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71. 发明授权

US07435823B2 Compounds and methods of use 有权
标题翻译：化合物和使用方法
公开(公告)号：US07435823B2
公开(公告)日：2008-10-14
申请号：US11042634
申请日：2005-01-24
申请人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , Gregory J. Habgood , David C. McGowan , Douglas A. Whittington , Daniel La , Vinod F. Patel
发明人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , Gregory J. Habgood , David C. McGowan , Douglas A. Whittington , Daniel La , Vinod F. Patel
IPC分类号： C07D215/38 , C07D265/34
CPC分类号： C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

72. 发明申请

US20070173521A1 Beta-secretase modulators and methods of use 有权
标题翻译： β-分泌酶调节剂和使用方法
公开(公告)号：US20070173521A1
公开(公告)日：2007-07-26
申请号：US11599901
申请日：2006-11-14
申请人： Qiufen Xue , Brian Albrecht , Denise Andersen , Michael Bartberger , James Brown , Ryan Brown , Stuart Chaffee , Yuan Cheng , Michael Croghan , Russell Graceffa , Scott Harried , Stephen Hitchcock , Randall Hungate , Ted Judd , Matthew Kaller , Charles Kreiman , Daniel La , Patricia Lopez , Craig Masse , Holger Monenschein , Thomas Nguyen , Thomas Nixey , Vinod Patel , Lewis Pennington , Matthew Weiss , Bryant Yang , Wenge Zhong
发明人： Qiufen Xue , Brian Albrecht , Denise Andersen , Michael Bartberger , James Brown , Ryan Brown , Stuart Chaffee , Yuan Cheng , Michael Croghan , Russell Graceffa , Scott Harried , Stephen Hitchcock , Randall Hungate , Ted Judd , Matthew Kaller , Charles Kreiman , Daniel La , Patricia Lopez , Craig Masse , Holger Monenschein , Thomas Nguyen , Thomas Nixey , Vinod Patel , Lewis Pennington , Matthew Weiss , Bryant Yang , Wenge Zhong
IPC分类号： A61K31/513 , A61K31/506
CPC分类号： C07D405/12 , C07D413/12
摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein R1, W, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译：本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。在一个实施方案中，化合物具有通式I，其中R 1，W，B，R 3，R 4，R 4， 5，i和j在本文中定义。本发明还包括药物组合物，其包括一种或多种式I化合物，这些化合物的使用方法，包括治疗AD和相关疾病，通过给受试者施用式I化合物或包含它们的组合物。本发明还包括式II和III的其它实施方案，可用于制备本发明化合物的中间体和方法。

73. 发明申请

US20070017100A1 Utility knife with quick release housing 有权
标题翻译：实用刀具快速释放外壳
公开(公告)号：US20070017100A1
公开(公告)日：2007-01-25
申请号：US11483473
申请日：2006-07-10
申请人： Donald Gringer , Yuan Cheng
发明人： Donald Gringer , Yuan Cheng
IPC分类号： B26B1/08
CPC分类号： B26B5/003
摘要： A cutting device includes (i) a housing having first and second separable portions, the first portion having a locking aperture, the second portion having an attachment aperture, and (ii) a locking apparatus for removably locking the first and second portions of the housing. The locking apparatus includes an attachment portion for being fixedly attached in the attachment aperture, and a locking arm adapted to be releasably locked into the locking aperture. The attachment aperture and locking aperture are correspondingly positioned so that the locking arm becomes aligned with the locking aperture when the first and second portions of the housing are aligned for assembly. The housing may be constructed of metal, and the locking apparatus constructed of plastic. The locking apparatus may also include a return spring and blade carrier integrally molded therewith.
摘要翻译：切割装置包括（i）具有第一和第二可分离部分的壳体，第一部分具有锁定孔，第二部分具有附接孔，和（ii）锁定装置，用于可拆卸地锁定壳体的第一和第二部分。锁定装置包括用于固定地附接在附接孔中的附接部分和适于可释放地锁定到锁定孔中的锁定臂。相应地定位安装孔和锁定孔，使得当壳体的第一和第二部分对齐以用于组装时，锁定臂与锁定孔对准。外壳可以由金属构成，锁定装置由塑料构成。锁定装置还可以包括与其一体模制的复位弹簧和刀片架。

74. 发明申请

US20060252777A1 Substituted heterocycles and methods of use 有权
标题翻译：取代的杂环和使用方法
公开(公告)号：US20060252777A1
公开(公告)日：2006-11-09
申请号：US11289659
申请日：2005-11-29
申请人： Tae-Seong Kim , Steven Bellon , Shon Booker , Noel D'Angelo , Celia Dominguez , Ingrid Fellows , Matthew Lee , Longbin Liu , Elizabeth Rainbeau , Aaron Siegmund , Andrew Tasker , Ning Xi , Yuan Cheng
发明人： Tae-Seong Kim , Steven Bellon , Shon Booker , Noel D'Angelo , Celia Dominguez , Ingrid Fellows , Matthew Lee , Longbin Liu , Elizabeth Rainbeau , Aaron Siegmund , Andrew Tasker , Ning Xi , Yuan Cheng
IPC分类号： A61K31/519 , A61K31/517 , A61K31/513 , A61K31/4709 , A61K31/4745 , C07D403/04 , C07D487/02 , C07D471/02
CPC分类号： C07D401/14 , C07D215/233 , C07D401/12 , C07D409/14 , C07D413/12
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

