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71. 发明申请

US20100178692A1 MODEL CELL CHIP, APPARATUS FOR EVALUATING DRUG EFFECT USING THE MODEL CELL CHIP AND METHOD OF EVALUATING DRUG EFFECT 有权
标题翻译：模型细胞芯片，使用模型细胞芯片评估药物效应的装置和评估药物效应的方法
公开(公告)号：US20100178692A1
公开(公告)日：2010-07-15
申请号：US12663468
申请日：2008-06-06
申请人： Kenji Yasuda , Atsushi Sugiyama , Kentaro Ando , Fumimasa Nomura , Hideyuki Terazono , Tomoyuki Kaneko , Mamoru Fukushima
发明人： Kenji Yasuda , Atsushi Sugiyama , Kentaro Ando , Fumimasa Nomura , Hideyuki Terazono , Tomoyuki Kaneko , Mamoru Fukushima
IPC分类号： C12M1/34
CPC分类号： G01N33/5061 , C12N2503/02 , G01N33/4836 , G01N33/54366
摘要： The present invention provides an apparatus for evaluating a drug effect enabling on-chip evaluation of the effect of a drug while the drug is acting on hERG-expressing cells. The present invention also provides a myocardial toxicity test apparatus and method therefor enabling in vitro myocardial toxicity testing that has previously been performed in vivo.A pulsating cell population and hERG-expressing cells (target model cells) are suitably isolated and arranged on a transparent substrate so that the two form gap junctions. The hERG-expressing cells are arranged on transparent electrodes provided on the transparent substrate. The hERG-expressing cells are exposed to a flow of a liquid containing a drug such that the drug acts thereon. The difference between the normal pulsation of hERG-expressing cells and the pulsation when a drug is acting thereon is captured via electric signals obtained from electrodes, and the properties of the change in potential are evaluated.
摘要翻译：本发明提供了一种药物效应评价装置，其能够在药物作用于表达hERG的细胞的同时对药物的作用进行片上评价。本发明还提供一种心肌毒性试验装置及其方法，其能够进行体外心肌毒性试验，其先前已在体内进行。脉动细胞群体和表达hERG的细胞（靶模型细胞）被适当地分离并排列在透明基底上，使得两个形成间隙连接。 hERG表达细胞设置在设置在透明基板上的透明电极上。将表达hERG的细胞暴露于含有药物的液体流中，使药物作用于其上。通过从电极获得的电信号捕获hERG表达细胞的正常脉动与药物作用于其上的脉动之间的差异，并评估电位变化的性质。

72. 发明申请

US20100016569A1 CELLOMICS SYSTEM 审中-公开
公开(公告)号：US20100016569A1
公开(公告)日：2010-01-21
申请号：US12472010
申请日：2009-05-26
申请人： Kazunori Okano , Kenji Yasuda
发明人： Kazunori Okano , Kenji Yasuda
IPC分类号： C07H21/04 , C40B40/08
CPC分类号： B01L7/50 , A01N1/0284 , G01N33/5061 , G01N33/566
摘要： In labeling a cell, and separating and collecting the cell according to a degree of the labeling using a cell separator, effects on the cell is minimized and the use of the collected cell is facilitated, thereby, when labeling a cell, the cell is labeled in the state where interaction of each cell is retained. In the labeling, a specific labeling material present on a surface of a target cell is taken in the cell via a transporter, and the cell is dispersed one by one to separate the same with a cell separator. Immediately after the separation, the cell is put in a solution not containing the specific labeling substance to remove the specific labeling substance taken in the cell. This series of steps is continuously conducted with a cell separation chip.

