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71. 发明申请

US20100159462A1 TUNABLE ELASTOMERIC NANOCHANNELS FOR NANOFLUIDIC MANIPULATION 有权
标题翻译：用于纳米液体操作的TUNNABLE弹性纳米通道
公开(公告)号：US20100159462A1
公开(公告)日：2010-06-24
申请号：US12597634
申请日：2008-04-23
申请人： Shuichi Takayama , Michael Thouless , Dongeun Huh , Kristen L. Mills , Nicholas Joseph Douville
发明人： Shuichi Takayama , Michael Thouless , Dongeun Huh , Kristen L. Mills , Nicholas Joseph Douville
IPC分类号： G01N33/48 , C12M1/34 , C08F6/28 , C12M3/00 , C12Q1/68 , G01N33/543 , C12N5/00 , B29C55/00
CPC分类号： B82Y30/00 , B01L3/502707 , B01L3/502761 , B01L2200/0663 , B01L2200/0668 , B01L2300/0864 , B01L2300/0896 , B01L2300/123 , B01L2400/0418 , B01L2400/0487 , B01L2400/082
摘要： The invention relates to tunable elastomeric nanochannels for nanofluidic manipulation. In particular, the present invention relates to nanochannels for performing biological assays.
摘要翻译：本发明涉及用于纳米流体操作的可调节弹性纳米通道。特别地，本发明涉及用于进行生物测定的纳米通道。

72. 发明授权

US07704728B2 Microfluidic gravity pump with constant flow rate 有权
标题翻译：微流量重力泵具有恒定流量
公开(公告)号：US07704728B2
公开(公告)日：2010-04-27
申请号：US10198477
申请日：2002-07-18
申请人： Shuichi Takayama , Joseph Chang , Dongeun Huh , Xiaoyue Zhu , Brenda Cho , Gary D. Smith
发明人： Shuichi Takayama , Joseph Chang , Dongeun Huh , Xiaoyue Zhu , Brenda Cho , Gary D. Smith
IPC分类号： C12M1/36
CPC分类号： B01L3/50273 , B01L3/502776 , B01L2200/0647 , B01L2300/163 , B01L2400/0457 , C12M23/16 , F04B19/006 , Y10T137/0318 , Y10T137/0357 , Y10T137/4449 , Y10T436/117497
摘要： A microfluidic system employs a microchannel and a gravity driven pump comprising horizontally oriented fluid supply reservoirs which supplies fluid to the microchannel at a substantially constant rate. The device is useful for numerous microfluidic applications, for example in the culture and/or treatment of biological systems under constant flow-induced stress, cell-size sorting, motile sperm sorting, or embryo culture.
摘要翻译：微流体系统采用微通道和重力驱动泵，其包括以基本恒定的速率向微通道供应流体的水平取向的流体供应储存器。该装置对于许多微流体应用是有用的，例如在恒定流动诱导应激，细胞大小分选，活动精子分选或胚胎培养的生物系统的培养和/或治疗中。

73. 发明授权

US07232686B2 Method of nanopatterning by forming cracks in a coated polymer substrate 有权
标题翻译：通过在涂覆的聚合物基底中形成裂纹的纳米图案化方法
公开(公告)号：US07232686B2
公开(公告)日：2007-06-19
申请号：US10602910
申请日：2003-06-24
申请人： Shuichi Takayama , Xiaoyue Zhu , Joong Hwan Bahng , Elizabeth Ho Liu , Jeongsup Shim
发明人： Shuichi Takayama , Xiaoyue Zhu , Joong Hwan Bahng , Elizabeth Ho Liu , Jeongsup Shim
IPC分类号： C12N5/00 , C12N11/00 , C12Q1/00 , C12Q1/02 , C07K17/08 , C07K17/14
CPC分类号： B82Y30/00 , B81C1/00444 , B82B3/00 , B82Y5/00 , B82Y40/00 , C12N5/0068 , C12N2533/30 , C12N2535/10 , Y10S530/811 , Y10S530/815
摘要： Nanopatterned devices are easily fabricated, over large surface areas when desired, by forming a multilayer article of deformable substrate, brittle layer, and coating layer, and deforming the multilayer film such that a plurality of cracks are formed therein. The cracks have different physicochemical properties than the non-cracked coating layer, and advantageously serve as attachment points for culturing microorganisms.
摘要翻译：通过形成可变形基板，脆性层和涂层的多层制品，并且使多层膜变形从而在其中形成多个裂缝，可以容易地在大面积上制造纳米图案化的器件。裂纹具有与非裂纹涂层不同的物理化学性质，有利地用作培养微生物的附着点。

