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71. 发明申请

US20070020304A1 Non-flammable insecticide composition and uses thereof 有权
标题翻译：不易燃杀虫剂组合物及其用途
公开(公告)号：US20070020304A1
公开(公告)日：2007-01-25
申请号：US11481596
申请日：2006-07-06
申请人： Dov Tamarkin , Doron Friedman , Meir Eini
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A01N25/00
CPC分类号： A01N25/16 , A01N53/00 , A01N65/12 , A61K8/046 , A61K8/31 , A61K8/37 , A61K8/375 , A61K8/4973 , A61K8/73 , A61K8/731 , A61Q17/02 , Y02A50/335 , Y02A50/337 , Y02A50/338 , Y02A50/34 , Y02A50/342 , Y02A50/343 , Y02A50/347 , Y02A50/352 , A01N2300/00 , A01N25/02 , A01N25/30 , A01N43/30 , A01N57/12
摘要： The present invention provides a safe and effective insecticide composition suitable for treating a subject infested with a parasitic anthropode or to prevent infestation by an arthropod. The insecticide composition is a foamable composition, including a first insecticide; at least one organic carrier selected from a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 5%, or about 5% to about 10%; or about 10% to about 20%; or about 20% to about 50% by weight; about 0.1% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent selected from a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; and (5) a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：本发明提供了一种安全有效的杀虫剂组合物，适用于治疗受寄生人体受体侵染的受试者或防止节肢动物侵染。杀虫剂组合物是可发泡组合物，包括第一种杀虫剂; 浓度为约2％至约5％，或约5％至约10％的至少一种选自疏水性有机载体，极性溶剂，软化剂及其混合物的有机载体; 或约10％至约20％; 或约20％至约50％; 约0.1重量％至约5重量％的表面活性剂; 约0.01重量％至约5重量％的至少一种选自生物粘附剂，胶凝剂，成膜剂和相变剂的聚合物; 和（5）浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂。

72. 发明申请

US20060018937A1 Steroid kit and foamable composition and uses thereof 审中-公开
标题翻译：类固醇试剂盒和可发泡组合物及其用途
公开(公告)号：US20060018937A1
公开(公告)日：2006-01-26
申请号：US11114410
申请日：2005-04-26
申请人： Doron Friedman , Alex Besonov , Dov Tamarkin , Meir Eini
发明人： Doron Friedman , Alex Besonov , Dov Tamarkin , Meir Eini
IPC分类号： A61K8/02
CPC分类号： A61K9/122 , A61K8/046 , A61K8/671 , A61K9/0014 , A61K31/07 , A61K31/203 , A61K31/56 , A61K31/568 , A61K31/573 , A61Q19/00
摘要： A composition and therapeutic kit including an aerosol packaging assembly including a container accommodating a pressurized product and an outlet capable of releasing a foamable composition, including a steroid as a foam. The pressurized product includes a foamable composition including: a container accommodating a pressurized product; and an outlet capable of releasing the pressurized product as a foam; wherein the pressurized product comprises a foamable composition including: i. a steroid; ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight; iii. a surface-active agent; iv. about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; v. water; and vi. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition. The composition further may include a therapeutically active foam adjuvant, selected from the group consisting of a fatty alcohol, a fatty acid, a hydroxyl fatty acid; and mixtures thereof.
摘要翻译：一种组合物和治疗试剂盒，其包括气溶胶包装组件，其包括容纳加压产品的容器和能够释放可发泡组合物的出口，其包括类固醇作为泡沫。加压产品包括可发泡组合物，其包括：容纳加压产品的容器; 以及能够释放作为泡沫的加压产品的出口; 其中所述加压产品包括可发泡组合物，其包含：i。类固醇 ii。选自浓度为约2％至约50％重量的至少一种选自疏水性有机载体，极性溶剂，软化剂及其混合物的有机载体; iii。表面活性剂; iv。约0.01重量％至约5重量％的至少一种选自生物粘附剂，胶凝剂，成膜剂和相变剂的聚合物添加剂; v。水和vi。液化或压缩气体推进剂的浓度为总组合物重量的约3％至约25％。组合物还可以包括治疗活性的泡沫佐剂，其选自脂肪醇，脂肪酸，羟基脂肪酸; 及其混合物。

