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    • 73. 发明申请
    • POLYMERSOMES, LIPOSOMES, AND OTHER SPECIES ASSOCIATED WITH FLUIDIC DROPLETS
    • 聚合物,脂质体和其他与液体相关的物质
    • US20140065234A1
    • 2014-03-06
    • US13967018
    • 2013-08-14
    • Ho Cheung ShumDaeyeon LeeInsun YoonDavid A. WeitzJin-Woong Kim
    • Ho Cheung ShumDaeyeon LeeInsun YoonDavid A. WeitzJin-Woong Kim
    • A61K47/34A61K9/16
    • A61K47/34A61K9/1273A61K9/1277A61K9/16A61K9/501A61K9/5031A61K9/5089A61K47/6907A61K47/6915
    • The present invention relates generally to vesicles such as liposomes, colloidosomes, and polymersomes, as well as techniques for making and using such vesicles. In some cases, the vesicles may be at least partially biocompatible and/or biodegradable. The vesicles may be formed, according to one aspect, by forming a multiple emulsion comprising a first droplet surrounded by a second droplet, which in turn is surrounded by a third fluid, where the second droplet comprises lipids and/or polymers, and removing fluid from the second droplet, e.g., through evaporation or diffusion, until a vesicle is formed. In certain aspects, the size of the vesicle may be controlled, e.g., through osmolarity, and in certain embodiments, the vesicle may be ruptured through a change in osmolarity. In some cases, the vesicle may contain other species, such as fluorescent molecules, microparticles, pharmaceutical agents, etc., which may be released upon rupture. Yet other aspects of the invention are generally directed to methods of making such vesicles, kits involving such vesicles, or the like.
    • 本发明一般涉及囊泡,例如脂质体,胶体体和聚合物囊泡,以及制造和使用这些囊泡的技术。 在一些情况下,囊泡可以是至少部分生物相容的和/或可生物降解的。 根据一个方面,可以通过形成多个乳液来形成囊泡,所述多重乳液包括由第二液滴包围的第一液滴,第二液滴又由第三流体包围,其中第二液滴包括脂质和/或聚合物,以及除去流体 从第二液滴,例如通过蒸发或扩散,直到形成囊泡。 在某些方面,可以例如通过渗透压控制囊泡的尺寸,并且在某些实施方案中,泡囊可以通过渗透压的变化破裂。 在一些情况下,泡囊可以含有其它物质,例如荧光分子,微粒,药剂等,其可在破裂时释放。 本发明的其它方面通常涉及制备这种囊泡的方法,涉及这种囊泡的试剂盒等。