73. 发明申请

US20090325215A1 CELLOMICS SYSTEM 审中-公开
公开(公告)号：US20090325215A1
公开(公告)日：2009-12-31
申请号：US12472037
申请日：2009-05-26
申请人： Kazunori Okano , Kenji Yasuda
发明人： Kazunori Okano , Kenji Yasuda
IPC分类号： C12Q1/02 , C12M1/00
CPC分类号： B01L7/50 , A01N1/0284 , G01N33/5061 , G01N33/566
摘要： In labeling a cell, and separating and collecting the cell according to a degree of the labeling using a cell separator, effects on the cell is minimized and the use of the collected cell is facilitated, thereby, when labeling a cell, the cell is labeled in the state where interaction of each cell is retained. In the labeling, a specific labeling material present on a surface of a target cell is taken in the cell via a transporter, and the cell is dispersed one by one to separate the same with a cell separator. Immediately after the separation, the cell is put in a solution not containing the specific labeling substance to remove the specific labeling substance taken in the cell. This series of steps is continuously conducted with a cell separation chip.

74. 发明授权

US07400753B2 Biological sample optical measuring method and biological sample optical measuring apparatus 有权
标题翻译：生物样品光学测量方法和生物样品光学测量仪器
公开(公告)号：US07400753B2
公开(公告)日：2008-07-15
申请号：US10482614
申请日：2001-07-03
申请人： Taisaku Seino , Satoshi Takahashi , Kenji Yasuda , Yoshitada Oshida
发明人： Taisaku Seino , Satoshi Takahashi , Kenji Yasuda , Yoshitada Oshida
IPC分类号： G06K9/00
CPC分类号： G01N21/6456 , G01N15/1475 , G01N21/6428 , G01N21/76 , G01N2021/1734 , G01N2021/6439 , G01N2021/6491
摘要： A fluorescent or luminescence image of at least part of a biological sample is imaged, then a transmission light image of at least part of the biological sample is imaged, and thereafter the fluorescent or luminescence image and the transmission light image are overlaid such that the identical area of the sample is coincided to display. The present invention allows detecting the accurate location of fluorescence or luminescence in a given part of the biological sample.
摘要翻译：将生物样品的至少一部分的荧光或发光图像成像，然后对生物样品的至少一部分的透射光图像进行成像，然后将荧光或发光图像和透射光图像重叠，使得相同样品的面积一致显示。本发明允许检测生物样品的给定部分中的荧光或发光的准确位置。

75. 发明申请

US20070154938A1 Method of inspecting a DNA chip and apparatus thereof 有权
标题翻译：检查DNA芯片的方法及其装置
公开(公告)号：US20070154938A1
公开(公告)日：2007-07-05
申请号：US11709120
申请日：2007-02-22
申请人： Yoshitada Oshida , Toshihiko Nakata , Tomoaki Sakata , Kenji Yasuda , Satoshi Takahashi
发明人： Yoshitada Oshida , Toshihiko Nakata , Tomoaki Sakata , Kenji Yasuda , Satoshi Takahashi
IPC分类号： C12Q1/68 , G01J3/42
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/6456 , Y10S436/80 , Y10T436/143333
摘要： A DNA inspecting apparatus including driving means for relatively changing positions of the multi-spot lights and a position of the DNA chip so as to detect the fluorescent lights in such a manner that a desired area on the DNA chip is irradiated with the multi-spot lights, and a control system for determining and inspecting DNA information about the to-be-inspected DNA chip from fluorescent light intensities and fluorescent light positions of the desired area on the DNA chip, the fluorescent light intensities and the fluorescent light positions being detected by the driving means and the fluorescent light detecting means.
摘要翻译：一种DNA检查装置，包括用于相对改变多点灯位置的驱动装置和DNA芯片的位置，以便以这样的方式检测荧光，使得DNA芯片上的期望区域被多点照射灯和用于从DNA芯片上的期望区域的荧光强度和荧光灯位置确定和检查关于待检查DNA芯片的DNA信息的控制系统，荧光强度和荧光灯位置由驱动装置和荧光检测装置。

