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71. 发明申请

US20060063782A1 3-Hetero arylmethoxy ! pyridines and their analogues as p38 map kinase inhibitors 审中-公开
标题翻译： 3-芳基甲氧基吡啶及其类似物作为p38映射激酶抑制剂
公开(公告)号：US20060063782A1
公开(公告)日：2006-03-23
申请号：US10519922
申请日：2003-07-03
申请人： Christopher Murray , Michael Hartshorn , Martyn Frederickson , Miles Congreve , Alessandro Padova , Steven Woodhead , Adrian Gill , Andrew Woodhead
发明人： Christopher Murray , Michael Hartshorn , Martyn Frederickson , Miles Congreve , Alessandro Padova , Steven Woodhead , Adrian Gill , Andrew Woodhead
IPC分类号： A61K31/4965 , C07D213/63 , A61K31/44
CPC分类号： C07D213/73 , C07D213/65 , C07D213/74 , C07D213/81 , C07D241/18 , C07D241/20 , C07D241/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12 , C07D417/14 , C07D513/04
摘要： Compounds of the formula (I), wherein: —X═Y— is selected from —CR =CR — and —CR ═N—; R is selected from H, halo, NRR′, NHC(═O)R, NHC(═O)NRR′, NH2SO2R, and C(═O)NRR′; R and R (where present) are independently selected from H, optionally substituted C1-7 alkyl, optionally substituted C5-20 aryl, optionally substituted C3-20 heterocyclyl, halo, amino, amido, hydroxy, ether, thio, thioether, acylamido, ureido and sulfonamino; R is an optionally substituted C5-20 aryl or C5-20 heteroaryl group; and R is selected from R , halo, NHR , C(═O)NHR , OR , SR , NHC(═O)R , NHC(═O)NHR , NHS(═O)R , wherein R is H or C1-3 alkyl (optionally substituted by halo, NH2, OH, SH) are disclosed for use in therapy and for treating diseases ameliorated by inhibiting p38 MAP kinase.
摘要翻译：式（I）的化合物，其中：-X-Y-选自-CR 2 = CR 3 - 和-CR 2 -N-; R 1选自H，卤素，NRR'，NHC（-O）R，NHC（-O）NRR'，NH 2 SO 2 R和C（-O）NRR'; R 2和R 3（如果存在）独立地选自H，任选取代的C 1-7烷基，任选取代的C 5-20芳基，任选取代的C 3-20杂环基，卤素，氨基，酰胺基，羟基，醚，硫代，硫醚，酰氨基，脲基和磺氨基; R 4是任选取代的C 5-20芳基或C 5-20杂芳基; R 5选自R 5，卤素，NHR 5，C（O）NHR 5，OR 5，SR 5，NHC（-O） R 5，NHC（-O）NHR 5，NHS（-O）R 5，其中R 5'是H或C 1-3烷基（任选地被卤素，NH 2，OH ，SH）被公开用于治疗和治疗通过抑制p38 MAP激酶而改善的疾病。

72. 发明申请

US20050238607A1 FGF-5 supported and binding peptides 有权
标题翻译： FGF-5支持和结合肽
公开(公告)号：US20050238607A1
公开(公告)日：2005-10-27
申请号：US10984410
申请日：2004-11-08
申请人： Anthony Day , Christopher Murray , Scott Power , Beverley Rider Turnquest
发明人： Anthony Day , Christopher Murray , Scott Power , Beverley Rider Turnquest
IPC分类号： A61K38/08 , A61K38/54 , A61K38/55 , C07H21/04 , C07K7/06 , C07K14/81 , C12N1/21 , C12N9/99 , C12N15/62 , C12N15/74 , C12P21/06 , A61K7/06 , A61K7/11
CPC分类号： C07K14/81 , A61K38/00 , C07K7/06 , C07K14/811 , C07K2319/00 , C12N15/62
摘要： The present invention provides peptides and supported peptides that bind to FGF-5.
摘要翻译：本发明提供了结合FGF-5的肽和负载的肽。

