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71. 发明授权

US08715223B2 Device and method for delivery of a drug depot near the nerve 有权
标题翻译：用于在神经附近递送药物库的装置和方法
公开(公告)号：US08715223B2
公开(公告)日：2014-05-06
申请号：US12507197
申请日：2009-07-22
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61M31/00
CPC分类号： A61M37/0069 , A61B5/04001 , A61B5/4839 , A61B5/4893
摘要： Drug depot delivery devices and methods are provided for delivering one or more drug depots in close proximity to the nerve of a patient with or without repositioning the cannula. The device includes an electronic monitor for detecting the proximity of the tip of the cannula to a nerve. In some embodiments, a method of delivering a drug depot is provided by detecting the nerve and delivering the drug depot near the nerve.
摘要翻译：提供药物库递送装置和方法用于在有或者没有重新定位插管的情况下递送一个或多个药物库，其紧邻患者的神经。该装置包括用于检测套管尖端与神经的接近的电子监视器。在一些实施方案中，通过检测神经并在神经附近递送药物库来提供递送药物库的方法。

72. 发明授权

US08702677B2 Device and method for directional delivery of a drug depot 有权
标题翻译：用于定向递送药物库的装置和方法
公开(公告)号：US08702677B2
公开(公告)日：2014-04-22
申请号：US12262823
申请日：2008-10-31
申请人： Thomas A. Simonton , Sean M. Haddock , John Myers Zanella , William F. McKay
发明人： Thomas A. Simonton , Sean M. Haddock , John Myers Zanella , William F. McKay
IPC分类号： A61M31/00 , A61M5/00 , A61M5/178 , A61M25/00
CPC分类号： A61M25/00 , A61B5/04001 , A61B5/4893 , A61M25/007 , A61M25/0084
摘要： Drug depot delivery devices and methods are provided for delivering one or more drug depots to one or more sites beneath the skin of a patient with or without repositioning the cannula. The device has a cannula capable of insertion to the site beneath the skin of the patient and one or more side port openings for delivering a drug depot. The side port openings are spaced a distance from the blunt tip, which will allow the user to implant at a set distance from a nerve. The device may also include an electronic monitor for detecting the proximity of the tip of the cannula to a nerve. In some embodiments, a method of delivering a drug depot is provided by detecting the nerve and delivering the drug depot at or near the nerve.
摘要翻译：提供药物库递送装置和方法用于将一个或多个药物储存器递送到具有或不具有重新定位插管的患者皮肤下方的一个或多个部位。该装置具有能够插入到患者皮肤下方的部位的插管和用于递送药物库的一个或多个侧口开口。侧端口与钝头间隔开一段距离，这将允许使用者以距离神经一定距离植入。该装置还可以包括用于检测套管尖端与神经的接近的电子监视器。在一些实施方案中，通过检测神经并将药物贮存库输送到神经中或附近来提供递送药物库的方法。

73. 发明申请

US20130297038A1 BONE IMPLANTS AND METHODS COMPRISING DEMINERALIZED BONE MATERIAL 有权
标题翻译：骨质植入物和包含骨化合物的方法
公开(公告)号：US20130297038A1
公开(公告)日：2013-11-07
申请号：US13465122
申请日：2012-05-07
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61F2/28
CPC分类号： A61F2/2846 , A61F2/28 , A61F2/4455 , A61F2002/2835 , A61F2002/2839 , A61F2002/30059 , A61F2002/302 , A61F2002/30795 , A61F2310/00359 , A61L27/28 , A61L27/3608 , A61L27/365 , A61L27/3834 , A61L27/3847 , A61L27/54 , A61L2300/412 , A61L2300/414 , A61L2430/02
摘要： Bone implant compositions and methods are provide that have an outer surface, the outer surface comprising demineralized bone and having a cavity disposed in the outer surface, the cavity having a demineralized bone material coated therein; and an inner surface of the bone implant comprising cortical bone, the inner surface contacting the outer surface. The bone implant compositions and methods provided are osteoinductive and allow rapid bone fusion.
摘要翻译：提供骨植入物组合物和方法，其具有外表面，外表面包括脱矿质骨，并且具有设置在外表面中的腔，所述腔具有涂覆在其中的软化骨材料; 以及包括皮质骨的骨植入物的内表面，所述内表面接触所述外表面。提供的骨植入物组合物和方法是骨诱导性的并且允许快速骨融合。