74. 发明授权

US06993756B2 Optimization apparatus that decreases delays in pipeline processing of loop and computer-readable storage medium storing optimization program 失效
标题翻译：降低循环流水线处理延迟和存储优化程序的计算机可读存储介质的优化装置
公开(公告)号：US06993756B2
公开(公告)日：2006-01-31
申请号：US09798490
申请日：2001-03-02
申请人： Hajime Ogawa , Shuichi Takayama
发明人： Hajime Ogawa , Shuichi Takayama
IPC分类号： G06F9/45
CPC分类号： G06F8/452 , G06F8/4452
摘要： An optimization apparatus is capable of improving the execution efficiency of a loop that includes a loop carry dependency between consecutive iterations of the loop. For example, a value resulting from one iteration is used in an immediately following iteration. When the arithmetic expression “a[i+1]=a[i]*3+2;” is included in a loop body, and a value resulting from the arithmetic expression “a[i+1]=a[i]*3+2;” in one iteration is used in a following iteration, execution delays occur in pipeline processing of the loop. Here, the arithmetic expression “a[i+1]=a[i]*3+2;” is transformed into the arithmetic expression “a[i+4]=a[i]*81+80;” to expand the dependency distance. By doing so, the execution delays can be decreased.
摘要翻译：优化装置能够提高循环的执行效率，该循环在循环的连续迭代之间包括循环进位依赖性。例如，由一次迭代产生的值在紧随其后的迭代中使用。当算术表达式“a [i + 1] = a [i] * 3 + 2;” 被包含在循环体中，并且由算术表达式“a [i + 1] = a [i] * 3 + 2]得到的值; 在一次迭代中，在下一次迭代中使用，在循环的流水线处理中出现执行延迟。这里，算术表达式“a [i + 1] = a [i] * 3 + 2;” 被转换成算术表达式“a [i + 4] = a [i] * 81 + 80;” 扩大依赖距离。通过这样做，可以减少执行延迟。

75. 发明授权

US06653089B2 Differential treatment of selected parts of a single cell with different fluid components 有权
公开(公告)号：US06653089B2
公开(公告)日：2003-11-25
申请号：US09954978
申请日：2001-09-18
申请人： Shuichi Takayama , Emanuele Ostuni , Philip LeDuc , Keiji Naruse , Donald E. Ingber , George M. Whitesides
发明人： Shuichi Takayama , Emanuele Ostuni , Philip LeDuc , Keiji Naruse , Donald E. Ingber , George M. Whitesides
IPC分类号： G01N3353
CPC分类号： G01N33/5011 , A61K35/12 , C12N5/00 , C12N5/069 , C12N2501/48 , C12N2501/58 , C12N2503/00 , C12N2503/02 , C12N2510/00 , G01N33/5008 , G01N33/502 , G01N33/5035 , G01N33/5076 , G01N33/5079 , G01N33/528 , G01N2800/52
摘要： The present invention is directed, in certain embodiments, to improved, small scale systems and methods able to selectively treat parts of a single cell, including, in certain embodiments, portions of a main body portion of a single cell, and able, in certain embodiments, to establish long-term gradients of active substances within subcellular regions of a single cell. The present invention provides, in some embodiments, techniques for selectively contacting a portion of the surface of a biological cell with a fluid or fluid component carrying a particular potential for a biophysical or biochemical interaction with the cell, and simultaneously contacting a different portion of the surface of the cell with another fluid or fluid component having a different potential for the biophysical or biochemical interaction with the cell.

