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    • 76. 发明申请
    • Process for production of hydroxybenzoic acids
    • 羟基苯甲酸的制备方法
    • US20060183939A1
    • 2006-08-17
    • US10547763
    • 2004-03-02
    • Ryuzo UenoMasaya KitayamaRyoichi OtsukaTakeshi Shirai
    • Ryuzo UenoMasaya KitayamaRyoichi OtsukaTakeshi Shirai
    • C07C51/15
    • C07C51/15C07C65/03
    • The present invention provides A method for producing a hydroxybenzoic acid compound comprising, preparing an alkali metal salt of a phenol compound from the phenol compound, and reacting the alkali metal salt of the phenol compound with carbon dioxide, wherein the step of preparing the alkali metal salt of the phenol compound from the phenol compound comprises the steps of: a) reacting an alkali metal alkoxide with an excess amount of the phenol compound, which is in excess of the alkali metal alkoxide, to give the alkali metal salt of the phenol compound, and b) distilling away the generated alcohol from the reaction simultaneously with carrying out step a). The method of the present invention makes it possible to produce hydroxybenzoic acid compound in high yield without using aprotic polar organic solvent.
    • 本发明提供一种羟基苯甲酸化合物的制造方法,其特征在于,含有由酚化合物制备酚化合物的碱金属盐,使酚化合物的碱金属盐与二氧化碳反应,其中,制备碱金属 酚酚化合物的盐包括以下步骤:a)使碱金属醇盐与过量碱金属醇盐的过量的酚化合物反应,得到酚化合物的碱金属盐 ,和b)在进行步骤a)的同时蒸馏生成的醇与反应物。 本发明的方法使得可以在不使用非质子极性有机溶剂的情况下高产率生产羟基苯甲酸化合物。
    • 78. 发明授权
    • Crystalline mixture solid composition and process for preparation thereof
    • 结晶混合物固体组合物及其制备方法
    • US06746541B2
    • 2004-06-08
    • US09958666
    • 2001-10-12
    • Ryuzo UenoAkihiko TabataJunya HondaYojiro FurukawaSho Arai
    • Ryuzo UenoAkihiko TabataJunya HondaYojiro FurukawaSho Arai
    • C13F300
    • C07H1/08A23L27/34C40B40/00
    • A crystalline mixture solid composition which has almost no hygroscopicity, is easy to handle and dissolve and hardly worn by abrasion, and comprises &agr;-D-glucopyranosyl-1,1-mannitol and &agr;-D-glucopyranosyl-1,6-sorbitol and may further comprise &agr;-D-glucopyranosyl-1,1-sorbitol in a certain case is obtained in an extremely short period of time by a power-saving and labor-saving process with a small-scale apparatus. A composition which comprises 20 to 75 wt % of &agr;-D-glucopyranosyl-1,1-mannitol, 23 to 70 wt % of &agr;-D-glucopyranosyl-1,6-sorbitol and 2 to 25 wt % of &agr;-D-glucopyranosyl-1,1-sorbitol and is in a crystalline mixture solid state or has a specific surface area of 0.07 to 0.1 m2/g, and a composition which comprises 30 to 75 wt % of &agr;-D-glucopyranosyl-l,1-mannitol, 25 to 70 wt % of &agr;-D-glucopyranosyl-1,6-sorbitol and has a specific surface area of 0.07 to 0.1 m2/g. The above compositions are produced by a process comprising supplying a raw material, which is obtained by optionally removing trehalulose from a mixture containing isomaltulose and trehalulose produced from cane sugar through an isomerization reaction and hydrogenating into a kneader having a thin and long cooling zone together with seed crystals and discharging the obtained composition from an outlet continuously.
    • 具有几乎没有吸湿性的结晶混合物固体组合物易于处理和溶解并且几乎不被磨损磨损,并且包括α-D-吡喃葡萄糖基-1,1-甘露醇和α-D-吡喃葡萄糖基-1,6-山梨糖醇,并且还可以包含α 通过小型装置的省电省力的方法,在极短的时间内可以获得一定的D-吡喃葡萄糖基-1,1-山梨醇.1。一种组合物,其含有20〜75重量% α-D-吡喃葡萄糖基-1,1-甘露醇,23〜70重量%的α-D-吡喃葡萄糖基-1,6-山梨醇和2〜25重量%的α-D-吡喃葡萄糖基-1,1-山梨醇, 结晶混合物固态或比表面积为0.07〜0.1m 2 / g,组成为30〜75重量%的α-D-吡喃葡萄糖基-1,1-甘露糖醇,25〜70重量% 的α-D-吡喃葡萄糖基-1,6-山梨糖醇,其比表面积为0.07〜0.1m 2 / g。上述组合物通过包括供给原料的方法制备, 通过任选地通过异构化反应从蔗糖产生的异麦芽酮糖和海藻糖醇的混合物中任选除去海藻糖糖,并将其与晶种一起氢化成具有薄而长的冷却区的捏合机,并连续从出口排出所得组合物。