73. 发明申请

US20050217728A1 Water feeder controller for boiler 有权
标题翻译：锅炉供水控制器
公开(公告)号：US20050217728A1
公开(公告)日：2005-10-06
申请号：US11141594
申请日：2005-05-31
申请人： Christopher Murray , Richard Lyons
发明人： Christopher Murray , Richard Lyons
IPC分类号： G05D9/12
CPC分类号： G05D9/12 , Y10T137/0324 , Y10T137/7306 , Y10T137/8342 , Y10T137/86389 , Y10T137/86413 , Y10T307/779 , Y10T307/957
摘要： A water feeder controller for a boiler monitors a low water cutoff sensor in a boiler and uses a feed timer to feed water to the boiler for a predetermined feed period of time. The feed timer brings the water level in the boiler well above the low water cutoff sensor. The feed timer supplies water to the boiler only if the low water cutoff sensor continues to indicate a low water level for a delay period of time measured by a delay timer. A resettable display indicates the quantity of water supplied by the water feeder to the boiler based on a feed counter incremented during water feeding. A manual feed button allows water to be manually fed to the boiler. The quantity of water manually supplied to the boiler is also shown on the display. The feed timer and delay timer are preferably implemented in software in a microcontroller in the water feeder controller. A lockout loop in the software prevents overfeeding of water to the boiler in the event of a failure of the low water cutoff sensor.
摘要翻译：用于锅炉的给水器控制器监测锅炉中的低水分截止传感器，并且使用进料定时器将水供给到锅炉预定的进料周期。进料定时器使锅炉中的水位高于低水位截止传感器。只有当低水位截止传感器在延迟定时器测量的延迟时间内继续显示低水位时，进给计时器才向锅炉供水。可复位的显示器表示供水给供水到锅炉的供水量是基于在给水期间递增的送料计数器。手动进给按钮可以将水手动进给锅炉。手动供应给锅炉的水量也显示在显示屏上。馈送定时器和延迟定时器优选地在供水控制器中的微控制器中以软件实现。如果低水位截止传感器发生故障，软件中的闭锁回路可防止水过量进入锅炉。

74. 发明授权

US06586464B2 Artemisinin analogs having antimalarial, antiproliferative, and antitumor activities and chemoselective methods of making the same 有权
标题翻译：具有抗疟疾，抗增殖和抗肿瘤活性的青蒿素类似物和制备相同的化学选择性方法
公开(公告)号：US06586464B2
公开(公告)日：2003-07-01
申请号：US09887922
申请日：2001-06-22
申请人： Gary H. Posner , Hardwin O'Dowd , Suji Xie , Theresa A. Shapiro , Christopher Murray
发明人： Gary H. Posner , Hardwin O'Dowd , Suji Xie , Theresa A. Shapiro , Christopher Murray
IPC分类号： C07D51900
CPC分类号： C07D493/18 , C07D519/00
摘要： Methods for producing novel artemisinin analogs and artemisinin dimers having antimalarial, antiproliferative and antitumor activities are described herein. These novel artemisinin analogs and artemisinin dimers have the following structure or diastereomers thereof, having antimalarial, and antiproliferative and antitumor activities wherein, the monomers of the present invention are formed when n is I and R is alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl. The dimers of the present invention are formed when n is 2 and R is a linker including, but not limited to, alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl.
摘要翻译：本文描述了具有抗疟疾，抗增殖和抗肿瘤活性的新型青蒿素类似物和青蒿素二聚体的生产方法。这些新型青蒿素类似物和青蒿素二聚体具有以下结构的非对映异构体，具有抗疟和抗增殖和抗肿瘤活性，其中当n为I时，本发明的单体形成，R为烷基，环烷基，杂烷基，杂环烷基，烯基，炔基，芳基或杂芳基。本发明的二聚体在n为2时形成，R为包括但不限于烷基，环烷基，杂烷基，杂环烷基，烯基，炔基，芳基或杂芳基的连接体。

