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71. 发明申请

US20060110457A1 Heat cured gel and method of making 有权
标题翻译：热固化凝胶及其制作方法
公开(公告)号：US20060110457A1
公开(公告)日：2006-05-25
申请号：US11237263
申请日：2005-09-28
申请人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Thomas Swanick
发明人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Thomas Swanick
IPC分类号： A61K9/14 , A61K31/225
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A method of curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of heat in both temperature and duration to achieve a desired amount of cross-linking forming the gel.
摘要翻译：提供固化方法和相应的所得非聚合交联凝胶。交联凝胶可以与医疗装置结构组合。除了改善愈合和抗炎反应之外，交联凝胶还可提供抗粘附特性。交联凝胶通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。固化方法可以在温度和持续时间内改变热量的应用以实现形成凝胶的所需量的交联。

72. 发明申请

US20060067974A1 Drug delivery coating for use with a stent 有权
标题翻译：用于支架的药物输送涂层
公开(公告)号：US20060067974A1
公开(公告)日：2006-03-30
申请号：US11236908
申请日：2005-09-28
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck
IPC分类号： A61K35/60 , A61F2/00
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： A coated medical device an a method of providing a coating on an implantable medical device result in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the therapeutic agent, to the patient.
摘要翻译：涂覆的医疗装置是在可植入医疗装置上提供涂层的方法，导致具有生物吸收性涂层的医疗装置。涂层包括生物吸收载体组分。除了生物可吸收载体组分之外，还可以提供治疗剂成分。涂覆的医疗装置可植入患者体内以实现对包括治疗剂在内的涂层的可控输送。

73. 发明授权

US06783554B2 Pile mesh prosthesis 有权
标题翻译：桩网假体
公开(公告)号：US06783554B2
公开(公告)日：2004-08-31
申请号：US09789333
申请日：2001-02-20
申请人： Ryan A. Amara , Peter H. Gingras , Theodore Karwoski , Steve A. Herweck
发明人： Ryan A. Amara , Peter H. Gingras , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61F202
CPC分类号： D04B1/22 , A61B17/12022 , A61B17/12099 , A61B17/12168 , A61B17/12177 , A61F2/0063 , A61F2250/0023 , D04B1/02 , D04B21/02 , D04B21/10 , D10B2509/08
摘要： A method and apparatus relating to a biocompatible soft tissue implant is disclosed. The implant, in the form of a prosthesis, is constructed of a knitted pile mesh material arranged into either a 3-dimensional structure or a planar shape or structure. The material or fabric includes a plurality of filament extensions projecting outwardly therefrom. The filament extensions can be radially projecting looping filaments from one or more rows of the knitted pile mesh material. The combination of the filament extensions with the 3-dimensional structure results in the biocompatible implant having a structural resistance to hinder anticipated crushing forces applied to the implant, and also provide a suitable 3-dimensional structure for promoting rapid tissue in-growth to anchor such implant without migration and strengthen the repaired tissue area.
摘要翻译：公开了一种与生物相容性软组织植入相关的方法和装置。以假体形式的植入物由布置成3维结构或平面形状或结构的针织绒头网状材料构成。材料或织物包括从其向外突出的多个细丝延伸部。丝线延伸部可以是一排或多排针织绒网材料的径向突出的细丝。长丝延伸与三维结构的组合导致生物相容性植入物具有阻碍施加到植入物的预期破碎力的结构阻力，并且还提供合适的三维结构，用于促进快速组织生长以锚定植入物没有迁移，并加强了修复的组织区域。

