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    • 73. 发明申请
    • Benzamidine derivatives and process for production thereof
    • 苄脒衍生物及其制备方法
    • US20050101675A1
    • 2005-05-12
    • US10470382
    • 2002-01-28
    • Takayuki HaraToru MinoshimaMasayasu Tabe
    • Takayuki HaraToru MinoshimaMasayasu Tabe
    • C07C257/18C07D211/26A61K31/155
    • C07C257/18C07D211/26
    • A process for production of an amidine derivative represented by the following Formula (II) [wherein, R represents a hydrogen atom, an unsubstituted or substituted phenyl group, an unsubstituted or substituted C1-C10 alkyl group, an unsubstituted or substituted C1-C10 alkoxy group, an unsubstituted or substituted C1-C10 alkoxycarbonyl group, or a hydroxyl group present at the ortho, meta, or para position] or a salt thereof, comprising the steps of reducing an amidoxime derivative represented by the following Formula (I) [wherein, R represents a hydrogen atom, an unsubstituted or substituted phenyl group, an unsubstituted or substituted C1-C10 alkyl group, an unsubstituted or substituted C1-C10 alkoxy group, an unsubstituted or substituted C1-C10 alkoxycarbonyl group, or a hydroxyl group present at the ortho, meta, or para position] with zinc in an acetic acid as a solvent.
    • 一种制备由下式(II)表示的脒衍生物的方法[其中,R表示氢原子,未取代或取代的苯基,未取代或取代的C1-C10烷基,未取代或取代的C1-C10烷氧基 基团,未取代或取代的C 1 -C 10烷氧基羰基,或邻位,间位或对位存在的羟基]或其盐,包括以下步骤:还原由下式(I)表示的偕胺肟衍生物[其中 R表示氢原子,未取代或取代的苯基,未取代或取代的C1-C10烷基,未取代或取代的C1-C10烷氧基,未取代或取代的C1-C10烷氧基羰基或存在于 邻位,间位或对位]与锌在乙酸中作为溶剂。