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71. 发明授权

US4210758A 1 ,5-Dihydro-1,5-dioxo-N-1H-tetrazol-5-yl-4H-[1]benzopyrano[3,4-b]pyridine- 2-carboxamides 失效
标题翻译： 1,5-二氢-1,5-二氧代-N-1H-四唑-5-基-4H- [1]苯并吡喃并[3,4-b]吡啶-2-甲酰胺
公开(公告)号：US4210758A
公开(公告)日：1980-07-01
申请号：US22391
申请日：1979-03-21
申请人： David T. Connor
发明人： David T. Connor
IPC分类号： C07D491/04 , C07D491/052
CPC分类号： C07D491/04 , Y10S514/826
摘要： The present invention relates to 1,5-dihydro-1,5-dioxo-N-1H-tetrazol-5-yl-4H-[1]benzopyrano[3,4-b]pyridine-2-carboxamides having the following structural formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, hydroxy, lower alkoxy, lower alkyl, or nitro and R.sub.2 is hydrogen or lower alkyl and the pharmaceutically acceptable salts thereof.These compounds and their pharmaceutically acceptable salts are useful in the management of allergic manifestations such as bronchial asthma, hay fever and the like.
摘要翻译：本发明涉及具有以下结构的1,5-二氢-1,5-二氧代-N-1H-四唑-5-基-4H- [1]苯并吡喃并[3,4-b]吡啶-2-甲酰胺式：其中R 1是氢，卤素，羟基，低级烷氧基，低级烷基或硝基，R 2是氢或低级烷基，及其药学上可接受的盐。这些化合物及其药学上可接受的盐可用于治疗过敏性表现如支气管哮喘，花粉症等。

72. 发明授权

US4191825A Diacyloxyacids derived from acid S, an antibiotic produced by Polyangium cellulosum var. fulvum 失效
标题翻译：衍生自酸S的二酰氧基酸，由Polyangium cellulosum var。 fulvum
公开(公告)号：US4191825A
公开(公告)日：1980-03-04
申请号：US948854
申请日：1978-10-05
申请人： David T. Connor , Samuel M. Ringel , Sidney Roemer , Maximillian von Strandtmann
发明人： David T. Connor , Samuel M. Ringel , Sidney Roemer , Maximillian von Strandtmann
IPC分类号： C07D309/16 , C09B23/00
CPC分类号： C07D309/16
摘要： The present invention relates to diacyloxyacids derived from the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), and to processes for their production. The diacyloxyacids derivatives of acid S of this invention are useful as antifungal and antibacterial agents.
摘要翻译：本发明涉及由Polyangium cellulosum var。生产的抗生素物质，称为酸S的二酰氧基酸。 fulvum（ATCC No.25532），以及其生产方法。本发明的酸S的二酰氧基酸衍生物可用作抗真菌剂和抗菌剂。

73. 发明授权

US4158663A Process for the production of 2-substituted chromones 失效
标题翻译： 2-取代色酮的制备方法
公开(公告)号：US4158663A
公开(公告)日：1979-06-19
申请号：US891983
申请日：1978-03-31
申请人： David T. Connor , Patricia A. Young , Max VON Strandtmann
发明人： David T. Connor , Patricia A. Young , Max VON Strandtmann
IPC分类号： C07D311/22
CPC分类号： C07D311/22 , Y10S514/826
摘要： This invention is concerned with a novel process for the production of 2-substituted chromones (I) from readily available 4-methoxycoumarins. ##STR1## These compounds are useful as antiallergy agents.
摘要翻译：本发明涉及从容易获得的4-甲氧基香豆素生产2-取代的色酮（I）的新方法。 I.

74. 发明授权

US4123536A Dialkyl ({[3-(alkoxycarbonyl)-1,4-dihydro-4-oxo-8-quinolinyl]amino}methylene)pro panedioates 失效
标题翻译：二烷基（{55 {8-（烷氧基羰基）-1,4-二氢-4-氧代-8-喹啉基{9氨基{56亚甲基）丙二酸二
公开(公告)号：US4123536A
公开(公告)日：1978-10-31
申请号：US860526
申请日：1977-12-14
申请人： David T. Connor , Patricia A. Young , Maximilian Von Strandtmann
发明人： David T. Connor , Patricia A. Young , Maximilian Von Strandtmann
IPC分类号： C07D215/56 , C07D471/04 , A61K31/47
CPC分类号： C07D471/04 , C07D215/56
摘要： The present invention relates to dialkyl ({[3-(alkoxy-carbonyl)-1,4-dihydro-4-oxo-8-quinolinyl]amino}methylene)-propanedioates having the following structural formula: ##STR1## wherein R.sub.1 is lower alkyl; and R.sub.2 is hydrogen, halogen, lower alkyl or nitro.These compounds exhibit antibacterial activity against gram positive and gram negative bacteria and are therefore useful in the treatment of bacterial infections caused by these organisms.
摘要翻译：本发明涉及具有以下结构式的（{[3-（烷氧基 - 羰基）-1,4-二氢-4-氧代-8-喹啉基]氨基}亚甲基） - 丙二酸二烷基酯低级烷基并且R 2是氢，卤素，低级烷基或硝基。