76. 发明授权

US5679216A Method of manufacturing a multi-degree-of-freedom manipulator 失效
标题翻译：制造多自由度机械手的方法
公开(公告)号：US5679216A
公开(公告)日：1997-10-21
申请号：US518260
申请日：1995-08-23
申请人： Shuichi Takayama , Takeaki Nakamura , Tatsuya Yamaguchi , Akio Nakada , Yasuhiro Ueda , Hideyuki Adachi , Katsunori Sakiyama , Yasukazu Tatsumi , Koji Fujio , Masaaki Hayashi , Shinji Kaneko , Yasuo Hirata , Toshimasa Kawai
发明人： Shuichi Takayama , Takeaki Nakamura , Tatsuya Yamaguchi , Akio Nakada , Yasuhiro Ueda , Hideyuki Adachi , Katsunori Sakiyama , Yasukazu Tatsumi , Koji Fujio , Masaaki Hayashi , Shinji Kaneko , Yasuo Hirata , Toshimasa Kawai
IPC分类号： A61B1/005 , H01L21/00
CPC分类号： A61B1/0058
摘要： A multi-degree-of-freedom manipulator includes a flexible tube having a plurality of flex portions provided therealong, a plurality of actuators made of shape memory alloy and respectively provided near the flex portions to correspond to the flex portions, for flexing the flex portions, two common energy transmission paths, extending along the flexible tube, for transmitting an energy to the actuators, and selective energy supply members, provided between the common energy transmission paths and the actuators in series, for controlling the energy supplied from the common energy transmission path to the actuators, thereby respectively independently driving the actuators to bend the flexible tube. The manipulator is made by forming electronic circuits in a plurality of regions on a semiconductor substrate, forming wiring regions to connect the electronic circuits with flexible wiring portions, and removing a region of the semiconductor substrate other than a region thereof on which the electronic circuits are formed, thereby forming an actuator controlled chip array, used in the manipulator.
摘要翻译：多自由度操纵器包括具有设置在其上的多个柔性部分的柔性管，由形状记忆合金制成的多个致动器，并且分别设置在柔性部分附近以对应于柔性部分，用于使柔性部分弯曲，沿着柔性管延伸的用于将能量传递到致动器的两个公共能量传输路径，以及设置在公共能量传输路径和致动器之间的选择性能量供应构件，用于控制从公共能量传输提供的能量从而分别独立地驱动致动器来弯曲柔性管。机械手是通过在半导体基板上的多个区域中形成电子电路而形成的，形成布线区域以将电子电路与柔性布线部分连接起来，以及除去其上电子电路的区域以外的半导体基板的区域从而形成用于机械手的致动器控制芯片阵列。

