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71. 发明授权

US5874285A Polynucleotide encoding a novel human nm23-like protein 失效
公开(公告)号：US5874285A
公开(公告)日：1999-02-23
申请号：US713825
申请日：1996-09-13
申请人： Olga Bandman , Phillip R. Hawkins
发明人： Olga Bandman , Phillip R. Hawkins
IPC分类号： A61K38/00 , C12N1/21 , C12N9/12 , C07H21/02 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N9/12 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode a novel human nm23-like protein (H-nm23). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding H-nm23 and for a method for producing the protein. The invention also provides for the use of substantially purified H-nm23 for the treatment of diseases associated with the expression of H-nm23. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding H-nm23 and antibodies which specifically bind to the protein.

72. 发明授权

US5869289A Human galectin homolog 失效
标题翻译：人半乳凝胶同源物
公开(公告)号：US5869289A
公开(公告)日：1999-02-09
申请号：US728521
申请日：1996-10-09
申请人： Phillip R. Hawkins , Olga Bandman
发明人： Phillip R. Hawkins , Olga Bandman
IPC分类号： C07K14/47 , C12N15/00 , C12N15/63 , C12N15/85 , C12Q1/68
CPC分类号： C07K14/4726
摘要： The present invention provides a polynucleotide which identifies and encodes a novel human galectin-8. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding human galectin-8. The invention also provides for the production and use of substantially purified human galectin-8 in pharmaceutical compositions to increase immune responses. The invention also provides for the use of antisense molecules and antibodies in pharmaceutical compositions to decrease immune response. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts and/or genomic DNA encoding human galectin-8 and anti-human galectin-8 antibodies which specifically bind to human galectin-8.
摘要翻译：本发明提供鉴定和编码新型人半乳凝素-8的多核苷酸。本发明提供了包含编码人半乳凝素-8的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供在药物组合物中生产和使用基本纯化的人半乳凝素-8以增加免疫应答。本发明还提供在药物组合物中使用反义分子和抗体来降低免疫应答。本发明还描述了利用多核苷酸与编码人galectin-8和特异性结合人galectin-8的抗人galectin-8抗体的转录物和/或基因组DNA杂交的诊断测定法。

73. 发明授权

US5861496A Human squalene epoxidase 失效
标题翻译：人角鲨烯环氧酶
公开(公告)号：US5861496A
公开(公告)日：1999-01-19
申请号：US745934
申请日：1996-11-07
申请人： Jennifer L. Hillman , Phillip R. Hawkins
发明人： Jennifer L. Hillman , Phillip R. Hawkins
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K38/44 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/06 , A61P9/10 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N15/09 , C12N15/53 , C12Q1/68 , G01N33/566 , C12N15/63 , C12N15/70
CPC分类号： C12N9/0083 , A61K38/00
摘要： The present invention provides a human squalene epoxidase (HSQEP) and polynucleotides which identify and encode HSQEP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HSQEP and a method for producing HSQEP. The invention also provides for the use of HSQEP and agonists, antibodies, or antagonists specifically binding HSQEP, in the prevention and treatment of diseases associated with expression of HSQEP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HSQEP for the treatment of diseases associated with the expression of HSQEP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HSQEP.
摘要翻译：本发明提供人角鲨烯环氧酶（HSQEP）和识别和编码HSQEP的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HSQEP的核酸序列和生产HSQEP的方法。本发明还提供HSQEP和激动剂，抗体或特异性结合HSQEP的拮抗剂在预防和治疗与HSQEP表达相关的疾病中的用途。另外，本发明提供反义分子用于编码HSQEP的多核苷酸用于治疗与HSQEP表达相关的疾病。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HSQEP的抗体的诊断测定法。

74. 发明授权

US5856128A Human nucleic acid binding protein 失效
公开(公告)号：US5856128A
公开(公告)日：1999-01-05
申请号：US698407
申请日：1996-08-15
申请人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61K38/00 , C07K14/47 , C12N15/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode a novel human nucleic acid binding protein (NABP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NABP. The invention also provides for the use of substantially purified NABP or its antagonists, in pharmaceutical compositions for the treatment of diseases associated with the expression of NABP. Additionally, the invention provides for the use of antisense molecules to NABP in pharmaceutical compositions for treatment of diseases associated with the expression of NABP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding NABP or anti-NABP antibodies which specifically bind to NABP.

75. 发明授权

US5840544A DNA encoding rantes homolog from prostate 失效
标题翻译：编码前列腺同源物的DNA
公开(公告)号：US5840544A
公开(公告)日：1998-11-24
申请号：US633682
申请日：1996-04-17
申请人： Phillip R. Hawkins , Olga Bandman , Lynn E. Murry
发明人： Phillip R. Hawkins , Olga Bandman , Lynn E. Murry
IPC分类号： C12N15/02 , A61K31/00 , A61K38/00 , A61K45/00 , A61K48/00 , A61P11/00 , A61P11/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P37/08 , C07K14/52 , C07K14/715 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566
CPC分类号： C07K14/523 , A61K38/00 , A61K48/00 , C12N2799/026 , Y10S930/14
摘要： The present invention provides a polynucleotide PTEC (prostate expressed chemokine) isolated from a prostate cDNA library which identifies and encodes a novel human rantes homolog PTEC (prostate expressed chemokine). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PTEC. The invention also provides for the therapeutic use of purified PTEC in the treatment of immune deficiency diseases, and for the therapeutic use of antisense molecules, antibodies, antagonists or inhibitors in the treatment of conditions or diseases associated with the expression of PTEC. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, or fragments thereof, or antibodies which specifically bind to the polypeptide.
摘要翻译：本发明提供从前列腺cDNA文库分离的多肽PTEC（前列腺表达的趋化因子），该文库鉴定并编码新的人类同源物PTEC（前列腺表达的趋化因子）。本发明提供了包含编码PTEC的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了纯化的PTEC在治疗免疫缺陷疾病中的治疗用途，以及用于治疗与PTEC表达相关的病症或疾病的反义分子，抗体，拮抗剂或抑制剂的治疗用途。本发明还描述了利用包含特异性结合多肽的多核苷酸或其片段或抗体的诊断组合物的诊断测定法。

