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71. 发明申请

US20050096309A1 Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors 有权
标题翻译：磺酰基氨基戊内酰胺及其衍生物作为因子Xa抑制剂
公开(公告)号：US20050096309A1
公开(公告)日：2005-05-05
申请号：US10952396
申请日：2004-09-28
申请人： Wei Han , Zilun Hu , Timur Gungor
发明人： Wei Han , Zilun Hu , Timur Gungor
IPC分类号： A61K20060101 , A61K31/4178 , A61K31/513 , A61K31/55 , A61K31/551 , C07D207/14 , C07D207/38 , C07D215/12 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D495/04 , C07D43/02
CPC分类号： C07D401/04 , C07D207/38 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula Ia-If: or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
摘要翻译：本申请描述了式Ia-If的磺酰基氨基戊内酰胺及其衍生物：或其药学上可接受的盐形式，其中环G是单环或双环碳环或杂环。本发明的化合物可用作胰蛋白酶样丝氨酸蛋白酶的抑制剂，特别是因子Xa。

72. 发明授权

US06829947B2 Acoustic Doppler downhole fluid flow measurement 有权
标题翻译：声学多普勒井下流体流量测量
公开(公告)号：US06829947B2
公开(公告)日：2004-12-14
申请号：US10437597
申请日：2003-05-14
申请人： Wei Han , Jean M. Beique , James R. Birchak , Alan T. Hemphill , Tim Wiemers , Paul F. Rodney
发明人： Wei Han , Jean M. Beique , James R. Birchak , Alan T. Hemphill , Tim Wiemers , Paul F. Rodney
IPC分类号： G01F120
CPC分类号： G01P5/241 , E21B47/01 , E21B47/101 , G01F1/663 , G01N29/024 , G01N29/036 , G01N2291/02836 , G01N2291/105
摘要： apparatus and system are disclosed for in situ measurement of downhole fluid flow using Doppler techniques. First, a baseline speed of sound is established as close to the desired measurement point as possible. This speed of sound measurement is then used in Doppler calculations for determining flow velocities based from induced Doppler shift resulting from fluid flow. A heterodyne receiver arrangement is preferably used for processing so that the flow direction can be determined and the detection sensitivity for low flow velocities can be enhanced. From in situ measurements, well kicks may be spotted and dealt with in real-time. In addition, current theoretical models of rheological properties may be verified and expounded upon using in situ downhole measurement techniques. Furthermore, the velocity measurements described herein can be used to recognize downhole lost circulation and/or gas/water/oil influxes as early as possible, even when the mud recirculation pumps are turned off.
摘要翻译：公开了使用多普勒技术进行井下流体流的原位测量的装置和系统。首先，将基线速度建立为尽可能接近所需的测量点。然后将这种声速测量用于多普勒计算，用于根据由流体流动引起的诱导多普勒频移来确定流速。外差接收器装置优选用于处理，从而可以确定流动方向，并且可以提高低流速的检测灵敏度。从现场测量，可以发现并处理好踢球。此外，现有的流变特性的理论模型可以在使用原位井下测量技术时得到验证和阐述。此外，即使当泥浆再循环泵被关闭时，本文所述的速度测量也可以用于尽可能早地识别井下漏液循环和/或气/水/油流入。

73. 发明授权

US06817229B2 Acoustic sensor for fluid characterization 有权
标题翻译：用于流体表征的声学传感器
公开(公告)号：US06817229B2
公开(公告)日：2004-11-16
申请号：US10384030
申请日：2003-03-07
申请人： Wei Han , James R. Birchak , Bruce H. Storm, Jr. , Thomas E. Ritter
发明人： Wei Han , James R. Birchak , Bruce H. Storm, Jr. , Thomas E. Ritter
IPC分类号： G01N2900
CPC分类号： E21B47/101 , E21B49/08 , G01N29/024 , G01N29/348 , G01N2291/015 , G01N2291/0222 , G01N2291/02416 , G01N2291/02433 , G01N2291/02818 , G01N2291/02836 , G01N2291/105
摘要： A method and apparatus for in-situ characterization of downhole fluids in a wellbore using ultrasonic acoustic signals. Measurements of the speed of sound, attenuation of the signal, and acoustic back-scattering are used to provide qualitative and quantitative data as to the composition, nature of solid particulates, compressibility, bubble point, and the oil/water ratio of the fluid. The tool generally comprises three sets of acoustic transducers mounted perpendicular to the direction of the flow. These transducers are capable of operating at different frequencies so that the spectrum of the acoustic signal can be optimized. The apparatus is capable of operating downhole to provide real time information as to conditions in the well.
摘要翻译：一种用于使用超声波信号在井筒中井下流体进行原位表征的方法和装置。用于测量声速，信号衰减和声反散射的方法来提供关于固体颗粒的组成，性质，可压缩性，起泡点和流体的油/水比的定性和定量数据。该工具通常包括垂直于流动方向安装的三组声换能器。这些传感器能够以不同的频率操作，从而可以优化声信号的频谱。该装置能够在井下操作以提供关于井中的条件的实时信息。