77. 发明授权

US5402788A Diagnostic system using nuclear magnetic resonance phenomenon 失效
标题翻译：诊断系统采用核磁共振现象
公开(公告)号：US5402788A
公开(公告)日：1995-04-04
申请号：US80224
申请日：1993-06-21
申请人： Koji Fujio , Masakazu Gotanda , Tatsuya Yamaguchi , Shuichi Takayama , Takashi Tsukaya , Toshihiko Hagiwara , Koichi Matsui , Hiroki Hibino , Keiichi Hiyama , Koichi Shimizu , Kenji Yoshino , Masaaki Hayashi
发明人： Koji Fujio , Masakazu Gotanda , Tatsuya Yamaguchi , Shuichi Takayama , Takashi Tsukaya , Toshihiko Hagiwara , Koichi Matsui , Hiroki Hibino , Keiichi Hiyama , Koichi Shimizu , Kenji Yoshino , Masaaki Hayashi
IPC分类号： A61B5/055 , A61M25/095 , G01R33/28 , G01R33/36
CPC分类号： G01R33/34084 , A61B5/055 , G01R33/285 , G01R33/288 , G01R33/3657
摘要： A diagnostic system using a nuclear magnetic resonance phenomenon comprises an external magnetic field generator, provided externally, for generating a magnetic field in a living body, a thin diameter member capable of being inserted into a body cavity and having flexibility, a high frequency coil, provided at a top end of the thin diameter member, for transmitting and receiving a high frequency, a nuclear magnetic resonance signal measuring device for receiving a nuclear magnetic resonance signal from the living body, and a transformer, provided between the high frequency coil and the nuclear magnetic resonance signal measuring device, for electrically isolating and separating the high frequency coil from the nuclear magnetic resonance signal measuring device in a manner such that the nuclear magnetic resonance signal is transmittable between the high frequency coil and the nuclear magnetic resonance signal measuring device.
摘要翻译：使用核磁共振现象的诊断系统包括外部设置的用于在生物体中产生磁场的外部磁场发生器，能够插入体腔并具有柔性的薄直径构件，高频线圈，设置在薄直径构件的顶端，用于发送和接收高频，用于从生物体接收核磁共振信号的核磁共振信号测量装置和设置在高频线圈和核磁共振信号测量装置，用于将核磁共振信号在高频线圈和核磁共振信号测量装置之间传输的方式与核磁共振信号测量装置电隔离和分离。

78. 发明授权

US5273027A Method for dissolving a thickened mass within a living body and dissolving therapeutic apparatus for same 失效
标题翻译：将增稠物质溶解在生物体内并溶解治疗仪器的方法
公开(公告)号：US5273027A
公开(公告)日：1993-12-28
申请号：US589945
申请日：1990-09-28
申请人： Naomi Sekino , Koji Fujio , Koichiro Ishiwara , Naoki Uchiyama , Kenji Noda , Seiji Iwasaki , Shuichi Takayama , Tsuyoshi Tsukagoshi , Koji Koda
发明人： Naomi Sekino , Koji Fujio , Koichiro Ishiwara , Naoki Uchiyama , Kenji Noda , Seiji Iwasaki , Shuichi Takayama , Tsuyoshi Tsukagoshi , Koji Koda
IPC分类号： A61B17/22 , A61B17/225 , A61B19/00 , A61M1/00 , A61N7/00 , A61B17/00 , A61B8/00
CPC分类号： A61N7/00 , A61B17/22 , A61B8/4209 , A61B2017/22082 , A61B2090/064 , A61B2217/005 , A61B8/4218
摘要： In the method and dissolving therapeutic apparatus for dissolving a coagulation within a living body, a medicinal liquid for dissolving the coagulation within the living body is injected into the living body, the injected medicinal liquid is left within the living body for a predetermined time and the fluid within the living body containing the coagulation dissolved by the medicinal liquid and the medicinal liquid is substantially all discharged out of the living body. A series of steps including at least respective injecting, leaving and discharging steps is repeated. Preferably, vibrating waves are radiated toward the coagulation during the leaving step.
摘要翻译：在将生物体内的凝固溶解的方法和溶解治疗装置中，将生物体内凝固的溶解用药液注入生物体内，将注入的药液留在生物体内规定时间，含有由药液溶解的凝固物的生物体内的液体和药液基本上全部从生物体排出。重复包括至少相应的注射，离开和放电步骤的一系列步骤。优选地，在离开步骤期间，振动波朝着凝结物辐射。

