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71. 发明申请

US20110237640A1 PYRAZOLE PHENYL DERIVATIVES 审中-公开
标题翻译：吡唑苯衍生物
公开(公告)号：US20110237640A1
公开(公告)日：2011-09-29
申请号：US13152756
申请日：2011-06-03
申请人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Blake Wright
发明人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Blake Wright
IPC分类号： A61K31/415 , C07D231/12 , A61P3/10
CPC分类号： C07D231/12
摘要： The invention relates to compounds of the formula I: wherein one of R5, R6 and R7 is and X1, X2, R1 to R15 and n are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR δ and/or PPARα agonists.
摘要翻译：本发明涉及式I化合物：其中R 5，R 6和R 7中的一个是和X 1，X 2，R 1至R 15和n如说明书中所定义，及其药学上可接受的盐和/或酯。本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防由PPARδ和/或PPARα激动剂调节的疾病的用途。

72. 发明授权

US07973051B2 Aminothiazoles as FBPase inhibitors for diabetes 失效
标题翻译：氨基噻唑作为糖尿病的FBPase抑制剂
公开(公告)号：US07973051B2
公开(公告)日：2011-07-05
申请号：US12267661
申请日：2008-11-10
申请人： Paul Hebeisen , Eric A. Kitas , Rudolf E. Minder , Peter Mohr , Hans Peter Wessel
发明人： Paul Hebeisen , Eric A. Kitas , Rudolf E. Minder , Peter Mohr , Hans Peter Wessel
IPC分类号： A61K31/4365 , A61K31/427 , A61K31/428
CPC分类号： C07D495/04 , C07D417/12 , C07D417/14 , C07D513/04
摘要： Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R3 have the significance given in claim 1 and which can be used in the form of pharmaceutical compositions.
摘要翻译：式（I）化合物及其药学上可接受的盐和酯，其中R 1至R 3具有权利要求1中给出的含义，并且可以以药物组合物的形式使用。

73. 发明申请

US20090143439A1 NEW PYRIDINES AS FBPASE INHIBITORS FOR TREATMENT OF DIABETES 失效
标题翻译：新型吡啶类作为FBPASE抑制剂治疗糖尿病
公开(公告)号：US20090143439A1
公开(公告)日：2009-06-04
申请号：US12276440
申请日：2008-11-24
申请人： Wolfgang Haap , Paul Hebeisen , Eric A. Kitas , Bernd Kuhn , Peter Mohr , Hans Peter Wessel
发明人： Wolfgang Haap , Paul Hebeisen , Eric A. Kitas , Bernd Kuhn , Peter Mohr , Hans Peter Wessel
IPC分类号： A61K31/4439 , C07D409/02 , C07D409/14 , C07D413/14 , A61K31/4436
CPC分类号： C07D213/75 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/14
摘要： Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof wherein the residues have the significance given in claim 1 and which can be used in the form of pharmaceutical compositions.
摘要翻译：式（I）化合物及其药学上可接受的盐和酯，其中残基具有权利要求1中给出的含义，其可以以药物组合物的形式使用。

74. 发明授权

US07495001B2 Benzannelated derivatives, their manufacture and use as pharmaceutical agents 失效
标题翻译：苄基化衍生物，其制造和用作药剂
公开(公告)号：US07495001B2
公开(公告)日：2009-02-24
申请号：US10977651
申请日：2004-10-29
申请人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Blake Wright
发明人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Blake Wright
IPC分类号： A01N43/54 , A61K31/435 , C07D239/02 , C07D211/70
CPC分类号： C07D213/30 , C07D213/38 , C07D239/26
摘要： There are presented compounds of the formula wherein R6 and R7 is R4 and R5 or R5 and R6 together with the carbon atoms to which they are attached, form a ring as defined in the description and X1, X2, Y1 to Y4, R1 to R13 and n are as specified in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
摘要翻译：提供下式的化合物其中R 6和R 7是R 4，R 5或R 5和R 6与它们所连接的碳原子一起形成如说明书中所定义的环，X 1，X 2，Y 1至Y 4，R 1至R 13 和n如说明书中所述，以及所有对映异构体及其药学上可接受的盐和/或酯。本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防由PPARδ和/或PPARα激动剂调节的疾病的用途。