74. 发明授权

US06470749B1 Method and apparatus for pulsed ultrasonic doppler measurement of wall deposition 有权
标题翻译：用于脉冲超声多普勒测量壁沉积的方法和装置
公开(公告)号：US06470749B1
公开(公告)日：2002-10-29
申请号：US09851509
申请日：2001-05-08
申请人： Wei Han , James R. Birchak , Crispin L. Richards , Vimal V. Shah , Bruce H. Storm , Rajnikant M. Amin
发明人： Wei Han , James R. Birchak , Crispin L. Richards , Vimal V. Shah , Bruce H. Storm , Rajnikant M. Amin
IPC分类号： G01N2900
CPC分类号： G01B17/02 , G01N29/024 , G01N29/07 , G01N29/38 , G01N29/449 , G01N2291/011 , G01N2291/017 , G01N2291/02854 , G01N2291/102 , G01N2291/2634
摘要： A method for monitoring and measuring the buildup of deposits on the inner surface of a pipeline containing flowing fluid comprises (a) transmitting a first acoustic signal into the pipeline through the pipeline wall, (b) receiving echoes of the transmitted signal, and (c) determining from the received echoes how far from the pipeline inner surface the interface between the deposits and the flowing fluid lies. An alternative method for monitoring and measuring the buildup of deposits on the inner surface of a pipeline containing flowing fluid comprises (a) transmitting a first acoustic signal into the pipeline through the pipeline wall, (b) receiving echoes of the signal, and (c) using the Doppler frequency shift of the received echoes to determine how far from the pipeline inner surface the interface between the deposits and the flowing fluid lies. An apparatus for monitoring and measuring the buildup of deposits on the inner surface of a pipeline containing flowing fluid, comprises a first transmitter in acoustic communication with the pipeline wall and generating a transmitted signal, a first receiver in acoustic communication with the pipeline wall generating received echo signal from a received signal comprising the reflection of the transmitted signal off the flowing fluid, and a microprocessor for determining from the received echo signal how far from the pipeline inner surface the interface between the deposits and the flowing fluid lies.
摘要翻译：一种用于监测和测量包含流动流体的管道的内表面上的沉积物积累的方法，包括（a）通过管道壁将第一声信号传输到管道中，（b）接收所发射信号的回波，和（c ）从接收到的回波确定离开管道内表面有多远，沉积物和流动流体之间的界面位于。用于监测和测量包含流动流体的管道的内表面上的沉积物积累的替代方法包括（a）通过管道壁将第一声信号传输到管道中，（b）接收信号的回波，和（c ）使用接收到的回波的多普勒频移来确定离开管道内表面的距离，沉积物和流动流体之间的界面位于多远处。一种用于监测和测量包含流动流体的管道的内表面上的沉积物积累的装置，包括与管道壁声学连通并产生传输信号的第一发射器，与接收的管道壁声学连通的第一接收器来自接收信号的回波信号包括从流动流体反射的发射信号;以及微处理器，用于根据接收到的回波信号确定沉积物和流动流体之间的界面离管道内表面有多远。