73. 发明申请

US20050244342A1 Moisturizing foam containing lanolin 有权
标题翻译：含羊毛脂的保湿泡沫
公开(公告)号：US20050244342A1
公开(公告)日：2005-11-03
申请号：US11099942
申请日：2005-04-06
申请人： Doron Friedman , Alex Besonov , Dov Tamarkin , Meir Eini
发明人： Doron Friedman , Alex Besonov , Dov Tamarkin , Meir Eini
IPC分类号： A61K9/00 , A61L9/04 , A61M11/00 , A61K7/15
CPC分类号： A61K45/06 , A61K8/046 , A61K8/062 , A61K8/31 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K31/575 , A61Q19/00
摘要： The present invention provides a highly tolerable, hydrating lanolin containing foamable composition for administration to the skin, body surface, body cavity or mucosal surface, e.g., the mucosa of the nose, mouth, eye, ear, respiratory system, vagina or rectum. The foamable composition includes lanolin, a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent, water, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：本发明提供了一种用于给予皮肤，身体表面，体腔或粘膜表面的高度耐受的水合羊毛脂含可发泡组合物，例如鼻，口，眼，耳，呼吸系统，阴道或直肠的粘膜。可发泡组合物包括羊毛脂，表面活性剂，约0.01％至约5％重量的至少一种聚合物添加剂，其选自生物粘附剂，胶凝剂，成膜剂和相变剂，水和液化或压缩气体推进剂，其浓度为总组合物重量的约3％至约25％。

74. 发明申请

US20050186142A1 Kit and composition of imidazole with enhanced bioavailability 审中-公开
标题翻译：具有增强的生物利用度的咪唑的试剂盒和组成
公开(公告)号：US20050186142A1
公开(公告)日：2005-08-25
申请号：US11041921
申请日：2005-01-24
申请人： Dov Tamarkin , Doron Friedman , Meir Eini
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K9/00 , A61L9/04 , A61M11/00
CPC分类号： A61M11/04 , A01N25/16 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/496 , A61K47/14 , A61K47/26 , A61K47/36 , A61K47/38
摘要： A composition and therapeutic kit provide a therapeutic azole with increased solubility. The kit includes an aerosol packaging assembly containing a container accommodating a pressurized product and an outlet capable of releasing the pressurized product as a foam. The pressurized product includes a foamable composition including: i. a therapeutic azole, wherein the solubility of the azole in the composition before foaming is less than the solubility of the azole in the composition after foaming; ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a co-solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight; iii. a surface-active agent; iv. about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; v. water; and vi. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：组合物和治疗试剂盒提供治疗性唑，溶解度增加。该试剂盒包括含有容纳加压产品的容器和能够释放作为泡沫的加压产品的出口的气溶胶包装组件。加压产品包括可发泡组合物，其包括：i。治疗性唑，其中唑在发泡前在组合物中的溶解度小于发泡后唑类在组合物中的溶解度; ii。选自浓度为约2重量％至约50重量％的至少一种选自疏水性有机载体，共溶剂，软化剂及其混合物的有机载体; iii。表面活性剂; iv。约0.01重量％至约5重量％的至少一种选自生物粘附剂，胶凝剂，成膜剂和相变剂的聚合物添加剂; v。水和vi。液化或压缩气体推进剂的浓度为总组合物重量的约3％至约25％。

