗与代谢有关的病症和病症。

72. 发明申请

US20090163511A1 Carboxamide, Sulfonamide and Amine Compounds and Methods for Using The Same 有权
标题翻译：甲酰胺，磺酰胺和胺化合物及其使用方法
公开(公告)号：US20090163511A1
公开(公告)日：2009-06-25
申请号：US12334201
申请日：2008-12-12
申请人： Ihab S. Darwish , Jiaxin Yu , Hui Hong , Rajinder Singh , Sambaiah Thota , Xiang Xu
发明人： Ihab S. Darwish , Jiaxin Yu , Hui Hong , Rajinder Singh , Sambaiah Thota , Xiang Xu
IPC分类号： A61K31/496 , C07D471/04 , A61K31/437 , C07D401/14 , C12N5/06 , A61P3/10
CPC分类号： C07D471/04 , C07D401/06 , C07D401/12 , C07D401/14
摘要： Disclosed are carboxamide, sulfonamide and amine compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R1, R2, R4, D, E, J, T, p, q and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.
摘要翻译：公开了羧酰胺，磺酰胺和胺化合物，以及药物组合物和使用方法。一个实施方案是具有其中R 1，R 2，R 4，D，E，J，T，p，q和x如本文所述的结构的化合物。在某些实施方案中，本文公开的化合物激活AMPK途径，并且可用于治疗与代谢有关的病症和病症。

73. 发明申请

US20080275628A1 METHOD AND APPARATUS FOR COMMUNICATING TRAFFIC INFORMATION 审中-公开
标题翻译：交通信息交流方法与装置
公开(公告)号：US20080275628A1
公开(公告)日：2008-11-06
申请号：US11743364
申请日：2007-05-02
申请人： Xiang Xu , Qi-Xiang Li , Zhao-Hui Li , Ke-Jiao Zhang
发明人： Xiang Xu , Qi-Xiang Li , Zhao-Hui Li , Ke-Jiao Zhang
IPC分类号： G06F19/00 , H04B1/02
CPC分类号： G08G1/096716 , G08G1/096741 , G08G1/096775 , H04L12/189 , H04L12/1895
摘要： A method and apparatus for communicating traffic information, that in certain embodiments performs the actions of associating (215) with a traffic group that corresponds to a traffic region, determining (220) at least one traffic related parameter of the mobile communication device while operating within the traffic region, and transmitting (235) to the traffic group a transmit traffic information message that includes the at least one traffic related parameter. In certain embodiments, the following actions are performed: receiving (225) one or more receive traffic information messages from mobile communication devices associated with the traffic group, wherein each receive traffic information message includes at least one traffic related parameter and preparing (240) a local traffic report using the receive traffic information messages.
摘要翻译：一种用于传送交通信息的方法和装置，在某些实施例中，执行将与业务区域相对应的业务组关联（215）的动作，确定（220）所述移动通信设备的至少一个业务相关参数，同时在所述业务区域，并且向所述业务组发送包括所述至少一个业务相关参数的发送业务信息消息（235）。在某些实施例中，执行以下动作：从与业务组相关联的移动通信设备接收（225）一个或多个接收业务信息消息，其中每个接收业务量信息消息包括至少一个业务相关参数并且准备（240）本地流量报告使用接收流量信息消息。

74. 发明授权

US07384761B2 Methods of identifying an agent capable of interfering with Rad9 dephosphorylation 有权
标题翻译：鉴定能够干扰Rad9去磷酸化的试剂的方法
公开(公告)号：US07384761B2
公开(公告)日：2008-06-10
申请号：US10220375
申请日：2001-03-02
申请人： Ying Luo , Xiang Xu
发明人： Ying Luo , Xiang Xu
IPC分类号： C12Q1/48 , C12N9/16
CPC分类号： C07K14/4738 , C12N9/16 , C12Y301/03016 , G01N33/5011 , G01N33/6872 , G01N2333/4739 , G01N2333/8114
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译：本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。本文还提供了与异源多肽序列融合的本发明的载体和宿主细胞多肽，与本发明的多肽结合的抗体和用于产生本发明的多肽的方法。本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