75. 发明授权

US06200998B1 Arylthiazolidinedione derivitives 失效
标题翻译：芳基噻唑烷二酮衍生物
公开(公告)号：US06200998B1
公开(公告)日：2001-03-13
申请号：US09448847
申请日：1999-11-23
申请人： Soumya P. Sahoo , Wei Han , Richard L. Tolman , Jeffrey Bergman , Conrad Santini , Ranjit Desai , Victoria K. Lombardo , Julia K. Boueres , Dominick F. Gratale
发明人： Soumya P. Sahoo , Wei Han , Richard L. Tolman , Jeffrey Bergman , Conrad Santini , Ranjit Desai , Victoria K. Lombardo , Julia K. Boueres , Dominick F. Gratale
IPC分类号： A01K31425
CPC分类号： C07D263/44 , C07D277/34 , C07D417/12
摘要： Substituted 5-aryl-2,4-thiazolidinediones are potent agonists of PPAR, and are therefore useful in the treatment, control or prevention of diabetes, hyperglycemia, hyperlipidemia (including hypercholesterolemia and hypertriglyceridemia), atherosclerosis, obesity, vascular restenosis, and other PPAR &agr;, &dgr; and/or &ggr; mediated diseases, disorders and conditions.
摘要翻译：取代的5-芳基-2,4-噻唑烷二酮是PPAR的有效激动剂，因此可用于治疗，控制或预防糖尿病，高血糖症，高脂血症（包括高胆固醇血症和高甘油三酯血症），动脉粥样硬化，肥胖症，血管再狭窄和其他PPAR α，δ和/或γ介导的疾病，病症和病症。

76. 发明授权

US6008237A Arylthiazolidinedione derivatives 失效
标题翻译：芳基噻唑烷二酮衍生物
公开(公告)号：US6008237A
公开(公告)日：1999-12-28
申请号：US213542
申请日：1998-12-17
申请人： Soumya P. Sahoo , Richard L. Tolman , Wei Han , Jeffrey Bergman , Conrad Santini , Victoria K. Lombardo , Ranjit Desai , Julia K. Boueres , Dominick F. Gratale
发明人： Soumya P. Sahoo , Richard L. Tolman , Wei Han , Jeffrey Bergman , Conrad Santini , Victoria K. Lombardo , Ranjit Desai , Julia K. Boueres , Dominick F. Gratale
IPC分类号： C07D263/44 , C07D277/34 , C07D417/12 , A61K31/425
CPC分类号： C07D263/44 , C07D277/34 , C07D417/12
摘要： Substituted 5-aryl-2,4-thiazolidinediones are potent agonists of PPAR, and are therefore useful in the treatment, control or prevention of diabetes, hyperglycemia, hyperlipidemia (including hypercholesterolemia and hypertriglyceridemia), atherosclerosis, obesity, vascular restenosis, and other PPAR .alpha., .delta. and/or .gamma. mediated diseases, disorders and conditions.
摘要翻译：取代的5-芳基-2,4-噻唑烷二酮是PPAR的有效激动剂，因此可用于治疗，控制或预防糖尿病，高血糖症，高脂血症（包括高胆固醇血症和高甘油三酯血症），动脉粥样硬化，肥胖症，血管再狭窄和其他PPAR α，δ和/或γ介导的疾病，病症和病症。

77. 发明授权

US5859051A Antidiabetic agents 失效
标题翻译：抗糖尿病药
公开(公告)号：US5859051A
公开(公告)日：1999-01-12
申请号：US791213
申请日：1997-01-31
申请人： Alan D. Adams , Gregory D. Berger , Jeffrey P. Bergman , Joel P. Berger , Wei Han , Mark D. Leibowitz , David E. Moller , Conrad Santini , Soumya P. Sahoo , Richard L. Tolman , Jonthan R. Young
发明人： Alan D. Adams , Gregory D. Berger , Jeffrey P. Bergman , Joel P. Berger , Wei Han , Mark D. Leibowitz , David E. Moller , Conrad Santini , Soumya P. Sahoo , Richard L. Tolman , Jonthan R. Young
IPC分类号： C07D209/08 , C07D217/06 , C07D271/12 , C07D307/79 , C07D307/82 , C07D307/83 , C07D307/91 , C07D311/16 , C07D307/78 , A61K31/365 , A61K31/37
CPC分类号： C07D307/79 , C07D209/08 , C07D217/06 , C07D271/12 , C07D307/82 , C07D307/83 , C07D307/91 , C07D311/16
摘要： The instant invention is concerned with acetylphenols which are useful as antiobesity and antidiabetic compounds. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering or modulating triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for increasing gut motility or for treating atherosclerosis are also disclosed.
摘要翻译：本发明涉及可用作抗肥胖和抗糖尿病化合物的乙酰苯酚。还公开了用于治疗糖尿病和肥胖以及用于降低或调节甘油三酯水平和胆固醇水平或提高高密度脂蛋白水平或用于增加肠运动性或用于治疗动脉粥样硬化的组合物和方法。

78. 外观设计

USD1019002S1 Fire extinguisher 有权
公开(公告)号：USD1019002S1
公开(公告)日：2024-03-19
申请号：US29906344
申请日：2023-11-03
申请人： Wei Han
设计人： Wei Han
摘要： FIG. 1 is a front, left and top perspective view of a fire extinguisher, showing my new design;
FIG. 2 is a rear, right and bottom perspective view thereof;
FIG. 3 is a front view thereof;
FIG. 4 is a rear view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a right side view thereof;
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.
The broken lines shown in the drawings illustrate portions of the fire extinguisher that form no part of the claimed design.