75. 发明申请

US20050069566A1 Foam carrier containing amphiphilic copolymeric gelling agent 审中-公开
标题翻译：含两亲共聚胶凝剂的泡沫载体
公开(公告)号：US20050069566A1
公开(公告)日：2005-03-31
申请号：US10911367
申请日：2004-08-04
申请人： Dov Tamarkin , Doron Friedman , Meir Eini
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K9/107 , A61K9/12 , A61K7/00
CPC分类号： A61K9/107 , A01N25/16 , A61K8/046 , A61K8/062 , A61K8/31 , A61K9/0014 , A61K9/122 , A61Q19/00
摘要： The invention relates to an alcohol-free cosmetic or pharmaceutical foam carrier including water, a hydrophobic solvent, a surface-active agent and a gelling agent. The cosmetic or pharmaceutical foam carrier does not contain aliphatic alcohols, making it non-irritating and non-drying. The alcohol-free foam carrier is suitable for inclusion of both water-soluble and oil soluble pharmaceutical and cosmetic agents.
摘要翻译：本发明涉及包含水，疏水性溶剂，表面活性剂和胶凝剂的无醇化妆品或药物泡沫载体。化妆品或药物泡沫载体不含脂肪醇，使其不刺激和不干燥。无醇泡沫载体适合包含水溶性和油溶性药物和化妆剂。

76. 发明授权

US5411992A Lice repellant composition 失效
标题翻译：虱子驱避剂组合物
公开(公告)号：US5411992A
公开(公告)日：1995-05-02
申请号：US55986
申请日：1993-04-29
申请人： Meir Eini , Dov Tamarkin
发明人： Meir Eini , Dov Tamarkin
IPC分类号： A01N27/00 , A01N31/02 , A01N31/04 , A01N31/06 , A01N35/06 , A01N37/02 , A01N49/00 , A01N65/00 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/37 , A61K36/00 , A61Q17/02 , A01N31/08
CPC分类号： A61K8/33 , A01N27/00 , A01N31/02 , A01N31/04 , A01N31/06 , A01N35/06 , A01N37/02 , A01N49/00 , A01N65/00 , A01N65/06 , A01N65/08 , A01N65/22 , A01N65/36 , A61K8/34 , A61K8/35 , A61K8/37 , A61Q17/02 , Y10S424/10 , Y10S514/919
摘要： It has been discovered that terpenoids, especially terpenoid-alcohols (terpene-ols) and terpenoid-esters, and some aldehydes and ketones of terpenes, in a concentration of between 0.01% and 50% by weight, most preferably between 0.01% and 10%, are very good lice repellents. The active agent can be combined with a pharmaceutically and/or cosmetically acceptable carrier for topical administration, such as an aqueous or alcohol solution, a gel, cream, or a powder, and administered with or without additives such as other insect repellents, agents increasing solubility or delaying release of active agents, antimicrobials, antioxidants and fragrances. Examples demonstrate efficacy in in vitro and in in vivo testing.
摘要翻译：已经发现萜类化合物，特别是萜烯醇（萜烯醇）和萜烯酯，以及萜烯的一些醛和酮，其浓度为0.01重量％至50重量％，最优选为0.01重量％至10重量％，是非常好的虱子驱避剂。活性剂可以与用于局部给药的药学和/或化妆品可接受的载体组合，例如水或醇溶液，凝胶，奶油或粉末，并且与或不与添加剂一起施用，例如其他驱虫剂，增加剂活性剂，抗微生物剂，抗氧化剂和香料的溶解度或延迟释放。实施例证明在体外和体内测试中的功效。

77. 发明授权

US09168224B2 Pimecrolimus foam composition containing hexylene glycol, optionally oleyl alcohol, dimethylisosorbide and/or medium chain triglycerides 有权
标题翻译：含有己二醇，任选的油醇，二甲基异山梨醇酯和/或中链甘油三酯的吡美罗莫司泡沫组合物
公开(公告)号：US09168224B2
公开(公告)日：2015-10-27
申请号：US11547226
申请日：2005-04-07
申请人： Meir Eini , Doron Friedman , Stefan Hirsch , Sabine Meyenburg , Nabila Sekkat , Dov Tamarkin
发明人： Meir Eini , Doron Friedman , Stefan Hirsch , Sabine Meyenburg , Nabila Sekkat , Dov Tamarkin
IPC分类号： A61K9/12 , A61K47/10 , A61K47/14 , A61K47/38 , A61K9/00 , A61K47/26
CPC分类号： A61K9/122 , A61K9/0014 , A61K47/10 , A61K47/14 , A61K47/26
摘要： Pharmaceutical foam compositions substantially free of ethanol and comprising pimecrolimus in a carrier vehicle comprising a mixture of oily solvents amounting to at least 40% of the total weight of the composition and consisting of: i) hexylene glycol; ii) optionally oleyl alcohol; and iii) dimethylisosorbide and/or medium chain triglycerides; and additionally: iv) when oleyl alcohol is absent, water in an amount of less than 25%; v) at least one consistency agent; vi) at least one preservative; and vii) at least one surfactant/emulgator; and propellant gas for foaming; and optionally further conventional excipients. They are indicated for use in the treatment of various skin, nail and mucosal diseases.
摘要翻译：药物泡沫组合物基本上不含乙醇，并且在载体载体中包含吡美莫司，其包含占组合物总重量的至少40％的油性溶剂的混合物，由以下组成：i）己二醇; ii）任选的油醇; 和iii）二甲基异山梨醇酯和/或中链甘油三酯; 另外：iv）当油醇不存在时，水量小于25％; v）至少一种稠度剂; vi）至少一种防腐剂; 和vii）至少一种表面活性剂/乳化剂; 用于发泡的推进剂气体; 和任选的其它常规赋形剂。它们被用于治疗各种皮肤，指甲和粘膜疾病。