75. 发明申请

US20080315535A1 Clamping Device 失效
标题翻译：夹紧装置
公开(公告)号：US20080315535A1
公开(公告)日：2008-12-25
申请号：US11816991
申请日：2006-01-21
申请人： Peter Mohr , Josef Greif
发明人： Peter Mohr , Josef Greif
IPC分类号： B23B31/107 , B23B31/26 , B23B31/10
CPC分类号： B23B31/265 , B23B31/02 , B23B2231/52 , Y10T279/17564 , Y10T279/17632 , Y10T279/17752 , Y10T409/309296 , Y10T409/309464 , Y10T409/30952
摘要： The invention relates to a clamping device for removably mounting a tool (3) or a tool fixture in a receiving part (1). Said clamping device comprises several pincers elements (33) which are concentrically arranged around a central axis (32) within the receiving part (1) and are impinged upon by a tension spring (39) so as to be moved into a clamping position in order to brace the tool (3) or the tool fixture. In order to be able to automatically replace a tool without using much force and energy, an axially movable closing element (17) is assigned to the pincers elements (33). Said closing element (17) impinges the pincers elements (33) in a forward position that is advanced in the direction of the pincers elements (33) for mounting purposes in the clamping position thereof, which is swiveled inward by means of the tension spring (39), while being movable into a retracted position with the aid of a detaching device (12, 16, 45, 46, 47) in order to release the pincers elements (3).
摘要翻译：本发明涉及一种用于将工具（3）或工具夹具可拆卸地安装在接收部件（1）中的夹紧装置。所述夹紧装置包括多个夹持器元件（33），其围绕接收部分（1）内的中心轴线（32）同心地布置并且被拉伸弹簧（39）撞击，以便按顺序移动到夹紧位置支撑工具（3）或工具夹具。为了能够在不用太多力和能量的情况下自动地更换工具，轴向移动的关闭元件（17）被分配给钳子元件（33）。所述关闭元件（17）将所述钳元件（33）向前方施力，所述向前位置在所述钳元件（33）的方向上前进，用于在其夹紧位置进行安装，所述夹紧位置通过所述拉伸弹簧 39），同时借助于分离装置（12,16,45,46,47）可移动到缩回位置，以便释放钳元件（3）。

76. 发明授权

US07348349B2 Oxazole derivatives 失效
标题翻译：恶唑衍生物
公开(公告)号：US07348349B2
公开(公告)日：2008-03-25
申请号：US11183360
申请日：2005-07-18
申请人： Alfred Binggeli , Markus Boehringer , Uwe Grether , Hans Hilpert , Georges Hirth , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Fabienne Ricklin
发明人： Alfred Binggeli , Markus Boehringer , Uwe Grether , Hans Hilpert , Georges Hirth , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Fabienne Ricklin
IPC分类号： A61K31/421 , C07D263/30
CPC分类号： C07D263/32
摘要： The present invention relates to compounds of formula (I) wherein wherein R1, R2, R3, R4, R5, R6 and n are as described herein. The compounds of the present invention can be used as medicaments for the treatment and/or prevention of diseases which are modulated by PPARα and/or PPARγ agonists. Examples of such diseases are diabetes, particularly non-insulin dependent diabetes mellitus, elevated blood pressure, increased lipid and cholesterol levels, atherosclerotic diseases, metabolic syndrome, endothelial dysfunction, procoagulant state, dyslipidemia, polycystic ovary syndrome, inflammatory diseases (such as e.g. crown disease, inflammatory bowel disease, collitis, pancreatitis, cholestasis/fibrosis of the liver, and diseases that have an inflammatory component such as e.g. Alzheimer's disease or impaired/improvable cognitive function) and proliferative diseases.
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 5，R 6和n如本文所述。本发明的化合物可用作治疗和/或预防由PPARα和/或PPARγ激动剂调节的疾病的药物。这些疾病的例子包括糖尿病，特别是非胰岛素依赖性糖尿病，升高的血压，升高的脂质和胆固醇水平，动脉粥样硬化疾病，代谢综合征，内皮功能障碍，促凝血状态，血脂异常，多囊卵巢综合征，炎性疾病（例如冠疾病，炎性肠病，结肠炎，胰腺炎，胆汁郁积/肝脏纤维化，以及具有诸如阿尔茨海默病和受损/可改善的认知功能等炎症成分的疾病）和增殖性疾病。