75. 发明授权

US4045451A 2-(Methylthio)naphtho[1,3-bc]pyran-3(2H)-one 失效
标题翻译： 2-（甲硫基）萘并[8，1,3-bc {9]吡喃-3（2H） - 酮
公开(公告)号：US4045451A
公开(公告)日：1977-08-30
申请号：US690751
申请日：1976-05-27
申请人： David T. Connor , Maximilian VON Strandtmann
发明人： David T. Connor , Maximilian VON Strandtmann
IPC分类号： C07D209/36 , C07D307/83 , C07D307/86 , C07D307/92 , C07D311/92 , C07D311/02 , A61K31/35
CPC分类号： C07D307/92 , C07D209/36 , C07D307/83 , C07D307/86 , C07D311/92
摘要： The invention relates to novel compounds having the formulas I and III: ##STR1## wherein, in formula I, X is --O-- or --N--COR wherein R is lower alkyl or aryl, and Z is ##STR2## WHEREIN R' is hydrogen, halogen or alkoxy. the compounds of this invention are prepared by a novel process which involves the cyclization of the corresponding aryl(methylsulfinyl)methyl ketones. The compounds of this invention having formulas I and III are useful in the treatment of hyperacidity and for alleviating allergic manifestations.
摘要翻译：本发明涉及具有式I和III的新化合物：其中在式I中，X是-O-或-N-COR，其中R是低级烷基或芳基，Z是R'是氢，卤素或烷氧基。本发明的化合物通过涉及使相应的芳基（甲基亚磺酰基）甲基酮环化的新方法制备。具有式I和III的本发明化合物可用于治疗过酸和缓解过敏性表现。

76. 发明授权

US4013673A 2,3-Dihydro-3-(2-pyridinyl)-4H-1-benzopyran-4-one N-oxides 失效
标题翻译： 2,3-二氢-3-（2-吡啶基）-4H-1-苯并噻喃-4-酮N-氧化物
公开(公告)号：US4013673A
公开(公告)日：1977-03-22
申请号：US676441
申请日：1976-04-13
申请人： David T. Connor , Patricia Young , Max Von Strandtmann
发明人： David T. Connor , Patricia Young , Max Von Strandtmann
IPC分类号： C07D405/04
CPC分类号： C07D405/04
摘要： There is disclosed 2,3-dihydro-3-(2-pyridinyl)-4H-1-benzopyran-4-one N-oxides of the formula: ##STR1## in which R.sub.1 is hydrogen, halogen, lower alkyl, hydroxy, lower alkoxy or amino; R.sub.2 is hydrogen or --CH.sub.2 OH. These compounds are indicated in the treatment of gastric ulcers.

77. 发明授权

US4001398A Octahydro and decahydro derivatives of acid S, an antibiotic produced by Polyangium cellulosum var. fulvum 失效
标题翻译：酸O O O O OF BY。。。。。。。。。。。。。。。。。。。。。 FULVUM
公开(公告)号：US4001398A
公开(公告)日：1977-01-04
申请号：US482058
申请日：1974-06-24
申请人： David T. Connor , Samuel M. Ringel , Sidney Roemer , Maximilian VON Strandtmann
发明人： David T. Connor , Samuel M. Ringel , Sidney Roemer , Maximilian VON Strandtmann
IPC分类号： A61K35/00
CPC分类号： C07D309/22
摘要： The present invention describes octahydro and decahydro derivatives of the novel antibiotic substance, acid S, produced by the organism Polyangium cellulosum var. fulvum (ATCC No. 25532) and to processes for their preparation. The octahydro and dechydro derivatives of acid S of this invention are useful as antifungal and antibacterial agents.