74. 发明授权

US5807358A Dry suction regulator blood collection device 失效
标题翻译：干式吸力调节器采血装置
公开(公告)号：US5807358A
公开(公告)日：1998-09-15
申请号：US472144
申请日：1995-06-07
申请人： Steve A. Herweck , Theodore Karwoski , David Cross
发明人： Steve A. Herweck , Theodore Karwoski , David Cross
IPC分类号： A61M1/00 , A61M1/36
CPC分类号： A61M1/3627 , A61M1/0013 , A61M1/0031 , A61M1/0033
摘要： A blood collection device has a modular suction regulator assembly in the form of an adjustable negative pressure relief valve which controls the level of suction in a collection chamber by admitting air to a short bleed-in passage proximate to a suction connection. The modular assembly is a canister which drops into a receptacle oriented transversely in the collection vessel, and defines a laterally-directed intake manifold which resists blockage. The intake passes centrally through the canister along a path spanned by a filter, past a hat-shaped poppet supported on a compression spring. Fluted and threaded members control the scale and range of poppet response so that the assembly may be calibrated before installation. A face plate covers the installed canister, and radial vanes in the intake manifold double as gripping elements for manual adjustment of the assembly. A bellows meter provides refined suction resolution by linearly advancing across an oblique or curved reference line. Other improvements include a compact and balanced layout of suction canister, seal chamber and collection chamber, and a rigid handle assembly having five faces integral with the device.
摘要翻译：血液采集装置具有可调式负压释放阀形式的模块式抽吸调节器组件，其通过将空气接近靠近抽吸连接处的短的通入通道来控制收集室中的抽吸水平。模块化组件是一种罐，该罐可以放入收集容器中横向定向的容器中，并限定一个防止阻塞的横向定向的进气歧管。进气口沿着由过滤器跨过的路径中心穿过罐体，经过支撑在压缩弹簧上的帽形提升阀。槽形和螺纹构件控制提升阀响应的尺寸和范围，以便在安装之前校准组件。面板覆盖安装的罐，并且进气歧管中的径向叶片作为用于手动调节组件的夹紧元件加倍。波纹管表通过线性前进穿过斜线或弯曲参考线提供精确的吸力分辨率。其他改进包括吸盘，密封腔和收集室的紧凑平衡的布局，以及具有与该装置一体的五个面的刚性手柄组件。

75. 发明授权

US5722964A Filtered blood collection device 失效
标题翻译：过滤采血装置
公开(公告)号：US5722964A
公开(公告)日：1998-03-03
申请号：US487468
申请日：1995-06-07
申请人： Steve A. Herweck , Theodore Karwoski , Nicholas Want
发明人： Steve A. Herweck , Theodore Karwoski , Nicholas Want
IPC分类号： A61M1/00 , A61M1/36
CPC分类号： A61M1/0013 , A61M1/0031 , A61M1/0033 , A61M1/3627
摘要： A blood collection vessel includes a blood inlet, a pooling region in which blood from the inlet collects, and an outlet in the pooling region for reinfusion of the collected blood. A filter located in the blood path between inlet and outlet extends at least in part into the pooling region and impounds clots so they remain away from the outlet but suspended in the collected blood. Preferably, the filter is located to provide venting between both sides of the filter. In one embodiment the filter is a vertical wall, which defines a shielded outlet column or chimney extending above the outlet. Blood permeates to the outlet region over a broad area, and the column forms an open suction path that prevents suction differentials from arising across the filter, so clots cannot be sucked through the large-pore material. With the clots residing in the collected fluid, the total fluid loss is directly displayed in a single window at all times, and maximal use is made of the limited volume in the vessel. In another embodiment, the filter constitutes a false floor or basket in the pooling region. A preferred construction employs filter material on a support grid, to form a flexible and self-supporting filter sheet, which inserts like a plate to compartmentalize the collection vessel and form an impounding surface in the pooling region.
摘要翻译：血液采集容器包括血液入口，来自入口的血液收集的汇集区域以及汇集区域中用于回收血液回输的出口。位于入口和出口之间的血液路径中的过滤器至少部分地延伸到汇集区域中并扣留凝块，使得它们保持远离出口但悬浮在收集的血液中。优选地，过滤器被定位成在过滤器的两侧之间提供排气。在一个实施例中，过滤器是垂直壁，其限定在出口上方延伸的屏蔽出口塔或烟囱。血液在大面积上渗透到出口区域，柱形成一个开放的吸入路径，防止吸入差异跨越过滤器，因此凝块不能通过大孔材料吸入。在收集的液体中存在凝块的情况下，总的流体损失始终直接显示在单个窗口中，并且最大限度地利用了容器中有限的体积。在另一个实施例中，过滤器构成汇集区域中的假地板或篮子。优选的结构是在支撑格栅上使用过滤材料，以形成柔性和自支撑的过滤片，其将类似板的插入物分隔成收集容器并在汇集区域中形成蓄水表面。