75. 发明授权

US07125865B2 Therapeutic compounds for treating dyslipidemic conditions 失效
标题翻译：用于治疗血脂异常的治疗化合物
公开(公告)号：US07125865B2
公开(公告)日：2006-10-24
申请号：US10522114
申请日：2003-07-21
申请人： A. Brian Jones , Alan D. Adams , Ahren I. Green , Shaei Y. Huang , Bruno Tse , Clare E. Gutteridge , Yuan Cheng
发明人： A. Brian Jones , Alan D. Adams , Ahren I. Green , Shaei Y. Huang , Bruno Tse , Clare E. Gutteridge , Yuan Cheng
IPC分类号： C07D277/04 , C07D277/12 , C07D261/20 , C07D421/00 , C07D241/00
CPC分类号： C07D413/12 , C07D261/20 , C07D413/14 , C07D417/12
摘要： The present invention relates to novel LXR ligands of Formula I and the pharmaceutically acceptable salts, esters and tautomers thereof, which are useful in the treatment of dyslipidemic conditions, particularly depressed levels of HDL cholesterol.
摘要翻译：本发明涉及式I的新型LXR配体及其药学上可接受的盐，酯和互变异构体，其可用于治疗血脂异常状况，特别是降低的HDL胆固醇水平。

76. 发明申请

US20060009453A1 Protein kinase modulators and method of use 有权
标题翻译：蛋白激酶调节剂及其使用方法
公开(公告)号：US20060009453A1
公开(公告)日：2006-01-12
申请号：US11126000
申请日：2005-05-09
申请人： Stephanie Geuns-Meyer , Brian Hodous , Stuart Chaffee , Paul Tempest , Philip Olivieri , Rebecca Johnson , Brian Albrecht , Vinod Patel , Victor Cee , Joseph Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Ning Xi , Karina Romero , Hanh Nguyen , Holly Deak
发明人： Stephanie Geuns-Meyer , Brian Hodous , Stuart Chaffee , Paul Tempest , Philip Olivieri , Rebecca Johnson , Brian Albrecht , Vinod Patel , Victor Cee , Joseph Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Ning Xi , Karina Romero , Hanh Nguyen , Holly Deak
IPC分类号： A61K31/53 , A61K31/506 , C07D43/14
CPC分类号： C07D213/73 , C07D239/42 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D471/04
摘要： The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.
摘要翻译：本发明涉及具有通式I的化合物，其中A，B，D，E，G，H 1-5和R 1-4如本文所定义，和合成中间体，其能够调节各种蛋白激酶受体酶，从而影响与这些激酶的活性相关的各种疾病状态和状况。例如，这些化合物能够调节激酶，从而影响血管生成过程并治疗血管生成相关疾病和其它包括癌症和炎症的复发性疾病。本发明还包括药物组合物，包括该化合物，以及治疗与蛋白激酶活性有关的疾病状态的方法。

77. 发明申请

US20050239769A1 Therapeutic compounds for treating dyslipidemic conditions 失效
标题翻译：用于治疗血脂异常的治疗化合物
公开(公告)号：US20050239769A1
公开(公告)日：2005-10-27
申请号：US10522114
申请日：2003-07-21
申请人： A. Jones , Alan Adams , Ahren Green , Shaei Huang , Bruno Tse , Clare Gutteridge , Yuan Cheng
发明人： A. Jones , Alan Adams , Ahren Green , Shaei Huang , Bruno Tse , Clare Gutteridge , Yuan Cheng
IPC分类号： A61K31/454 , A61K31/496 , A61K31/513 , A61K31/53 , A61K31/5377 , A61K31/551 , C07D261/20 , C07D413/02 , C07D413/12 , C07D413/14 , C07D417/12
CPC分类号： C07D413/12 , C07D261/20 , C07D413/14 , C07D417/12
摘要： The present invention relates to novel LXR ligands of Formula I and the pharmaceutically acceptable salts, esters and tautomers thereof, which are useful in the treatment of dyslipidemic conditions, particularly depressed levels of HDL cholesterol.
摘要翻译：本发明涉及式I的新型LXR配体及其药学上可接受的盐，酯和互变异构体，其可用于治疗血脂异常状况，特别是降低的HDL胆固醇水平。

78. 发明申请

US20050097753A1 Soft handle non-retractable utility knife with quick release latch and method for making same 有权
标题翻译：软手柄不可伸缩实用刀具快速释放闩锁及其制作方法
公开(公告)号：US20050097753A1
公开(公告)日：2005-05-12
申请号：US11001102
申请日：2004-12-01
申请人： Donald Gringer , Yuan Cheng
发明人： Donald Gringer , Yuan Cheng
IPC分类号： B26B5/00
CPC分类号： B26B5/00
摘要： A metallic housing utility knife and method for making the device with a soft over molded elastomeric cover to provide blister free comfort and slip proof safety. The cover or skin is molded into the unique structure of the housing in a fashion that results in mechanical bonds that embrace the cover on the housing. The knife includes flexible posts from the cover that project into the blade storage compartment of the housing to prevent internally stored spare blades from moving within the storage compartment. An elastomeric blade clamp integrally formed with the cover serves to restrict lateral movement of blades of varying sizes when installed in a cutting position within the knife assembly. A rear quick release latch and interlocking housing sections provide a convenient way to open and close the knife and assure that it is also secure and firmly held when locked in a safe cutting position.
摘要翻译：一种金属外壳实用刀和方法，用于使该装置具有柔软的过模制弹性体盖，以提供无泡罩舒适性和防滑安全性。盖子或皮肤被模制成壳体的独特结构，其结果是机壳接合壳体上的盖子。该刀包括从外壳伸出到壳体的刀片储存室中的柔性柱，以防止内部存储的备用刀片在储藏室内移动。与盖一体形成的弹性叶片夹具用于在安装在刀组件内的切割位置时限制不同尺寸的叶片的横向运动。后部快速释放闩锁和互锁壳体部分提供了打开和关闭刀具的便利方式，并且确保当锁定在安全切割位置时它也是牢固且牢固地保持的。

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