78. 发明授权

US08518378B2 Oleaginous pharmaceutical and cosmetic foam 有权
公开(公告)号：US08518378B2
公开(公告)日：2013-08-27
申请号：US12881856
申请日：2010-09-14
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61K9/12
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K9/0034 , A61K9/107 , A61K9/12 , A61K31/351 , A61K31/436 , A61K31/496 , A61K31/522 , A61K31/573 , A61K38/13 , A61K47/10 , A61K47/14 , A61Q19/00
摘要： The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.

79. 发明授权

US08486376B2 Moisturizing foam containing lanolin 有权
标题翻译：含羊毛脂的保湿泡沫
公开(公告)号：US08486376B2
公开(公告)日：2013-07-16
申请号：US11099942
申请日：2005-04-06
申请人： Doron Friedman , Alex Besonov , Dov Tamarkin , Meir Eini
发明人： Doron Friedman , Alex Besonov , Dov Tamarkin , Meir Eini
IPC分类号： A61K9/00
CPC分类号： A61K45/06 , A61K8/046 , A61K8/062 , A61K8/31 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K31/575 , A61Q19/00
摘要： The present invention provides a highly tolerable, hydrating lanolin containing foamable composition for administration to the skin, body surface, body cavity or mucosal surface, e.g., the mucosa of the nose, mouth, eye, ear, respiratory system, vagina or rectum. The foamable composition includes lanolin, a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent, water, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：本发明提供了一种用于给予皮肤，身体表面，体腔或粘膜表面的高度耐受的水合羊毛脂含可发泡组合物，例如鼻，口，眼，耳，呼吸系统，阴道或直肠的粘膜。可发泡组合物包括羊毛脂，表面活性剂，约0.01％至约5％重量的至少一种聚合物添加剂，其选自生物粘附剂，胶凝剂，成膜剂和相变剂，水和液化或压缩气体推进剂，其浓度为总组合物重量的约3％至约25％。

80. 发明授权

US08486375B2 Foamable compositions 有权
标题翻译：可发泡组合物
公开(公告)号：US08486375B2
公开(公告)日：2013-07-16
申请号：US13400337
申请日：2012-02-20
申请人： Dov Tamarkin , Doron Friedman , Meir Eini
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K9/00 , A61K9/12 , A61K33/18
CPC分类号： A61K33/18 , A61K9/122 , Y10S514/828 , Y10S514/887 , Y10S514/928 , Y10S514/945
摘要： The present invention is related to a foamable composition of matter comprising iodine, water, a foam adjuvant, a surface-active agent and a gelling agent. This foamable composition, which may be provided in a propellant free foaming device, or alternatively may further comprise a propellant, evolves into foam, which is effective in the topical treatment and prevention of various skin disorders.
摘要翻译：本发明涉及包含碘，水，泡沫助剂，表面活性剂和胶凝剂的可发泡组合物。该可发泡组合物可以以不含推进剂的发泡装置提供，或者可以进一步包含推进剂，演变成泡沫，其在局部治疗和预防各种皮肤病中是有效的。

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