76. 发明授权

US5141504A Fluid recovery system with stopcock suction control 失效
标题翻译：流体回收系统采用活塞抽吸控制
公开(公告)号：US5141504A
公开(公告)日：1992-08-25
申请号：US385823
申请日：1989-07-26
申请人： Steve A. Herweck , Theodore Karwoski
发明人： Steve A. Herweck , Theodore Karwoski
IPC分类号： A61M1/00
CPC分类号： A61M1/0013 , A61M1/0056 , A61M2205/3348 , A61M2205/59
摘要： A drainage device includes a vessel having a plurality of sub-chambers one of which is a regulated drainage collection chamber, and two of which cooperate to maintain a selected suction level in the drainage collection chamber. A stopcock proximate to the vessel communicates directly with the two cooperating sub-chambers, and allows quick adjustment and stable operation in varying environments. A float ball arrangement provides an indication of water loss that may compromise the water seal. The device is suitable for wound drainage, and may be used as a cardiotomy reservoir or a thoracic cavity drain device. Different embodiments collect blood for autologous infusion.
摘要翻译：排水装置包括具有多个子室的容器，其中一个是受调节的排水收集室，其中两个辅助以在排液收集室中保持选定的吸入水平。靠近船舶的旋塞阀与两个协作的子舱直接通信，并且允许在不同的环境中进行快速调节和稳定的操作。浮球布置提供可能损害水封的失水指示。该装置适用于伤口引流，可用作心脏切开术储存器或胸腔排液装置。不同的实施例收集用于自体输注的血液。

77. 发明授权

US5397299A Fluid recovery system with improvements molded in body 失效
标题翻译：流体回收系统，改进成型在体内
公开(公告)号：US5397299A
公开(公告)日：1995-03-14
申请号：US817594
申请日：1992-01-07
申请人： Theodore Karwoski , Steve A. Herweck , David Cross
发明人： Theodore Karwoski , Steve A. Herweck , David Cross
IPC分类号： A61M1/00
CPC分类号： A61M1/0001 , A61M1/0013 , A61M1/0015 , A61M1/0056 , A61M2205/3348 , A61M2205/59 , A61M2209/082
摘要： A collection vessel for drainage of body fluids includes a molded body with internal dividers constituting ports, baffles and subchambers, and a face plate that closes the body to form a suction-regulated multi-chamber vessel. The vessel has overpressure and underpressure protection, and resists tipping. The molded body includes a wall structure that enhances its utility for blood collection, monitoring, and reinfusion, and incorporates novel valves, ports, handle and stand.
摘要翻译：用于排出体液的收集容器包括具有构成端口，挡板和子室的内部分隔件的模制体和封闭主体以形成抽吸多腔室容器的面板。该船具有超压和欠压保护，并且抵抗倾翻。成型体包括壁结构，其增强其对采血，监测和再灌注的效用，并且结合新颖的阀，口，手柄和支架。

78. 发明授权

US5380314A In-line fluid recovery system 失效
标题翻译：在线流体回收系统
公开(公告)号：US5380314A
公开(公告)日：1995-01-10
申请号：US755032
申请日：1991-09-04
申请人： Steve A. Herweck , Theodore Karwoski
发明人： Steve A. Herweck , Theodore Karwoski
IPC分类号： A61M1/00
CPC分类号： A61M1/0001 , A61M1/0015 , A61M1/0056
摘要： Apparatus for blood collection includes a collection bag with a suction inlet, a fluid inlet, and an outlet, and an internal stent that resiliently biases the bag into a fixed shape while moving to modulate abrupt variations in suction level. A gross filter about the outlet is located out of the suction path, eliminating blood damage from drying or cell trauma. Different graduation scales show the true volume of collected fluid under suction conditions during collection and with no suction during reinfusion. Two quick-connects allow in-line connection with a chest drain to provide suction, and mate with each other to close the inlets when the filtered bag is removed for gravity reinfusion. When multiple units are piggy-backed, they fill sequentially and may be removed for reinfusion quickly, with only a single tube reconnection required during surgery.
摘要翻译：用于采集血液的装置包括具有抽吸入口，流体入口和出口的收集袋，以及内部支架，其在移动时弹性地将袋偏压以调节吸入水平的突然变化。关于出口的总过滤器位于吸入路径之外，消除了由于干燥或细胞损伤引起的血液损伤。不同的刻度表示收集过程中抽吸条件下收集的液体的真实体积，并且在再灌注期间没有吸力。两个快速连接允许与胸部排水管线连接以提供抽吸，并且当过滤的袋子被移除以重力输入时，彼此配合以关闭入口。当多个单位捎带时，它们依次填充，并且可以快速地移除以进行再灌注，在手术期间仅需要单个管重新连接。