75. 发明申请

US20070275610A1 Electrical Terminal 有权
标题翻译：电气终端
公开(公告)号：US20070275610A1
公开(公告)日：2007-11-29
申请号：US10579324
申请日：2004-11-19
申请人： Xiang Xu
发明人： Xiang Xu
IPC分类号： H01R13/24
CPC分类号： H01R13/2421
摘要： An electrical terminal includes first and second contact members having outer pressure contacting end portions for pressure engaging a pair of spaced electrical devices. The contact members have enlarged inner end portions. A sleeve includes a through hole for slidably receiving the inner end portions of the contact members at opposite ends thereof. The through hole has opposite open ends through which the pressure contacting end portions of the contact members project. Restricted stops are formed at the open ends of the through holes for abutting the enlarged inner ends of the contact members to define outer limit positions of the pressure contacting end portions of the contact members. A biasing member is disposed in the through hole to resiliently bias the contact members in opposite directions. The invention contemplates that an outside diameter of the sleeve at a first end thereof be smaller than an out-side diameter of the sleeve at a second end thereof. Thereby, the smaller diameter end is easily formed into a restricted stop, and the larger diameter end of the sleeve can be used for clamping and disassembling the terminal from an electrical device without damaging the sleeve.
摘要翻译：电端子包括第一和第二接触构件，其具有用于压力接合一对间隔开的电气装置的外部压力接触端部。接触构件具有扩大的内端部。套筒包括用于在其相对端可滑动地容纳接触构件的内端部的通孔。通孔具有相对的开口端，接触构件的压力接触端部通过该开口端突出。在通孔的开口端处形成有限制的止动件，用于抵靠接触构件的扩大的内端，以限定接触构件的压力接触端部的外部极限位置。偏置构件设置在通孔中以沿相反的方向弹性地偏置接触构件。本发明设想在其第一端处的套筒的外径小于在其第二端处的套筒的外侧直径。因此，较小直径的端部容易地形成为限制止动件，并且套筒的较大直径端可用于将端子与电气装置夹紧和拆卸而不损坏套筒。

76. 发明授权

US07300780B2 Germinal center kinase proteins, compositions, and methods of use 有权
标题翻译：生发中心激酶蛋白，组合物和使用方法
公开(公告)号：US07300780B2
公开(公告)日：2007-11-27
申请号：US10493164
申请日：2002-10-21
申请人： Cindy Leo , Ying Luo , Xiang Xu , Simon Yu
发明人： Cindy Leo , Ying Luo , Xiang Xu , Simon Yu
IPC分类号： C12N9/12 , C07K1/00
CPC分类号： C12N9/1205 , C12Q1/485 , G01N33/5041 , G01N2500/02
摘要： The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic adds encoding proteins and proteins so encoded which are capable of modulating proliferation, survival, morphology and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology and migration in mammalian cells.
摘要翻译：本发明提供调节细胞增殖，存活，形态和迁移的组合物和方法。核酸添加编码蛋白质和如此编码的蛋白质，其能够调节哺乳动物细胞中的增殖，存活，形态和迁移。还提供了用于治疗与细胞增殖，存活，形态和迁移相关的病症的组合物和方法。还提供了预防和预防这种疾病的方法。还提供了用于诊断和预测这些疾病的组合物和方法。还提供了用于鉴定能够调节哺乳动物细胞中增殖，存活，形态和迁移的生物活性剂的测定。

