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71. 发明授权

US07759355B2 Adenosine A2A receptor antagonists for treating restless legs syndrome or nocturnal myoclonus 有权
标题翻译：用于治疗不宁腿综合征或夜间肌阵挛的腺苷A2A受体拮抗剂
公开(公告)号：US07759355B2
公开(公告)日：2010-07-20
申请号：US10523603
申请日：2003-08-27
申请人： Hiroshi Kase , Naoki Seno , Akihisa Mori , Dayao Zhao
发明人： Hiroshi Kase , Naoki Seno , Akihisa Mori , Dayao Zhao
IPC分类号： A61K31/522 , A61P25/00 , A61P25/14
CPC分类号： A61K31/00 , A61K31/522
摘要： The present invention provides methods of treating restless legs syndrome or related disorders, comprising administering an effective amount of at least one adenosine A2A receptor antagonist to a patient in need thereof. More preferably the adenosine A2A receptor antagonist is a xanthine derivative or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了治疗不宁腿症状或相关病症的方法，包括向有需要的患者施用有效量的至少一种腺苷A 2A受体拮抗剂。更优选地，腺苷A 2A受体拮抗剂是黄嘌呤衍生物或其药学上可接受的盐。

72. 发明申请

US20080039337A1 Method for Detection of Conformational Change of a Protein Immobilized on a Substrate 审中-公开
标题翻译：检测固定在基质上的蛋白质构象变化的方法
公开(公告)号：US20080039337A1
公开(公告)日：2008-02-14
申请号：US11662361
申请日：2005-09-21
申请人： Hiromi Nonaka , Hiroshi Kase , Kozo Inoue
发明人： Hiromi Nonaka , Hiroshi Kase , Kozo Inoue
IPC分类号： C40B30/04 , C12Q1/34 , G01N33/48
CPC分类号： G01N21/6428 , G01N33/542 , G01N33/54306
摘要： This invention provides a method for detection of conformational change of a protein immobilized on a substrate. In concrete, the method comprises, forming a sample film comprising a protein immobilized on a substrate, adding a substance to be detected for its activity to affect to the conformational change of the protein onto the sample film, and detecting the conformational change of the protein. The method enables to measure conformational change of a protein with immobilized state, using minute amount of protein in a short period for a number of samples in a short period all at once, rapidly and simply.
摘要翻译：本发明提供一种检测固定在基质上的蛋白质的构象变化的方法。具体而言，该方法包括：形成包含固定在底物上的蛋白质的样品膜，加入待检测物质的活性以影响蛋白质在样品膜上的构象变化，以及检测蛋白质的构象变化。该方法使得能够在短时间内快速且简单地测量在短时间内在短时间内使用微量蛋白质的固定状态的蛋白质的构象变化。

73. 发明申请

US20080003691A1 Method of Detecting Conformational Change of an Amyloid Protein, a Method of Searching a Substance Having an Activity that Affects to Conformational Change of an Amyloid Protein, and Method of Searching a Therapeutic or Diagnostic Agent for Amyloid-Related Diseases 审中-公开
标题翻译：检测淀粉样蛋白构象变化的方法，检索具有影响淀粉样蛋白构象变化的活性的物质的方法以及搜索治疗或诊断代谢物与淀粉样蛋白相关疾病的方法
公开(公告)号：US20080003691A1
公开(公告)日：2008-01-03
申请号：US10593880
申请日：2005-03-24
申请人： Masayoshi Tachibana , Machiko Tachibana , Hiromi Nonaka , Hiroshi Kase
发明人： Masayoshi Tachibana , Machiko Tachibana , Hiromi Nonaka , Hiroshi Kase
IPC分类号： G01N33/68 , G01N33/53 , G01N33/566
CPC分类号： G01N33/68 , G01N33/6896 , G01N2203/0282
摘要： The inventors investigated to provide a means for real-time detection and measurement on the process of the amyloid protein aggregation as change(s) in tension and/or elasticity using a force sensor. The present invention provided a method of detecting an amyloidgenic conformational change of a protein using a mechanochemical sensor. The present invention further provided a method of searching a substance having an activity that affects to an amyloidgenic conformational change using said detecting method, as well as a method of searching a therapeutic or diagnostic agent for amyloid-related diseases. The method of the present invention is assumed to contribute to obtain a novel therapeutic or diagnostic agent for amyloid diseases.
摘要翻译：发明人研究提供了一种用于使用力传感器在淀粉样蛋白聚集过程中实时检测和测量作为张力和/或弹性变化的方法。本发明提供了使用机械化学传感器检测蛋白质的淀粉样蛋白原构象变化的方法。本发明还提供了一种使用所述检测方法来搜索具有影响淀粉样变性基因构象变化的活性的物质的方法，以及搜索治疗或诊断药物淀粉样蛋白相关疾病的方法。假定本发明的方法有助于获得淀粉样蛋白病的新型治疗或诊断剂。