75. 发明授权

US06297272B1 Artemisinin analogs having antimalarial antiproliferative and antitumor activities and chemoselective methods of making the same 失效
标题翻译：具有抗疟疾抗增殖和抗肿瘤活性的青蒿素类似物和制备相同的化学选择性方法
公开(公告)号：US06297272B1
公开(公告)日：2001-10-02
申请号：US09228668
申请日：1999-01-12
申请人： Gary H. Posner , Hardwin O'Dowd , Suji Xie , Theresa A. Shapiro , Christopher Murray
发明人： Gary H. Posner , Hardwin O'Dowd , Suji Xie , Theresa A. Shapiro , Christopher Murray
IPC分类号： A61K21357
CPC分类号： C07D493/18 , C07D519/00
摘要： Methods for producing novel artemisinin analogs and artemisinin dimers having antimalarial, antiproliferative and antitumor activities are described herein. These novel artemisinin analogs and artemisinin dimers have the following structure or diastereomers thereof, having antimalarial, and antiproliferative and antitumor activities wherein, the monomers of the present invention are formed when n is 1 and R is alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl. The dimers of the present invention are formed when n is 2 and R is a linker including, but not limited to, alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl.
摘要翻译：本文描述了具有抗疟疾，抗增殖和抗肿瘤活性的新型青蒿素类似物和青蒿素二聚体的生产方法。这些新型青蒿素类似物和青蒿素二聚体具有以下结构的非对映体，具有抗疟疾和抗增殖和抗肿瘤活性，其中当n为1时，本发明的单体形成，R为烷基，环烷基，杂烷基，杂环烷基，烯基，炔基，芳基或杂芳基。本发明的二聚体在n为2时形成，R为包括但不限于烷基，环烷基，杂烷基，杂环烷基，烯基，炔基，芳基或杂芳基的连接体。

76. 发明授权

US5840925A Trioxane dimer compounds having antiproliferative and antitumor activities 失效
标题翻译：具有抗增殖和抗肿瘤活性的三恶烷二聚体化合物
公开(公告)号：US5840925A
公开(公告)日：1998-11-24
申请号：US759254
申请日：1996-12-02
申请人： Qun Y. Zheng , Christopher Murray , Randall J. Daughenbaugh , Poonsakdi Ploypradith , Gary H. Posner
发明人： Qun Y. Zheng , Christopher Murray , Randall J. Daughenbaugh , Poonsakdi Ploypradith , Gary H. Posner
IPC分类号： C07D493/18 , A61K31/352 , A61P35/00 , C07D519/00 , C07D321/02
CPC分类号： C07D519/00 , A61K47/481
摘要： Described herein are novel trioxane dimers of structure ##STR1## which possess antiproliferative and antitumor activities.
摘要翻译：本文描述了具有抗增殖和抗肿瘤活性的结构“IMAGE”的新型三恶烷二聚体。

77. 发明授权

US5171201A Back exercise device 失效
标题翻译：背部锻炼装置
公开(公告)号：US5171201A
公开(公告)日：1992-12-15
申请号：US400799
申请日：1989-08-30
申请人： Christopher Murray , Binyamin Rothstein
发明人： Christopher Murray , Binyamin Rothstein
IPC分类号： A63B23/02
CPC分类号： A63B23/0233 , A63B2210/50
摘要： A back exerciser is portable, stores in a collapsed position, accommodates people of all different sizes, and allows one to safely exercise all the muscle groups in one's back using resistance provided by one's own weight. First and second pairs of support legs are pivotally connected together at one end of each. Pivotal movement between a collapsed position and an operative position in which the legs of the supports have an angular relationship of about 45.degree.-75.degree. with respect to each other is provided, with positive stops supporting the legs in their maximum angular orientation. The first legs have an angle of about 20.degree.-30.degree. to the vertical. A platform is mounted for movement between a first position in which it is between and parallel to the legs of the first support, and a second position in which it is generally horizontal and disposed above the second support legs. With the platform in the first position one can exercise one's upper back by standing on rungs extending between the legs of the first support legs, engaging the platform with one's legs, and bending one's torso over the second support. With the platform in the horizontal position, one can exercise the lower back by laying on the platform, gripping the legs of the second support with one's hands, and raising one's legs separately or in unison to progressively tense the muscles of the lower back.
摘要翻译：背部运动器是便携式的，存放在折叠的位置，容纳所有不同尺寸的人，并且允许人们使用自身重量提供的阻力来安全地锻炼身体的所有肌群。第一和第二对支撑腿在每个的一端枢转连接在一起。提供折叠位置和支撑腿之间相对于彼此具有约45°-75°的角度关系的操作位置之间的枢转运动，其中止动器支撑腿处于其最大角度定向。第一条腿的垂直角度约为20°-30°。平台安装成在第一位置和第二位置之间移动，第一位置在第一位置和第二位置之间，第二位置大致水平并且设置在第二支撑腿的上方。在平台处于第一位置的情况下，可以站立在第一支撑腿的腿部之间延伸的梯级上，使平台与腿部接合，并将身体的躯干弯曲到第二支撑件上，从而锻炼自己的上背部。平台处于水平位置时，可以通过躺在平台上锻炼下背部，用手握住第二支撑的腿部，单独或一致地抬起腿部，逐渐拉紧下背部肌肉。