79. 发明授权

US4988342A Improved fluid recovery system 失效
标题翻译：改进流体回收系统
公开(公告)号：US4988342A
公开(公告)日：1991-01-29
申请号：US255764
申请日：1988-10-11
申请人： Steve A. Herweck , Theodore Karwoski
发明人： Steve A. Herweck , Theodore Karwoski
IPC分类号： A61M1/00
CPC分类号： A61M1/0013 , A61M1/0031 , A61M1/0056 , A61M2205/3348 , A61M2205/59
摘要： A thoracic cavity drainage device includes a first vessel having a plurality of chambers one of which is a regulated drainage chamber, and a separate transfer vessel which receives fluid collected in the drainage chamber of the first vessel. The chambers of both vessels are interconnected in a series by fluid passageways which cooperate to maintain a uniform range of suction in the drainage chamber while preventing passage of water into the drainage chamber and permitting a different level of suction in the transfer vessel. This operation is effective despite relatively large pressure and vacuum impulses caused by stripping of drainage lines, patient coughing, and the like, and despite discrete changes in the physical configuration of the system caused by disconnection of the transfer vessel, connection of the transfer vessel to an infusion line or the opening or closing of fluid lines and ports. A novel transfer vessel empties the drainage device and provides gravity reinfusion of the collected fluids. A mechanism within the transfer vessel provides an effective suction without vacuum connections or pressure regulating adjustments.
摘要翻译：胸腔引流装置包括具有多个腔室的第一容器，其中一个腔室是受调节的排液室，以及接收收集在第一容器的排液室中的流体的单独转运容器。两个容器的腔室通过流体通道串联连接，这些通道协作以在排水室中保持均匀的吸力范围，同时防止水进入排水室并允许转移容器中的不同吸力水平。尽管相当大的压力和排水管线的排出引起的真空冲击，患者咳嗽等，尽管由转移容器的断开引起的系统的物理结构发生离散的变化，但是转移容器连接到输液管线或流体管线和端口的打开或关闭。一个新的转移容器排空排水装置，并提供收集的流体的重力回输。转移容器内的机构提供无需真空连接或压力调节调节的有效吸力。

80. 发明授权

US4652263A Elasticization of microporous woven tubes 失效
标题翻译：微孔编织管的弹性
公开(公告)号：US4652263A
公开(公告)日：1987-03-24
申请号：US747035
申请日：1985-06-20
申请人： Steve A. Herweck , Theodore Karwoski
发明人： Steve A. Herweck , Theodore Karwoski
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2002/065
摘要： Disclosed are the product and method for making a macroscopically smooth, microporous, flexible, elastic tubular prosthetic device from a substantially non-elastic woven fabric tube. The method involves axially compressing the substantially non-elastic tube on a tight fitting cylindrical mandrel so that the individual axially oriented threads of the fabric form loops projecting radially outwardly between circumferential threads. The threads are set to return to this loop configuration upon release of tension applied axially to the tube. The exterior of the tube presents an easily deformed, macroscopically smooth surface having a multiplicity of interstices among the threads and among the fibers of the threads into which cells can grow after implantation.
摘要翻译：公开了用于从基本上非弹性的机织织物管制造宏观平滑，微孔，柔性，弹性的管状假体装置的产品和方法。该方法包括在紧密配合的圆柱形心轴上轴向压缩基本上非弹性的管，使得织物的各个轴向定向的线形成在圆周螺纹之间径向向外突出的环。当释放沿轴向施加到管上的张力时，螺纹被设置为返回到该回路结构。管的外部呈现容易变形的宏观光滑表面，其在螺纹之间以及在植入后细胞能够生长的螺纹的纤维之间具有多个间隙。

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