79. 发明授权

US5078144A System for applying ultrasonic waves and a treatment instrument to a body part 失效
标题翻译：将超声波应用于身体部位的治疗仪器系统
公开(公告)号：US5078144A
公开(公告)日：1992-01-07
申请号：US366162
申请日：1989-06-14
申请人： Naomi Sekino , Shuichi Takayama , Masakazu Gotanda , Koichiro Ishihara , Naoki Uchiyama , Nobuhiko Watanabe , Masaaki Nakazawa , Tsuguhisa Sasai , Tsutomu Okada , Takeo Haneda , Masaaki Hayashi
发明人： Naomi Sekino , Shuichi Takayama , Masakazu Gotanda , Koichiro Ishihara , Naoki Uchiyama , Nobuhiko Watanabe , Masaaki Nakazawa , Tsuguhisa Sasai , Tsutomu Okada , Takeo Haneda , Masaaki Hayashi
IPC分类号： A61B8/08 , A61B17/00 , A61B17/22 , A61B17/225 , A61B17/34 , A61B19/00 , A61M5/42 , A61M37/00
CPC分类号： A61B17/2251 , A61B17/2256 , A61B8/0833 , A61B8/0841 , A61B8/4209 , A61B8/4218 , A61M37/0092 , A61M5/427 , A61B17/3403 , A61B2017/00106 , A61B2017/00115 , A61B2017/22072 , A61B2017/22084 , A61B2017/22088 , A61B2090/064
摘要： An ultrasonic treatment system for conducting treatment by converging ultrasonic waves which are generated outside of a body to a part to be treated in the body comprising an ultrasonic wave generator for generating the ultrasonic waves to be converged to the part to be treated; and an insertion tube connected to the ultrasonic wave generator for guiding an instrument, such as a syringe, employed to introduce and/or return a treatment material to the body.
摘要翻译：一种超声波处理系统，用于通过将在身体外部产生的超声波聚焦到所述体内的被处理部分进行处理，所述超声波发生器用于产生超声波以收敛到待处理的部分; 以及连接到超声波发生器的插入管，用于引导用于将治疗材料引入和/或返回到身体的诸如注射器的器械。

80. 发明授权

US5035231A Endoscope apparatus 失效
标题翻译：内窥镜装置
公开(公告)号：US5035231A
公开(公告)日：1991-07-30
申请号：US186332
申请日：1988-04-25
申请人： Hiroaki Kubokawa , Takashi Tsukaya , Yasuhiro Ueda , Yutaka Ohshima , Takeaki Nakamura , Hiroki Hibino , Shuichi Takayama , Tadao Hagino
发明人： Hiroaki Kubokawa , Takashi Tsukaya , Yasuhiro Ueda , Yutaka Ohshima , Takeaki Nakamura , Hiroki Hibino , Shuichi Takayama , Tadao Hagino
IPC分类号： A61B1/005 , A61B1/015 , A61B1/018 , G01R33/28
CPC分类号： A61B1/0008 , A61B1/00082 , A61B1/0055 , A61B1/015 , A61B1/018 , G01R33/285 , A61B17/32056
摘要： This endoscope apparatus adapted to meter NMR (nuclear magnetic resonance) is provided with an endoscope having a channel and an NMR metering probe insertable through the channel. The endoscope has an elongate insertable part having an observing window and illuminating window in the tip part, an observing system for observing an object to be imaged by receiving a light from the object entering through the observing window, an illuminating light output system emitting an illuminating light through the illuminating window and a hollow channel formed within the insertable part and opening in the tip part. Preferably, at least the tip side of the insertable part if formed of a non-ferromagnetic characteristic material. The NMR metering probe has a signal transmitting member insertable through the channel of the endoscope, connected at one end to the NMR metering apparatus and able to transmit high frequency signals and a loop-like antenna part connected to the other end of the signal transmitting member and projected out of the opening of the channel.
摘要翻译：适于测量NMR（核磁共振）的内窥镜装置设置有具有通过通道插入的通道和NMR计量探针的内窥镜。内窥镜具有细长的可插入部分，其具有在尖端部分中的观察窗口和照明窗口，观察系统，用于通过接收来自通过观察窗口进入的物体的光来观察待成像对象;照明光输出系统，发射照明通过照明窗口的光线和形成在可插入部分内的中空通道和在尖端部分中的开口。优选地，如果由非铁磁特性材料形成，则至少可插入部分的末端侧。 NMR计量探针具有通过内窥镜的通道插入的信号传递构件，其一端连接到NMR计量装置并且能够传输高频信号和连接到信号传输构件的另一端的环状天线部分并投射出渠道的开放。

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