77. 发明申请

US20070052124A1 Apparatus and method for advanced structural foam molding 审中-公开
标题翻译：先进的结构发泡成型装置和方法
公开(公告)号：US20070052124A1
公开(公告)日：2007-03-08
申请号：US11219309
申请日：2005-09-02
申请人： Chul Park , Xiang Xu
发明人： Chul Park , Xiang Xu
IPC分类号： C08J9/00 , B29C44/46
CPC分类号： B29C44/421 , B29C44/3442 , B29C44/3469 , B29C48/0011 , B29C48/0012 , B29C48/295 , B29C48/387 , B29C48/475 , B29K2105/041 , Y10T428/249953
摘要： An advanced structural foam molding technology for improving the dispersion of the blowing agent in the polymer matrix has been invented. This technological innovation is an improvement on the well-known existing low-pressure structural foam molding technology based on the preplasticating-type (so-called piggy-bag) injection-molding machines. By introducing means for continuing the polymer matrix melt flow stream, preferably an additional accumulator and a gear primp, the processing conditions become more consistent to disperse the injected gas more uniformly in the polymer matrix. By using this technology, the structural foams have a smaller cell size, a more uniform cell structure, a larger void fraction (i.e., more material saving), less surface swirl, and less weld line contrast.
摘要翻译：已经发明了用于改善发泡剂在聚合物基质中的分散性的先进的结构泡沫塑模技术。这种技术创新是对基于预塑型（所谓的小袋）注塑机的已知的现有低压结构泡沫塑料成型技术的改进。通过引入用于连续聚合物基质熔体流动流的装置，优选地是附加的储存器和齿轮引导装置，加工条件变得更加一致以将注入的气体更均匀地分散在聚合物基质中。通过使用该技术，结构泡沫具有更小的泡孔尺寸，更均匀的泡孔结构，较大的空隙率（即更节省材料），更少的表面涡流和更少的焊接线对比度。

78. 发明申请

US20060057559A1 High-throughput cell migration screening assay 审中-公开
标题翻译：高通量细胞迁移筛选试验
公开(公告)号：US20060057559A1
公开(公告)日：2006-03-16
申请号：US11166920
申请日：2005-06-23
申请人： Xiang Xu , Yuanming Hu
发明人： Xiang Xu , Yuanming Hu
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/5029
摘要： The invention relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, sphingolipid analogs, and ribozymes, that modulate cell activation or migration, e.g., lymphocyte migration, via modulation of the expression and/or activity of migration molecules such as, for example, EDG molecules (e.g., EDG1 and EDG3), selectins, integrins, cadherins, certain members of the immunoglobulin superfamily of molecules, or chemokine receptor molecule. The methods of the invention are efficient and readily amenable to high-throughput drug screening protocols. High-throughput screening (HTS) methods, compositions, and kits for performing the assays are also provided.
摘要翻译：本发明涉及用于鉴定和使用调节细胞活化或迁移的小的有机分子，抗体，肽，环肽，核酸，反义核酸，鞘脂类似物和核酶的试剂的方法，所述方法通过调节迁移分子的表达和/或活性，例如EDG分子（例如EDG1和EDG3），选择素，整联蛋白，钙黏着蛋白，分子的免疫球蛋白超家族的某些成员或趋化因子受体分子。本发明的方法对于高通量药物筛选方案是有效和容易的。还提供了用于进行测定的高通量筛选（HTS）方法，组合物和试剂盒。

79. 发明授权

US06619968B2 Electrical connector having terminal inserts 失效
标题翻译：具有端子插入件的电连接器
公开(公告)号：US06619968B2
公开(公告)日：2003-09-16
申请号：US10013395
申请日：2001-12-07
申请人： Xiang Xu
发明人： Xiang Xu
IPC分类号： H01R909
CPC分类号： H01R12/7029 , H01R12/724 , H01R13/658
摘要： An electrical connector (1) comprises an insulating housing (10) defining a number of terminal receiving channels (140) and a first and a second openings (102, 104) in communication with the receiving channels, and a pair of terminal inserts (20, 30) respectively inserted into the first and the second openings. Each terminal insert includes an insulating portion (22, 32) and a number of terminals (24, 34) retained in the insulating portion. Each terminal has a mating portion (240, 340) received in a corresponding terminal receiving channel of the housing.
摘要翻译：电连接器（1）包括限定多个端子接收通道（140）的绝缘壳体（10）和与接收通道连通的第一和第二开口（102,104）和一对端子插入件（20 ，30）分别插入到第一和第二开口中。每个端子插件包括绝缘部分（22,32）和多个保持在绝缘部分中的端子（24,34）。每个端子具有接收在壳体的对应的端子接收通道中的配合部分（240,340）。

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