74. 发明申请

US20130261634A1 BONE DELIVERY SYSTEMS INCLUDING HOLDING AND FILLING DEVICES AND METHODS 有权
公开(公告)号：US20130261634A1
公开(公告)日：2013-10-03
申请号：US13438590
申请日：2012-04-03
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61B17/58
CPC分类号： A61F2/2846 , A61F2002/2835 , A61F2002/30462 , A61F2002/30586 , A61F2002/30588 , A61F2002/30729 , A61F2210/0004
摘要： A delivery system comprising a biodegradable single or multi compartment covering is provided. The covering can be a mesh bag including a pre-attached detachable holding member surrounding the opening of at least one compartment and a pre-attached removable filling member configured to fit within the opening of the at least one compartment. The opening of the bag can include a closing member. The pre-attached detachable holding member can be a collar including finger grips and is used to hold the bag in one position while filling it. In some embodiments, the pre-attached detachable filling member can be a funnel for loading the mesh bag with bone graft material. Once the covering is filled, the holding member and filling member can be removed and the covering is closed with a closing member such as a drawstring. A method of treatment utilizing the delivery system is also provided.

75. 发明申请

US20130261596A1 DRUG DELIVERY SYSTEM 有权
标题翻译：药物递送系统
公开(公告)号：US20130261596A1
公开(公告)日：2013-10-03
申请号：US13432129
申请日：2012-03-28
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61M5/31
CPC分类号： A61M5/31 , A61M25/0108 , A61M37/0069
摘要： A drug delivery device for delivering a drug pellet to a site beneath the skin of a patient is provided, the drug delivery device including a housing having a chamber configured to hold at least one drug pellet, the chamber having a loading end and a delivery end, the loading end of the chamber having an opening for receiving a plunger and a drug pellet and the delivery end having an opening for receiving the plunger and passage of the drug pellet. The housing includes at least one hole substantially perpendicular to the chamber and formed to at least partially intersect the chamber. A capture pin is provided configured to be receivable within the at least one hole.
摘要翻译：提供了一种用于将药物丸粒输送到患者皮肤下方的部位的药物递送装置，所述药物递送装置包括具有被配置为保持至少一个药物丸粒的腔室的壳体，所述腔室具有装载端和输送端所述腔室的装载端具有用于容纳柱塞和药丸的开口，并且所述输送端具有用于容纳所述柱塞和所述药丸的通道的开口。所述壳体包括至少一个基本上垂直于所述腔室并且形成为至少部分地与所述腔室相交的孔。捕获销被配置为可接收在至少一个孔内。

76. 发明授权

US08475824B2 Resorbable matrix having elongated particles 有权
标题翻译：具有细长颗粒的可再吸收基质
公开(公告)号：US08475824B2
公开(公告)日：2013-07-02
申请号：US12693770
申请日：2010-01-26
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61F2/00
CPC分类号： A61L27/54 , A61K38/1875 , A61L27/446 , A61L27/46 , A61L27/58 , A61L2300/414 , C08L89/06
摘要： Compression resistant matrices and methods are provided that have elongated particles embedded therein. The compression resistant matrices provide improved stability and mechanical strength and resists shifting, extrusion and rotation after implantation. In some embodiments, the matrices provided reduce or prevent surface compression of the implantable matrix which will cause unwanted increased amounts of growth factor (e.g., bone morphogenic protein) to leak from the matrix.
摘要翻译：提供具有嵌入其中的细长颗粒的抗压基质和方法。耐压基质提供改进的稳定性和机械强度，并且抵抗植入后的移位，挤出和旋转。在一些实施方案中，所提供的基质降低或防止可植入基质的表面压缩，这将导致生长因子（例如，骨形态发生蛋白）不必要地增加从基质中泄漏。

77. 发明授权

US08470046B2 Bone augmentation device and method 有权
标题翻译：骨增强装置及方法
公开(公告)号：US08470046B2
公开(公告)日：2013-06-25
申请号：US13093144
申请日：2011-04-25
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61F2/02
CPC分类号： A61C8/0006 , A61C8/0028
摘要： A bone augmentation device includes at least one axial member defining a longitudinal axis and a plurality of transverse members. Each transverse member extends from a first end, or removably connected to the at least one axial member to a second end configured for fixation with bone. The transverse members are spaced apart and disposed along the longitudinal axis. The at least one axial member and the transverse members are disposed in a configuration to define a bone graft cavity. Methods of use are also disclosed.
摘要翻译：骨增强装置包括限定纵向轴线和多个横向构件的至少一个轴向构件。每个横向构件从第一端部延伸，或者可移除地连接到至少一个轴向构件，构造成用于与骨固定的第二端。横向构件沿着纵向轴线间隔开并设置。至少一个轴向构件和横向构件设置成构造以限定骨移植物腔。还公开了使用方法。