74. 发明申请

US20070149555A1 Prophylatic and/or therapeutic agents for chronic musculoskeletal pain 审中-公开
标题翻译：用于慢性肌肉骨骼疼痛的预防和/或治疗剂
公开(公告)号：US20070149555A1
公开(公告)日：2007-06-28
申请号：US10594684
申请日：2005-03-30
申请人： Hiroshi Kase , Isami Takahashi , Shunji Kunori , Minoru Kobayashi , Shizuo Shiozaki , Shiro Shirakura
发明人： Hiroshi Kase , Isami Takahashi , Shunji Kunori , Minoru Kobayashi , Shizuo Shiozaki , Shiro Shirakura
IPC分类号： A61K31/522
CPC分类号： A61K31/522 , C07D473/06 , Y02A50/401
摘要： A prophylactic and/or therapeutic agent for diseases accompanied by chronic musculoskeletal pain comprising as an active ingredient a compound having an adenosine A2A receptor antagonistic action, for example, represented by the following formula (I) (wherein R1, R2 and R3 are the same or different, each representing a hydrogen atom, lower alkyl, lower alkenyl or lower alkynyl; R4 represents cycloalkyl, —(CH2)n—R5 or the following formula (II); and X1 and X2 are the same or different, each representing an oxygen atom or a sulfur atom) or a pharmaceutically acceptable salt thereof.
摘要翻译：一种伴有慢性肌肉骨骼疼痛的疾病的预防和/或治疗剂，其包含作为活性成分的具有腺苷A 2A受体拮抗作用的化合物，例如由下式（I）表示的化合物（其中 R 1，R 2和R 3相同或不同，各自表示氢原子，低级烷基，低级烯基或低级炔基; R 4表示环烷基， - （CH 2）n - R 5 -R 5或下式（II）; 和X 1和X 2相同或不同，各自表示氧原子或硫原子）或其药学上可接受的盐。

75. 发明授权

US06176373B1 Embossed carrier tape 失效
标题翻译：压花载带
公开(公告)号：US06176373B1
公开(公告)日：2001-01-23
申请号：US09024594
申请日：1998-02-17
申请人： Hiroshi Kato , Tomoyasu Kato , Yasuyuki Takao , Hiroshi Kase
发明人： Hiroshi Kato , Tomoyasu Kato , Yasuyuki Takao , Hiroshi Kase
IPC分类号： B65D8590
CPC分类号： B65D73/02 , H05K13/0084
摘要： An embossed carrier tape capable of accurately accomplishing an automatic inspection of leads or the like of an electronic component by means of a camera. The carrier tape is formed with a plurality of receiving recesses in which electronic components are to be received, respectively. The receiving recesses are each formed at a lower portion of each of side surfaces thereof opposite to leads of the electronic component with an inclined surface. Such construction results in the leads being abutted against the inclined surface, to thereby be subjected to positional regulation if the electronic component is undesirably moved during inspection thereof. This permits a reflected image of the leads from the side surface of the receiving recess to be substantially separated from a directly-viewed image thereof during an inspection of the electronic component by image processing using a camera, to thereby ensure accurate judgment of any defect of the electronic component, such as bending of the leads or the like.
摘要翻译：能够通过照相机精确地实现电子部件的引线等的自动检查的压花载带。载带形成有分别接收电子部件的多个容纳凹部。接收凹部各自形成在与倾斜表面的电子部件的引线相对的每个侧表面的下部。这种结构导致引线抵靠倾斜表面，从而如果电子部件在检查期间不期望地移动，则进行位置调节。这允许通过使用照相机的图像处理在电子部件的检查期间从接收凹部的侧表面引出的引线的反射图像与其直接观看的图像基本上分离，从而确保准确地判断任何缺陷电子部件，例如引线的弯曲等。

76. 发明授权

US5648353A Quinazolines and phthalazines having adenosine uptake inhibitor activity 失效
标题翻译：喹唑啉和具有腺苷摄取抑制剂活性的酞嗪酮
公开(公告)号：US5648353A
公开(公告)日：1997-07-15
申请号：US446235
申请日：1995-05-22
申请人： Shigeki Fujiwara , Daisuke Machii , Haruki Takai , Hiromi Nonaka , Hiroshi Kase , Kozo Yao , Michiyo Kawakage , Hideaki Kusaka , Akira Karasawa
发明人： Shigeki Fujiwara , Daisuke Machii , Haruki Takai , Hiromi Nonaka , Hiroshi Kase , Kozo Yao , Michiyo Kawakage , Hideaki Kusaka , Akira Karasawa
IPC分类号： C07D401/14 , C07D491/04 , C07D401/04 , A61K31/445 , A61K31/50 , A61K31/505
CPC分类号： C07D401/14 , C07D491/04
摘要： The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, alkenyl, or substituted or unsubstituted aralkyl; R.sup.2, R.sup.3, R.sup.4, and R.sup.5 independently represent hydrogen, halogen, amino, mono- or di(lower alkyl)amino, lower alkanoylamino, nitro, cyano, substituted or unsubstituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy, or lower alkanoyloxy; R.sup.6, R.sup.7, R.sup.8, and R.sup.9 independently represent hydrogen, hydroxy, substituted or unsubstituted lower alkoxy, or aralkyloxy, or any adjoining two of them are combined to form methylenedioxy; R.sup.10 represents hydrogen or lower alkyl; and Y and Z independently represent N or C--R.sup.11 (wherein R.sup.11 represents hydrogen, substituted or unsubstituted lower alkyl, or halogen),or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明涉及腺苷摄取抑制剂和用于心肌保护或预防或治疗炎性水肿的药剂，其包含由式（I）表示的1,2,3,4-四氢-2,4-二氧代喹唑啉衍生物：（I）其中R 1表示氢，取代或未取代的低级烷基，烯基或取代或未取代的芳烷基; R2，R3，R4和R5独立地表示氢，卤素，氨基，一或二（低级烷基）氨基，低级烷酰基氨基，硝基，氰基，取代或未取代的低级烷基，羟基，低级烷氧基，低级烷硫基，羧基，低级烷氧基羰基，低级烷酰基，芳烷氧基或低级烷酰氧基; R 6，R 7，R 8和R 9独立地表示氢，羟基，取代或未取代的低级烷氧基或芳烷氧基，或者它们中的任何相邻的两个被结合形成亚甲二氧基; R 10表示氢或低级烷基; 并且Y和Z独立地表示作为活性成分的N或C-R11（其中R11表示氢，取代或未取代的低级烷基或卤素）或其药学上可接受的盐。