76. 发明授权

US07092154B2 Apparatus for microscopic observation of long-term culture of single cell 有权
标题翻译：用于显微镜观察单细胞长期培养的装置
公开(公告)号：US07092154B2
公开(公告)日：2006-08-15
申请号：US10432396
申请日：2001-11-22
申请人： Kenji Yasuda , Kunihiko Kaneko , Tetsuya Yomo , Ippei Inoue , Yuichi Wakamoto
发明人： Kenji Yasuda , Kunihiko Kaneko , Tetsuya Yomo , Ippei Inoue , Yuichi Wakamoto
IPC分类号： G01N21/01 , G02B21/34
CPC分类号： C12M25/02 , B01L3/502 , C12M25/00 , C12M41/36 , C12M41/46 , G01N35/028 , G01N35/1002 , G02B21/34
摘要： An apparatus is provided with a cell culture container having a cell culture region made of a hole formed on a substrate, a semi-permeable membrane covering a top plane of the cell culture region and a culture medium replacement part provided over the semi-permeable membrane, a mechanism for supplying a cell culture medium into the cell culture container, and a microscopic optical mechanism for enabling long-term observation of the cell within the cell culture region. This apparatus makes it possible to culture a cell group originating from a particular single cell, to perform culture and observation while identifying cells to be subjected to interaction during the process of culturing cells, and observe a difference in variation between the particular cell and other cells. There is also provided a mechanism which makes it possible to collect only a cell assuming a particular state and perform analysis or biochemical measurement of a gene of the cell, an expressed mRNA and the like.
摘要翻译：本发明提供一种细胞培养容器，该细胞培养容器具有由形成在基材上的孔形成的细胞培养区域，覆盖细胞培养区域的顶面的半透膜和设置在半透膜上的培养基置换部件用于向细胞培养容器供给细胞培养基的机理，以及能够长期观察细胞培养区域内的细胞的微观光学机构。该装置可以培养来自特定单细胞的细胞群，进行培养和观察，同时确定在培养细胞过程中待相互作用的细胞，并观察特定细胞与其它细胞之间的差异。还提供了一种使得可以仅收集假设特定状态的细胞并进行细胞基因，表达的mRNA等的分析或生物化学测量的机制。

77. 发明申请

US20060039828A1 Droplet operation device 失效
标题翻译：液滴操作装置
公开(公告)号：US20060039828A1
公开(公告)日：2006-02-23
申请号：US10525521
申请日：2003-08-26
申请人： Kenji Yasuda , Takanori Ichiki , Kazunori Okano
发明人： Kenji Yasuda , Takanori Ichiki , Kazunori Okano
IPC分类号： G01N21/00
CPC分类号： B01F13/0071 , B01F13/0076 , B01L3/502792 , B01L2300/089 , B01L2400/0415 , G01N15/1468 , G01N35/00029 , G01N2015/149 , G01N2035/0097 , Y10T436/2575
摘要： A droplet operation device having a substrate having a light transmissibility and subjected to a water repellent treatment, a means for supplying droplets onto the substrate, a means for transporting the droplets on the water repellent substrate, and a means for measuring the state of the droplets, comprising the light transmittable substrate (11) receiving the water repellent treatment on the surface thereof, solvent feeding ports (21), (22), and (23) for leading reagent or specimen droplets (51) onto the substrate (11), optical measuring units (61), (62), and (63), and electric field application units (71), (72), and (73), whereby the inside of the droplets can be observed with a microscope, and the results of the reaction of the droplets against the other droplets can be measured and classified by stopping and moving the droplets in any direction.
摘要翻译：一种液滴操作装置，具有具有透光性且进行防水处理的基板，用于将液滴供给到基板上的装置，用于在憎水基板上输送液滴的装置，以及用于测量液滴状态的装置包括在其表面上接受防水处理的透光性基材（11），将试剂或试样液滴（51）引导到基材（11）上的溶剂供给口（21），（22）和（23）光学测量单元（61），（62）和（63）以及电场施加单元（71），（72）和（73），由此可以用显微镜观察液滴的内部，结果可以通过在任何方向上停止和移动液滴来测量和分类液滴对其他液滴的反应。

