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    • 73. 发明授权
    • Bragg grating pressure sensor
    • 布拉格光栅压力传感器
    • US06422084B1
    • 2002-07-23
    • US09455867
    • 1999-12-06
    • Mark R. FernaldTimothy J. BaileyMatthew B. MillerJames M. SullivanJames R. DunphyMichael A. DavisChristopher J. WrightAlan D. KerseyMartin A. PutnamRobert N. BrucatoPaul E. Sanders
    • Mark R. FernaldTimothy J. BaileyMatthew B. MillerJames M. SullivanJames R. DunphyMichael A. DavisChristopher J. WrightAlan D. KerseyMartin A. PutnamRobert N. BrucatoPaul E. Sanders
    • G01L900
    • G01L11/025
    • A fiber grating pressure sensor includes an optical sensing element 20, 600 which includes an optical fiber 10 having a Bragg grating 12 impressed therein which is encased within and fused to at least a portion of a glass capillary tube 20 and/or a large diameter waveguide grating 600 having a core and a wide cladding and which has an outer transverse dimension of at least 0.3 mm. Light 14 is incident on the grating 12 and light 16 is reflected from the grating 12 at a reflection wavelength &lgr;1. The sensing element 20, 600 may be used by itself as a sensor or located within a housing 48, 60, 90, 270, 300. When external pressure P increases, the grating 12 is compressed and the reflection wavelength &lgr;1 changes. The shape of the sensing element 20, 600 may have other geometries, e.g., a “dogbone” shape, so as to enhance the sensitivity of shift in &lgr;1 due to applied external pressure and may be fused to an outer shell 50. At least a portion of the sensing element may be doped between a pair of gratings 150, 152, to form a compression-tuned laser or the grating 12 or gratings 150, 152 may be constructed as a tunable DFB laser. Also, the axial ends of element 20, 600 where the fiber 10 exits the tube 20 may have an inner tapered region 22 and/or a protruding tapered (or fluted) axial section 27 to provide strain relief or improved pull strength for the fiber 10. A temperature grating 270 may be used to measure temperature and allow for a temperature-corrected pressure measurement. The sensor may be suspended within an outer housing 112, by a fluid, spacers, or other means. The invention may also be used as a force transducer.
    • 光纤光栅压力传感器包括光学感测元件20,600,光学传感元件20,600包括光纤10,该光纤10具有印刷在其中的布拉格光栅12,该光纤10包围玻璃毛细管20和/或大直径波导的至少一部分 光栅600具有芯和宽包层,并且具有至少0.3mm的外横向尺寸。 光14入射到光栅12上,光16以反射波长lambd1从光栅12反射。 感测元件20,600可以自身用作传感器或位于壳体48,60,90,270,3300内。当外部压力P增加时,光栅12被压缩并且反射波长lambd1改变。 感测元件20,600的形状可以具有其他几何形状,例如“狗骨”形状,以便增强由于施加的外部压力而导致的羔羊皮1偏移的灵敏度,并且可以将其熔合到外壳50上。至少 感测元件的一部分可以掺杂在一对光栅150,152之间以形成压缩调谐的激光器,或者光栅12或光栅150,152可被构造为可调DFB激光器。 此外,纤维10离开管20的元件20,600的轴向端部可以具有内锥形区域22和/或突出的锥形(或槽纹)轴向部分27,以提供应变消除或改进的纤维10的拉伸强度 可以使用温度光栅270来测量温度并允许进行温度校正的压力测量。 传感器可以通过流体,间隔件或其他装置悬挂在外壳体112内。 本发明也可以用作力传感器。
    • 78. 发明申请
    • Method and Apparatus for Performing Assays
    • 执行分析的方法和装置
    • US20130011859A1
    • 2013-01-10
    • US13511593
    • 2010-11-23
    • Martin A. PutnamAlan D. Kersey
    • Martin A. PutnamAlan D. Kersey
    • G01N21/75G01N21/00G01N21/64C12M1/34
    • G01N33/54366B01L3/502715B01L3/502784B01L3/527B01L2200/10B01L2300/0636B01L2400/0633G01N35/1097
    • An apparatus is provided for performing an chemical, biochemical, or biological assay on a sample comprising: a microfluidic assay cartridge (1) that contains at least one sample inlet well (2) configured to receive a sample; and a microfluidic sub-unit (3) associated with the microfluidic assay cartridge (1) and comprising microfluidic channels (8), micro-valves (4, 4a, 9) and at least one separate and fluidicly-isolated isolation channel (5), and at least one hollow element (14); the at least one hollow element (14) being functionalized with a capture moiety or molecules (15) so as to form at least one reaction vessel (19); the microfluidic channels (8) and micro-valves (4, 4a, 9) configured to respond to signaling containing information about performing the assay and to controllably receive the sample and at least one reagent in the at least one reaction vessel (19), and to provide from the at least one reaction vessel (19) light containing information about the assay performed on the sample inside the at least one reaction vessel (19) as a result of said at least one reagent.
    • 提供了一种用于对样品进行化学,生化或生物测定的装置,包括:微流体测定盒(1),其包含至少一个被配置为接收样品的样品入口孔(2) 和与微流体测定盒(1)相关联并且包括微流体通道(8),微阀(4,4a,9)和至少一个单独和流体隔离的隔离通道(5)的微流体子单元(3) ,和至少一个中空元件(14); 所述至少一个中空元件(14)被捕获部分或分子(15)功能化,以形成至少一个反应容器(19); 微流体通道(8)和微阀(4,4a,9)被配置为对包含关于进行测定的信息的信号进行响应并且可控制地接收样品和至少一个反应容器(19)中的至少一个试剂, 并且从所述至少一个反应容器(19)提供含有关于由所述至少一种试剂的结果对所述至少一个反应容器(19)内的样品进行的测定的信息的光。