77. 发明授权

US07265149B2 Indolyl derivatives 失效
标题翻译：吲哚衍生物
公开(公告)号：US07265149B2
公开(公告)日：2007-09-04
申请号：US11074474
申请日：2005-03-08
申请人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Blake Wright
发明人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Blake Wright
IPC分类号： A61K31/4155 , C07D231/10
CPC分类号： C07D403/12
摘要： This invention relates to compounds of the formula I: wherein one of R6, R7 and R8 is and R1 to R15 and n are as defined in the description, and all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR δ and/or PPARα agonists.
摘要翻译：本发明涉及式I化合物：其中R 6，R 7和R 8中的一个是R 1和R 2， R 15和R 15如在说明书中所定义，以及所有对映异构体及其药学上可接受的盐和/或酯。本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防由PPARδ和/或PPARα激动剂调节的疾病的用途。

78. 发明授权

US07235572B2 Thiazolyl-indole derivatives, their manufacture and use as pharmaceutical agents 失效
标题翻译：噻唑基 - 吲哚衍生物，其制造和用作药剂
公开(公告)号：US07235572B2
公开(公告)日：2007-06-26
申请号：US10878473
申请日：2004-06-28
申请人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Blake Wright
发明人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Blake Wright
IPC分类号： A61K31/427 , C07D417/12
CPC分类号： C07D417/12
摘要： This invention relates to compounds of the formula wherein one of R6, R7 or R8 is and all enantiomers and pharmaceutically acceptable salts and/or esters thereof as well as pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
摘要翻译：本发明涉及下式的化合物，其中R 6，R 7或R 8中的一个是和所有对映异构体和药学上可接受的盐和/ 或其酯，以及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防由PPARδ和/或PPARα激动剂调节的疾病的用途。

79. 发明授权

US07109225B2 Substituted oxazole derivatives 失效
标题翻译：取代的恶唑衍生物
公开(公告)号：US07109225B2
公开(公告)日：2006-09-19
申请号：US10700417
申请日：2003-11-04
申请人： Alfred Binggeli , Uwe Grether , Hans Hilpert , Georges Hirth , Hans-Peter Maerki , Markus Meyer , Peter Mohr
发明人： Alfred Binggeli , Uwe Grether , Hans Hilpert , Georges Hirth , Hans-Peter Maerki , Markus Meyer , Peter Mohr
IPC分类号： A61K31/421 , A61K31/422 , C07D263/32
CPC分类号： C07D413/12 , C07D263/32 , C07D263/38
摘要： The present invention relates to compounds of formula (I) wherein R1 to R8 and n are as defined in the description and claims, and pharmaceutically acceptable salts and esters thereof. The compounds are useful for the treatment of diseases such as diabetes.
摘要翻译：本发明涉及其中R 1至R 8和n如说明书和权利要求书中所定义的式（I）化合物及其药学上可接受的盐和酯。该化合物可用于治疗糖尿病等疾病。

80. 发明授权

US07098228B2 Indolyl derivatives 失效
标题翻译：吲哚衍生物
公开(公告)号：US07098228B2
公开(公告)日：2006-08-29
申请号：US10719556
申请日：2003-11-21
申请人： Alfred Binggeli , Uwe Grether , Hans Hilpert , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr
发明人： Alfred Binggeli , Uwe Grether , Hans Hilpert , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr
IPC分类号： A61K31/425 , A61K31/42 , A61K31/40 , C07D277/30 , C07D263/30
CPC分类号： C07D413/06 , C07D417/06
摘要： The present invention provides compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R4, A and n have the significance given in the specification. The compounds or their salts may be administered to a patient for treating non-insulin dependent diabetes mellitus.
摘要翻译：本发明提供式I化合物及其药学上可接受的盐和酯，其中R 1至R 4，A和n具有说明书中给出的含义。化合物或其盐可以施用于患者以治疗非胰岛素依赖性糖尿病。

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