78. 发明授权

US08449622B2 Multi-phase osteochondral implantable device 有权
标题翻译：多阶段骨软骨植入装置
公开(公告)号：US08449622B2
公开(公告)日：2013-05-28
申请号：US11518680
申请日：2006-09-11
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61F2/28
CPC分类号： A61F2/30756 , A61F2/28 , A61F2/30749 , A61F2002/2817 , A61F2002/2839 , A61F2002/30011 , A61F2002/30014 , A61F2002/30062 , A61F2002/30113 , A61F2002/30125 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30225 , A61F2002/30235 , A61F2002/30354 , A61F2002/30405 , A61F2002/30426 , A61F2002/30448 , A61F2002/30502 , A61F2002/30677 , A61F2002/30772 , A61F2002/30777 , A61F2002/30784 , A61F2002/30892 , A61F2002/30957 , A61F2002/4649 , A61F2210/0004 , A61F2220/0008 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2230/0006 , A61F2230/0008 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0069 , A61F2250/0018 , A61F2250/0023 , A61F2310/00179 , A61F2310/00293 , A61F2310/00365 , A61L27/12 , A61L27/46 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/602
摘要： An osteochondral implantable device is provided, comprising an upper cap and at least one insert comprising a non-polymeric material in physical contact with the upper cap, said lower insert comprising at least one non-polymeric material, wherein the porosity of the upper cap is greater than the porosity of the insert and the Young's modulus of the upper cap is smaller than the Young's modulus of the insert.
摘要翻译：提供了一种软骨软骨植入装置，其包括上帽和至少一个插入物，其包含与上帽物理接触的非聚合材料，所述下插入物包含至少一种非聚合材料，其中上盖的孔隙率为大于插入件的孔隙率，并且上盖的杨氏模量小于插入件的杨氏模量。

79. 发明授权

US08409286B2 Expandable spinal fusion device and methods of promoting spinal fusion 有权
标题翻译：可扩展的脊柱融合装置和促进脊柱融合的方法
公开(公告)号：US08409286B2
公开(公告)日：2013-04-02
申请号：US11332959
申请日：2006-01-17
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61F2/28 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4611 , A61F2002/2817 , A61F2002/2835 , A61F2002/30069 , A61F2002/30092 , A61F2002/30113 , A61F2002/30153 , A61F2002/30225 , A61F2002/30233 , A61F2002/30265 , A61F2002/30364 , A61F2002/3038 , A61F2002/30392 , A61F2002/30393 , A61F2002/30411 , A61F2002/30433 , A61F2002/30451 , A61F2002/30462 , A61F2002/30476 , A61F2002/3052 , A61F2002/30523 , A61F2002/30525 , A61F2002/3055 , A61F2002/30556 , A61F2002/30563 , A61F2002/30566 , A61F2002/30571 , A61F2002/30579 , A61F2002/30616 , A61F2002/30772 , A61F2002/30841 , A61F2002/3085 , A61F2002/30975 , A61F2002/4475 , A61F2210/0014 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2220/0058 , A61F2220/0075 , A61F2230/0006 , A61F2230/0019 , A61F2230/0069 , A61F2230/0082 , A61F2250/0009 , A61F2310/00293
摘要： An intervertebral disc space implant includes spaced-apart bone engagement portions that define an intermediate chamber that holds bone growth inducing material into contact with adjacent vertebral bodies. The implant is expandable to establish and maintain desired intervertebral spacing during fusion. The implant includes a first member and a second member arranged to move relative to each other by action of an expansion member, the first member being engageable with the vertebral body below the disc space.
摘要翻译：椎间盘间隙植入物包括间隔开的骨接合部分，其限定将骨生长诱导材料保持与相邻椎体接触的中间室。植入物可扩张以在融合期间建立并保持所需的椎间间距。植入物包括第一构件和第二构件，其布置成通过膨胀构件的作用相对于彼此移动，第一构件可与盘空间下方的椎体接合。

80. 发明授权

US08408250B2 Bone replacement material mixing and delivery devices and methods of use 有权
标题翻译：骨置换材料的混合和输送装置及使用方法
公开(公告)号：US08408250B2
公开(公告)日：2013-04-02
申请号：US12818300
申请日：2010-06-18
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： B65B1/04
CPC分类号： A61B17/8833 , A61B2017/8838
摘要： Bone cement mixing and delivery devices and methods of using the devices are provided. The bone cement mixing and delivery devices and methods comprise a container having a bottom opening that can be sealed by a spacer in a syringe where movement of the plunger of the syringe moves the spacer away from the bottom opening in the container to dispense bone cement into the syringe. In some embodiments, the devices and methods increases efficiency and reduce the mess associated with transferring the bone cement to the syringe for delivery to a patient.
摘要翻译：提供了骨水泥混合输送装置及其使用方法。骨水泥混合和递送装置和方法包括具有底部开口的容器，该底部开口可以通过注射器中的间隔件密封，其中注射器的柱塞的移动使垫片远离容器中的底部开口移动以将骨水泥分配到注射器。在一些实施例中，装置和方法提高了效率并减少了将骨粘固剂转移到注射器以用于递送给患者的混乱。

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