78. 发明授权

US3973020A 3-(2-Pyridinyl)-4(1H)-cinnolinone N-oxides 失效
标题翻译： 3-（2-吡啶基）-4（1H） - 噌啉酮N-氧化物
公开(公告)号：US3973020A
公开(公告)日：1976-08-03
申请号：US611120
申请日：1975-09-08
申请人： David T. Connor , Patricia A. Young , Maximilian VON Strandtmann
发明人： David T. Connor , Patricia A. Young , Maximilian VON Strandtmann
IPC分类号： C07D401/04 , A61K31/495 , C07D237/28
CPC分类号： C07D401/04 , Y10S514/819
摘要： 3-(2-Pyridinyl)-4(1H)-cinnolinone N-oxides of the formula I: ##SPC1##wherein R is hydrogen, halogen, lower alkyl, hydroxy or alkoxy; the pharmaceutically acceptable acid addition salts thereof; and a process for the preparation thereof, are described. The compounds of the invention are useful for the treatment of hyperacidity.
摘要翻译： 3-（2-吡啶基）-4（1H） - 噌啉酮式I的N-氧化物：

79. 发明授权

US5612330A Methods for inhibiting and controlling viral growth 失效
标题翻译：抑制和控制病毒生长的方法
公开(公告)号：US5612330A
公开(公告)日：1997-03-18
申请号：US408431
申请日：1995-03-22
申请人： David T. Connor , Stephen J. Gracheck
发明人： David T. Connor , Stephen J. Gracheck
IPC分类号： C07D487/04 , A61K31/34 , A61K31/38 , A61K31/40 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61P29/00 , A61P31/12 , A61P31/18 , A61P31/22 , A61P37/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D495/04 , A61K31/551 , A61K31/553 , A61K31/554 , C07D513/04
摘要： Benzothiophene, benzofuran and indolethiazepinones, oxazepinones, and diazepinones are effective therapeutic agents for treating viral diseases, including those caused by herpesvirus and HIV.
摘要翻译：苯并噻吩，苯并呋喃和吲哚噻嗪酮，恶唑嗪酮和二氮杂酮是治疗病毒性疾病，包括由疱疹病毒和HIV引起的疾病的有效治疗剂。

80. 发明授权

US5356898A Substituted 4,6-di-tertiary-butyl 5-hydroxy-pyrimidines 失效
标题翻译：取代的4,6-二叔丁基5-羟基嘧啶
公开(公告)号：US5356898A
公开(公告)日：1994-10-18
申请号：US84188
申请日：1993-07-01
申请人： Thomas R. Belliotti , Catherine R. Kostlan , David T. Connor
发明人： Thomas R. Belliotti , Catherine R. Kostlan , David T. Connor
IPC分类号： A61K31/505 , A61K31/506 , A61P1/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P29/00 , A61P43/00 , C07D239/34 , C07D239/36 , C07D401/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D239/02
CPC分类号： C07D239/36 , C07D239/34 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , Y02P20/55
摘要： The present invention is novel compounds which are 4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidine substituted 1,2,4- and 1,3,4-thiadiazoles and oxadiazoles, and 1,2,4-triazoles, and pharmaceutically acceptable additions and base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and particularly rheumatoid arthritis, osteoarthritis, other inflammatory conditions, psoriasis, allergic diseases, asthma, inflammatory bowel disease, GI ulcers, cardiovascular conditions, including ischemic heart disease and atherosclerosis, and ischemia-induced cell damage, particularly brain damage caused by stroke. They can also be used topically for treating acne, sunburn, psoriasis, and eczema. Also included are leukotriene mediated pulmonary, gastrointestinal, inflammatory, dermatological, and cardiovascular conditions. The disclosed compounds also have potential utility as antioxidants. The preferred use is in treating inflammatory conditions. Thus, the present invention is also a pharmaceutical composition or method of manufacturing a pharmaceutical composition for the use of treating the noted conditions.
摘要翻译： PCT No.PCT / US92 / 00442 Sec。 371日期：1993年7月1日 102（e）日期1993年7月1日PCT提交1992年1月17日PCT公布。出版物WO92 / 本发明是4,6-二叔丁基-5-羟基-1,3-嘧啶取代的1,2,4-和1,3,4-噻二唑的新化合物，以及恶二唑和1,2,4-三唑及其药学上可接受的添加剂和碱盐，药物组合物及其使用方法。现在发现本发明化合物具有作为5-脂氧合酶和/或环加氧酶的抑制剂的活性，其提供有利地受到包括炎症，关节炎，疼痛，发烧，特别是类风湿性关节炎，骨关节炎，其它炎性病症，牛皮癣，过敏性疾病，哮喘，炎症性肠病，GI溃疡，心血管疾病，包括缺血性心脏病和动脉粥样硬化，以及缺血诱导的细胞损伤，特别是脑卒中引起的脑损伤。它们也可以局部用于治疗痤疮，晒伤，牛皮癣和湿疹。还包括白三烯介导的肺，胃肠道，炎症，皮肤病学和心血管疾病。所公开的化合物还具有作为抗氧化剂的潜在用途。优选的用途是治疗炎性病症。因此，本发明也是制备用于治疗所述病症的药物组合物的药物组合物或方法。

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