78. 发明申请

US20130302358A1 MORPHOLOGICALLY AND SIZE UNIFORM MONODISPERSE PARTICLES AND THEIR SHAPE-DIRECTED SELF-ASSEMBLY 审中-公开
标题翻译：形态和尺寸均匀单体颗粒及其形状指导的自组装
公开(公告)号：US20130302358A1
公开(公告)日：2013-11-14
申请号：US13876266
申请日：2011-10-03
申请人： Joshua E. Collins , Howard Y. Bell , Xingchen Ye , Christopher Murray
发明人： Joshua E. Collins , Howard Y. Bell , Xingchen Ye , Christopher Murray
IPC分类号： C09K11/77 , B42D15/00 , C30B7/08
CPC分类号： C09K11/7791 , B42D15/00 , B82Y30/00 , C01F17/0031 , C01F17/0043 , C01F17/0062 , C01F17/0087 , C01P2002/52 , C01P2002/54 , C01P2002/72 , C01P2002/84 , C01P2004/04 , C01P2004/10 , C01P2004/11 , C01P2004/16 , C01P2004/20 , C01P2004/32 , C01P2004/40 , C01P2004/42 , C01P2004/52 , C01P2004/62 , C01P2004/64 , C09K11/7773 , C30B7/08 , Y10T428/2933
摘要： Monodisperse particles having: a single pure crystalline phase of a rare earth-containing lattice, a uniform three-dimensional size, and a uniform polyhedral morphology are disclosed. Due to their uniform size and shape, the monodisperse particles self assemble into superlattices. The particles may be luminescent particles such as down-converting phosphor particles and up-converting phosphors. The monodisperse particles of the invention have a rare earth-containing lattice which in one embodiment may be an yttrium-containing lattice or in another may be a lanthanide-containing lattice. The monodisperse particles may have different optical properties based on their composition, their size, and/or their morphology (or shape). Also disclosed is a combination of at least two types of monodisperse particles, where each type is a plurality of monodisperse particles having a single pure crystalline phase of a rare earth-containing lattice, a uniform three-dimensional size, and a uniform polyhedral morphology; and where the types of monodisperse particles differ from one another by composition, by size, or by morphology. In a preferred embodiment, the types of monodisperse particles have the same composition but different morphologies. Methods of making and methods of using the monodisperse particles are disclosed.
摘要翻译：公开了具有：含有稀土晶格的单一纯晶相，均匀的三维尺寸和均匀的多面体形态的单分散颗粒。由于其均匀的尺寸和形状，单分散颗粒自组装成超晶格。颗粒可以是发光颗粒，例如下转换荧光体颗粒和上转换荧光体。本发明的单分散颗粒具有含稀土晶格，在一个实施方案中可以是含钇的晶格，或者另一个可以是含镧系元素的晶格。基于它们的组成，它们的尺寸和/或其形态（或形状），单分散颗粒可以具有不同的光学性质。还公开了至少两种类型的单分散颗粒的组合，其中每种类型是具有单一纯结晶相的含稀土晶格的单分散颗粒，均匀的三维尺寸和均匀的多面体形态; 并且其中单分散颗粒的类型通过组成，尺寸或形态彼此不同。在优选的实施方案中，单分散颗粒的类型具有相同的组成但不同的形态。公开了制备方法和使用单分散颗粒的方法。