79. 发明授权

US09366133B2 Acoustic standoff and mud velocity using a stepped transmitter 有权
标题翻译：使用阶梯式发射机的声学隔离和泥浆速度
公开(公告)号：US09366133B2
公开(公告)日：2016-06-14
申请号：US14278839
申请日：2014-05-15
申请人： Rocco DiFoggio , Wei Han
发明人： Rocco DiFoggio , Wei Han
IPC分类号： G01V1/44 , E21B47/10 , G01N29/024 , G01N29/028 , G01N29/44 , G01F23/24 , G01F23/296 , G01V1/50
CPC分类号： E21B47/101 , G01F23/247 , G01F23/2961 , G01N29/024 , G01N29/028 , G01N29/4418 , G01N2291/02818 , G01N2291/02836 , G01N2291/045 , G01V1/50
摘要： A system, apparatus and method for determining an acoustic property of a fluid in a wellbore is disclosed. A faceplate is placed in the wellbore with a stepped surface of the faceplate in contact with the fluid. The stepped surface includes a non-stepped face and a stepped face. A first portion of an acoustic pulse passes from the faceplate into the fluid via the non-stepped face and a second portion of the acoustic pulse passes from the faceplate into the fluid via the stepped face. A first reflected acoustic pulse related to the first portion of the acoustic pulse is received. A second reflected acoustic pulse related to the second portion of the acoustic pulse is received. A measurement of the first reflected acoustic pulse and a measurement of the second reflected pulse are used to determine the acoustic property of the fluid in the wellbore.
摘要翻译：公开了一种用于确定井眼中的流体的声学特性的系统，装置和方法。面板放置在井眼中，面板与流体接触的台阶表面。阶梯面包括非阶梯面和阶梯面。声脉冲的第一部分经由非阶梯面从面板传送到流体中，并且声脉冲的第二部分经由台阶面从面板流入流体。接收与声脉冲的第一部分相关的第一反射声脉冲。接收与声脉冲的第二部分有关的第二反射声脉冲。使用第一反射声脉冲的测量和第二反射脉冲的测量来确定井眼中的流体的声学特性。

80. 发明授权

US09339528B2 Methods for treating epithelium trauma of the intestinal mucosa using interleukin-1 receptor antagonist 有权
标题翻译：使用白细胞介素-1受体拮抗剂治疗肠粘膜上皮创伤的方法
公开(公告)号：US09339528B2
公开(公告)日：2016-05-17
申请号：US13504114
申请日：2010-10-26
申请人： Wei Han , Di Xiang , Zhenqian Wu
发明人： Wei Han , Di Xiang , Zhenqian Wu
IPC分类号： A61K38/20 , A61K38/17 , C07K14/54
CPC分类号： A61K38/2006 , A61K38/1709 , C07K14/54
摘要： The invention provides a use of the interleukin-1 receptor antagonist protein for preparing a medicament for preventing or treating epithelium trauma of the intestinal mucosa, wherein the protein is selected from: (a) a protein having an amino acid sequence as shown in SEQ ID NO: 1; (b) a protein which has a sequence having at least 70% homology with the amino acid sequence in the (a) and has the effect of preventing or treating epithelium trauma of the intestinal mucosa. The invention also provides a pharmaceutical composition comprising the protein (a) or (b) as the active component.
摘要翻译：本发明提供白细胞介素-1受体拮抗剂蛋白质用于制备用于预防或治疗肠粘膜上皮创伤的药物的用途，其中所述蛋白质选自：（a）具有SEQ ID NO：1所示氨基酸序列的蛋白质 NO：1; （b）具有与（a）中的氨基酸序列具有至少70％同源性的序列的蛋白质，并具有预防或治疗肠粘膜上皮创伤的作用。本发明还提供了包含蛋白质（a）或（b）作为活性组分的药物组合物。

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