77. 发明授权

US5142096A 2,4-dihydroxy-3,5,6-trimethylbenzoic acid compounds 失效
标题翻译： 2,4-二羟基-3,5,6-三甲基苯甲酸化合物
公开(公告)号：US5142096A
公开(公告)日：1992-08-25
申请号：US329329
申请日：1989-03-27
申请人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
发明人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
IPC分类号： C07C323/20 , C07C327/26 , C12P7/00
CPC分类号： C07C327/26 , C07C323/20 , C12P7/00
摘要： KS-506a, KS-506x and KS-506g having an activity to inhibit cyclic nucleotide phosphodiesterase and KS-506m and KS-506h having an activity to inhibit histamine release are produced by culturing a microorganism belonging to the genus Mortierella.

78. 发明授权

US5079232A Compound KS-505 useful for improving cerebral function 失效
标题翻译：化合物KS-505有助于改善小脑功能
公开(公告)号：US5079232A
公开(公告)日：1992-01-07
申请号：US447891
申请日：1989-12-08
申请人： Keiko Ohsawa , Satoshi Nakanishi , Hiroshi Kase , Isao Kawamoto , Tohru Yasuzawa , Yutaka Saito , Hiroshi Sano , Shizuo Shiozaki , Katsuichi Shutoh
发明人： Keiko Ohsawa , Satoshi Nakanishi , Hiroshi Kase , Isao Kawamoto , Tohru Yasuzawa , Yutaka Saito , Hiroshi Sano , Shizuo Shiozaki , Katsuichi Shutoh
IPC分类号： C07H15/26 , C12P19/62
CPC分类号： C07H15/26 , C12P19/62
摘要： A new compound designated KS-505 having amnesia-inhibiting activity may be prepared by fermentation of a suitable strain of Streptomyces, preferably Streptomyces argenteolus A-2 (FERM BP-2065). The compound is thought to have the structure: ##STR1##

79. 发明授权

US4983775A Novel substances KS-504a, KS-504b, KS-504d and KS-504e and process for their preparation 失效
标题翻译：新型物质KS-504a，KS-504b，KS-504d和KS-504e及其制备方法
公开(公告)号：US4983775A
公开(公告)日：1991-01-08
申请号：US465893
申请日：1990-01-16
申请人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
发明人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
IPC分类号： C07C35/48 , C07C45/58 , C07C47/46 , C07D303/48 , C12P7/02 , C12P7/24 , C12P17/02
CPC分类号： C12R1/645 , C07C35/48 , C07C45/58 , C07C47/46 , C07D303/48 , C12P17/02 , C12P7/02 , C12P7/24
摘要： Novel physiologically active substances Ks-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.

80. 发明授权

US4962125A Novel substance KS-619-1, preparation process and pharmaceutical composition 失效
标题翻译：新型物质KS-619-1，制备方法和药物组成
公开(公告)号：US4962125A
公开(公告)日：1990-10-09
申请号：US235654
申请日：1988-08-24
申请人： Hiroshi Kase , Yuzuru Matauda , Kunikatsu Shirahata , Toru Yasuzawa , Koji Yamada
发明人： Hiroshi Kase , Yuzuru Matauda , Kunikatsu Shirahata , Toru Yasuzawa , Koji Yamada
IPC分类号： C07G99/00 , A61K31/19 , A61K35/74 , A61P9/08 , C12P1/06 , C12P29/00 , C12R1/465
CPC分类号： C12P1/06
摘要： A novel physiologically active substance KS-619-1 having a vasodilative activity is produced by culturing Streptomyces californicus ATCC 3312.
摘要翻译：具有血管扩张活性的新型生理活性物质KS-619-1是通过培养加利福尼亚镰刀菌（Streptomyces californicus）ATCC 3312产生的。

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