78. 发明申请

US20050272039A1 Nucleic acid analysis chip and nucleic acid analyzer 审中-公开
标题翻译：核酸分析芯片和核酸分析仪
公开(公告)号：US20050272039A1
公开(公告)日：2005-12-08
申请号：US10525876
申请日：2003-08-26
申请人： Kenji Yasuda
发明人： Kenji Yasuda
IPC分类号： G01N21/64 , C07H21/00 , C12M1/00 , G01N21/03 , G01N21/17 , G01N33/483 , G01N33/53 , C12Q1/68 , C12M1/34
CPC分类号： C07H21/00
摘要： Means for performing direct quantitative analysis of the components of nucleic acids of cell 103 placed in a well as culture container (102) of a cell culture microchamber, comprising means for optically measuring each of the culture containers (102) of cell culture microchamber, means for effecting optical heating, means for introducing a reaction fluid in each of the culture containers (102) of cell culture microchamber and means for inhibiting diffusion and evaporation of the reaction fluid in each of the culture containers (102). These enable analyzing the components of nucleic acids of each of the cells cultured in single-cell culture microchamber.
摘要翻译：用于对放置在细胞培养物微室的培养容器（102）的孔中的细胞103的核酸成分进行直接定量分析的方法，包括用于光学测量细胞培养物微室的培养容器（102）的装置，用于实现光学加热的装置，用于在细胞培养微量室的每个培养容器（102）中引入反应流体的装置和用于抑制每个培养容器（102）中的反应流体的扩散和蒸发的装置。这些能够分析在单细胞培养微量室中培养的每种细胞的核酸成分。

79. 发明申请

US20050069874A1 Method and system for offering gene analysis information and autentication identification method 审中-公开
标题翻译：提供基因分析信息和自动识别方法的方法和系统
公开(公告)号：US20050069874A1
公开(公告)日：2005-03-31
申请号：US10432932
申请日：2000-11-30
申请人： Kenji Yasuda , Yuichi Takegawa
发明人： Kenji Yasuda , Yuichi Takegawa
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00 , G06F19/28 , G06F17/60
CPC分类号： G06Q50/24 , G16B50/00 , G16H10/40
摘要： A service of analyzing a homo gene is offered in the form conforming to the requirement of the customer. A service of carrying out gene analysis required by the customer through an electronic request method. A gene information access center is set up, where the gene and its analysis information of the customer is stored. The gene is analyzed in response to the request of the customer and the result is provided. Information meeting the needs of the customer from among a huge amount of information on genome genes is provided with time and in phase.
摘要翻译：以符合客户要求的形式提供分析同源基因的服务。通过电子请求方式进行客户要求的基因分析服务。建立基因信息访问中心，存储客户的基因及其分析信息。根据客户的要求分析基因，并提供结果。提供了从大量基因组基因信息中满足客户需求的信息，并且提供了时间和相位。

80. 发明授权

US06760105B2 Method and apparatus for inspecting DNA and method for detecting fluorescence 有权
标题翻译：检测DNA的方法和装置及荧光检测方法
公开(公告)号：US06760105B2
公开(公告)日：2004-07-06
申请号：US10053976
申请日：2002-01-18
申请人： Yoshitada Oshida , Satoshi Takahashi , Taisaku Seino , Kenji Yasuda
发明人： Yoshitada Oshida , Satoshi Takahashi , Taisaku Seino , Kenji Yasuda
IPC分类号： G01N2164
CPC分类号： G01N21/6452 , G01N21/6428 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441
摘要： A DNA sample added with a plurality of fluorescent marks is irradiated with excitation lights having a plurality of wavelengths and when fluorescence intensities are detected separately, the excitation light and a position on the sample are relatively changed over a desired area once to thereby detect the plurality of fluorescent marks at high speed.
摘要翻译：用多个荧光标记添加的DNA样品用具有多个波长的激发光照射，并且当单独检测荧光强度时，激发光和样品上的位置在期望的区域上相对地改变一次，从而检测多个的荧光标记。

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