79. 发明授权

US08101648B2 Hydroxybenzamide derivatives and their use as inhibitors of HSP90 有权
标题翻译：羟基苯甲酰胺衍生物及其作为HSP90抑制剂的用途
公开(公告)号：US08101648B2
公开(公告)日：2012-01-24
申请号：US11911490
申请日：2006-04-13
申请人： Gianni Chessari , Miles Stuart Congreve , Eva Figueroa Navarro , Martyn Frederickson , Christopher Murray , Alison Jo-Anne Woolford , Maria Grazia Carr , Michael Alistair O'Brien , Andrew James Woodhead , Robert Downham , Theresa Rachel Phillips
发明人： Gianni Chessari , Miles Stuart Congreve , Eva Figueroa Navarro , Martyn Frederickson , Christopher Murray , Alison Jo-Anne Woolford , Maria Grazia Carr , Michael Alistair O'Brien , Andrew James Woodhead , Robert Downham , Theresa Rachel Phillips
IPC分类号： A01N43/38 , A61K31/40 , C07D209/44
CPC分类号： C07D401/12 , C07C65/21 , C07D209/08 , C07D209/44 , C07D215/08 , C07D217/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D471/04 , C07D471/10 , C07D491/08 , C07D491/10
摘要： The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydrogen; R2 is hydroxy or methoxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors.
摘要翻译：本发明提供式（I）的化合物：或其盐，互变异构体，溶剂合物和N-氧化物; 其中R1是氢; R2是羟基或甲氧基; R3选自氢; 卤素; 氰基; 任选取代的C 1-5烃基和任选取代的C 1-5烃氧基; R4选自氢; 其中n为0或1，R7为任选取代的无环C 1-5烃基或具有3至7个环成员的单环碳环或杂环基团 - （O）n -R 7基团; 卤素; 氰基; 羟基; 氨基; 和任选取代的单或二-C 1-5烃基 - 氨基; 或R 3和R 4一起形成5至7个环成员的单环碳环或杂环; 并且NR 5 R 6形成具有8至12个环成员的任选取代的双环杂环基，其中多达5个环成员是选自氧，氮和硫的杂原子。该化合物具有作为Hsp90抑制剂的活性。

80. 发明授权

US07847120B2 Compositions of allosteric hemoglobin modifiers and methods of making the same 有权
标题翻译：变构血红蛋白修饰剂的组成及其制备方法
公开(公告)号：US07847120B2
公开(公告)日：2010-12-07
申请号：US11112389
申请日：2005-04-22
申请人： Al Quick , Antonio M. Santos , Alexandre J G G Carvalho , Douglas G. Johnson , Jeffrey B. Etter , Christopher Murray
发明人： Al Quick , Antonio M. Santos , Alexandre J G G Carvalho , Douglas G. Johnson , Jeffrey B. Etter , Christopher Murray
IPC分类号： C07C229/00 , C07C65/03
CPC分类号： A61K31/195
摘要： The present invention provides novel compositions of allosteric hemoglobin modifiers which are substantially free of impurities, specifically polymeric impurities. In one embodiment, the novel compositions contain an allosteric hemoglobin modifier compound and less than 100 ppm of the polymeric impurities generated during the preparation of this compound. Included in the present invention are novel methods for preparing allosteric hemoglobin modifiers that are substantially free of polymeric impurities. Also included in the present invention are improved methods for the purification of the product formed by the method of this invention. The novel methods of purification comprise extracting the crude composition with a water immiscible or partially immiscible solvent such as methylisobutyl ketone (MIBK) to lower amounts of impurities, specifically polymeric impurities. Also included are methods to reduce impurities by recrystallization of the crude synthesized product, followed by filtration of the recrystallized product. The present invention also includes the products made by the processes of the invention and methods for analyzing compositions comprised of these products.
摘要翻译：本发明提供基本上不含杂质，特别是聚合物杂质的变构血红蛋白改性剂的新型组合物。在一个实施方案中，新型组合物含有变构血红蛋白改性剂化合物，并且在制备该化合物期间产生小于100ppm的聚合物杂质。本发明包括制备基本上不含聚合物杂质的变构型血红蛋白改性剂的新方法。本发明还包括用于纯化通过本发明方法形成的产品的改进方法。新颖的纯化方法包括用与水不混溶或部分不混溶的溶剂如甲基异丁基酮（MIBK）提取粗组合物以降低杂质量，特别是聚合物杂质。还包括通过粗合成产物的重结晶减少杂质的方法，然后过滤重结晶产物。本发明还包括通过本发明的方法制备的产品和用于分析由这些产品组成的组合物的方法。

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