76. 发明授权

US5837493A Human galectins 失效
标题翻译：人类半乳凝素
公开(公告)号：US5837493A
公开(公告)日：1998-11-17
申请号：US788584
申请日：1997-01-23
申请人： Jennifer L. Hillman , Surya K. Goli , Olga Bandman , Phillip R. Hawkins , Joanne R. Petithory
发明人： Jennifer L. Hillman , Surya K. Goli , Olga Bandman , Phillip R. Hawkins , Joanne R. Petithory
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C12N15/00 , C07H21/04 , C12N1/20
CPC分类号： C07K14/4726 , A61K38/00
摘要： The present invention provides two novel human galectins (designated individually as GAL-5HA and GAL-5HB, and collectively as GAL-5H) and polynucleotides which identify and encode GAL-5H. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding GAL-5H and a method for producing GAL-5H. The invention also provides for use of GAL-5H and agonists, antibodies, or antagonists specifically binding GAL-5H, in the prevention and treatment of diseases associated with expression of GAL-5H. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding GAL-5H for the treatment of diseases associated with the expression of GAL-5H. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding GAL-5H.
摘要翻译：本发明提供两种新型人半乳凝素（单独命名为GAL-5HA和GAL-5HB，统称为GAL-5H）和识别和编码GAL-5H的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码GAL-5H的核酸序列和产生GAL-5H的方法。本发明还提供使用GAL-5H和特异性结合GAL-5H的激动剂，抗体或拮抗剂来预防和治疗与GAL-5H表达相关的疾病。另外，本发明提供了反义分子用于编码GAL-5H的多核苷酸用于治疗与GAL-5H表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合GAL-5H的抗体的诊断测定法。

77. 发明授权

US5747319A Human mRNA editing enzyme 失效
标题翻译：人类mRNA编辑酶
公开(公告)号：US5747319A
公开(公告)日：1998-05-05
申请号：US687895
申请日：1996-07-25
申请人： Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： C12N15/09 , A61K31/711 , A61K35/76 , A61K38/00 , A61K38/43 , A61K48/00 , A61P9/10 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/28 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/22 , C07H21/04 , C12N5/00 , C12N15/63
CPC分类号： C12N9/00 , A61K38/00
摘要： The present invention provides a polynucleotide which identifies and encodes a novel human mRNA editing enzyme (REE). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding REE. The invention also provides for the use of substantially purified REE and its agonists, antagonists, or inhibitors in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of REE. Additionally, the invention provides for the use of antisense molecules to REE in pharmaceutical compositions for treatment of diseases associated with the expression of REE. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding REE or anti-REE antibodies which specifically bind to REE.
摘要翻译：本发明提供鉴定和编码新的人mRNA编辑酶（REE）的多核苷酸。本发明提供了包含编码REE的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了在商业生产重组蛋白质和用于治疗与REE表达有关的疾病的药物组合物中使用基本上纯化的REE及其激动剂，拮抗剂或抑制剂。此外，本发明提供了用于治疗与REE表达相关的疾病的药物组合物中REE的反义分子的用途。本发明还描述了使用包含多核苷酸，其片段或其互补物的诊断组合物的诊断测定法，其与编码特异性结合REE的REE或抗REE抗体的多核苷酸的基因组序列或转录物杂交。

78. 发明授权

US5739009A Adipocyte-specific differentiation-related protein 失效
标题翻译：脂肪细胞特异性分化相关蛋白
公开(公告)号：US5739009A
公开(公告)日：1998-04-14
申请号：US764343
申请日：1996-12-12
申请人： Jennifer L. Hillman , Phillip R. Hawkins
发明人： Jennifer L. Hillman , Phillip R. Hawkins
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12Q1/68 , C07K14/435 , C12N15/86
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a human adipocyte-specific differentiation-related protein (HADRP) and polynucleotides which identify and encode HADRP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HADRP and a method for producing HADRP. The invention also provides for agonists, antibodies, or antagonists specifically binding HADRP, and their use, in the prevention and treatment of diseases associated with expression of HADRP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HADRP for the treatment of diseases associated with the expression of HADRP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HADRP.
摘要翻译：本发明提供了鉴定和编码HADRP的人类脂肪细胞特异性分化相关蛋白（HADRP）和多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HADRP的核酸序列和生产HADRP的方法。本发明还提供了特异性结合HADRP的激动剂，抗体或拮抗剂及其在预防和治疗与HADRP表达有关的疾病中的用途。另外，本发明提供反义分子用于编码HADRP的多核苷酸用于治疗与HADRP表达相关的疾病。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HADRP的抗体的诊断测定法。

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